{"id":"https://openalex.org/W4296706417","doi":"https://doi.org/10.1109/jbhi.2022.3208517","title":"Disease Progression Score Estimation From Multimodal Imaging and MicroRNA Data Using Supervised Variational Autoencoders","display_name":"Disease Progression Score Estimation From Multimodal Imaging and MicroRNA Data Using Supervised Variational Autoencoders","publication_year":2022,"publication_date":"2022-09-21","ids":{"openalex":"https://openalex.org/W4296706417","doi":"https://doi.org/10.1109/jbhi.2022.3208517","pmid":"https://pubmed.ncbi.nlm.nih.gov/36129856"},"language":"en","primary_location":{"id":"doi:10.1109/jbhi.2022.3208517","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2022.3208517","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hal.science/hal-03789357","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089217518","display_name":"Virgilio Kmetzsch","orcid":"https://orcid.org/0000-0003-3691-0180"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210152724","display_name":"Institut du Cerveau","ror":"https://ror.org/050gn5214","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210152724"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Virgilio Kmetzsch","raw_affiliation_strings":["Institut du Cerveau - Paris Brain Institute - ICM, CNRS, Inria, Inserm, AP-HP, Sorbonne Universit&#x00E9;, Paris, France"],"affiliations":[{"raw_affiliation_string":"Institut du Cerveau - Paris Brain Institute - ICM, CNRS, Inria, Inserm, AP-HP, Sorbonne Universit&#x00E9;, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210097159","https://openalex.org/I39804081","https://openalex.org/I4210152724","https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008418938","display_name":"E. Becker","orcid":"https://orcid.org/0000-0002-7673-0582"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2802519937","display_name":"Institut de Recherche en Informatique et Syst\u00e8mes Al\u00e9atoires","ror":"https://ror.org/00myn0z94","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I205703379","https://openalex.org/I2802204017","https://openalex.org/I2802519937","https://openalex.org/I28221208","https://openalex.org/I4210127572","https://openalex.org/I4210159245","https://openalex.org/I56067802"]},{"id":"https://openalex.org/I56067802","display_name":"Universit\u00e9 de Rennes","ror":"https://ror.org/015m7wh34","country_code":"FR","type":"education","lineage":["https://openalex.org/I56067802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Emmanuelle Becker","raw_affiliation_strings":["Inria, CNRS, IRISA, Univ Rennes, Rennes, France","Dyliss - Dynamics, Logics and Inference for biological Systems and Sequences (Campus de Beaulieu 35042 Rennes cedex - France)"],"affiliations":[{"raw_affiliation_string":"Inria, CNRS, IRISA, Univ Rennes, Rennes, France","institution_ids":["https://openalex.org/I2802519937","https://openalex.org/I56067802","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Dyliss - Dynamics, Logics and Inference for biological Systems and Sequences (Campus de Beaulieu 35042 Rennes cedex - France)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063744167","display_name":"Dario Saracino","orcid":"https://orcid.org/0000-0002-4299-9743"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210152724","display_name":"Institut du Cerveau","ror":"https://ror.org/050gn5214","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210152724"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Dario Saracino","raw_affiliation_strings":["Institut du Cerveau - Paris Brain Institute - ICM, CNRS, Inria, Inserm, AP-HP, Sorbonne Universit&#x00E9;, Paris, France"],"affiliations":[{"raw_affiliation_string":"Institut du Cerveau - Paris Brain Institute - ICM, CNRS, Inria, Inserm, AP-HP, Sorbonne Universit&#x00E9;, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210097159","https://openalex.org/I39804081","https://openalex.org/I4210152724","https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083101187","display_name":"Daisy Rinaldi","orcid":null},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210152724","display_name":"Institut du Cerveau","ror":"https://ror.org/050gn5214","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210152724"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Daisy Rinaldi","raw_affiliation_strings":["Institut du Cerveau - Paris Brain Institute - ICM, CNRS, Inserm, AP-HP, Sorbonne Universit&#x00E9;, Paris, France"],"affiliations":[{"raw_affiliation_string":"Institut du Cerveau - Paris Brain Institute - ICM, CNRS, Inserm, AP-HP, Sorbonne Universit&#x00E9;, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210097159","https://openalex.org/I39804081","https://openalex.org/I4210152724","https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109698979","display_name":"Agn\u00e8s Camuzat","orcid":null},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210152724","display_name":"Institut du Cerveau","ror":"https://ror.org/050gn5214","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210152724"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Agn\u00e8s Camuzat","raw_affiliation_strings":["Institut du Cerveau - Paris Brain Institute - ICM, CNRS, Inserm, AP-HP, Sorbonne Universit&#x00E9;, Paris, France"],"affiliations":[{"raw_affiliation_string":"Institut du Cerveau - Paris Brain Institute - ICM, CNRS, Inserm, AP-HP, Sorbonne Universit&#x00E9;, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210097159","https://openalex.org/I39804081","https://openalex.org/I4210152724","https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042566383","display_name":"Isabelle Le Ber","orcid":"https://orcid.org/0000-0002-2508-5181"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210152724","display_name":"Institut du Cerveau","ror":"https://ror.org/050gn5214","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210152724"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Isabelle Le Ber","raw_affiliation_strings":["Institut du Cerveau - Paris Brain Institute - ICM, CNRS, Inserm, AP-HP, H&#x00F4;pital de la Piti&#x00E9; Salp&#x00EA;tri&#x00E8;re, Institute of Memory and Alzheimer&#x0027;s Disease (IM2A), Sorbonne Universit&#x00E9;, Paris, France"],"affiliations":[{"raw_affiliation_string":"Institut du Cerveau - Paris Brain Institute - ICM, CNRS, Inserm, AP-HP, H&#x00F4;pital de la Piti&#x00E9; Salp&#x00EA;tri&#x00E8;re, Institute of Memory and Alzheimer&#x0027;s Disease (IM2A), Sorbonne Universit&#x00E9;, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210097159","https://openalex.org/I39804081","https://openalex.org/I4210152724","https://openalex.org/I154526488"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005778444","display_name":"Olivier Colliot","orcid":"https://orcid.org/0000-0002-9836-654X"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210152724","display_name":"Institut du Cerveau","ror":"https://ror.org/050gn5214","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210152724"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olivier Colliot","raw_affiliation_strings":["Institut du Cerveau - Paris Brain Institute - ICM, CNRS, Inria, Inserm, AP-HP, Sorbonne Universit&#x00E9;, Paris, France"],"affiliations":[{"raw_affiliation_string":"Institut du Cerveau - Paris Brain Institute - ICM, CNRS, Inria, Inserm, AP-HP, Sorbonne Universit&#x00E9;, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210097159","https://openalex.org/I39804081","https://openalex.org/I4210152724","https://openalex.org/I154526488"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5089217518"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210097159","https://openalex.org/I4210152724"],"apc_list":null,"apc_paid":null,"fwci":1.4934,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.83801286,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"26","issue":"12","first_page":"6024","last_page":"6035"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9783999919891357,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autoencoder","display_name":"Autoencoder","score":0.6465266942977905},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6347872018814087},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5878829956054688},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.4977011978626251},{"id":"https://openalex.org/keywords/metric","display_name":"Metric (unit)","score":0.47721749544143677},{"id":"https://openalex.org/keywords/frontotemporal-dementia","display_name":"Frontotemporal dementia","score":0.4268021583557129},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.417672723531723},{"id":"https://openalex.org/keywords/dementia","display_name":"Dementia","score":0.2813358008861542},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.24880430102348328},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2372337281703949},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.12653577327728271}],"concepts":[{"id":"https://openalex.org/C101738243","wikidata":"https://www.wikidata.org/wiki/Q786435","display_name":"Autoencoder","level":3,"score":0.6465266942977905},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6347872018814087},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5878829956054688},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4977011978626251},{"id":"https://openalex.org/C176217482","wikidata":"https://www.wikidata.org/wiki/Q860554","display_name":"Metric (unit)","level":2,"score":0.47721749544143677},{"id":"https://openalex.org/C2778641062","wikidata":"https://www.wikidata.org/wiki/Q18592","display_name":"Frontotemporal dementia","level":4,"score":0.4268021583557129},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.417672723531723},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.2813358008861542},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.24880430102348328},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2372337281703949},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12653577327728271},{"id":"https://openalex.org/C21547014","wikidata":"https://www.wikidata.org/wiki/Q1423657","display_name":"Operations management","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D064847","descriptor_name":"Multimodal Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064847","descriptor_name":"Multimodal Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064847","descriptor_name":"Multimodal Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/jbhi.2022.3208517","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2022.3208517","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},{"id":"pmid:36129856","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36129856","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE journal of biomedical and health informatics","raw_type":null},{"id":"pmh:oai:HAL:hal-03789357v1","is_oa":true,"landing_page_url":"https://hal.science/hal-03789357","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics, 2022, 26 (12), pp.1-12. &#x27E8;10.1109/JBHI.2022.3208517&#x27E9;","raw_type":"Journal articles"}],"best_oa_location":{"id":"pmh:oai:HAL:hal-03789357v1","is_oa":true,"landing_page_url":"https://hal.science/hal-03789357","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics, 2022, 26 (12), pp.1-12. &#x27E8;10.1109/JBHI.2022.3208517&#x27E9;","raw_type":"Journal articles"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5799999833106995,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W1522301498","https://openalex.org/W1968698114","https://openalex.org/W1999493217","https://openalex.org/W2010461414","https://openalex.org/W2101234009","https://openalex.org/W2106786486","https://openalex.org/W2107018762","https://openalex.org/W2108501770","https://openalex.org/W2114104545","https://openalex.org/W2136195493","https://openalex.org/W2150523249","https://openalex.org/W2154945114","https://openalex.org/W2168818001","https://openalex.org/W2577478840","https://openalex.org/W2593011127","https://openalex.org/W2621357189","https://openalex.org/W2743901732","https://openalex.org/W2773789615","https://openalex.org/W2791743234","https://openalex.org/W2886266252","https://openalex.org/W2899335103","https://openalex.org/W2908996697","https://openalex.org/W2909504023","https://openalex.org/W2909627766","https://openalex.org/W2946459790","https://openalex.org/W2951799803","https://openalex.org/W2952686744","https://openalex.org/W2963618904","https://openalex.org/W2964363195","https://openalex.org/W2991808555","https://openalex.org/W3007486523","https://openalex.org/W3007853192","https://openalex.org/W3011161969","https://openalex.org/W3031318751","https://openalex.org/W3093409256","https://openalex.org/W3109474882","https://openalex.org/W3110913339","https://openalex.org/W3118156069","https://openalex.org/W3120209873","https://openalex.org/W3128740055","https://openalex.org/W3143007731","https://openalex.org/W3182889567","https://openalex.org/W3189824096","https://openalex.org/W3190128877","https://openalex.org/W3205797556","https://openalex.org/W3206815807","https://openalex.org/W4220680274","https://openalex.org/W4251002338","https://openalex.org/W4391602018","https://openalex.org/W6631190155","https://openalex.org/W6640963894","https://openalex.org/W6675354045","https://openalex.org/W6675944832","https://openalex.org/W6742111061","https://openalex.org/W6762582914","https://openalex.org/W6766890313","https://openalex.org/W6774081775","https://openalex.org/W6786697239","https://openalex.org/W6787865951"],"related_works":["https://openalex.org/W3013693939","https://openalex.org/W2159052453","https://openalex.org/W2566616303","https://openalex.org/W3131327266","https://openalex.org/W2734887215","https://openalex.org/W4297051394","https://openalex.org/W2752972570","https://openalex.org/W2145836866","https://openalex.org/W2803255133","https://openalex.org/W2909431601"],"abstract_inverted_index":{"Frontotemporal":[0],"dementia":[1],"and":[2,33,147,160],"amyotrophic":[3],"lateral":[4],"sclerosis":[5],"are":[6,60,123],"rare":[7,65],"neurodegenerative":[8],"diseases":[9],"with":[10,143,148,193,213,222,233,242],"no":[11,46,169],"effective":[12],"treatment.":[13],"The":[14,225],"development":[15],"of":[16,22],"biomarkers":[17,82],"allowing":[18],"an":[19],"accurate":[20,207],"assessment":[21],"disease":[23,77,97,127,240],"progression":[24,52,78,98],"is":[25,68,131,168],"crucial":[26],"for":[27,63,94,172],"evaluating":[28],"new":[29,92],"therapies.":[30],"Concretely,":[31],"neuroimaging":[32],"transcriptomic":[34],"(microRNA)":[35],"data":[36],"have":[37],"been":[38],"shown":[39],"useful":[40],"in":[41,53,175,220,245],"tracking":[42],"their":[43],"progression.":[44],"However,":[45],"single":[47],"biomarker":[48],"can":[49,75,114],"accurately":[50],"measure":[51,239],"these":[54],"complex":[55],"diseases.":[56],"Additionally,":[57],"large":[58],"samples":[59],"not":[61],"available":[62],"such":[64],"disorders.":[66],"It":[67],"thus":[69,228],"essential":[70],"to":[71,237],"develop":[72],"methods":[73],"that":[74,113],"model":[76],"by":[79,133],"combining":[80],"multiple":[81,144],"from":[83,101,163],"small":[84,234],"samples.":[85],"In":[86],"this":[87,137,198],"paper,":[88],"we":[89,106,179],"propose":[90],"a":[91,96,108,116,126,149,189],"framework":[93,142,227],"computing":[95],"score":[99,130],"(DPS)":[100],"cross-sectional":[102,230],"multimodal":[103,110,231],"data.":[104],"Specifically,":[105],"introduce":[107],"supervised":[109],"variational":[111],"autoencoder":[112],"infer":[115],"meaningful":[117],"latent":[118,121],"space,":[119],"where":[120],"representations":[122],"placed":[124],"along":[125],"trajectory.":[128],"A":[129],"computed":[132],"orthogonal":[134],"projections":[135],"onto":[136],"path.":[138],"We":[139],"evaluate":[140],"our":[141],"synthetic":[145,195],"datasets":[146,196,232],"real":[150,215],"dataset":[151,216],"containing":[152],"14":[153],"patients,":[154],"40":[155],"presymptomatic":[156],"genetic":[157],"mutation":[158],"carriers":[159],"37":[161],"controls":[162],"the":[164,173,181,184,194,201,203,205,208,214],"PREV-DEMALS":[165],"study.":[166],"There":[167],"ground":[170],"truth":[171],"DPS":[174],"real-world":[176],"scenarios,":[177],"therefore":[178],"use":[180],"area":[182],"under":[183],"ROC":[185],"curve":[186],"(AUC)":[187],"as":[188],"proxy":[190],"metric.":[191],"Results":[192],"support":[197],"choice,":[199],"since":[200],"higher":[202],"AUC,":[204],"more":[206],"predicted":[209],"simulated":[210],"DPS.":[211],"Experiments":[212],"demonstrate":[217],"better":[218],"performance":[219],"comparison":[221],"state-of-the-art":[223],"approaches.":[224],"proposed":[226],"leverages":[229],"sample":[235],"sizes":[236],"objectively":[238],"progression,":[241],"potential":[243],"application":[244],"clinical":[246],"trials.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}
