{"id":"https://openalex.org/W3033541301","doi":"https://doi.org/10.1109/jbhi.2020.2994970","title":"Antibody Supervised Training of a Deep Learning Based Algorithm for Leukocyte Segmentation in Papillary Thyroid Carcinoma","display_name":"Antibody Supervised Training of a Deep Learning Based Algorithm for Leukocyte Segmentation in Papillary Thyroid Carcinoma","publication_year":2020,"publication_date":"2020-05-29","ids":{"openalex":"https://openalex.org/W3033541301","doi":"https://doi.org/10.1109/jbhi.2020.2994970","mag":"3033541301","pmid":"https://pubmed.ncbi.nlm.nih.gov/32750899"},"language":"en","primary_location":{"id":"doi:10.1109/jbhi.2020.2994970","is_oa":true,"landing_page_url":"https://doi.org/10.1109/jbhi.2020.2994970","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1109/jbhi.2020.2994970","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091755656","display_name":"S Stenman","orcid":"https://orcid.org/0000-0001-5780-0285"},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]},{"id":"https://openalex.org/I4210107997","display_name":"Finland University","ror":"https://ror.org/014rks409","country_code":"FI","type":"education","lineage":["https://openalex.org/I4210107997"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Sebastian Stenman","raw_affiliation_strings":["Helsinki University Hospital, Helsinki, Finland","University of Helsinki, Helsinki, Finland","Helsinki University Hospital, Helsinki, Finland; University of Helsinki, Helsinki, Finland"],"raw_orcid":"https://orcid.org/0000-0001-5780-0285","affiliations":[{"raw_affiliation_string":"Helsinki University Hospital, Helsinki, Finland","institution_ids":["https://openalex.org/I2800394112"]},{"raw_affiliation_string":"University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Helsinki University Hospital, Helsinki, Finland; University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112","https://openalex.org/I4210107997"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058211125","display_name":"Dmitrii Bychkov","orcid":"https://orcid.org/0000-0003-1579-1127"},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Dmitrii Bychkov","raw_affiliation_strings":["University of Helsinki, Helsinki, Finland"],"raw_orcid":"https://orcid.org/0000-0003-1579-1127","affiliations":[{"raw_affiliation_string":"University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058537325","display_name":"Hakan K\u00fcc\u00fckel","orcid":null},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Hakan Kucukel","raw_affiliation_strings":["University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049991876","display_name":"Nina Linder","orcid":"https://orcid.org/0000-0003-3930-0513"},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI","SE"],"is_corresponding":false,"raw_author_name":"Nina Linder","raw_affiliation_strings":["Department of Women's and Children's Health, International Maternal and Child Health, Uppsala University, Uppsala, Sweden","University of Helsinki, Helsinki, Finland","Department of Women's and Children's Health, International Maternal and Child Health, Uppsala University, Uppsala, Sweden; University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Women's and Children's Health, International Maternal and Child Health, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Department of Women's and Children's Health, International Maternal and Child Health, Uppsala University, Uppsala, Sweden; University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055369999","display_name":"Caj Haglund","orcid":"https://orcid.org/0000-0003-0456-4965"},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]},{"id":"https://openalex.org/I4210107997","display_name":"Finland University","ror":"https://ror.org/014rks409","country_code":"FI","type":"education","lineage":["https://openalex.org/I4210107997"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Caj Haglund","raw_affiliation_strings":["Helsinki University Hospital, Helsinki, Finland","University of Helsinki, Helsinki, Finland","Helsinki University Hospital, Helsinki, Finland; University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helsinki University Hospital, Helsinki, Finland","institution_ids":["https://openalex.org/I2800394112"]},{"raw_affiliation_string":"University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Helsinki University Hospital, Helsinki, Finland; University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112","https://openalex.org/I4210107997"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061963131","display_name":"Johanna Arola","orcid":"https://orcid.org/0000-0003-3865-5507"},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Johanna Arola","raw_affiliation_strings":["University of Helsinki, Helsinki, Finland","HUSLAB Pathology Department, University of Helsinki, Helsinki, Finland"],"raw_orcid":"https://orcid.org/0000-0003-3865-5507","affiliations":[{"raw_affiliation_string":"University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"HUSLAB Pathology Department, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061523469","display_name":"Johan Lundin","orcid":"https://orcid.org/0000-0002-2681-4139"},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210121512","display_name":"Karolinska Development (Sweden)","ror":"https://ror.org/02pscrx27","country_code":"SE","type":"company","lineage":["https://openalex.org/I4210121512"]}],"countries":["FI","SE"],"is_corresponding":false,"raw_author_name":"Johan Lundin","raw_affiliation_strings":["Karolinska Insitutet, Solna, Sweden","University of Helsinki, Helsinki, Finland","Karolinska Insitutet, Solna, Sweden; University of Helsinki, Helsinki, Finland"],"raw_orcid":"https://orcid.org/0000-0002-2681-4139","affiliations":[{"raw_affiliation_string":"Karolinska Insitutet, Solna, Sweden","institution_ids":["https://openalex.org/I4210121512"]},{"raw_affiliation_string":"University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Karolinska Insitutet, Solna, Sweden; University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2836,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.90395974,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"25","issue":"2","first_page":"422","last_page":"428"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9811000227928162,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.7252588272094727},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6658564805984497},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.6521626710891724},{"id":"https://openalex.org/keywords/h-e-stain","display_name":"H&E stain","score":0.5798888206481934},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"Immunohistochemistry","score":0.5063654184341431},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.49024707078933716},{"id":"https://openalex.org/keywords/thyroid-carcinoma","display_name":"Thyroid carcinoma","score":0.4683736264705658},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.4421394169330597},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.4290947914123535},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4210212528705597},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.41908693313598633},{"id":"https://openalex.org/keywords/pixel","display_name":"Pixel","score":0.4113854169845581},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.381686270236969},{"id":"https://openalex.org/keywords/thyroid","display_name":"Thyroid","score":0.24195420742034912},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.13097131252288818}],"concepts":[{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.7252588272094727},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6658564805984497},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.6521626710891724},{"id":"https://openalex.org/C125473707","wikidata":"https://www.wikidata.org/wiki/Q9914","display_name":"H&E stain","level":3,"score":0.5798888206481934},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5063654184341431},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.49024707078933716},{"id":"https://openalex.org/C2993294228","wikidata":"https://www.wikidata.org/wiki/Q13632630","display_name":"Thyroid carcinoma","level":3,"score":0.4683736264705658},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.4421394169330597},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4290947914123535},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4210212528705597},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41908693313598633},{"id":"https://openalex.org/C160633673","wikidata":"https://www.wikidata.org/wiki/Q355198","display_name":"Pixel","level":2,"score":0.4113854169845581},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.381686270236969},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.24195420742034912},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13097131252288818}],"mesh":[{"descriptor_ui":"D000077273","descriptor_name":"Thyroid Cancer, Papillary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077273","descriptor_name":"Thyroid Cancer, Papillary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077273","descriptor_name":"Thyroid Cancer, Papillary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1109/jbhi.2020.2994970","is_oa":true,"landing_page_url":"https://doi.org/10.1109/jbhi.2020.2994970","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},{"id":"pmid:32750899","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32750899","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE journal of biomedical and health informatics","raw_type":null},{"id":"pmh:oai:DiVA.org:uu-448199","is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-448199","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:helda.helsinki.fi:10138/326498","is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/326498","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1109/jbhi.2020.2994970","is_oa":true,"landing_page_url":"https://doi.org/10.1109/jbhi.2020.2994970","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5299999713897705,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320311797","display_name":"Medicinska Underst\u00f6dsf\u00f6reningen Liv och H\u00e4lsa","ror":"https://ror.org/00qx9g681"},{"id":"https://openalex.org/F4320311816","display_name":"Finska L\u00e4kares\u00e4llskapet","ror":"https://ror.org/04vbzm272"},{"id":"https://openalex.org/F4320328139","display_name":"Biocenter Finland","ror":"https://ror.org/03aay6c48"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1522301498","https://openalex.org/W1597336200","https://openalex.org/W1859257957","https://openalex.org/W1901129140","https://openalex.org/W1964110679","https://openalex.org/W1988116788","https://openalex.org/W2034269086","https://openalex.org/W2036432090","https://openalex.org/W2043973773","https://openalex.org/W2049887610","https://openalex.org/W2107863647","https://openalex.org/W2108598243","https://openalex.org/W2109197651","https://openalex.org/W2120431466","https://openalex.org/W2128387862","https://openalex.org/W2194775991","https://openalex.org/W2221588520","https://openalex.org/W2231156824","https://openalex.org/W2273189723","https://openalex.org/W2344654247","https://openalex.org/W2515717359","https://openalex.org/W2533800772","https://openalex.org/W2767493769","https://openalex.org/W2794616003","https://openalex.org/W2794803511","https://openalex.org/W2883648445","https://openalex.org/W2891800461","https://openalex.org/W2902947426","https://openalex.org/W2905483812","https://openalex.org/W2905502540","https://openalex.org/W2947293739","https://openalex.org/W2964121744","https://openalex.org/W2966895632","https://openalex.org/W3099287508","https://openalex.org/W6631190155","https://openalex.org/W6635816984","https://openalex.org/W6639824700"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W1986945230","https://openalex.org/W3055032190","https://openalex.org/W2887807965","https://openalex.org/W185692665","https://openalex.org/W2099326649","https://openalex.org/W4226493464","https://openalex.org/W3133861977","https://openalex.org/W2951211570","https://openalex.org/W3103566983"],"abstract_inverted_index":{"The":[0,81,100,193],"quantity":[1],"of":[2,84,94,96,137,202,206,246],"leukocytes":[3,32,207,247],"in":[4,33,134,182,208,242,248],"papillary":[5],"thyroid":[6],"carcinoma":[7],"(PTC)":[8],"potentially":[9],"have":[10],"prognostic":[11],"and":[12,44,55,58,66,78,91,105,132,154,181],"treatment":[13],"predictive":[14],"value.":[15],"Here,":[16],"we":[17],"propose":[18],"a":[19,24,138,151],"novel":[20],"method":[21,229],"for":[22,30,148,166,204,230],"training":[23,136,149],"convolutional":[25],"neural":[26],"network":[27],"(CNN)":[28],"algorithm":[29,174,196],"segmenting":[31],"PTCs.":[34],"Tissue":[35],"samples":[36],"from":[37,48],"two":[38,82,157],"retrospective":[39],"PTC":[40],"cohort":[41],"were":[42,51,64,89,98,103,115,123,146,159,191],"obtained":[43],"representative":[45,86],"tissue":[46,87,250],"slides":[47,63,88,158],"twelve":[49,179],"patients":[50],"stained":[52,109],"with":[53,70],"hematoxylin":[54],"eosin":[56],"(HE)":[57],"digitized.":[59],"Then,":[60],"the":[61,73,106,128,135,155,167,173,209,215,219,236],"HE":[62,129,210,249],"destained":[65],"restained":[67],"immunohistochemically":[68],"(IHC)":[69],"antibodies":[71],"to":[72,218],"pan-leukocyte":[74],"anti":[75,112,222],"CD45":[76,113,223],"antigen":[77],"scanned":[79],"again.":[80],"stain-pairs":[83],"all":[85,178],"registered,":[90],"image":[92,101,130,211],"tiles":[93,102,131,185,212],"regions":[95],"interests":[97],"exported.":[99],"processed":[104],"3,3'-diaminobenzidine":[107],"(DAB)":[108],"areas":[110],"representing":[111],"expression":[114],"turned":[116],"into":[117],"binary":[118,121],"masks.":[119],"These":[120],"masks":[122,217],"applied":[124],"as":[125,161],"annotations":[126,234,240],"on":[127,177],"used":[133,147,160],"CNN":[139,195],"algorithm.":[140],"Ten":[141],"whole":[142],"slide":[143],"images":[144],"(WSIs)":[145],"using":[150,235],"five-fold":[152],"cross-validation":[153],"remaining":[156],"an":[162,198],"independent":[163],"test":[164],"set":[165],"trained":[168,194],"model.":[169],"For":[170],"visual":[171],"evaluation,":[172],"was":[175],"run":[176],"WSIs,":[180],"total":[183],"238,144":[184],"sized":[186],"500":[187,189],"\u00d7":[188],"pixels":[190],"analyzed.":[192],"had":[197],"intersection":[199],"over":[200],"union":[201],"0.82":[203],"detection":[205],"when":[213],"comparing":[214],"prediction":[216],"ground":[220],"truth":[221],"mask.":[224],"We":[225],"conclude":[226],"that":[227],"this":[228],"generating":[231],"antibody":[232],"supervised":[233],"destain-restain":[237],"IHC":[238],"guided":[239],"resulted":[241],"high":[243],"accuracy":[244],"segmentations":[245],"images.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":1}],"updated_date":"2026-08-08T01:25:22.217667","created_date":"2025-10-10T00:00:00"}