{"id":"https://openalex.org/W3217467156","doi":"https://doi.org/10.1109/jbhi.2021.3131671","title":"MSANet: Multiscale Aggregation Network Integrating Spatial and Channel Information for Lung Nodule Detection","display_name":"MSANet: Multiscale Aggregation Network Integrating Spatial and Channel Information for Lung Nodule Detection","publication_year":2021,"publication_date":"2021-11-30","ids":{"openalex":"https://openalex.org/W3217467156","doi":"https://doi.org/10.1109/jbhi.2021.3131671","mag":"3217467156","pmid":"https://pubmed.ncbi.nlm.nih.gov/34847048"},"language":"en","primary_location":{"id":"doi:10.1109/jbhi.2021.3131671","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2021.3131671","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Zhitao Guo","orcid":"https://orcid.org/0000-0001-5398-2026"},"institutions":[{"id":"https://openalex.org/I184843921","display_name":"Hebei University of Technology","ror":"https://ror.org/018hded08","country_code":"CN","type":"education","lineage":["https://openalex.org/I184843921"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhitao Guo","raw_affiliation_strings":["School of Electronic and Information Engineering, Hebei University of Technology, Tianjin, China"],"raw_orcid":"https://orcid.org/0000-0001-5398-2026","affiliations":[{"raw_affiliation_string":"School of Electronic and Information Engineering, Hebei University of Technology, Tianjin, China","institution_ids":["https://openalex.org/I184843921"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Linlin Zhao","orcid":"https://orcid.org/0000-0003-3936-0137"},"institutions":[{"id":"https://openalex.org/I184843921","display_name":"Hebei University of Technology","ror":"https://ror.org/018hded08","country_code":"CN","type":"education","lineage":["https://openalex.org/I184843921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linlin Zhao","raw_affiliation_strings":["School of Electronic and Information Engineering, Hebei University of Technology, Tianjin, China"],"raw_orcid":"https://orcid.org/0000-0003-3936-0137","affiliations":[{"raw_affiliation_string":"School of Electronic and Information Engineering, Hebei University of Technology, Tianjin, China","institution_ids":["https://openalex.org/I184843921"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jinli Yuan","orcid":null},"institutions":[{"id":"https://openalex.org/I184843921","display_name":"Hebei University of Technology","ror":"https://ror.org/018hded08","country_code":"CN","type":"education","lineage":["https://openalex.org/I184843921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinli Yuan","raw_affiliation_strings":["School of Electronic and Information Engineering, Hebei University of Technology, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electronic and Information Engineering, Hebei University of Technology, Tianjin, China","institution_ids":["https://openalex.org/I184843921"]}]},{"author_position":"last","author":{"id":null,"display_name":"Hengyong Yu","orcid":"https://orcid.org/0000-0002-5852-0813"},"institutions":[{"id":"https://openalex.org/I133738476","display_name":"University of Massachusetts Lowell","ror":"https://ror.org/03hamhx47","country_code":"US","type":"education","lineage":["https://openalex.org/I133738476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hengyong Yu","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Massachusetts Lowell, Lowell, MA, USA"],"raw_orcid":"https://orcid.org/0000-0002-5852-0813","affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Massachusetts Lowell, Lowell, MA, USA","institution_ids":["https://openalex.org/I133738476"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I184843921"],"apc_list":null,"apc_paid":null,"fwci":4.3738,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.9546387,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"26","issue":"6","first_page":"2547","last_page":"2558"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.904699981212616,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.904699981212616,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11775","display_name":"COVID-19 diagnosis using AI","score":0.020500000566244125,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10036","display_name":"Advanced Neural Network Applications","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/feature-extraction","display_name":"Feature extraction","score":0.7039999961853027},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.6237000226974487},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.6194000244140625},{"id":"https://openalex.org/keywords/ranking","display_name":"Ranking (information retrieval)","score":0.5058000087738037},{"id":"https://openalex.org/keywords/nodule","display_name":"Nodule (geology)","score":0.4699000120162964},{"id":"https://openalex.org/keywords/channel","display_name":"Channel (broadcasting)","score":0.4487999975681305},{"id":"https://openalex.org/keywords/image-resolution","display_name":"Image resolution","score":0.35199999809265137}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.781499981880188},{"id":"https://openalex.org/C52622490","wikidata":"https://www.wikidata.org/wiki/Q1026626","display_name":"Feature extraction","level":2,"score":0.7039999961853027},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.6237000226974487},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.6194000244140625},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6065000295639038},{"id":"https://openalex.org/C189430467","wikidata":"https://www.wikidata.org/wiki/Q7293293","display_name":"Ranking (information retrieval)","level":2,"score":0.5058000087738037},{"id":"https://openalex.org/C2776731575","wikidata":"https://www.wikidata.org/wiki/Q2916245","display_name":"Nodule (geology)","level":2,"score":0.4699000120162964},{"id":"https://openalex.org/C127162648","wikidata":"https://www.wikidata.org/wiki/Q16858953","display_name":"Channel (broadcasting)","level":2,"score":0.4487999975681305},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.37070000171661377},{"id":"https://openalex.org/C205372480","wikidata":"https://www.wikidata.org/wiki/Q210521","display_name":"Image resolution","level":2,"score":0.35199999809265137},{"id":"https://openalex.org/C159620131","wikidata":"https://www.wikidata.org/wiki/Q1938983","display_name":"Spatial analysis","level":2,"score":0.3176000118255615},{"id":"https://openalex.org/C32022120","wikidata":"https://www.wikidata.org/wiki/Q797225","display_name":"Interference (communication)","level":3,"score":0.31450000405311584},{"id":"https://openalex.org/C195807954","wikidata":"https://www.wikidata.org/wiki/Q1662562","display_name":"Information extraction","level":2,"score":0.3028999865055084},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.2874999940395355},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.28040000796318054},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.2676999866962433},{"id":"https://openalex.org/C2776151529","wikidata":"https://www.wikidata.org/wiki/Q3045304","display_name":"Object detection","level":3,"score":0.2515999972820282},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.250900000333786}],"mesh":[{"descriptor_ui":"D003074","descriptor_name":"Solitary Pulmonary Nodule","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D003074","descriptor_name":"Solitary Pulmonary Nodule","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D003074","descriptor_name":"Solitary Pulmonary Nodule","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D011857","descriptor_name":"Radiographic Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011857","descriptor_name":"Radiographic Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011857","descriptor_name":"Radiographic Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055613","descriptor_name":"Multiple Pulmonary Nodules","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055613","descriptor_name":"Multiple Pulmonary Nodules","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055613","descriptor_name":"Multiple Pulmonary Nodules","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/jbhi.2021.3131671","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2021.3131671","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},{"id":"pmid:34847048","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34847048","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE journal of biomedical and health informatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G8430290716","display_name":null,"funder_award_id":"61801164","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1516595210","https://openalex.org/W1901129140","https://openalex.org/W2067123389","https://openalex.org/W2122692815","https://openalex.org/W2148076415","https://openalex.org/W2164160732","https://openalex.org/W2194775991","https://openalex.org/W2322371438","https://openalex.org/W2325627219","https://openalex.org/W2339885376","https://openalex.org/W2524399695","https://openalex.org/W2581082771","https://openalex.org/W2584017349","https://openalex.org/W2769848455","https://openalex.org/W2789973801","https://openalex.org/W2791104228","https://openalex.org/W2791142503","https://openalex.org/W2887808321","https://openalex.org/W2899912692","https://openalex.org/W2903104347","https://openalex.org/W2919115771","https://openalex.org/W2929868177","https://openalex.org/W2961148992","https://openalex.org/W2963420686","https://openalex.org/W2963777800","https://openalex.org/W3000282918","https://openalex.org/W3005617351","https://openalex.org/W3028412523","https://openalex.org/W3034552520","https://openalex.org/W3034752215","https://openalex.org/W3035134467","https://openalex.org/W3035422681","https://openalex.org/W3134900589","https://openalex.org/W6772954633"],"related_works":[],"abstract_inverted_index":{"Improving":[0],"the":[1,12,46,83,97,113,122,125,139,146,154,160,183,198,208],"detection":[2,180,224],"accuracy":[3],"of":[4,17,86,134,143,162,190,211],"pulmonary":[5,38,178,202,222,231],"nodules":[6,203],"plays":[7],"an":[8],"important":[9],"role":[10],"in":[11,124,221,230],"diagnosis":[13],"and":[14,31,52,68,89,107,115,137,167,186,206,225],"early":[15],"treatment":[16],"lung":[18],"cancer.":[19],"In":[20],"this":[21],"paper,":[22],"a":[23,187],"multiscale":[24,54,58],"aggregation":[25,59],"network":[26],"(MSANet),":[27],"which":[28,129],"integrates":[29],"spatial":[30,117],"channel":[32,105],"information,":[33],"is":[34,42,101,151,173,192,204,213],"proposed":[35,171,217],"for":[36,103,200],"3D":[37],"nodule":[39,179,223,232],"detection.":[40,233],"MSANet":[41,172],"designed":[43,102],"to":[44,49,64,91,111,158],"improve":[45],"network's":[47],"ability":[48,142],"extract":[50,65],"information":[51,55,85,140],"realize":[53,131],"fusion.":[56],"First,":[57],"interaction":[60],"strategies":[61,79],"are":[62],"used":[63],"multilevel":[66],"features":[67,123],"avoid":[69],"feature":[70,98,126,135],"fusion":[71],"interference":[72],"caused":[73],"by":[74],"large":[75],"resolution":[76],"differences.":[77],"These":[78],"can":[80,130,226],"effectively":[81,214,227],"integrate":[82],"contextual":[84],"adjacent":[87],"resolutions":[88],"help":[90],"detect":[92],"different":[93],"sized":[94],"nodules.":[95],"Second,":[96],"extraction":[99,127,141],"module":[100],"efficient":[104],"attention":[106],"self-calibrated":[108],"convolutions":[109],"(ECA-SC)":[110],"enhance":[112,138],"interchannel":[114],"local":[116],"information.":[118],"ECA-SC":[119],"also":[120],"recalibrates":[121],"process,":[128],"adaptive":[132],"learning":[133],"weights":[136],"features.":[144],"Third,":[145],"distribution":[147],"ranking":[148],"(DR)":[149],"loss":[150,156],"introduced":[152],"as":[153],"classification":[155],"function":[157],"solve":[159],"problem":[161],"imbalanced":[163],"data":[164],"between":[165],"positive":[166],"negative":[168],"samples.":[169],"The":[170,194,216],"comprehensively":[174],"compared":[175],"with":[176],"other":[177],"networks":[181],"on":[182],"LUNA16":[184],"dataset,":[185],"CPM":[188],"score":[189],"0.920":[191],"obtained.":[193],"results":[195],"show":[196],"that":[197,207],"sensitivity":[199],"detecting":[201],"improved":[205],"average":[209],"number":[210],"false-positives":[212],"reduced.":[215],"method":[218],"has":[219],"advantages":[220],"assist":[228],"radiologists":[229]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":1}],"updated_date":"2026-05-08T15:41:06.802602","created_date":"2021-12-06T00:00:00"}