{"id":"https://openalex.org/W3018123158","doi":"https://doi.org/10.1109/jbhi.2020.2988720","title":"Multi-Label Fusion Collaborative Matrix Factorization for Predicting LncRNA-Disease Associations","display_name":"Multi-Label Fusion Collaborative Matrix Factorization for Predicting LncRNA-Disease Associations","publication_year":2020,"publication_date":"2020-04-22","ids":{"openalex":"https://openalex.org/W3018123158","doi":"https://doi.org/10.1109/jbhi.2020.2988720","mag":"3018123158","pmid":"https://pubmed.ncbi.nlm.nih.gov/32324583"},"language":"en","primary_location":{"id":"doi:10.1109/jbhi.2020.2988720","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2020.2988720","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086778639","display_name":"Mingming Gao","orcid":null},"institutions":[{"id":"https://openalex.org/I202126657","display_name":"Qufu Normal University","ror":"https://ror.org/03ceheh96","country_code":"CN","type":"education","lineage":["https://openalex.org/I202126657"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ming-Ming Gao","raw_affiliation_strings":["School of Information Science and Engineering, Qufu Normal University, Shandong, Rizhao, China"],"raw_orcid":"https://orcid.org/0000-0002-2614-2600","affiliations":[{"raw_affiliation_string":"School of Information Science and Engineering, Qufu Normal University, Shandong, Rizhao, China","institution_ids":["https://openalex.org/I202126657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058029547","display_name":"Zhen Cui","orcid":"https://orcid.org/0000-0001-5522-6750"},"institutions":[{"id":"https://openalex.org/I202126657","display_name":"Qufu Normal University","ror":"https://ror.org/03ceheh96","country_code":"CN","type":"education","lineage":["https://openalex.org/I202126657"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen Cui","raw_affiliation_strings":["School of Information Science and Engineering, Qufu Normal University, Shandong, Rizhao, China"],"raw_orcid":"https://orcid.org/0000-0001-5522-6750","affiliations":[{"raw_affiliation_string":"School of Information Science and Engineering, Qufu Normal University, Shandong, Rizhao, China","institution_ids":["https://openalex.org/I202126657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026569643","display_name":"Ying-Lian Gao","orcid":"https://orcid.org/0000-0003-0483-5622"},"institutions":[{"id":"https://openalex.org/I202126657","display_name":"Qufu Normal University","ror":"https://ror.org/03ceheh96","country_code":"CN","type":"education","lineage":["https://openalex.org/I202126657"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying-Lian Gao","raw_affiliation_strings":["Qufu Normal University Library, Qufu Normal University, Shandong, Rizhao, China"],"raw_orcid":"https://orcid.org/0000-0003-0483-5622","affiliations":[{"raw_affiliation_string":"Qufu Normal University Library, Qufu Normal University, Shandong, Rizhao, China","institution_ids":["https://openalex.org/I202126657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100347490","display_name":"Juan Wang","orcid":"https://orcid.org/0000-0003-3934-0435"},"institutions":[{"id":"https://openalex.org/I202126657","display_name":"Qufu Normal University","ror":"https://ror.org/03ceheh96","country_code":"CN","type":"education","lineage":["https://openalex.org/I202126657"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan Wang","raw_affiliation_strings":["School of Information Science and Engineering, Qufu Normal University, Shandong, Rizhao, China"],"raw_orcid":"https://orcid.org/0000-0003-3934-0435","affiliations":[{"raw_affiliation_string":"School of Information Science and Engineering, Qufu Normal University, Shandong, Rizhao, China","institution_ids":["https://openalex.org/I202126657"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073144090","display_name":"Jin\u2010Xing Liu","orcid":"https://orcid.org/0000-0001-6104-2149"},"institutions":[{"id":"https://openalex.org/I202126657","display_name":"Qufu Normal University","ror":"https://ror.org/03ceheh96","country_code":"CN","type":"education","lineage":["https://openalex.org/I202126657"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin-Xing Liu","raw_affiliation_strings":["School of Information Science and Engineering, Qufu Normal University, Shandong, Rizhao, China"],"raw_orcid":"https://orcid.org/0000-0001-6104-2149","affiliations":[{"raw_affiliation_string":"School of Information Science and Engineering, Qufu Normal University, Shandong, Rizhao, China","institution_ids":["https://openalex.org/I202126657"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5086778639"],"corresponding_institution_ids":["https://openalex.org/I202126657"],"apc_list":null,"apc_paid":null,"fwci":1.6766,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.83826822,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"25","issue":"3","first_page":"881","last_page":"890"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.699741542339325},{"id":"https://openalex.org/keywords/matrix-decomposition","display_name":"Matrix decomposition","score":0.5872754454612732},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.49914026260375977},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.46847620606422424},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4482557475566864},{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.4481111466884613},{"id":"https://openalex.org/keywords/kernel","display_name":"Kernel (algebra)","score":0.43900197744369507},{"id":"https://openalex.org/keywords/encode","display_name":"ENCODE","score":0.42519474029541016},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3819919526576996},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1551515758037567},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.13928723335266113},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.09435495734214783}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.699741542339325},{"id":"https://openalex.org/C42355184","wikidata":"https://www.wikidata.org/wiki/Q1361088","display_name":"Matrix decomposition","level":3,"score":0.5872754454612732},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.49914026260375977},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.46847620606422424},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4482557475566864},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.4481111466884613},{"id":"https://openalex.org/C74193536","wikidata":"https://www.wikidata.org/wiki/Q574844","display_name":"Kernel (algebra)","level":2,"score":0.43900197744369507},{"id":"https://openalex.org/C66746571","wikidata":"https://www.wikidata.org/wiki/Q1134833","display_name":"ENCODE","level":3,"score":0.42519474029541016},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3819919526576996},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1551515758037567},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13928723335266113},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09435495734214783},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C158693339","wikidata":"https://www.wikidata.org/wiki/Q190524","display_name":"Eigenvalues and eigenvectors","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/jbhi.2020.2988720","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2020.2988720","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},{"id":"pmid:32324583","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32324583","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE journal of biomedical and health informatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4099999964237213,"display_name":"Partnerships for the goals","id":"https://metadata.un.org/sdg/17"}],"awards":[{"id":"https://openalex.org/G5609717784","display_name":null,"funder_award_id":"61872220","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5860415692","display_name":null,"funder_award_id":"61572284","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1986694679","https://openalex.org/W2002185065","https://openalex.org/W2024715297","https://openalex.org/W2071756586","https://openalex.org/W2090234932","https://openalex.org/W2096451472","https://openalex.org/W2128983843","https://openalex.org/W2141222510","https://openalex.org/W2152970345","https://openalex.org/W2183183868","https://openalex.org/W2280878893","https://openalex.org/W2343107734","https://openalex.org/W2345181615","https://openalex.org/W2365351506","https://openalex.org/W2401244321","https://openalex.org/W2410866022","https://openalex.org/W2439800732","https://openalex.org/W2507951309","https://openalex.org/W2512308096","https://openalex.org/W2524219270","https://openalex.org/W2531500048","https://openalex.org/W2532794119","https://openalex.org/W2563206593","https://openalex.org/W2567465856","https://openalex.org/W2587685360","https://openalex.org/W2611747160","https://openalex.org/W2614101761","https://openalex.org/W2736555335","https://openalex.org/W2739280501","https://openalex.org/W2757038198","https://openalex.org/W2772618228","https://openalex.org/W2782571367","https://openalex.org/W2793027356","https://openalex.org/W2793951981","https://openalex.org/W2801501532","https://openalex.org/W2802569084","https://openalex.org/W2802616725","https://openalex.org/W2810992649","https://openalex.org/W2901312953","https://openalex.org/W2903730942","https://openalex.org/W2911989462","https://openalex.org/W2918193787","https://openalex.org/W2926842391","https://openalex.org/W2940891808","https://openalex.org/W2941503969","https://openalex.org/W2943254651","https://openalex.org/W2953066704","https://openalex.org/W2960796721","https://openalex.org/W2961565435","https://openalex.org/W2970225329","https://openalex.org/W6695410578","https://openalex.org/W6715224733"],"related_works":["https://openalex.org/W2468279273","https://openalex.org/W2354198838","https://openalex.org/W1989130879","https://openalex.org/W2103419012","https://openalex.org/W1974414866","https://openalex.org/W2057568687","https://openalex.org/W2063982682","https://openalex.org/W2338543196","https://openalex.org/W1544691147","https://openalex.org/W2113565103"],"abstract_inverted_index":{"As":[0],"we":[1,72],"all":[2],"know,":[3],"science":[4],"and":[5,10,14,33,64,91,105,107,196,213],"technology":[6],"are":[7,21,94,176],"developing":[8],"faster":[9],"faster.":[11],"Many":[12],"experts":[13],"scholars":[15],"have":[16,30],"demonstrated":[17],"that":[18,226],"human":[19],"diseases":[20,65],"related":[22],"to":[23,38,58,98,108,126,139,191],"lncRNA,":[24],"but":[25],"only":[26],"a":[27,49,74,116],"few":[28],"associations":[29,36,61,85,175],"been":[31],"confirmed,":[32],"many":[34],"unknown":[35],"need":[37],"be":[39,150,224],"found.":[40],"In":[41,69],"the":[42,60,88,100,122,131,134,141,154,169,173,179,193,217],"process":[43],"of":[44,51,118,156,161,181,204,208],"finding":[45,54],"associations,":[46],"it":[47,222],"takes":[48],"lot":[50],"time,":[52],"so":[53],"an":[55,201,231],"efficient":[56],"way":[57],"predict":[59],"between":[62,103,143],"lncRNAs":[63],"is":[66,137,189,230],"particularly":[67],"important.":[68],"this":[70],"paper,":[71],"propose":[73],"multi-label":[75,97,128],"fusion":[76,135],"collaborative":[77,182],"matrix":[78,183],"factorization":[79],"(MLFCMF)":[80],"approach":[81],"for":[82,234],"predicting":[83,235],"lncRNA-disease":[84,174,236],"(LDAs).":[86],"Firstly,":[87],"lncRNA":[89,104],"space":[90,93],"disease":[92,106],"optimized":[95],"by":[96,152,178],"enhance":[99],"intrinsic":[101],"link":[102],"tap":[109],"potential":[110],"information.":[111],"Multi-label":[112],"learning":[113],"can":[114,167,223],"encode":[115],"variety":[117],"data":[119,132],"information":[120,129,148],"from":[121],"sample":[123],"space.":[124],"Secondly,":[125],"learn":[127],"in":[130,216],"space,":[133],"method":[136,180,188,198,228],"used":[138,190],"handle":[140],"relationship":[142],"multiple":[144],"labels.":[145,158],"More":[146],"comprehensive":[147],"will":[149],"obtained":[151],"weighing":[153],"effects":[155],"different":[157],"The":[159,185],"addition":[160],"Gaussian":[162],"interaction":[163],"profile":[164],"(GIP)":[165],"kernel":[166],"increase":[168],"network":[170],"similarity.":[171],"Finally,":[172],"predicted":[177],"factorization.":[184],"ten-fold":[186],"cross-validation":[187],"evaluate":[192],"MLFCMF":[194,229],"method,":[195],"our":[197,227],"finally":[199],"obtains":[200],"AUC":[202],"value":[203],"0.8612.":[205],"Detailed":[206],"analysis":[207],"ovarian":[209],"cancer,":[210,212],"colorectal":[211],"lung":[214],"cancer":[215],"simulation":[218],"experiment":[219],"results.":[220],"So":[221],"seen":[225],"effective":[232],"model":[233],"associations.":[237]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}