{"id":"https://openalex.org/W4220832109","doi":"https://doi.org/10.1109/jbhi.2022.3160103","title":"The Impact of Wearable Electronics in Assessing the Effectiveness of Levodopa Treatment in Parkinson's Disease","display_name":"The Impact of Wearable Electronics in Assessing the Effectiveness of Levodopa Treatment in Parkinson's Disease","publication_year":2022,"publication_date":"2022-03-22","ids":{"openalex":"https://openalex.org/W4220832109","doi":"https://doi.org/10.1109/jbhi.2022.3160103","pmid":"https://pubmed.ncbi.nlm.nih.gov/35316198"},"language":"en","primary_location":{"id":"doi:10.1109/jbhi.2022.3160103","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2022.3160103","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033842105","display_name":"Mariachiara Ricci","orcid":"https://orcid.org/0000-0001-8456-9795"},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Mariachiara Ricci","raw_affiliation_strings":["Department of Electronic Engineering, University of Rome “Tor Vergata”, Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0001-8456-9795","affiliations":[{"raw_affiliation_string":"Department of Electronic Engineering, University of Rome “Tor Vergata”, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029956142","display_name":"Giulia Di Lazzaro","orcid":"https://orcid.org/0000-0003-2413-1788"},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Di Lazzaro","raw_affiliation_strings":["Neurology Unit, Department of Systems Medicine, University of Rome “Tor Vergata”, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Unit, Department of Systems Medicine, University of Rome “Tor Vergata”, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023412489","display_name":"Vito Errico","orcid":"https://orcid.org/0000-0003-1229-7449"},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vito Errico","raw_affiliation_strings":["Department of Electronic Engineering, University of Rome “Tor Vergata”, Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0003-1229-7449","affiliations":[{"raw_affiliation_string":"Department of Electronic Engineering, University of Rome “Tor Vergata”, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022210828","display_name":"Antonio Pisani","orcid":"https://orcid.org/0000-0002-8432-594X"},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Pisani","raw_affiliation_strings":["Department of Brain and Behavioral Sciences, University of Pavia, and IRCCS Mondino Foundation, Pavia, Italy"],"raw_orcid":"https://orcid.org/0000-0002-8432-594X","affiliations":[{"raw_affiliation_string":"Department of Brain and Behavioral Sciences, University of Pavia, and IRCCS Mondino Foundation, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079371866","display_name":"F. Giannini","orcid":"https://orcid.org/0000-0003-0132-2522"},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Franco Giannini","raw_affiliation_strings":["Department of Electronic Engineering, University of Rome “Tor Vergata”, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electronic Engineering, University of Rome “Tor Vergata”, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012383192","display_name":"Giovanni Saggio","orcid":"https://orcid.org/0000-0002-9034-9921"},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Saggio","raw_affiliation_strings":["Department of Electronic Engineering, University of Rome “Tor Vergata”, Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0002-9034-9921","affiliations":[{"raw_affiliation_string":"Department of Electronic Engineering, University of Rome “Tor Vergata”, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5033842105"],"corresponding_institution_ids":["https://openalex.org/I116067653"],"apc_list":null,"apc_paid":null,"fwci":2.4769,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.90328044,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"26","issue":"7","first_page":"2920","last_page":"2928"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.7735999822616577,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.7735999822616577,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10114","display_name":"Balance, Gait, and Falls Prevention","score":0.07639999687671661,"subfield":{"id":"https://openalex.org/subfields/3612","display_name":"Physical Therapy, Sports Therapy and Rehabilitation"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.07029999792575836,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/levodopa","display_name":"Levodopa","score":0.6540851593017578},{"id":"https://openalex.org/keywords/accelerometer","display_name":"Accelerometer","score":0.6082004904747009},{"id":"https://openalex.org/keywords/wearable-computer","display_name":"Wearable computer","score":0.5888254046440125},{"id":"https://openalex.org/keywords/wearable-technology","display_name":"Wearable technology","score":0.569430410861969},{"id":"https://openalex.org/keywords/physical-medicine-and-rehabilitation","display_name":"Physical medicine and rehabilitation","score":0.5442280173301697},{"id":"https://openalex.org/keywords/parkinsons-disease","display_name":"Parkinson's disease","score":0.5391824841499329},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.46600469946861267},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4439695477485657},{"id":"https://openalex.org/keywords/inertial-measurement-unit","display_name":"Inertial measurement unit","score":0.43980327248573303},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.4018452763557434},{"id":"https://openalex.org/keywords/physical-therapy","display_name":"Physical therapy","score":0.34400686621665955},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3159952163696289},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.268015056848526},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.1180768609046936},{"id":"https://openalex.org/keywords/embedded-system","display_name":"Embedded system","score":0.11569017171859741}],"concepts":[{"id":"https://openalex.org/C2780304432","wikidata":"https://www.wikidata.org/wiki/Q300989","display_name":"Levodopa","level":4,"score":0.6540851593017578},{"id":"https://openalex.org/C89805583","wikidata":"https://www.wikidata.org/wiki/Q192940","display_name":"Accelerometer","level":2,"score":0.6082004904747009},{"id":"https://openalex.org/C150594956","wikidata":"https://www.wikidata.org/wiki/Q1334829","display_name":"Wearable computer","level":2,"score":0.5888254046440125},{"id":"https://openalex.org/C54290928","wikidata":"https://www.wikidata.org/wiki/Q4845080","display_name":"Wearable technology","level":3,"score":0.569430410861969},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.5442280173301697},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.5391824841499329},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.46600469946861267},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4439695477485657},{"id":"https://openalex.org/C79061980","wikidata":"https://www.wikidata.org/wiki/Q941680","display_name":"Inertial measurement unit","level":2,"score":0.43980327248573303},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4018452763557434},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.34400686621665955},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3159952163696289},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.268015056848526},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1180768609046936},{"id":"https://openalex.org/C149635348","wikidata":"https://www.wikidata.org/wiki/Q193040","display_name":"Embedded system","level":1,"score":0.11569017171859741},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000076251","descriptor_name":"Wearable Electronic Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000076251","descriptor_name":"Wearable Electronic Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000076251","descriptor_name":"Wearable Electronic Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007980","descriptor_name":"Levodopa","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007980","descriptor_name":"Levodopa","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007980","descriptor_name":"Levodopa","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014202","descriptor_name":"Tremor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014202","descriptor_name":"Tremor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014202","descriptor_name":"Tremor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018476","descriptor_name":"Hypokinesia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018476","descriptor_name":"Hypokinesia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018476","descriptor_name":"Hypokinesia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/jbhi.2022.3160103","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2022.3160103","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},{"id":"pmid:35316198","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35316198","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE journal of biomedical and health informatics","raw_type":null},{"id":"pmh:oai:art.torvergata.it:2108/320887","is_oa":false,"landing_page_url":"https://hdl.handle.net/2108/320887","pdf_url":null,"source":{"id":"https://openalex.org/S4306400993","display_name":"Cineca Institutional Research Information System (Tor Vergata University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I116067653","host_organization_name":"University of Rome Tor Vergata","host_organization_lineage":["https://openalex.org/I116067653"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W147048037","https://openalex.org/W1492061961","https://openalex.org/W1933560451","https://openalex.org/W1985386089","https://openalex.org/W1999633152","https://openalex.org/W2025267673","https://openalex.org/W2025337852","https://openalex.org/W2058190976","https://openalex.org/W2065999099","https://openalex.org/W2067102702","https://openalex.org/W2089085990","https://openalex.org/W2104033295","https://openalex.org/W2109866592","https://openalex.org/W2110672886","https://openalex.org/W2112455323","https://openalex.org/W2114345300","https://openalex.org/W2125948867","https://openalex.org/W2137355200","https://openalex.org/W2163508918","https://openalex.org/W2165434118","https://openalex.org/W2469579823","https://openalex.org/W2472939032","https://openalex.org/W2503761517","https://openalex.org/W2518267365","https://openalex.org/W2538723685","https://openalex.org/W2588873903","https://openalex.org/W2610024937","https://openalex.org/W2738137475","https://openalex.org/W2763160983","https://openalex.org/W2765936263","https://openalex.org/W2790446951","https://openalex.org/W2883001709","https://openalex.org/W2887568519","https://openalex.org/W2904387281","https://openalex.org/W2904886137","https://openalex.org/W2911892615","https://openalex.org/W2921625730","https://openalex.org/W2944322971","https://openalex.org/W2964100420","https://openalex.org/W2977919425","https://openalex.org/W2990929233","https://openalex.org/W3049215642","https://openalex.org/W3101213025"],"related_works":["https://openalex.org/W2992410632","https://openalex.org/W2768717251","https://openalex.org/W2025756212","https://openalex.org/W3090300519","https://openalex.org/W2514492205","https://openalex.org/W4250401876","https://openalex.org/W2943851981","https://openalex.org/W2095299560","https://openalex.org/W2907667791","https://openalex.org/W3047461507"],"abstract_inverted_index":{"OBJECTIVE:":[0],"In":[1],"order":[2],"to":[3,9,121,130,154],"evaluate":[4],"Parkinson":[5],"disease":[6],"patients'":[7],"response":[8],"therapeutic":[10],"interventions,":[11],"sources":[12,27],"of":[13,22,46,56,82,98,113,175,178],"information":[14],"are":[15],"mainly":[16],"patient":[17,187],"reports":[18],"and":[19,33,49,72,86,91,107,115,186],"clinicians'":[20],"assessment":[21,177],"motor":[23,61,179],"functions.":[24],"However,":[25],"these":[26],"can":[28,162,171],"suffer":[29],"from":[30,34],"patient's":[31,137],"subjectivity":[32],"inter/intra":[35],"rater's":[36],"score":[37],"variability.":[38],"Our":[39],"work":[40],"aimed":[41],"at":[42,79],"determining":[43],"the":[44,54,80,136,155,173,176,183],"impact":[45],"wearable":[47,70],"electronics":[48,71,96],"data":[50,74,111],"analysis":[51,112],"in":[52,119,139],"objectifying":[53],"effectiveness":[55],"levodopa":[57,156],"treatment.":[58],"METHODS:":[59],"Seven":[60],"tasks":[62],"performed":[63],"by":[64,69,181],"thirty-six":[65],"patients":[66],"were":[67,75],"measured":[68],"related":[73],"analyzed.":[76],"This":[77],"was":[78],"time":[81],"therapy":[83,134,166],"initiation":[84],"(T0),":[85],"repeated":[87],"after":[88],"six":[89],"(T1)":[90],"12":[92],"months":[93],"(T2).":[94],"Wearable":[95],"consisted":[97],"inertial":[99],"measurement":[100],"units":[101],"each":[102],"equipped":[103],"with":[104,151],"3-axis":[105,108],"accelerometer":[106],"gyroscope,":[109],"while":[110],"ANOVA":[114],"Pearson":[116],"correlation":[117,153],"algorithms,":[118],"addition":[120],"a":[122],"support":[123],"vector":[124],"machine":[125],"(SVM)":[126],"classification.":[127],"RESULTS:":[128],"According":[129],"our":[131],"findings,":[132],"levodopa-based":[133,165],"alters":[135],"conditions":[138],"general,":[140],"ameliorating":[141],"something":[142],"(e.g.,":[143,148],"bradykinesia),":[144],"leaving":[145],"unchanged":[146],"others":[147],"tremor),":[149],"but":[150],"poor":[152],"dose.":[157],"CONCLUSION:":[158],"A":[159],"technology-based":[160],"approach":[161],"objectively":[163],"assess":[164],"effectiveness.":[167],"SIGNIFICANCE:":[168],"Novel":[169],"devices":[170],"improve":[172],"accuracy":[174],"function,":[180],"integrating":[182],"clinical":[184],"evaluation":[185],"reports.":[188]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":2}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}