{"id":"https://openalex.org/W3043553871","doi":"https://doi.org/10.1109/jbhi.2020.3008821","title":"Towards Automatic Protein Co-Expression Quantification in Immunohistochemical TMA Slides","display_name":"Towards Automatic Protein Co-Expression Quantification in Immunohistochemical TMA Slides","publication_year":2020,"publication_date":"2020-07-13","ids":{"openalex":"https://openalex.org/W3043553871","doi":"https://doi.org/10.1109/jbhi.2020.3008821","mag":"3043553871","pmid":"https://pubmed.ncbi.nlm.nih.gov/32750958"},"language":"en","primary_location":{"id":"doi:10.1109/jbhi.2020.3008821","is_oa":true,"landing_page_url":"https://doi.org/10.1109/jbhi.2020.3008821","pdf_url":"https://ieeexplore.ieee.org/ielx7/6221020/9348958/09139320.pdf","source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ieeexplore.ieee.org/ielx7/6221020/9348958/09139320.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077935635","display_name":"Leslie Solorzano","orcid":"https://orcid.org/0000-0001-8658-6417"},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Leslie Solorzano","raw_affiliation_strings":["Department of Information Technology and SciLifeLab, Uppsala University, Uppsala, Sweden"],"raw_orcid":"https://orcid.org/0000-0001-8658-6417","affiliations":[{"raw_affiliation_string":"Department of Information Technology and SciLifeLab, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024362169","display_name":"Carla Pereira","orcid":"https://orcid.org/0000-0001-5892-0764"},"institutions":[{"id":"https://openalex.org/I4210158732","display_name":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto","ror":"https://ror.org/04wjk1035","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Carla Pereira","raw_affiliation_strings":["i3S - Institute Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade and the Institute of Molecular Pathology and Immunology (IPATIMUP), University of Porto, Porto, Portugal"],"raw_orcid":"https://orcid.org/0000-0001-5892-0764","affiliations":[{"raw_affiliation_string":"i3S - Institute Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade and the Institute of Molecular Pathology and Immunology (IPATIMUP), University of Porto, Porto, Portugal","institution_ids":["https://openalex.org/I4210158732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088058402","display_name":"Diana Martins","orcid":"https://orcid.org/0000-0002-1457-8992"},"institutions":[{"id":"https://openalex.org/I293362453","display_name":"Polytechnic Institute of Coimbra","ror":"https://ror.org/01n8x4993","country_code":"PT","type":"education","lineage":["https://openalex.org/I293362453"]},{"id":"https://openalex.org/I4210158732","display_name":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto","ror":"https://ror.org/04wjk1035","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Diana Martins","raw_affiliation_strings":["Department of Biomedical Laboratory Sciences, Polytechnic Institute of Coimbra, Coimbra, Portugal","i3S - Institute Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, University of Porto, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Laboratory Sciences, Polytechnic Institute of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I293362453"]},{"raw_affiliation_string":"i3S - Institute Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, University of Porto, Porto, Portugal","institution_ids":["https://openalex.org/I4210158732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016034491","display_name":"Raquel Almeida","orcid":"https://orcid.org/0000-0002-5622-1633"},"institutions":[{"id":"https://openalex.org/I4210158732","display_name":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto","ror":"https://ror.org/04wjk1035","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Raquel Almeida","raw_affiliation_strings":["i3S - Institute Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, the Institute of Molecular Pathology and Immunology (IPATIMUP), the Faculty of Sciences, and the Faculty of Medicine, Univer-sity of Porto, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"i3S - Institute Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, the Institute of Molecular Pathology and Immunology (IPATIMUP), the Faculty of Sciences, and the Faculty of Medicine, Univer-sity of Porto, Porto, Portugal","institution_ids":["https://openalex.org/I4210158732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026242093","display_name":"F\u00e1tima Carneiro","orcid":"https://orcid.org/0000-0002-1964-1006"},"institutions":[{"id":"https://openalex.org/I4210158732","display_name":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto","ror":"https://ror.org/04wjk1035","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Fatima Carneiro","raw_affiliation_strings":["i3S - Institute Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, the Institute of Molecular Pathology and Immunology (IPATIMUP), the Faculty of Sciences, and the Department of Pathology, Faculty of Medicine, University of Porto, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"i3S - Institute Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, the Institute of Molecular Pathology and Immunology (IPATIMUP), the Faculty of Sciences, and the Department of Pathology, Faculty of Medicine, University of Porto, Porto, Portugal","institution_ids":["https://openalex.org/I4210158732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049422869","display_name":"Gabriela M. Almeida","orcid":"https://orcid.org/0000-0001-8712-7394"},"institutions":[{"id":"https://openalex.org/I4210158732","display_name":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto","ror":"https://ror.org/04wjk1035","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Gabriela M. Almeida","raw_affiliation_strings":["i3S - Institute Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, the Institute of Molecular Pathology and Immunology (IPATIMUP), and the Faculty of Medicine, University of Porto, Porto, Portugal"],"raw_orcid":"https://orcid.org/0000-0001-8712-7394","affiliations":[{"raw_affiliation_string":"i3S - Institute Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, the Institute of Molecular Pathology and Immunology (IPATIMUP), and the Faculty of Medicine, University of Porto, Porto, Portugal","institution_ids":["https://openalex.org/I4210158732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064854472","display_name":"Carla Olive\u00edra","orcid":"https://orcid.org/0000-0001-8340-2264"},"institutions":[{"id":"https://openalex.org/I4210158732","display_name":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto","ror":"https://ror.org/04wjk1035","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Carla Oliveira","raw_affiliation_strings":["i3S - Institute Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, the Institute of Molecular Pathology and Immunology (IPATIMUP), and the Faculty of Medicine, University of Porto, Porto, Portugal"],"raw_orcid":"https://orcid.org/0000-0001-8340-2264","affiliations":[{"raw_affiliation_string":"i3S - Institute Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, the Institute of Molecular Pathology and Immunology (IPATIMUP), and the Faculty of Medicine, University of Porto, Porto, Portugal","institution_ids":["https://openalex.org/I4210158732"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028372092","display_name":"Carolina W\u00e4hlby","orcid":"https://orcid.org/0000-0002-4139-7003"},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Carolina Wahlby","raw_affiliation_strings":["Department of Information Technology and SciLifeLab, Uppsala University, Uppsala, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-4139-7003","affiliations":[{"raw_affiliation_string":"Department of Information Technology and SciLifeLab, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":{"value":2217,"currency":"EUR","value_usd":2391},"fwci":0.4473,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.58396701,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"25","issue":"2","first_page":"393","last_page":"402"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9929999709129333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9929999709129333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9912999868392944,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9696000218391418,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"Immunohistochemistry","score":0.673505425453186},{"id":"https://openalex.org/keywords/protein-expression","display_name":"Protein expression","score":0.6265661120414734},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.46729353070259094},{"id":"https://openalex.org/keywords/expression","display_name":"Expression (computer science)","score":0.4621937870979309},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2720462679862976},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.2615714371204376},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.24542996287345886},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10748064517974854},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.10502341389656067},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.09198105335235596}],"concepts":[{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.673505425453186},{"id":"https://openalex.org/C6856738","wikidata":"https://www.wikidata.org/wiki/Q331672","display_name":"Protein expression","level":3,"score":0.6265661120414734},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.46729353070259094},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.4621937870979309},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2720462679862976},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2615714371204376},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24542996287345886},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10748064517974854},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10502341389656067},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.09198105335235596}],"mesh":[{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1109/jbhi.2020.3008821","is_oa":true,"landing_page_url":"https://doi.org/10.1109/jbhi.2020.3008821","pdf_url":"https://ieeexplore.ieee.org/ielx7/6221020/9348958/09139320.pdf","source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},{"id":"pmid:32750958","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32750958","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE journal of biomedical and health informatics","raw_type":null},{"id":"pmh:oai:DiVA.org:uu-416504","is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-416504","pdf_url":null,"source":{"id":"https://openalex.org/S4306402042","display_name":"Uppsala University Publications (Uppsala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I123387679","host_organization_name":"Uppsala University","host_organization_lineage":["https://openalex.org/I123387679"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1109/jbhi.2020.3008821","is_oa":true,"landing_page_url":"https://doi.org/10.1109/jbhi.2020.3008821","pdf_url":"https://ieeexplore.ieee.org/ielx7/6221020/9348958/09139320.pdf","source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1516346500","display_name":null,"funder_award_id":"01-0145","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G1578237752","display_name":null,"funder_award_id":"COMPETE","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G1763632427","display_name":null,"funder_award_id":"POCI-01-0145","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G3026659519","display_name":null,"funder_award_id":"PORTUGAL2020","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G4064133483","display_name":null,"funder_award_id":"SFRH/BD/113031/2015","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G4176497637","display_name":null,"funder_award_id":"COMPETE 2020","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G5224927334","display_name":null,"funder_award_id":"POCI-01-","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G5744213601","display_name":null,"funder_award_id":"POCI-01-0145-FEDER-016390","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G6186202971","display_name":null,"funder_award_id":"POCI-01-0145-FEDER-007274","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G7112586566","display_name":null,"funder_award_id":"POCI-01-0145-FEDER-030164","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G7584003722","display_name":null,"funder_award_id":"NORTE-01-0145","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G8862270368","display_name":null,"funder_award_id":"POCI-01-0145-FEDER","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G933011615","display_name":"Uma plataforma de microarrays em 3D para a an\u00e1lise de alto rendimento do papel da matriz extracelular nas transi\u00e7\u00f5es epitelial-mesenquimal em cancro","funder_award_id":"PTDC/BBB-ECT/2518/2014","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"}],"funders":[{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3043553871.pdf","grobid_xml":"https://content.openalex.org/works/W3043553871.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1597336200","https://openalex.org/W1976661769","https://openalex.org/W2000601094","https://openalex.org/W2010943731","https://openalex.org/W2012317937","https://openalex.org/W2017950947","https://openalex.org/W2019130576","https://openalex.org/W2030667313","https://openalex.org/W2031502025","https://openalex.org/W2037255757","https://openalex.org/W2039892899","https://openalex.org/W2055186246","https://openalex.org/W2106525823","https://openalex.org/W2114489245","https://openalex.org/W2119653719","https://openalex.org/W2125782175","https://openalex.org/W2136503713","https://openalex.org/W2147555557","https://openalex.org/W2156875677","https://openalex.org/W2166562585","https://openalex.org/W2168768703","https://openalex.org/W2781180031","https://openalex.org/W2793622148","https://openalex.org/W2802643674","https://openalex.org/W2889646458","https://openalex.org/W2891340270","https://openalex.org/W2904197960","https://openalex.org/W2916221863","https://openalex.org/W2952481429","https://openalex.org/W2975634117","https://openalex.org/W2998768810","https://openalex.org/W3028450988","https://openalex.org/W3105392623","https://openalex.org/W3124379793","https://openalex.org/W4211007657","https://openalex.org/W6635816984"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2999877485","https://openalex.org/W2355920994","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W4388280821","https://openalex.org/W2007755580","https://openalex.org/W2373445029"],"abstract_inverted_index":{"Immunohistochemical":[0],"(IHC)":[1],"analysis":[2,70,137],"of":[3,12,22,48,120,129],"tissue":[4,28,75],"biopsies":[5],"is":[6],"currently":[7],"used":[8],"for":[9,198],"clinical":[10,57],"screening":[11],"solid":[13],"cancers":[14],"to":[15,35,72,172,191,207],"assess":[16],"protein":[17,49,63,89],"expression.":[18,133],"The":[19,96,179],"large":[20],"amount":[21],"image":[23,69,78],"data":[24,200],"produced":[25],"from":[26],"these":[27],"samples":[29],"requires":[30],"specialized":[31],"computational":[32,185],"pathology":[33,189],"methods":[34],"perform":[36],"integrative":[37],"analysis.":[38],"Even":[39],"though":[40],"proteins":[41],"are":[42],"traditionally":[43],"studied":[44],"independently,":[45],"the":[46,110,127,144,148,164,174],"study":[47],"co-expression":[50,168],"may":[51],"offer":[52],"new":[53],"insights":[54],"towards":[55],"patients'":[56],"and":[58,86,92,114,131,142,201],"therapeutic":[59],"decisions.":[60],"To":[61,108],"explore":[62,192],"co-expression,":[64,193],"we":[65,116],"constructed":[66],"a":[67,118,196],"modular":[68],"pipeline":[71,97,181],"spatially":[73],"align":[74],"microarray":[76],"(TMA)":[77],"slides,":[79],"evaluate":[80,109],"alignment":[81],"quality,":[82],"define":[83],"tumor":[84,94,159],"regions,":[85],"ultimately":[87],"quantify":[88],"expression,":[90],"before":[91],"after":[93],"segmentation.":[95],"was":[98,170],"built":[99],"with":[100,147,163],"open-source":[101],"tools":[102,186],"that":[103,155],"can":[104],"manage":[105],"gigapixel":[106],"slides.":[107],"consensus":[111],"between":[112],"pathologist":[113],"computer,":[115],"characterized":[117],"cohort":[119],"142":[121],"gastric":[122],"cancer":[123],"(GC)":[124],"cases":[125],"regarding":[126],"extent":[128],"E-cadherin":[130],"CD44v6":[132],"We":[134],"performed":[135],"IHC":[136],"in":[138,204],"consecutive":[139],"TMA":[140],"slides":[141],"compared":[143],"automated":[145,156],"quantification":[146,157],"pathologists'":[149,165],"manual":[150],"assessment.":[151],"Our":[152],"results":[153],"show":[154],"within":[158],"regions":[160],"improves":[161],"agreement":[162],"classification.":[166],"A":[167],"map":[169],"created":[171],"identify":[173],"cores":[175],"co-expressing":[176],"both":[177],"proteins.":[178],"proposed":[180],"provides":[182],"not":[183],"only":[184],"forwarding":[187],"current":[188],"practices":[190],"but":[194],"also":[195],"framework":[197],"merging":[199],"transferring":[202],"information":[203],"learning-based":[205],"approaches":[206],"pathology.":[208]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4}],"updated_date":"2026-07-20T07:56:41.581041","created_date":"2025-10-10T00:00:00"}
