{"id":"https://openalex.org/W4367320794","doi":"https://doi.org/10.1109/jbhi.2023.3271611","title":"Artificial Intelligence-Based Model for Predicting the Minimum Inhibitory Concentration of Antibacterial Peptides Against ESKAPEE Pathogens","display_name":"Artificial Intelligence-Based Model for Predicting the Minimum Inhibitory Concentration of Antibacterial Peptides Against ESKAPEE Pathogens","publication_year":2023,"publication_date":"2023-04-28","ids":{"openalex":"https://openalex.org/W4367320794","doi":"https://doi.org/10.1109/jbhi.2023.3271611","pmid":"https://pubmed.ncbi.nlm.nih.gov/37115837"},"language":"en","primary_location":{"id":"doi:10.1109/jbhi.2023.3271611","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2023.3271611","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035200740","display_name":"Ritesh Sharma","orcid":"https://orcid.org/0000-0002-8542-5096"},"institutions":[{"id":"https://openalex.org/I56404289","display_name":"Indian Institute of Technology BHU","ror":"https://ror.org/01kh5gc44","country_code":"IN","type":"education","lineage":["https://openalex.org/I56404289"]},{"id":"https://openalex.org/I91357014","display_name":"Banaras Hindu University","ror":"https://ror.org/04cdn2797","country_code":"IN","type":"education","lineage":["https://openalex.org/I91357014"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Ritesh Sharma","raw_affiliation_strings":["Department of Computer Science and Engineering, Indian Institute of Technology, BHU, Varanasi, India"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, Indian Institute of Technology, BHU, Varanasi, India","institution_ids":["https://openalex.org/I56404289","https://openalex.org/I91357014"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060733665","display_name":"Sameer Shrivastava","orcid":"https://orcid.org/0000-0001-8296-0010"},"institutions":[{"id":"https://openalex.org/I185790649","display_name":"Indian Veterinary Research Institute","ror":"https://ror.org/02jcfzc36","country_code":"IN","type":"facility","lineage":["https://openalex.org/I179420787","https://openalex.org/I185790649"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sameer Shrivastava","raw_affiliation_strings":["Division of Veterinary Biotechnology, ICAR-Indian Veterinary Research Institute, Izatnagar, India"],"affiliations":[{"raw_affiliation_string":"Division of Veterinary Biotechnology, ICAR-Indian Veterinary Research Institute, Izatnagar, India","institution_ids":["https://openalex.org/I185790649"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100696254","display_name":"Sanjay Kumar Singh","orcid":"https://orcid.org/0000-0002-9061-6313"},"institutions":[{"id":"https://openalex.org/I56404289","display_name":"Indian Institute of Technology BHU","ror":"https://ror.org/01kh5gc44","country_code":"IN","type":"education","lineage":["https://openalex.org/I56404289"]},{"id":"https://openalex.org/I91357014","display_name":"Banaras Hindu University","ror":"https://ror.org/04cdn2797","country_code":"IN","type":"education","lineage":["https://openalex.org/I91357014"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sanjay Kumar Singh","raw_affiliation_strings":["Department of Computer Science and Engineering, Indian Institute of Technology, BHU, Varanasi, India"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, Indian Institute of Technology, BHU, Varanasi, India","institution_ids":["https://openalex.org/I56404289","https://openalex.org/I91357014"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101860102","display_name":"Abhinav Kumar","orcid":"https://orcid.org/0000-0001-9741-4020"},"institutions":[{"id":"https://openalex.org/I56404289","display_name":"Indian Institute of Technology BHU","ror":"https://ror.org/01kh5gc44","country_code":"IN","type":"education","lineage":["https://openalex.org/I56404289"]},{"id":"https://openalex.org/I91357014","display_name":"Banaras Hindu University","ror":"https://ror.org/04cdn2797","country_code":"IN","type":"education","lineage":["https://openalex.org/I91357014"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Abhinav Kumar","raw_affiliation_strings":["Department of Computer Science and Engineering, Indian Institute of Technology, BHU, Varanasi, India"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, Indian Institute of Technology, BHU, Varanasi, India","institution_ids":["https://openalex.org/I56404289","https://openalex.org/I91357014"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100634925","display_name":"Amit Kumar Singh","orcid":"https://orcid.org/0000-0001-7359-2068"},"institutions":[{"id":"https://openalex.org/I11793825","display_name":"National Institute of Technology Patna","ror":"https://ror.org/056wyhh33","country_code":"IN","type":"education","lineage":["https://openalex.org/I11793825","https://openalex.org/I4210152752"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Amit Kumar Singh","raw_affiliation_strings":["Department of Computer Science and Engineering, National Institute of Technology, Patna, India"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, National Institute of Technology, Patna, India","institution_ids":["https://openalex.org/I11793825"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062501121","display_name":"Sonal Saxena","orcid":"https://orcid.org/0000-0001-6501-3097"},"institutions":[{"id":"https://openalex.org/I185790649","display_name":"Indian Veterinary Research Institute","ror":"https://ror.org/02jcfzc36","country_code":"IN","type":"facility","lineage":["https://openalex.org/I179420787","https://openalex.org/I185790649"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sonal Saxena","raw_affiliation_strings":["Division of Veterinary Biotechnology, ICAR-Indian Veterinary Research Institute, Izatnagar, India"],"affiliations":[{"raw_affiliation_string":"Division of Veterinary Biotechnology, ICAR-Indian Veterinary Research Institute, Izatnagar, India","institution_ids":["https://openalex.org/I185790649"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5035200740"],"corresponding_institution_ids":["https://openalex.org/I56404289","https://openalex.org/I91357014"],"apc_list":null,"apc_paid":null,"fwci":3.0875,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.91633552,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"28","issue":"4","first_page":"1949","last_page":"1958"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9866999983787537,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6299117803573608},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5690078735351562},{"id":"https://openalex.org/keywords/transfer-of-learning","display_name":"Transfer of learning","score":0.5224305987358093},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5048109292984009},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"Antimicrobial peptides","score":0.49297022819519043},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.43129175901412964},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.39312267303466797},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3779529333114624},{"id":"https://openalex.org/keywords/antimicrobial","display_name":"Antimicrobial","score":0.36972856521606445},{"id":"https://openalex.org/keywords/microbiology","display_name":"Microbiology","score":0.16774216294288635}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6299117803573608},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5690078735351562},{"id":"https://openalex.org/C150899416","wikidata":"https://www.wikidata.org/wiki/Q1820378","display_name":"Transfer of learning","level":2,"score":0.5224305987358093},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5048109292984009},{"id":"https://openalex.org/C540938839","wikidata":"https://www.wikidata.org/wiki/Q1201508","display_name":"Antimicrobial peptides","level":3,"score":0.49297022819519043},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.43129175901412964},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39312267303466797},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3779529333114624},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.36972856521606445},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.16774216294288635}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/jbhi.2023.3271611","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2023.3271611","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},{"id":"pmid:37115837","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37115837","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE journal of biomedical and health informatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W2011615074","https://openalex.org/W2163316049","https://openalex.org/W2173732482","https://openalex.org/W2565686633","https://openalex.org/W2589065420","https://openalex.org/W2791848964","https://openalex.org/W2920961832","https://openalex.org/W2955305484","https://openalex.org/W2970152602","https://openalex.org/W2984592028","https://openalex.org/W2990340097","https://openalex.org/W2995514860","https://openalex.org/W3024693033","https://openalex.org/W3026779156","https://openalex.org/W3081784187","https://openalex.org/W3092660066","https://openalex.org/W3097405028","https://openalex.org/W3150808126","https://openalex.org/W3154253723","https://openalex.org/W3175581533","https://openalex.org/W3178663131","https://openalex.org/W3205595869","https://openalex.org/W3206489957","https://openalex.org/W3217372366","https://openalex.org/W4200038759","https://openalex.org/W4205376624","https://openalex.org/W4205689731","https://openalex.org/W4288356534","https://openalex.org/W4292092827","https://openalex.org/W4296793746","https://openalex.org/W4309769692","https://openalex.org/W6762357143","https://openalex.org/W6805241974"],"related_works":["https://openalex.org/W1973192249","https://openalex.org/W2354039930","https://openalex.org/W2044458410","https://openalex.org/W4375855538","https://openalex.org/W2388831772","https://openalex.org/W3087020980","https://openalex.org/W2107525095","https://openalex.org/W4211241221","https://openalex.org/W4206357785","https://openalex.org/W2511368942"],"abstract_inverted_index":{"In":[0],"response":[1],"to":[2,13,18,25,39,109,122,217],"environmental":[3],"threats,":[4],"pathogens":[5,21,149],"make":[6],"several":[7,79],"changes":[8],"in":[9,62,69,157],"their":[10],"genome,":[11],"leading":[12],"antimicrobial":[14],"resistance":[15],"(AMR).":[16],"Due":[17],"AMR,":[19],"the":[20,30,49,70,128,132,141,147,151,158,184,192,219],"do":[22,138],"not":[23,139],"respond":[24],"antibiotics.":[26,84,102],"Amongst":[27],"drug-resistant":[28],"pathogens,":[29],"ESKAPEE":[31,148],"group":[32],"of":[33,59,74,94,131,177,194],"bacteria":[34],"poses":[35],"a":[36,57,66,86,92,164,212],"major":[37],"threat":[38],"humans,":[40],"and":[41,107,171],"therefore":[42],"World":[43],"Health":[44],"Organization":[45],"has":[46,208],"given":[47],"them":[48],"highest":[50],"priority":[51],"status.":[52],"Antibacterial":[53],"peptides":[54,60],"(ABPs)":[55],"are":[56],"family":[58],"found":[61],"nature":[63],"that":[64,136,167],"play":[65],"crucial":[67],"role":[68],"innate":[71],"immune":[72],"systems":[73],"organisms.":[75],"These":[76],"ABPs":[77,111,125],"offer":[78],"advantages":[80],"over":[81],"widely":[82],"used":[83],"As":[85],"result,":[87],"they":[88,137],"have":[89],"recently":[90],"received":[91],"lot":[93],"attention":[95],"as":[96,211],"potential":[97],"replacements":[98],"for":[99,150],"currently":[100],"available":[101],"But":[103],"it":[104],"is":[105,135],"expensive":[106],"time-consuming":[108],"identify":[110],"from":[112],"natural":[113],"sources.":[114],"Thus,":[115],"wet":[116],"lab":[117],"researchers":[118],"employ":[119],"various":[120],"tools":[121,134],"screen":[123],"promising":[124],"rapidly.":[126],"However,":[127],"main":[129],"limitation":[130],"existing":[133],"provide":[140],"minimum":[142],"inhibitory":[143],"concentration":[144],"values":[145],"against":[146],"identified":[152],"ABP.":[153],"To":[154],"address":[155],"this,":[156],"current":[159],"work,":[160],"we":[161],"developed":[162],"ESKAPEE-MICpred,":[163],"two-input":[165],"model":[166,207],"utilizes":[168],"transfer":[169,195],"learning":[170,173,179,189,196],"ensemble":[172,178],"techniques.":[174],"The":[175,205],"concept":[176,193],"was":[180,197],"realized":[181,198],"by":[182,187,199],"combining":[183],"decisions":[185],"provided":[186],"deep":[188],"algorithms,":[190],"whereas":[191],"utilizing":[200],"pretrained":[201],"amino":[202],"acid":[203],"embeddings.":[204],"proposed":[206],"been":[209],"deployed":[210],"web":[213],"server":[214],"at":[215],"https://eskapee-micpred.anvil.app/":[216],"aid":[218],"scientific":[220],"community.":[221]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6}],"updated_date":"2026-04-16T08:26:57.006410","created_date":"2025-10-10T00:00:00"}
