{"id":"https://openalex.org/W3187046408","doi":"https://doi.org/10.1109/jbhi.2021.3100424","title":"dbMCS: A Database for Exploring the Mutation Markers of Anti-Cancer Drug Sensitivity","display_name":"dbMCS: A Database for Exploring the Mutation Markers of Anti-Cancer Drug Sensitivity","publication_year":2021,"publication_date":"2021-07-27","ids":{"openalex":"https://openalex.org/W3187046408","doi":"https://doi.org/10.1109/jbhi.2021.3100424","mag":"3187046408","pmid":"https://pubmed.ncbi.nlm.nih.gov/34314366"},"language":"en","primary_location":{"id":"doi:10.1109/jbhi.2021.3100424","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2021.3100424","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074475840","display_name":"Yueyue Shen","orcid":null},"institutions":[{"id":"https://openalex.org/I140221134","display_name":"Anhui Agricultural University","ror":"https://ror.org/0327f3359","country_code":"CN","type":"education","lineage":["https://openalex.org/I140221134"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yueyue Shen","raw_affiliation_strings":["School of Information and Computer, Anhui Provincial Engineering Laboratory for Beidou Precision Agriculture Information, Anhui Agricultural University, Hefei, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information and Computer, Anhui Provincial Engineering Laboratory for Beidou Precision Agriculture Information, Anhui Agricultural University, Hefei, Anhui, China","institution_ids":["https://openalex.org/I140221134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030976490","display_name":"Youhua Zhang","orcid":"https://orcid.org/0000-0002-6488-0153"},"institutions":[{"id":"https://openalex.org/I140221134","display_name":"Anhui Agricultural University","ror":"https://ror.org/0327f3359","country_code":"CN","type":"education","lineage":["https://openalex.org/I140221134"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Youhua Zhang","raw_affiliation_strings":["School of Information and Computer, Anhui Provincial Engineering Laboratory for Beidou Precision Agriculture Information, Anhui Agricultural University, Hefei, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information and Computer, Anhui Provincial Engineering Laboratory for Beidou Precision Agriculture Information, Anhui Agricultural University, Hefei, Anhui, China","institution_ids":["https://openalex.org/I140221134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100408966","display_name":"Wei Xue","orcid":"https://orcid.org/0000-0003-0124-9433"},"institutions":[{"id":"https://openalex.org/I140221134","display_name":"Anhui Agricultural University","ror":"https://ror.org/0327f3359","country_code":"CN","type":"education","lineage":["https://openalex.org/I140221134"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Xue","raw_affiliation_strings":["School of Information and Computer, Anhui Provincial Engineering Laboratory for Beidou Precision Agriculture Information, Anhui Agricultural University, Hefei, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information and Computer, Anhui Provincial Engineering Laboratory for Beidou Precision Agriculture Information, Anhui Agricultural University, Hefei, Anhui, China","institution_ids":["https://openalex.org/I140221134"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044447237","display_name":"Zhenyu Yue","orcid":"https://orcid.org/0000-0002-9370-2540"},"institutions":[{"id":"https://openalex.org/I140221134","display_name":"Anhui Agricultural University","ror":"https://ror.org/0327f3359","country_code":"CN","type":"education","lineage":["https://openalex.org/I140221134"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenyu Yue","raw_affiliation_strings":["School of Information and Computer, Anhui Provincial Engineering Laboratory for Beidou Precision Agriculture Information, Anhui Agricultural University, Hefei, Anhui, China"],"raw_orcid":"https://orcid.org/0000-0002-9370-2540","affiliations":[{"raw_affiliation_string":"School of Information and Computer, Anhui Provincial Engineering Laboratory for Beidou Precision Agriculture Information, Anhui Agricultural University, Hefei, Anhui, China","institution_ids":["https://openalex.org/I140221134"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I140221134"],"apc_list":null,"apc_paid":null,"fwci":1.0133,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.79760492,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"25","issue":"11","first_page":"4229","last_page":"4237"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9927999973297119,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9927999973297119,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.98089998960495,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9724000096321106,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmacogenomics","display_name":"Pharmacogenomics","score":0.7349478006362915},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.7137421369552612},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.607950747013092},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"Drug resistance","score":0.5462994575500488},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4908602833747864},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.4714943766593933},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4304564297199249},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4177218973636627},{"id":"https://openalex.org/keywords/drug-response","display_name":"Drug response","score":0.4152461886405945},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4059031009674072},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3656349778175354},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.17771312594413757},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.15740936994552612}],"concepts":[{"id":"https://openalex.org/C170734499","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenomics","level":2,"score":0.7349478006362915},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.7137421369552612},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.607950747013092},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.5462994575500488},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4908602833747864},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4714943766593933},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4304564297199249},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4177218973636627},{"id":"https://openalex.org/C2994119904","wikidata":"https://www.wikidata.org/wiki/Q1251001","display_name":"Drug response","level":3,"score":0.4152461886405945},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4059031009674072},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3656349778175354},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17771312594413757},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.15740936994552612},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/jbhi.2021.3100424","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2021.3100424","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},{"id":"pmid:34314366","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34314366","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE journal of biomedical and health informatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7599999904632568,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W1809016129","https://openalex.org/W1829137581","https://openalex.org/W1976526581","https://openalex.org/W2003984225","https://openalex.org/W2005841386","https://openalex.org/W2016809033","https://openalex.org/W2017818880","https://openalex.org/W2057796192","https://openalex.org/W2096439166","https://openalex.org/W2096777589","https://openalex.org/W2097606916","https://openalex.org/W2098650870","https://openalex.org/W2101234009","https://openalex.org/W2102140136","https://openalex.org/W2109791697","https://openalex.org/W2118621341","https://openalex.org/W2122732537","https://openalex.org/W2129360604","https://openalex.org/W2129656399","https://openalex.org/W2139804581","https://openalex.org/W2145191876","https://openalex.org/W2159092541","https://openalex.org/W2160995259","https://openalex.org/W2167179525","https://openalex.org/W2171777347","https://openalex.org/W2174602966","https://openalex.org/W2178775247","https://openalex.org/W2180426023","https://openalex.org/W2226979499","https://openalex.org/W2261193987","https://openalex.org/W2295598076","https://openalex.org/W2309021002","https://openalex.org/W2322120487","https://openalex.org/W2342478867","https://openalex.org/W2407198816","https://openalex.org/W2516164871","https://openalex.org/W2526413677","https://openalex.org/W2527487948","https://openalex.org/W2583911935","https://openalex.org/W2612692962","https://openalex.org/W2614443510","https://openalex.org/W2727436210","https://openalex.org/W2765235107","https://openalex.org/W2766837662","https://openalex.org/W2767891136","https://openalex.org/W2769659311","https://openalex.org/W2792363117","https://openalex.org/W2807675497","https://openalex.org/W2883814060","https://openalex.org/W2898789672","https://openalex.org/W2899996910","https://openalex.org/W2900857957","https://openalex.org/W2905130244","https://openalex.org/W2913820789","https://openalex.org/W2947626248","https://openalex.org/W2948505931","https://openalex.org/W2949492942","https://openalex.org/W2952845469","https://openalex.org/W2955609197","https://openalex.org/W2991142480","https://openalex.org/W2997757919","https://openalex.org/W3017283277","https://openalex.org/W3037601773","https://openalex.org/W3038114454","https://openalex.org/W3095583226","https://openalex.org/W3096270667","https://openalex.org/W3102476541","https://openalex.org/W4205247356","https://openalex.org/W4250708691","https://openalex.org/W6675354045","https://openalex.org/W6728363623"],"related_works":["https://openalex.org/W4231349869","https://openalex.org/W2896304141","https://openalex.org/W4239789534","https://openalex.org/W2019271482","https://openalex.org/W4387225326","https://openalex.org/W1537547840","https://openalex.org/W2563611238","https://openalex.org/W2117099437","https://openalex.org/W134690430","https://openalex.org/W2015885257"],"abstract_inverted_index":{"The":[0],"identification":[1],"of":[2,8,23,29,40,48,59,104,130,161],"mutation":[3,49,60,112,159],"markers":[4,43,113,160],"and":[5,26,44,72,77,81,125,145,165,179],"the":[6,21,27,37,91,96,102,111,137,143,153],"selection":[7],"appropriate":[9],"treatment":[10],"for":[11,32,62,79,157,182],"patients":[12],"with":[13,84,95],"specific":[14],"genome":[15],"mutations":[16,71,92],"are":[17],"important":[18],"steps":[19],"in":[20,93,122,142],"development":[22],"targeted":[24],"therapies":[25],"realization":[28],"precision":[30],"medicine":[31],"human":[33],"cancers.":[34],"To":[35],"investigate":[36],"baseline":[38],"characteristics":[39,103],"drug":[41,64,105,163],"sensitivity":[42,80,106,144,164],"develop":[45],"computational":[46],"methods":[47,156],"effect":[50],"prediction,":[51],"we":[52,100,150],"presented":[53,132],"a":[54,172],"manually":[55],"curated":[56],"online-based":[57],"database":[58],"Markers":[61],"anti-Cancer":[63],"Sensitivity":[65],"(dbMCS).":[66],"Currently,":[67],"dbMCS":[68,94,187],"contains":[69],"1271":[70],"4427":[73],"mutation-disease-drug":[74],"associations":[75],"(3151":[76],"1276":[78],"resistance,":[82],"respectively)":[83],"their":[85],"PubMed":[86],"indexed":[87],"articles.":[88],"By":[89],"comparing":[90],"putative":[97],"neutral":[98],"polymorphisms,":[99],"investigated":[101],"markers.":[107],"We":[108],"found":[109],"that":[110,171],"tend":[114],"to":[115],"significantly":[116],"impact":[117],"on":[118,136],"high-conservative":[119],"regions":[120],"both":[121],"DNA":[123],"sequences":[124],"protein":[126],"domains.":[127],"And":[128],"some":[129],"them":[131],"pleiotropic":[133],"effects":[134],"depending":[135],"tumor":[138],"context,":[139],"appearing":[140],"concurrently":[141],"resistance":[146],"categories.":[147],"In":[148],"addition,":[149],"preliminarily":[151],"explored":[152],"machine":[154],"learning-based":[155],"identifying":[158],"anti-cancer":[162],"produced":[166],"optimistic":[167],"results,":[168],"which":[169],"suggests":[170],"reliable":[173],"dataset":[174],"may":[175],"provide":[176],"new":[177],"insights":[178],"essential":[180],"clues":[181],"future":[183],"cancer":[184],"pharmacogenomics":[185],"studies.":[186],"is":[188],"available":[189],"at":[190],"http://bioinfo.aielab.cc/dbMCS/.":[191]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
