{"id":"https://openalex.org/W4285077048","doi":"https://doi.org/10.1109/jbhi.2022.3190038","title":"Integrative Network Modeling Highlights the Crucial Roles of Rho-GDI Signaling Pathway in the Progression of non-Small Cell Lung Cancer","display_name":"Integrative Network Modeling Highlights the Crucial Roles of Rho-GDI Signaling Pathway in the Progression of non-Small Cell Lung Cancer","publication_year":2022,"publication_date":"2022-07-12","ids":{"openalex":"https://openalex.org/W4285077048","doi":"https://doi.org/10.1109/jbhi.2022.3190038","pmid":"https://pubmed.ncbi.nlm.nih.gov/35820010"},"language":"en","primary_location":{"id":"doi:10.1109/jbhi.2022.3190038","is_oa":true,"landing_page_url":"https://doi.org/10.1109/jbhi.2022.3190038","pdf_url":"https://ieeexplore.ieee.org/ielx7/6221020/9882959/09827995.pdf","source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ieeexplore.ieee.org/ielx7/6221020/9882959/09827995.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025585140","display_name":"Saransh Gupta","orcid":"https://orcid.org/0000-0003-3995-8163"},"institutions":[{"id":"https://openalex.org/I145894827","display_name":"Indian Institute of Technology Kharagpur","ror":"https://ror.org/03w5sq511","country_code":"IN","type":"education","lineage":["https://openalex.org/I145894827"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Saransh Gupta","raw_affiliation_strings":["Indian Institute of Technology Kharagpur, Kharagpur, WB, India"],"raw_orcid":"https://orcid.org/0000-0003-3995-8163","affiliations":[{"raw_affiliation_string":"Indian Institute of Technology Kharagpur, Kharagpur, WB, India","institution_ids":["https://openalex.org/I145894827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021324799","display_name":"Haswanth Vundavilli","orcid":"https://orcid.org/0000-0002-3283-7732"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haswanth Vundavilli","raw_affiliation_strings":["Department of Electrical and Computer Engineering and The Center for Bioinformatics and Genomic Systems Engineering, Texas A&M University, College Station, TX, USA"],"raw_orcid":"https://orcid.org/0000-0002-3283-7732","affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering and The Center for Bioinformatics and Genomic Systems Engineering, Texas A&M University, College Station, TX, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041859799","display_name":"Rodolfo S. Allendes Osorio","orcid":"https://orcid.org/0000-0002-9627-9338"},"institutions":[{"id":"https://openalex.org/I4210086383","display_name":"National Institute of Biomedical Innovation, Health and Nutrition","ror":"https://ror.org/001rkbe13","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210086383"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Rodolfo S. Allendes Osorio","raw_affiliation_strings":["Laboratory of Bioinformatics, Artificial Intelligence Center for Health and Biomedical Research (ArCHER), National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Osaka, Japan"],"raw_orcid":"https://orcid.org/0000-0002-9627-9338","affiliations":[{"raw_affiliation_string":"Laboratory of Bioinformatics, Artificial Intelligence Center for Health and Biomedical Research (ArCHER), National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Osaka, Japan","institution_ids":["https://openalex.org/I4210086383"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013538724","display_name":"M Itoh","orcid":"https://orcid.org/0000-0001-7917-2830"},"institutions":[{"id":"https://openalex.org/I4210086383","display_name":"National Institute of Biomedical Innovation, Health and Nutrition","ror":"https://ror.org/001rkbe13","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210086383"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mari N. Itoh","raw_affiliation_strings":["Laboratory of Bioinformatics, Artificial Intelligence Center for Health and Biomedical Research (ArCHER), National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Osaka, Japan"],"raw_orcid":"https://orcid.org/0000-0001-7917-2830","affiliations":[{"raw_affiliation_string":"Laboratory of Bioinformatics, Artificial Intelligence Center for Health and Biomedical Research (ArCHER), National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Osaka, Japan","institution_ids":["https://openalex.org/I4210086383"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049385580","display_name":"Attayeb Mohsen","orcid":"https://orcid.org/0000-0003-0690-8012"},"institutions":[{"id":"https://openalex.org/I4210086383","display_name":"National Institute of Biomedical Innovation, Health and Nutrition","ror":"https://ror.org/001rkbe13","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210086383"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Attayeb Mohsen","raw_affiliation_strings":["Laboratory of Bioinformatics, Artificial Intelligence Center for Health and Biomedical Research (ArCHER), National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Osaka, Japan"],"raw_orcid":"https://orcid.org/0000-0003-0690-8012","affiliations":[{"raw_affiliation_string":"Laboratory of Bioinformatics, Artificial Intelligence Center for Health and Biomedical Research (ArCHER), National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Osaka, Japan","institution_ids":["https://openalex.org/I4210086383"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045462352","display_name":"Aniruddha Datta","orcid":"https://orcid.org/0000-0003-1213-3807"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aniruddha Datta","raw_affiliation_strings":["Department of Electrical and Computer Engineering and The Center for Bioinformatics and Genomic Systems Engineering, Texas A&M University, College Station, TX, USA"],"raw_orcid":"https://orcid.org/0000-0003-1213-3807","affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering and The Center for Bioinformatics and Genomic Systems Engineering, Texas A&M University, College Station, TX, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061134485","display_name":"Kenji Mizuguchi","orcid":"https://orcid.org/0000-0003-3021-7078"},"institutions":[{"id":"https://openalex.org/I4210086383","display_name":"National Institute of Biomedical Innovation, Health and Nutrition","ror":"https://ror.org/001rkbe13","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210086383"]},{"id":"https://openalex.org/I4210152009","display_name":"Protein Research Foundation","ror":"https://ror.org/03yzv7g36","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210152009"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Mizuguchi","raw_affiliation_strings":["Laboratory of Bioinformatics, Artificial Intelligence Center for Health and Biomedical Research (ArCHER), National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Osaka, Japan","Institute for Protein Research, Osaka University, Suita, Osaka, Japan"],"raw_orcid":"https://orcid.org/0000-0003-3021-7078","affiliations":[{"raw_affiliation_string":"Laboratory of Bioinformatics, Artificial Intelligence Center for Health and Biomedical Research (ArCHER), National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Osaka, Japan","institution_ids":["https://openalex.org/I4210086383"]},{"raw_affiliation_string":"Institute for Protein Research, Osaka University, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I4210152009","https://openalex.org/I98285908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063108133","display_name":"Lokesh P. Tripathi","orcid":"https://orcid.org/0000-0001-5812-2252"},"institutions":[{"id":"https://openalex.org/I4210086383","display_name":"National Institute of Biomedical Innovation, Health and Nutrition","ror":"https://ror.org/001rkbe13","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210086383"]},{"id":"https://openalex.org/I4210150921","display_name":"RIKEN Center for Integrative Medical Sciences","ror":"https://ror.org/04mb6s476","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652","https://openalex.org/I4210150921"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Lokesh P. Tripathi","raw_affiliation_strings":["Laboratory of Bioinformatics, Artificial Intelligence Center for Health and Biomedical Research (ArCHER), National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Osaka, Japan","Laboratory of Transcriptome Technology, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan"],"raw_orcid":"https://orcid.org/0000-0001-5812-2252","affiliations":[{"raw_affiliation_string":"Laboratory of Bioinformatics, Artificial Intelligence Center for Health and Biomedical Research (ArCHER), National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Osaka, Japan","institution_ids":["https://openalex.org/I4210086383"]},{"raw_affiliation_string":"Laboratory of Transcriptome Technology, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan","institution_ids":["https://openalex.org/I4210150921"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5025585140"],"corresponding_institution_ids":["https://openalex.org/I145894827"],"apc_list":null,"apc_paid":null,"fwci":0.9548,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.73078538,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"26","issue":"9","first_page":"4785","last_page":"4793"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9908999800682068,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.49506130814552307},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4916747212409973},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.42105984687805176},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.4141343832015991},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.37675055861473083},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.35032957792282104},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.33478865027427673},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3292931318283081},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.24705737829208374},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.18365177512168884},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.1564888060092926},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.12049984931945801}],"concepts":[{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.49506130814552307},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4916747212409973},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42105984687805176},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4141343832015991},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37675055861473083},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35032957792282104},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33478865027427673},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3292931318283081},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24705737829208374},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.18365177512168884},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.1564888060092926},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12049984931945801}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020662","descriptor_name":"Guanine Nucleotide Exchange Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020662","descriptor_name":"Guanine Nucleotide Exchange Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020662","descriptor_name":"Guanine Nucleotide Exchange Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062947","descriptor_name":"rho-Specific Guanine Nucleotide Dissociation Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062947","descriptor_name":"rho-Specific Guanine Nucleotide Dissociation Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062947","descriptor_name":"rho-Specific Guanine Nucleotide Dissociation Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/jbhi.2022.3190038","is_oa":true,"landing_page_url":"https://doi.org/10.1109/jbhi.2022.3190038","pdf_url":"https://ieeexplore.ieee.org/ielx7/6221020/9882959/09827995.pdf","source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},{"id":"pmid:35820010","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35820010","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE journal of biomedical and health informatics","raw_type":null}],"best_oa_location":{"id":"doi:10.1109/jbhi.2022.3190038","is_oa":true,"landing_page_url":"https://doi.org/10.1109/jbhi.2022.3190038","pdf_url":"https://ieeexplore.ieee.org/ielx7/6221020/9882959/09827995.pdf","source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G5566833324","display_name":null,"funder_award_id":"ECCS-1609236","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6214763678","display_name":null,"funder_award_id":"ECCS-1917166","funder_id":"https://openalex.org/F4320335353","funder_display_name":"National Science Foundation of Sri Lanka"},{"id":"https://openalex.org/G6408125998","display_name":"Cancer Therapeutics through Theory and Experiment: From Cell Lines to Canine Tumors Grown on the Back of Mice","funder_award_id":"1917166","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6553786292","display_name":null,"funder_award_id":"17K07268","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7298664808","display_name":"Identification of Drug Targets and Their Validation in Cancer Therapy Design","funder_award_id":"1609236","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8154939268","display_name":null,"funder_award_id":"ECCS-1609236 and ECCS-1917166","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8849486789","display_name":null,"funder_award_id":"ECCS-1609236","funder_id":"https://openalex.org/F4320335353","funder_display_name":"National Science Foundation of Sri Lanka"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320335353","display_name":"National Science Foundation of Sri Lanka","ror":"https://ror.org/010xaa060"},{"id":"https://openalex.org/F4320337392","display_name":"Division of Electrical, Communications and Cyber Systems","ror":"https://ror.org/01krpsy48"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285077048.pdf","grobid_xml":"https://content.openalex.org/works/W4285077048.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W97059505","https://openalex.org/W1257817829","https://openalex.org/W1927233378","https://openalex.org/W1966327575","https://openalex.org/W1990912589","https://openalex.org/W2010572071","https://openalex.org/W2144687580","https://openalex.org/W2145025818","https://openalex.org/W2148143831","https://openalex.org/W2152575451","https://openalex.org/W2155653793","https://openalex.org/W2156665896","https://openalex.org/W2295598076","https://openalex.org/W2611370172","https://openalex.org/W2770358930","https://openalex.org/W2781180031","https://openalex.org/W2783953185","https://openalex.org/W2795769326","https://openalex.org/W2799346978","https://openalex.org/W2807816325","https://openalex.org/W2883837134","https://openalex.org/W2911964244","https://openalex.org/W2913936525","https://openalex.org/W2913997948","https://openalex.org/W2941424978","https://openalex.org/W2950595506","https://openalex.org/W2970665879","https://openalex.org/W2972034517","https://openalex.org/W2972188055","https://openalex.org/W2972817233","https://openalex.org/W2984432074","https://openalex.org/W3031003892","https://openalex.org/W3032087714","https://openalex.org/W3043624627","https://openalex.org/W3096828292","https://openalex.org/W3112535213","https://openalex.org/W3133775961","https://openalex.org/W4233698560","https://openalex.org/W4294214983","https://openalex.org/W4313729819","https://openalex.org/W6675354045","https://openalex.org/W6750729320"],"related_works":["https://openalex.org/W2064573700","https://openalex.org/W2376385980","https://openalex.org/W2967366602","https://openalex.org/W1496498748","https://openalex.org/W2129774558","https://openalex.org/W1997032381","https://openalex.org/W1979593122","https://openalex.org/W2287922696","https://openalex.org/W2190548886","https://openalex.org/W2783341158"],"abstract_inverted_index":{"Non-small":[0],"cell":[1],"lung":[2,11],"cancer":[3,12],"(NSCLC)":[4],"is":[5],"the":[6,56,93,109,143,163,200,221],"most":[7],"prevalent":[8],"form":[9],"of":[10,17,60,108,202],"and":[13,41,49,58,76,127,188,191,194,239],"a":[14,27,139,169],"leading":[15],"cause":[16],"cancer-related":[18],"deaths":[19],"worldwide.":[20],"Using":[21],"an":[22],"integrative":[23],"approach,":[24],"we":[25,63,114,161],"analyzed":[26],"publicly":[28],"available":[29],"merged":[30],"NSCLC":[31,75],"transcriptome":[32],"dataset":[33],"using":[34,68,97,149,168],"machine":[35,70,110],"learning,":[36],"protein-protein":[37],"interaction":[38],"(PPI)":[39],"networks":[40],"bayesian":[42,170],"modeling":[43],"to":[44,52,73,87,131,152,158,184,199,211],"pinpoint":[45],"key":[46,197],"cellular":[47],"factors":[48],"pathways":[50],"likely":[51,130],"be":[53,132],"involved":[54,118],"with":[55,89,106],"onset":[57,201],"progression":[59],"NSCLC.":[61,135,159,205,225,244],"First,":[62],"generated":[64],"multiple":[65],"prediction":[66,82],"models":[67,80],"various":[69],"learning":[71,111],"classifiers":[72],"classify":[74],"healthy":[77],"cohorts.":[78],"Our":[79,226],"achieved":[81],"accuracies":[83],"ranging":[84],"from":[85],"0.83":[86],"1.0,":[88],"XGBoost":[90],"emerging":[91],"as":[92],"best":[94],"performer.":[95],"Next,":[96],"functional":[98],"enrichment":[99],"analysis":[100,105],"(and":[101],"gene":[102,181],"co-expression":[103],"network":[104,141],"WGCNA)":[107],"feature-selected":[112,144],"genes,":[113],"determined":[115],"that":[116,123,146,175,208],"genes":[117,145],"in":[119,134,165,177,204,224,243],"Rho":[120],"GTPase":[121],"signaling":[122,167,187],"modulate":[124],"actin":[125,190],"stability":[126],"cytoskeleton":[128,192],"were":[129,195],"crucial":[133],"We":[136,206],"further":[137],"assembled":[138],"PPI":[140],"for":[142,231],"was":[147],"partitioned":[148],"Markov":[150],"clustering":[151],"detect":[153],"protein":[154],"complexes":[155],"functionally":[156],"relevant":[157],"Finally,":[160],"modeled":[162],"perturbations":[164],"RhoGDI":[166],"network;":[171],"our":[172],"simulations":[173],"suggest":[174],"aberrations":[176],"ARHGEF19":[178,214],"and/or":[179,215],"RAC2":[180,216],"activities":[182],"contributed":[183],"impaired":[185],"MAPK":[186],"disrupted":[189],"organization":[193],"arguably":[196],"contributors":[198],"tumorigenesis":[203],"hypothesize":[207],"targeted":[209,236],"measures":[210],"restore":[212],"aberrant":[213],"functions":[217],"could":[218],"conceivably":[219],"rescue":[220],"cancerous":[222],"phenotype":[223],"findings":[227],"offer":[228],"promising":[229],"avenues":[230],"early":[232],"predictive":[233],"biomarker":[234],"discovery,":[235],"therapeutic":[237],"intervention":[238],"improved":[240],"clinical":[241],"outcomes":[242]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}