{"id":"https://openalex.org/W4206025448","doi":"https://doi.org/10.1109/jbhi.2022.3141076","title":"An Algorithm to Mine Therapeutic Motifs for Cancer From Networks of Genetic Interactions","display_name":"An Algorithm to Mine Therapeutic Motifs for Cancer From Networks of Genetic Interactions","publication_year":2022,"publication_date":"2022-01-06","ids":{"openalex":"https://openalex.org/W4206025448","doi":"https://doi.org/10.1109/jbhi.2022.3141076","pmid":"https://pubmed.ncbi.nlm.nih.gov/34990373"},"language":"en","primary_location":{"id":"doi:10.1109/jbhi.2022.3141076","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2022.3141076","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002269690","display_name":"Herty Liany","orcid":"https://orcid.org/0000-0001-6609-3287"},"institutions":[{"id":"https://openalex.org/I4210137145","display_name":"National Cancer Centre Singapore","ror":"https://ror.org/03bqk3e80","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210137145"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Herty Liany","raw_affiliation_strings":["National Cancer Centre Singapore, Singapore"],"affiliations":[{"raw_affiliation_string":"National Cancer Centre Singapore, Singapore","institution_ids":["https://openalex.org/I4210137145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079714822","display_name":"Yu Lin","orcid":"https://orcid.org/0000-0001-6339-2644"},"institutions":[{"id":"https://openalex.org/I118347636","display_name":"Australian National University","ror":"https://ror.org/019wvm592","country_code":"AU","type":"education","lineage":["https://openalex.org/I118347636"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Yu Lin","raw_affiliation_strings":["School of Computing, Australian National University, Canberra, Australia"],"affiliations":[{"raw_affiliation_string":"School of Computing, Australian National University, Canberra, Australia","institution_ids":["https://openalex.org/I118347636"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008789298","display_name":"Anand D. Jeyasekharan","orcid":"https://orcid.org/0000-0001-9816-6137"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210103786","display_name":"National University Cancer Institute, Singapore","ror":"https://ror.org/025yypj46","country_code":"SG","type":"education","lineage":["https://openalex.org/I4210103786","https://openalex.org/I4210150261"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Anand Jeyasekharan","raw_affiliation_strings":["Cancer Science Institute of Singapore, National University of Singapore, Singapore"],"affiliations":[{"raw_affiliation_string":"Cancer Science Institute of Singapore, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I4210103786","https://openalex.org/I165932596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079452621","display_name":"Vaibhav Rajan","orcid":"https://orcid.org/0000-0002-6748-6864"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Vaibhav Rajan","raw_affiliation_strings":["Department of Information Systems and Analytics, School of Computing, National University of Singapore, Singapore"],"affiliations":[{"raw_affiliation_string":"Department of Information Systems and Analytics, School of Computing, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5002269690"],"corresponding_institution_ids":["https://openalex.org/I4210137145"],"apc_list":null,"apc_paid":null,"fwci":0.19,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.42871594,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"26","issue":"6","first_page":"2830","last_page":"2838"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9872000217437744,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9787999987602234,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pairwise-comparison","display_name":"Pairwise comparison","score":0.7522803544998169},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6144371628761292},{"id":"https://openalex.org/keywords/integer-programming","display_name":"Integer programming","score":0.6071860790252686},{"id":"https://openalex.org/keywords/bipartite-graph","display_name":"Bipartite graph","score":0.572729766368866},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.3862467408180237},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.36267223954200745},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2934926748275757},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.130295991897583}],"concepts":[{"id":"https://openalex.org/C184898388","wikidata":"https://www.wikidata.org/wiki/Q1435712","display_name":"Pairwise comparison","level":2,"score":0.7522803544998169},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6144371628761292},{"id":"https://openalex.org/C56086750","wikidata":"https://www.wikidata.org/wiki/Q6042592","display_name":"Integer programming","level":2,"score":0.6071860790252686},{"id":"https://openalex.org/C197657726","wikidata":"https://www.wikidata.org/wiki/Q174733","display_name":"Bipartite graph","level":3,"score":0.572729766368866},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.3862467408180237},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.36267223954200745},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2934926748275757},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.130295991897583}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/jbhi.2022.3141076","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2022.3141076","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},{"id":"pmid:34990373","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34990373","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE journal of biomedical and health informatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W1276568096","https://openalex.org/W1772536836","https://openalex.org/W1965222635","https://openalex.org/W1990777291","https://openalex.org/W2008190138","https://openalex.org/W2011039300","https://openalex.org/W2013520054","https://openalex.org/W2023689647","https://openalex.org/W2034837176","https://openalex.org/W2037225069","https://openalex.org/W2037566862","https://openalex.org/W2039366890","https://openalex.org/W2042851051","https://openalex.org/W2045953361","https://openalex.org/W2062185406","https://openalex.org/W2085967512","https://openalex.org/W2098013039","https://openalex.org/W2100439220","https://openalex.org/W2110017381","https://openalex.org/W2117692326","https://openalex.org/W2121443461","https://openalex.org/W2125179362","https://openalex.org/W2136093015","https://openalex.org/W2138157888","https://openalex.org/W2139027526","https://openalex.org/W2141811925","https://openalex.org/W2147069866","https://openalex.org/W2147551134","https://openalex.org/W2147554928","https://openalex.org/W2151763757","https://openalex.org/W2154444902","https://openalex.org/W2154947819","https://openalex.org/W2158485828","https://openalex.org/W2164568999","https://openalex.org/W2168399952","https://openalex.org/W2171212733","https://openalex.org/W2253342312","https://openalex.org/W2289427232","https://openalex.org/W2294446650","https://openalex.org/W2370468903","https://openalex.org/W2600452401","https://openalex.org/W2611492308","https://openalex.org/W2753100140","https://openalex.org/W2753385986","https://openalex.org/W2807675497","https://openalex.org/W2895954295","https://openalex.org/W2947691621","https://openalex.org/W2949363897","https://openalex.org/W2951296328","https://openalex.org/W2977712660","https://openalex.org/W2990747402","https://openalex.org/W3006811481","https://openalex.org/W3012614768","https://openalex.org/W3024911178","https://openalex.org/W3028304854","https://openalex.org/W3097864120","https://openalex.org/W4237739197","https://openalex.org/W4242011915","https://openalex.org/W4294216483","https://openalex.org/W6638087726","https://openalex.org/W6680209505","https://openalex.org/W6708072188","https://openalex.org/W6775083537"],"related_works":["https://openalex.org/W2371352078","https://openalex.org/W2487162673","https://openalex.org/W2942366970","https://openalex.org/W2953461625","https://openalex.org/W2793211469","https://openalex.org/W2077383796","https://openalex.org/W2949152769","https://openalex.org/W4372354731","https://openalex.org/W2286030698","https://openalex.org/W3088754131"],"abstract_inverted_index":{"Study":[0],"of":[1,14,20,26,72,131],"pairwise":[2],"genetic":[3],"interactions,":[4],"such":[5,27,43,61],"as":[6],"mutually":[7],"exclusive":[8],"mutations,":[9],"has":[10],"led":[11],"to":[12,31,93,107,117,142],"understanding":[13],"underlying":[15],"mechanisms":[16],"in":[17,138],"cancer.":[18,144],"Investigation":[19],"various":[21],"combinatorial":[22],"motifs":[23,63,133],"within":[24],"networks":[25],"interactions":[28],"can":[29,56,135],"lead":[30],"deeper":[32],"insights":[33],"into":[34],"its":[35],"mutational":[36],"landscape":[37],"and":[38],"inform":[39],"therapy":[40],"development.":[41],"One":[42],"motif":[44],"called":[45],"the":[46,73,103],"Between-Pathway":[47],"Model":[48],"(BPM)":[49],"represents":[50],"redundant":[51],"or":[52],"compensatory":[53],"pathways":[54],"that":[55,134],"be":[57],"therapeutically":[58],"exploited.":[59],"Finding":[60],"BPM":[62,109,132],"is":[64],"challenging":[65],"since":[66],"most":[67],"formulations":[68],"require":[69],"solving":[70],"variants":[71],"NP-complete":[74],"maximum":[75],"weight":[76],"bipartite":[77],"subgraph":[78],"problem.":[79,96],"In":[80,97],"this":[81,95,125],"paper":[82],"we":[83],"design":[84],"an":[85],"algorithm":[86],"based":[87],"on":[88],"Integer":[89],"Linear":[90],"Programming":[91],"(ILP)":[92],"solve":[94],"our":[98,100,112],"experiments,":[99],"approach":[101,114],"outperforms":[102],"best":[104],"previous":[105],"method":[106],"mine":[108],"motifs.":[110],"Further,":[111],"ILP-based":[113],"allows":[115],"us":[116],"easily":[118],"model":[119],"additional":[120],"application-specific":[121],"constraints.":[122],"We":[123],"illustrate":[124],"advantage":[126],"through":[127],"a":[128],"new":[129],"application":[130],"potentially":[136],"aid":[137],"finding":[139],"combination":[140],"therapies":[141],"combat":[143]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2}],"updated_date":"2026-04-04T08:04:53.788161","created_date":"2025-10-10T00:00:00"}
