{"id":"https://openalex.org/W4224224129","doi":"https://doi.org/10.1109/jbhi.2022.3168008","title":"Multi-Relation Graph Embedding for Predicting miRNA-Target Gene Interactions by Integrating Gene Sequence Information","display_name":"Multi-Relation Graph Embedding for Predicting miRNA-Target Gene Interactions by Integrating Gene Sequence Information","publication_year":2022,"publication_date":"2022-04-19","ids":{"openalex":"https://openalex.org/W4224224129","doi":"https://doi.org/10.1109/jbhi.2022.3168008","pmid":"https://pubmed.ncbi.nlm.nih.gov/35439150"},"language":"en","primary_location":{"id":"doi:10.1109/jbhi.2022.3168008","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2022.3168008","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026469278","display_name":"Jiawei Luo","orcid":"https://orcid.org/0000-0003-2385-8272"},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiawei Luo","raw_affiliation_strings":["College of Computer Science and Electronic Engineering, Hunan University, Changsha, China"],"raw_orcid":"https://orcid.org/0000-0003-2385-8272","affiliations":[{"raw_affiliation_string":"College of Computer Science and Electronic Engineering, Hunan University, Changsha, China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077006907","display_name":"Wenjue Ouyang","orcid":"https://orcid.org/0000-0002-0366-8220"},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenjue Ouyang","raw_affiliation_strings":["College of Computer Science and Electronic Engineering, Hunan University, Changsha, China"],"raw_orcid":"https://orcid.org/0000-0002-0366-8220","affiliations":[{"raw_affiliation_string":"College of Computer Science and Electronic Engineering, Hunan University, Changsha, China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071431436","display_name":"Cong Shen","orcid":"https://orcid.org/0000-0001-8505-6406"},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cong Shen","raw_affiliation_strings":["College of Computer Science and Electronic Engineering, Hunan University, Changsha, China"],"raw_orcid":"https://orcid.org/0000-0001-8505-6406","affiliations":[{"raw_affiliation_string":"College of Computer Science and Electronic Engineering, Hunan University, Changsha, China","institution_ids":["https://openalex.org/I16609230"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079611154","display_name":"Jie Cai","orcid":"https://orcid.org/0000-0002-6561-5626"},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Cai","raw_affiliation_strings":["College of Computer Science and Electronic Engineering, Hunan University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer Science and Electronic Engineering, Hunan University, Changsha, China","institution_ids":["https://openalex.org/I16609230"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I16609230"],"apc_list":null,"apc_paid":null,"fwci":0.8539,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.69125044,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"26","issue":"8","first_page":"4345","last_page":"4353"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6004274487495422},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.5521440505981445},{"id":"https://openalex.org/keywords/embedding","display_name":"Embedding","score":0.53452068567276},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5043231248855591},{"id":"https://openalex.org/keywords/relation","display_name":"Relation (database)","score":0.49714091420173645},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.48879024386405945},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.44401639699935913},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.4219534993171692},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.39108818769454956},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.3664836883544922},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.28029459714889526},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.27981677651405334},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1968306005001068},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.19130468368530273}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6004274487495422},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.5521440505981445},{"id":"https://openalex.org/C41608201","wikidata":"https://www.wikidata.org/wiki/Q980509","display_name":"Embedding","level":2,"score":0.53452068567276},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5043231248855591},{"id":"https://openalex.org/C25343380","wikidata":"https://www.wikidata.org/wiki/Q277521","display_name":"Relation (database)","level":2,"score":0.49714091420173645},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.48879024386405945},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.44401639699935913},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4219534993171692},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.39108818769454956},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.3664836883544922},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.28029459714889526},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27981677651405334},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1968306005001068},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.19130468368530273}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/jbhi.2022.3168008","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2022.3168008","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},{"id":"pmid:35439150","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35439150","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE journal of biomedical and health informatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1342612824","display_name":"MicroRNA\u5bf9\u57fa\u56e0\u7684\u8c03\u63a7\u4f5c\u7528\u53ca\u5176\u4e0e\u75be\u75c5\u5173\u8054\u5173\u7cfb\u7684\u8ba1\u7b97\u65b9\u6cd5\u7814\u7a76","funder_award_id":"61873089","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5186779112","display_name":null,"funder_award_id":"CX20200436","funder_id":"https://openalex.org/F4320326217","funder_display_name":"Hunan Provincial Innovation Foundation for Postgraduate"},{"id":"https://openalex.org/G6549098544","display_name":null,"funder_award_id":"62032007","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320326217","display_name":"Hunan Provincial Innovation Foundation for Postgraduate","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1888005072","https://openalex.org/W1983826553","https://openalex.org/W2026417691","https://openalex.org/W2040191060","https://openalex.org/W2045949302","https://openalex.org/W2049088975","https://openalex.org/W2053279156","https://openalex.org/W2053333794","https://openalex.org/W2053611784","https://openalex.org/W2070571588","https://openalex.org/W2074231493","https://openalex.org/W2083381199","https://openalex.org/W2089142809","https://openalex.org/W2090891622","https://openalex.org/W2103760949","https://openalex.org/W2120456037","https://openalex.org/W2123688186","https://openalex.org/W2130674065","https://openalex.org/W2134497014","https://openalex.org/W2154851992","https://openalex.org/W2163199119","https://openalex.org/W2393319904","https://openalex.org/W2567465856","https://openalex.org/W2597014394","https://openalex.org/W2604314403","https://openalex.org/W2750282177","https://openalex.org/W2786016794","https://openalex.org/W2789254732","https://openalex.org/W2807021761","https://openalex.org/W2890579117","https://openalex.org/W2890590258","https://openalex.org/W2899728356","https://openalex.org/W2954361737","https://openalex.org/W2969845879","https://openalex.org/W3000082418","https://openalex.org/W3004052817","https://openalex.org/W3010678464","https://openalex.org/W3048594585","https://openalex.org/W3100848837","https://openalex.org/W3104097132","https://openalex.org/W3113731542","https://openalex.org/W3127542603","https://openalex.org/W4255156463","https://openalex.org/W6631943919","https://openalex.org/W6713134421","https://openalex.org/W6726873649","https://openalex.org/W6836575638"],"related_works":["https://openalex.org/W4234874385","https://openalex.org/W2081900870","https://openalex.org/W2323648130","https://openalex.org/W2157140558","https://openalex.org/W2378782423","https://openalex.org/W3111219495","https://openalex.org/W2737319532","https://openalex.org/W3151405604","https://openalex.org/W2050308539","https://openalex.org/W4233308809"],"abstract_inverted_index":{"Accumulated":[0],"studies":[1,191],"have":[2],"found":[3],"that":[4,82],"miRNAs":[5,31,142],"are":[6],"in":[7,32,55,95,199],"charge":[8],"of":[9,30,39,43,116,141,153,170,178,184,189,197],"many":[10],"complex":[11],"diseases":[12],"such":[13],"as":[14,49,51],"cancers":[15],"by":[16],"modulating":[17],"gene":[18,92],"expression.":[19],"Predicting":[20],"miRNA-target":[21,117,154],"interactions":[22],"is":[23,94],"beneficial":[24],"for":[25,61,75,98,113],"uncovering":[26],"the":[27,37,52,88,100,114,121,127,150,168,181,194],"crucial":[28],"roles":[29],"regulating":[33],"target":[34,63],"genes":[35,144],"and":[36,46,91,126,135,143,163],"progression":[38],"diseases.":[40],"The":[41,138,186],"emergence":[42],"large-scale":[44],"genomic":[45],"biological":[47],"data":[48],"well":[50],"recent":[53],"development":[54],"heterogeneous":[56,89],"networks":[57],"provides":[58],"new":[59],"opportunities":[60],"miRNA":[62],"identification.":[64],"Compared":[65],"with":[66,157],"conventional":[67],"methods,":[68],"computational":[69],"methods":[70,162],"become":[71],"a":[72,80,108],"decent":[73],"solution":[74],"high":[76],"efficiency.":[77],"Thus,":[78],"designing":[79],"method":[81],"could":[83],"excavate":[84],"valid":[85],"information":[86],"from":[87],"network":[90,133],"sequences":[93],"great":[96],"demand":[97],"improving":[99],"prediction":[101,115,151],"accuracy.":[102],"In":[103],"this":[104],"study,":[105],"we":[106],"proposed":[107],"graph-based":[109],"model":[110],"named":[111],"MRMTI":[112,119,171,179,198],"interactions.":[118],"utilized":[120],"multi-relation":[122],"graph":[123,160],"convolution":[124],"module":[125,129],"Bi-LSTM":[128],"to":[130,148],"incorporate":[131],"both":[132],"topology":[134],"sequential":[136],"information.":[137],"learned":[139],"embeddings":[140],"were":[145],"then":[146],"used":[147],"calculate":[149],"scores":[152],"pairs.":[155],"Comparisons":[156],"other":[158],"state-of-the-art":[159],"embedding":[161],"existing":[164],"bioinformatic":[165],"tools":[166],"illustrated":[167],"superiority":[169],"under":[172],"multiple":[173],"criteria":[174],"metrics.":[175],"Three":[176],"variants":[177],"implied":[180],"positive":[182],"effect":[183],"multi-relation.":[185],"experimental":[187],"results":[188],"case":[190],"further":[192],"demonstrated":[193],"prominent":[195],"ability":[196],"predicting":[200],"novel":[201],"associations.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}