{"id":"https://openalex.org/W4362692509","doi":"https://doi.org/10.1109/jbhi.2023.3265364","title":"A Structure-Guided Effective and Temporal-Lag Connectivity Network for Revealing Brain Disorder Mechanisms","display_name":"A Structure-Guided Effective and Temporal-Lag Connectivity Network for Revealing Brain Disorder Mechanisms","publication_year":2023,"publication_date":"2023-04-07","ids":{"openalex":"https://openalex.org/W4362692509","doi":"https://doi.org/10.1109/jbhi.2023.3265364","pmid":"https://pubmed.ncbi.nlm.nih.gov/37027258"},"language":"en","primary_location":{"id":"doi:10.1109/jbhi.2023.3265364","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2023.3265364","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058607404","display_name":"Zhengwang Xia","orcid":"https://orcid.org/0000-0002-6815-5856"},"institutions":[{"id":"https://openalex.org/I36399199","display_name":"Nanjing University of Science and Technology","ror":"https://ror.org/00xp9wg62","country_code":"CN","type":"education","lineage":["https://openalex.org/I36399199"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhengwang Xia","raw_affiliation_strings":["School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing, China"],"raw_orcid":"https://orcid.org/0000-0002-6815-5856","affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing, China","institution_ids":["https://openalex.org/I36399199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061274720","display_name":"Tao Zhou","orcid":"https://orcid.org/0000-0002-2592-1688"},"institutions":[{"id":"https://openalex.org/I36399199","display_name":"Nanjing University of Science and Technology","ror":"https://ror.org/00xp9wg62","country_code":"CN","type":"education","lineage":["https://openalex.org/I36399199"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Zhou","raw_affiliation_strings":["School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing, China"],"raw_orcid":"https://orcid.org/0000-0002-2592-1688","affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing, China","institution_ids":["https://openalex.org/I36399199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078588700","display_name":"Saqib Mamoon","orcid":"https://orcid.org/0000-0002-8392-5118"},"institutions":[{"id":"https://openalex.org/I36399199","display_name":"Nanjing University of Science and Technology","ror":"https://ror.org/00xp9wg62","country_code":"CN","type":"education","lineage":["https://openalex.org/I36399199"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Saqib Mamoon","raw_affiliation_strings":["School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing, China"],"raw_orcid":"https://orcid.org/0000-0002-8392-5118","affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing, China","institution_ids":["https://openalex.org/I36399199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019576971","display_name":"Amani Alfakih","orcid":"https://orcid.org/0009-0005-0168-0567"},"institutions":[{"id":"https://openalex.org/I36399199","display_name":"Nanjing University of Science and Technology","ror":"https://ror.org/00xp9wg62","country_code":"CN","type":"education","lineage":["https://openalex.org/I36399199"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Amani Alfakih","raw_affiliation_strings":["School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing, China","institution_ids":["https://openalex.org/I36399199"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037595310","display_name":"Jianfeng Lu","orcid":"https://orcid.org/0000-0002-9190-507X"},"institutions":[{"id":"https://openalex.org/I36399199","display_name":"Nanjing University of Science and Technology","ror":"https://ror.org/00xp9wg62","country_code":"CN","type":"education","lineage":["https://openalex.org/I36399199"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianfeng Lu","raw_affiliation_strings":["School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing, China"],"raw_orcid":"https://orcid.org/0000-0002-9190-507X","affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing, China","institution_ids":["https://openalex.org/I36399199"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I36399199"],"apc_list":null,"apc_paid":null,"fwci":2.4347,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.88877078,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"27","issue":"6","first_page":"2990","last_page":"3001"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.9939000010490417,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7417770624160767},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.6633350849151611},{"id":"https://openalex.org/keywords/lag","display_name":"Lag","score":0.5296204686164856},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5128090977668762},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.511608898639679},{"id":"https://openalex.org/keywords/brain-disease","display_name":"Brain disease","score":0.42060309648513794},{"id":"https://openalex.org/keywords/causal-model","display_name":"Causal model","score":0.4124296307563782},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3870604932308197},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.3410372734069824},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.20530694723129272},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.12503689527511597},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.11864060163497925}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7417770624160767},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.6633350849151611},{"id":"https://openalex.org/C75778745","wikidata":"https://www.wikidata.org/wiki/Q342626","display_name":"Lag","level":2,"score":0.5296204686164856},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5128090977668762},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.511608898639679},{"id":"https://openalex.org/C2991673738","wikidata":"https://www.wikidata.org/wiki/Q5062122","display_name":"Brain disease","level":3,"score":0.42060309648513794},{"id":"https://openalex.org/C11671645","wikidata":"https://www.wikidata.org/wiki/Q5054567","display_name":"Causal model","level":2,"score":0.4124296307563782},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3870604932308197},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3410372734069824},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.20530694723129272},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.12503689527511597},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11864060163497925},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/jbhi.2023.3265364","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2023.3265364","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},{"id":"pmid:37027258","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37027258","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE journal of biomedical and health informatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G7640495683","display_name":null,"funder_award_id":"BK20221487","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"},{"id":"https://openalex.org/G8249999852","display_name":null,"funder_award_id":"62172228","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322769","display_name":"Natural Science Foundation of Jiangsu Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1480908191","https://openalex.org/W1967699765","https://openalex.org/W2001334414","https://openalex.org/W2003704897","https://openalex.org/W2007369824","https://openalex.org/W2012423033","https://openalex.org/W2020245429","https://openalex.org/W2058227754","https://openalex.org/W2061564920","https://openalex.org/W2075727087","https://openalex.org/W2078204079","https://openalex.org/W2112151839","https://openalex.org/W2113762408","https://openalex.org/W2134963415","https://openalex.org/W2138905229","https://openalex.org/W2143426320","https://openalex.org/W2151226328","https://openalex.org/W2154480805","https://openalex.org/W2304929042","https://openalex.org/W2502203196","https://openalex.org/W2557632452","https://openalex.org/W2576036995","https://openalex.org/W2588147423","https://openalex.org/W2729610843","https://openalex.org/W2752012950","https://openalex.org/W2752072074","https://openalex.org/W2803679388","https://openalex.org/W2805998310","https://openalex.org/W2950085789","https://openalex.org/W2951582858","https://openalex.org/W2982051960","https://openalex.org/W2982155962","https://openalex.org/W2992364697","https://openalex.org/W3005600289","https://openalex.org/W3022315685","https://openalex.org/W3184179570","https://openalex.org/W4200259153","https://openalex.org/W4239510810","https://openalex.org/W6682361391","https://openalex.org/W6748689981"],"related_works":["https://openalex.org/W2167436245","https://openalex.org/W2327340211","https://openalex.org/W2027542625","https://openalex.org/W4292199793","https://openalex.org/W2282195379","https://openalex.org/W2089784006","https://openalex.org/W2295388821","https://openalex.org/W2102312026","https://openalex.org/W2885663991","https://openalex.org/W2071433170"],"abstract_inverted_index":{"Brain":[0],"network":[1,120],"provides":[2],"important":[3],"insights":[4],"for":[5,71],"the":[6,17,24,28,43,61,72,82,90,99,126,130,154,163,171,174],"diagnosis":[7,73],"of":[8,23,30,63,74,156,173],"many":[9],"brain":[10,18,31,50,75,94,104,134,157],"disorders,":[11],"and":[12,129],"how":[13],"to":[14,41,106,123,151],"effectively":[15],"model":[16],"structure":[19],"has":[20],"become":[21],"one":[22],"core":[25],"issues":[26],"in":[27,89,140],"domain":[29],"imaging":[32],"analysis.":[33],"Recently,":[34],"various":[35],"computational":[36],"methods":[37,79],"have":[38],"been":[39],"proposed":[40,175],"estimate":[42],"causal":[44,127],"relationship":[45],"(i.e.,":[46],"effective":[47,57,117],"connectivity)":[48],"between":[49,102,133],"regions.":[51],"Compared":[52],"with":[53],"traditional":[54],"correlation-based":[55],"methods,":[56],"connectivity":[58],"can":[59,137],"provide":[60,68],"direction":[62],"information":[64,70,91],"flow,":[65],"which":[66,136],"may":[67],"additional":[69],"diseases.":[76],"However,":[77],"existing":[78],"either":[80],"ignore":[81],"fact":[83],"that":[84],"there":[85],"is":[86],"a":[87,107],"temporal-lag":[88,100,118,131],"transmission":[92],"across":[93],"regions,":[95,135],"or":[96],"simply":[97],"set":[98],"value":[101],"all":[103],"regions":[105],"fixed":[108],"value.":[109],"To":[110],"overcome":[111],"these":[112],"issues,":[113],"we":[114,146],"design":[115],"an":[116,141],"neural":[119],"(termed":[121],"ETLN)":[122],"simultaneously":[124],"infer":[125],"relationships":[128],"values":[132],"be":[138],"trained":[139],"end-to-end":[142],"manner.":[143],"In":[144],"addition,":[145],"also":[147],"introduce":[148],"three":[149],"mechanisms":[150],"better":[152],"guide":[153],"modeling":[155],"networks.":[158],"The":[159],"evaluation":[160],"results":[161],"on":[162],"Alzheimer's":[164],"Disease":[165],"Neuroimaging":[166],"Initiative":[167],"(ADNI)":[168],"database":[169],"demonstrate":[170],"effectiveness":[172],"method.":[176]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}