{"id":"https://openalex.org/W3079866518","doi":"https://doi.org/10.1109/jbhi.2020.3017540","title":"Neuron Image Segmentation via Learning Deep Features and Enhancing Weak Neuronal Structures","display_name":"Neuron Image Segmentation via Learning Deep Features and Enhancing Weak Neuronal Structures","publication_year":2020,"publication_date":"2020-08-18","ids":{"openalex":"https://openalex.org/W3079866518","doi":"https://doi.org/10.1109/jbhi.2020.3017540","mag":"3079866518","pmid":"https://pubmed.ncbi.nlm.nih.gov/32809948"},"language":"en","primary_location":{"id":"doi:10.1109/jbhi.2020.3017540","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2020.3017540","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100657705","display_name":"Bo Yang","orcid":"https://orcid.org/0000-0002-0814-3781"},"institutions":[{"id":"https://openalex.org/I4210144102","display_name":"Wuhu Hit Robot Technology Research Institute","ror":"https://ror.org/049w4dp92","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210144102"]},{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bo Yang","raw_affiliation_strings":["Hunan University, Changsha, China","National Engineering Laboratory for Robot Visual Perception and Control Technology, Changsha, China"],"affiliations":[{"raw_affiliation_string":"Hunan University, Changsha, China","institution_ids":["https://openalex.org/I16609230"]},{"raw_affiliation_string":"National Engineering Laboratory for Robot Visual Perception and Control Technology, Changsha, China","institution_ids":["https://openalex.org/I4210144102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011466255","display_name":"Weixun Chen","orcid":"https://orcid.org/0000-0002-1583-5807"},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]},{"id":"https://openalex.org/I4210144102","display_name":"Wuhu Hit Robot Technology Research Institute","ror":"https://ror.org/049w4dp92","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210144102"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weixun Chen","raw_affiliation_strings":["Hunan University, Changsha, China","National Engineering Laboratory for Robot Visual Perception and Control Technology, Changsha, China"],"affiliations":[{"raw_affiliation_string":"Hunan University, Changsha, China","institution_ids":["https://openalex.org/I16609230"]},{"raw_affiliation_string":"National Engineering Laboratory for Robot Visual Perception and Control Technology, Changsha, China","institution_ids":["https://openalex.org/I4210144102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070569058","display_name":"Huiqiong Luo","orcid":null},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]},{"id":"https://openalex.org/I4210144102","display_name":"Wuhu Hit Robot Technology Research Institute","ror":"https://ror.org/049w4dp92","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210144102"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huiqiong Luo","raw_affiliation_strings":["Hunan University, Changsha, China","National Engineering Laboratory for Robot Visual Perception and Control Technology, Changsha, China"],"affiliations":[{"raw_affiliation_string":"Hunan University, Changsha, China","institution_ids":["https://openalex.org/I16609230"]},{"raw_affiliation_string":"National Engineering Laboratory for Robot Visual Perception and Control Technology, Changsha, China","institution_ids":["https://openalex.org/I4210144102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011942105","display_name":"Yinghui Tan","orcid":"https://orcid.org/0000-0002-3617-8252"},"institutions":[{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]},{"id":"https://openalex.org/I4210144102","display_name":"Wuhu Hit Robot Technology Research Institute","ror":"https://ror.org/049w4dp92","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210144102"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yinghui Tan","raw_affiliation_strings":["Hunan University, Changsha, China","National Engineering Laboratory for Robot Visual Perception and Control Technology, Changsha, China"],"affiliations":[{"raw_affiliation_string":"Hunan University, Changsha, China","institution_ids":["https://openalex.org/I16609230"]},{"raw_affiliation_string":"National Engineering Laboratory for Robot Visual Perception and Control Technology, Changsha, China","institution_ids":["https://openalex.org/I4210144102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100343854","display_name":"Min Liu","orcid":"https://orcid.org/0000-0001-6406-4896"},"institutions":[{"id":"https://openalex.org/I4210144102","display_name":"Wuhu Hit Robot Technology Research Institute","ror":"https://ror.org/049w4dp92","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210144102"]},{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Liu","raw_affiliation_strings":["Hunan University, Changsha, China","National Engineering Laboratory for Robot Visual Perception and Control Technology, Changsha, China"],"affiliations":[{"raw_affiliation_string":"Hunan University, Changsha, China","institution_ids":["https://openalex.org/I16609230"]},{"raw_affiliation_string":"National Engineering Laboratory for Robot Visual Perception and Control Technology, Changsha, China","institution_ids":["https://openalex.org/I4210144102"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025640070","display_name":"Yaonan Wang","orcid":"https://orcid.org/0000-0002-0519-6458"},"institutions":[{"id":"https://openalex.org/I4210144102","display_name":"Wuhu Hit Robot Technology Research Institute","ror":"https://ror.org/049w4dp92","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210144102"]},{"id":"https://openalex.org/I16609230","display_name":"Hunan University","ror":"https://ror.org/05htk5m33","country_code":"CN","type":"education","lineage":["https://openalex.org/I16609230"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaonan Wang","raw_affiliation_strings":["Hunan University, Changsha, China","National Engineering Laboratory for Robot Visual Perception and Control Technology, Changsha, China"],"affiliations":[{"raw_affiliation_string":"Hunan University, Changsha, China","institution_ids":["https://openalex.org/I16609230"]},{"raw_affiliation_string":"National Engineering Laboratory for Robot Visual Perception and Control Technology, Changsha, China","institution_ids":["https://openalex.org/I4210144102"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5100657705"],"corresponding_institution_ids":["https://openalex.org/I16609230","https://openalex.org/I4210144102"],"apc_list":null,"apc_paid":null,"fwci":3.5318,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.93234792,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"25","issue":"5","first_page":"1634","last_page":"1645"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13114","display_name":"Image Processing Techniques and Applications","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2214","display_name":"Media Technology"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12874","display_name":"Digital Imaging for Blood Diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.8020185232162476},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.7266711592674255},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7044445276260376},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.579746663570404},{"id":"https://openalex.org/keywords/tracing","display_name":"Tracing","score":0.546844482421875},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.5198960304260254},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.4977457821369171},{"id":"https://openalex.org/keywords/neuron","display_name":"Neuron","score":0.46905070543289185},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.41531169414520264},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.07306817173957825}],"concepts":[{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.8020185232162476},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.7266711592674255},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7044445276260376},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.579746663570404},{"id":"https://openalex.org/C138673069","wikidata":"https://www.wikidata.org/wiki/Q322229","display_name":"Tracing","level":2,"score":0.546844482421875},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.5198960304260254},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.4977457821369171},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.46905070543289185},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.41531169414520264},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07306817173957825},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/jbhi.2020.3017540","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2020.3017540","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},{"id":"pmid:32809948","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32809948","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE journal of biomedical and health informatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3261378140","display_name":null,"funder_award_id":"2020JJ2008","funder_id":"https://openalex.org/F4320322843","funder_display_name":"Natural Science Foundation of\u00a0Hunan Province"},{"id":"https://openalex.org/G8810697831","display_name":null,"funder_award_id":"61771189","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322843","display_name":"Natural Science Foundation of\u00a0Hunan Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W22040386","https://openalex.org/W1427337929","https://openalex.org/W1871050032","https://openalex.org/W1901129140","https://openalex.org/W1932624639","https://openalex.org/W1983364832","https://openalex.org/W1992621211","https://openalex.org/W1998874218","https://openalex.org/W2014252132","https://openalex.org/W2014281241","https://openalex.org/W2018227909","https://openalex.org/W2019305522","https://openalex.org/W2061272711","https://openalex.org/W2109037308","https://openalex.org/W2124257654","https://openalex.org/W2129534965","https://openalex.org/W2134557905","https://openalex.org/W2156114286","https://openalex.org/W2157408013","https://openalex.org/W2171234607","https://openalex.org/W2196620636","https://openalex.org/W2202170526","https://openalex.org/W2256981962","https://openalex.org/W2404192493","https://openalex.org/W2544277621","https://openalex.org/W2574038793","https://openalex.org/W2584131486","https://openalex.org/W2587001086","https://openalex.org/W2594660495","https://openalex.org/W2750661942","https://openalex.org/W2761731085","https://openalex.org/W2794642825","https://openalex.org/W2798122215","https://openalex.org/W2884739365","https://openalex.org/W2889676079","https://openalex.org/W2891656998","https://openalex.org/W2909295255","https://openalex.org/W2910669864","https://openalex.org/W2912059704","https://openalex.org/W2912077506","https://openalex.org/W2938571347","https://openalex.org/W2950062384","https://openalex.org/W2952846208","https://openalex.org/W2957395818","https://openalex.org/W2962914239","https://openalex.org/W2966593583","https://openalex.org/W2969643617","https://openalex.org/W2979910668","https://openalex.org/W4300956932","https://openalex.org/W6628308968","https://openalex.org/W6639824700","https://openalex.org/W6750104346","https://openalex.org/W6750469568"],"related_works":["https://openalex.org/W2888673113","https://openalex.org/W2056065966","https://openalex.org/W2352602608","https://openalex.org/W2062641654","https://openalex.org/W2212288070","https://openalex.org/W3149975758","https://openalex.org/W4375867731","https://openalex.org/W1517786189","https://openalex.org/W164695339","https://openalex.org/W1522196789"],"abstract_inverted_index":{"Neuron":[0],"morphology":[1],"reconstruction":[2,204],"(tracing)":[3],"in":[4,22,65,89,101,119,164,223],"3D":[5,45,96,197],"volumetric":[6],"images":[7,28,209],"is":[8,112,134,142,152],"critical":[9],"for":[10,196],"neuronal":[11,56,72,162],"research.":[12],"However,":[13],"most":[14],"existing":[15],"neuron":[16,27,46,97,128,173,198,203],"tracing":[17],"methods":[18,195],"are":[19,29,243],"not":[20],"applicable":[21],"challenging":[23],"datasets":[24],"where":[25],"the":[26,60,66,70,75,95,106,116,123,126,131,139,156,170,176,202,207,215,224,235,249],"contaminated":[30],"by":[31,144,159,169,211],"noises":[32],"or":[33],"containing":[34],"weak":[35,55,161],"filament":[36],"signals.":[37],"In":[38,74,105],"this":[39],"paper,":[40],"we":[41,78],"present":[42],"a":[43,80,109,149,165],"two-stage":[44],"segmentation":[47,99,120,186,190,213],"approach":[48,187,217],"via":[49],"learning":[50,90],"deep":[51,91],"features":[52],"and":[53,68,125,136,175,220,231,245],"enhancing":[54,160],"structures,":[57,158],"to":[58,93,114,154],"reduce":[59],"impact":[61],"of":[62,122,130,138,234],"image":[63,98],"noise":[64],"data":[67],"enhance":[69],"weak-signal":[71],"structures.":[73],"first":[76],"stage,":[77,108],"train":[79],"voxel-wise":[81],"multi-level":[82],"fully":[83],"convolutional":[84],"network":[85],"(FCN),":[86],"which":[87],"specializes":[88],"features,":[92],"obtain":[94],"maps":[100],"an":[102],"end-to-end":[103],"manner.":[104],"second":[107],"ray-shooting":[110],"model":[111,151],"employed":[113],"detect":[115],"discontinued":[117],"segments":[118],"results":[121,181,205,251],"first-stage,":[124],"local":[127,172],"diameter":[129,174],"broken":[132,157],"point":[133,237],"estimated":[135,171],"direction":[137],"filamentary":[140,177],"fragment":[141,178],"detected":[143],"rayburst":[145],"sampling":[146],"algorithm.":[147],"Then,":[148],"Hessian-repair":[150],"built":[153],"repair":[155],"structures":[163],"fibrous":[166],"structure":[167],"determined":[168],"direction.":[179],"Experimental":[180],"demonstrate":[182],"that":[183],"our":[184,240],"proposed":[185,216,241],"achieves":[188],"better":[189],"performance":[191],"than":[192,248],"other":[193,212],"state-of-the-art":[194],"segmentation.":[199,253],"Compared":[200],"with":[201,239],"on":[206],"segmented":[208],"produced":[210],"methods,":[214],"gains":[218],"47.83%":[219],"34.83%":[221],"improvement":[222],"average":[225,229],"distance":[226],"scores.":[227],"The":[228],"Precision":[230],"Recall":[232],"rates":[233],"branch":[236],"detection":[238,250],"method":[242],"38.74%":[244],"22.53%":[246],"higher":[247],"without":[252]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
