{"id":"https://openalex.org/W3014467983","doi":"https://doi.org/10.1109/jbhi.2020.2984647","title":"Characterization of Spatio-Temporal Cardiac Action Potential Variability at Baseline and Under $\\beta$-Adrenergic Stimulation by Combined Unscented Kalman Filter and Double Greedy Dimension Reduction","display_name":"Characterization of Spatio-Temporal Cardiac Action Potential Variability at Baseline and Under $\\beta$-Adrenergic Stimulation by Combined Unscented Kalman Filter and Double Greedy Dimension Reduction","publication_year":2020,"publication_date":"2020-04-02","ids":{"openalex":"https://openalex.org/W3014467983","doi":"https://doi.org/10.1109/jbhi.2020.2984647","mag":"3014467983","pmid":"https://pubmed.ncbi.nlm.nih.gov/32248135"},"language":"en","primary_location":{"id":"doi:10.1109/jbhi.2020.2984647","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2020.2984647","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://zaguan.unizar.es/record/101193","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018588145","display_name":"David Adolfo Sampedro-Puente","orcid":"https://orcid.org/0000-0002-1927-1762"},"institutions":[{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]},{"id":"https://openalex.org/I4210105141","display_name":"Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine","ror":"https://ror.org/01gm5f004","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210105141"]},{"id":"https://openalex.org/I4210136512","display_name":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n","ror":"https://ror.org/03njn4610","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210136512"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"David Adolfo Sampedro-Puente","raw_affiliation_strings":["BSICoS group, I3A, IIS Arag\u00f3n, University of Zaragoza, Zaragoza, Spain","CIBER-BBN, Zaragoza, Spain"],"raw_orcid":"https://orcid.org/0000-0002-1927-1762","affiliations":[{"raw_affiliation_string":"BSICoS group, I3A, IIS Arag\u00f3n, University of Zaragoza, Zaragoza, Spain","institution_ids":["https://openalex.org/I255234318","https://openalex.org/I4210136512"]},{"raw_affiliation_string":"CIBER-BBN, Zaragoza, Spain","institution_ids":["https://openalex.org/I4210105141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052433374","display_name":"Fabien Raphel","orcid":"https://orcid.org/0000-0002-3994-7555"},"institutions":[{"id":"https://openalex.org/I1326498283","display_name":"Institut national de recherche en sciences et technologies du num\u00e9rique","ror":"https://ror.org/02kvxyf05","country_code":"FR","type":"government","lineage":["https://openalex.org/I1326498283"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210158291","display_name":"Laboratoire Jacques-Louis Lions","ror":"https://ror.org/04xmteb38","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210141950","https://openalex.org/I4210158291"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fabien Raphel","raw_affiliation_strings":["INRIA and LJLL Sorbonne Universit\u00e9, Paris, France"],"raw_orcid":"https://orcid.org/0000-0002-3994-7555","affiliations":[{"raw_affiliation_string":"INRIA and LJLL Sorbonne Universit\u00e9, Paris, France","institution_ids":["https://openalex.org/I4210158291","https://openalex.org/I1326498283","https://openalex.org/I39804081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002321906","display_name":"Jes\u00fas Fern\u00e1ndez-Bes","orcid":"https://orcid.org/0000-0001-5175-3166"},"institutions":[{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]},{"id":"https://openalex.org/I4210105141","display_name":"Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine","ror":"https://ror.org/01gm5f004","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210105141"]},{"id":"https://openalex.org/I4210136512","display_name":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n","ror":"https://ror.org/03njn4610","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210136512"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jesus Fernandez-Bes","raw_affiliation_strings":["BSICoS group, I3A, IIS Arag\u00f3n, University of Zaragoza, Zaragoza, Spain","CIBER-BBN, Zaragoza, Spain"],"raw_orcid":"https://orcid.org/0000-0001-5175-3166","affiliations":[{"raw_affiliation_string":"BSICoS group, I3A, IIS Arag\u00f3n, University of Zaragoza, Zaragoza, Spain","institution_ids":["https://openalex.org/I255234318","https://openalex.org/I4210136512"]},{"raw_affiliation_string":"CIBER-BBN, Zaragoza, Spain","institution_ids":["https://openalex.org/I4210105141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084527753","display_name":"Pablo Laguna","orcid":"https://orcid.org/0000-0003-3434-9254"},"institutions":[{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]},{"id":"https://openalex.org/I4210105141","display_name":"Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine","ror":"https://ror.org/01gm5f004","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210105141"]},{"id":"https://openalex.org/I4210136512","display_name":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n","ror":"https://ror.org/03njn4610","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210136512"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pablo Laguna","raw_affiliation_strings":["BSICoS group, I3A, IIS Arag\u00f3n, University of Zaragoza, Zaragoza, Spain","CIBER-BBN, Zaragoza, Spain"],"raw_orcid":"https://orcid.org/0000-0003-3434-9254","affiliations":[{"raw_affiliation_string":"BSICoS group, I3A, IIS Arag\u00f3n, University of Zaragoza, Zaragoza, Spain","institution_ids":["https://openalex.org/I255234318","https://openalex.org/I4210136512"]},{"raw_affiliation_string":"CIBER-BBN, Zaragoza, Spain","institution_ids":["https://openalex.org/I4210105141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036338360","display_name":"Damiano Lombardi","orcid":"https://orcid.org/0000-0002-5001-924X"},"institutions":[{"id":"https://openalex.org/I1326498283","display_name":"Institut national de recherche en sciences et technologies du num\u00e9rique","ror":"https://ror.org/02kvxyf05","country_code":"FR","type":"government","lineage":["https://openalex.org/I1326498283"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210158291","display_name":"Laboratoire Jacques-Louis Lions","ror":"https://ror.org/04xmteb38","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210141950","https://openalex.org/I4210158291"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Damiano Lombardi","raw_affiliation_strings":["INRIA and LJLL Sorbonne Universit\u00e9, Paris, France"],"raw_orcid":"https://orcid.org/0000-0002-5001-924X","affiliations":[{"raw_affiliation_string":"INRIA and LJLL Sorbonne Universit\u00e9, Paris, France","institution_ids":["https://openalex.org/I4210158291","https://openalex.org/I1326498283","https://openalex.org/I39804081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065688490","display_name":"Esther Pueyo","orcid":"https://orcid.org/0000-0002-1960-407X"},"institutions":[{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]},{"id":"https://openalex.org/I4210105141","display_name":"Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine","ror":"https://ror.org/01gm5f004","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210105141"]},{"id":"https://openalex.org/I4210136512","display_name":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n","ror":"https://ror.org/03njn4610","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210136512"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Esther Pueyo","raw_affiliation_strings":["BSICoS group, I3A, IIS Arag\u00f3n, University of Zaragoza, Zaragoza, Spain","CIBER-BBN, Zaragoza, Spain"],"raw_orcid":"https://orcid.org/0000-0002-1960-407X","affiliations":[{"raw_affiliation_string":"BSICoS group, I3A, IIS Arag\u00f3n, University of Zaragoza, Zaragoza, Spain","institution_ids":["https://openalex.org/I255234318","https://openalex.org/I4210136512"]},{"raw_affiliation_string":"CIBER-BBN, Zaragoza, Spain","institution_ids":["https://openalex.org/I4210105141"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4618,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.66333069,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"25","issue":"1","first_page":"276","last_page":"288"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11021","display_name":"ECG Monitoring and Analysis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kalman-filter","display_name":"Kalman filter","score":0.6260420083999634},{"id":"https://openalex.org/keywords/repolarization","display_name":"Repolarization","score":0.4901898503303528},{"id":"https://openalex.org/keywords/dimensionality-reduction","display_name":"Dimensionality reduction","score":0.4369746744632721},{"id":"https://openalex.org/keywords/uncertainty-quantification","display_name":"Uncertainty quantification","score":0.42938870191574097},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.4223899245262146},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.37821775674819946},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.35204559564590454},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3507542610168457},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.31987929344177246},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2052290141582489},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.1772218942642212},{"id":"https://openalex.org/keywords/electrophysiology","display_name":"Electrophysiology","score":0.09035858511924744}],"concepts":[{"id":"https://openalex.org/C157286648","wikidata":"https://www.wikidata.org/wiki/Q846780","display_name":"Kalman filter","level":2,"score":0.6260420083999634},{"id":"https://openalex.org/C146403970","wikidata":"https://www.wikidata.org/wiki/Q205729","display_name":"Repolarization","level":3,"score":0.4901898503303528},{"id":"https://openalex.org/C70518039","wikidata":"https://www.wikidata.org/wiki/Q16000077","display_name":"Dimensionality reduction","level":2,"score":0.4369746744632721},{"id":"https://openalex.org/C32230216","wikidata":"https://www.wikidata.org/wiki/Q7882499","display_name":"Uncertainty quantification","level":2,"score":0.42938870191574097},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.4223899245262146},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.37821775674819946},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.35204559564590454},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3507542610168457},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.31987929344177246},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2052290141582489},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1772218942642212},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.09035858511924744},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018663","descriptor_name":"Adrenergic Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018663","descriptor_name":"Adrenergic Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018663","descriptor_name":"Adrenergic Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1109/jbhi.2020.2984647","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2020.2984647","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},{"id":"pmid:32248135","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32248135","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE journal of biomedical and health informatics","raw_type":null},{"id":"pmh:oai:zaguan.unizar.es:101193","is_oa":true,"landing_page_url":"http://zaguan.unizar.es/record/101193","pdf_url":"http://zaguan.unizar.es/record/101193","source":{"id":"https://openalex.org/S4306401812","display_name":"Zaguan (University of Zaragoza Repository)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I255234318","host_organization_name":"Universidad de Zaragoza","host_organization_lineage":["https://openalex.org/I255234318"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-02532554v1","is_oa":true,"landing_page_url":"https://inria.hal.science/hal-02532554","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics, In press, &#x27E8;10.1109/JBHI.2020.2984647&#x27E9;","raw_type":"Journal articles"}],"best_oa_location":{"id":"pmh:oai:zaguan.unizar.es:101193","is_oa":true,"landing_page_url":"http://zaguan.unizar.es/record/101193","pdf_url":"http://zaguan.unizar.es/record/101193","source":{"id":"https://openalex.org/S4306401812","display_name":"Zaguan (University of Zaragoza Repository)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I255234318","host_organization_name":"Universidad de Zaragoza","host_organization_lineage":["https://openalex.org/I255234318"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7200000286102295}],"awards":[],"funders":[{"id":"https://openalex.org/F4320326208","display_name":"Gobierno de Arag\u00f3n","ror":"https://ror.org/0425pg203"},{"id":"https://openalex.org/F4320334678","display_name":"European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3014467983.pdf"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W88520345","https://openalex.org/W788330839","https://openalex.org/W1556274719","https://openalex.org/W1844405629","https://openalex.org/W1969629906","https://openalex.org/W1969813878","https://openalex.org/W1970806193","https://openalex.org/W1975255825","https://openalex.org/W1998687211","https://openalex.org/W2017987862","https://openalex.org/W2020500996","https://openalex.org/W2023201524","https://openalex.org/W2025511072","https://openalex.org/W2030858573","https://openalex.org/W2038066028","https://openalex.org/W2050699386","https://openalex.org/W2060489949","https://openalex.org/W2061451182","https://openalex.org/W2061518199","https://openalex.org/W2073885480","https://openalex.org/W2076548466","https://openalex.org/W2079329400","https://openalex.org/W2082812462","https://openalex.org/W2084709656","https://openalex.org/W2090619430","https://openalex.org/W2096351727","https://openalex.org/W2099544223","https://openalex.org/W2115765852","https://openalex.org/W2123487311","https://openalex.org/W2146322526","https://openalex.org/W2147857057","https://openalex.org/W2149462844","https://openalex.org/W2158824271","https://openalex.org/W2159730220","https://openalex.org/W2160235532","https://openalex.org/W2188956206","https://openalex.org/W2212249654","https://openalex.org/W2213612645","https://openalex.org/W2256815008","https://openalex.org/W2329718483","https://openalex.org/W2368935538","https://openalex.org/W2414196587","https://openalex.org/W2607727511","https://openalex.org/W2615268531","https://openalex.org/W2706448119","https://openalex.org/W2740882666","https://openalex.org/W2890459934","https://openalex.org/W2952238256","https://openalex.org/W2954378893","https://openalex.org/W3000012389","https://openalex.org/W3015571647","https://openalex.org/W3085442150","https://openalex.org/W4232464081","https://openalex.org/W6687182661","https://openalex.org/W6715552535","https://openalex.org/W6736517126","https://openalex.org/W6782932179"],"related_works":["https://openalex.org/W3176621072","https://openalex.org/W1991093342","https://openalex.org/W2369647917","https://openalex.org/W1986248273","https://openalex.org/W2389895109","https://openalex.org/W2078622645","https://openalex.org/W2170798819","https://openalex.org/W3127311823","https://openalex.org/W1580685205","https://openalex.org/W2760382975"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Elevated":[1],"spatio-temporal":[2,327],"variability":[3,40,99,262,329,336],"of":[4,35,63,82,97,118,148,157,167,184,214,241,263,285,326,335],"human":[5,66,121,286],"ventricular":[6,15,67,122,287],"repolarization":[7,39,264,328],"has":[8],"been":[9],"related":[10],"to":[11,47,134,205,228,252,312,330,341],"increased":[12],"risk":[13],"for":[14,32,110,194,279,323,333],"arrhythmias":[16],"and":[17,37,44,60,84,136,154,160,196,221,231,259,281,296,305,315,318,338],"sudden":[18],"cardiac":[19],"death,":[20],"particularly":[21],"under":[22,224,297],"\u03b2-adrenergic":[23],"stimulation":[24],"(":[25],"\u03b2-AS).":[26],"This":[27,234,299],"work":[28],"presents":[29],"a":[30,115,320],"methodology":[31,56,203,276,300],"theoretical":[33,91],"characterization":[34,92,96,325],"temporal":[36,258],"spatial":[38,260],"at":[41,218,238,294],"baseline":[42,120,195,219,295],"conditions":[43,220],"in":[45,114,208],"response":[46],"\u03b2-AS.":[48,298],"For":[49],"any":[50],"measured":[51],"voltage":[52],"trace,":[53,107],"the":[54,58,85,111,119,142,173,209,239,253,269,302,307],"proposed":[55,278],"estimates":[57,109,132,140],"parameters":[59,159],"state":[61,161,282],"variables":[62],"an":[64,105,149,181],"underlying":[65,98],"action":[68],"potential":[69],"(AP)":[70],"model":[71,126,138,158],"by":[72,129,141,172,179,248,268],"combining":[73],"Double":[74],"Greedy":[75],"Dimension":[76],"Reduction":[77],"(DGDR)":[78],"with":[79,212,226,250,310],"automatic":[80],"selection":[81],"biomarkers":[83],"Unscented":[86],"Kalman":[87],"Filter":[88],"(UKF).":[89],"Such":[90],"can":[93],"facilitate":[94],"subsequent":[95],"mechanisms.":[100],"MATERIAL":[101],"AND":[102],"METHODS:":[103],"Given":[104],"AP":[106,190,261,292],"initial":[108],"ionic":[112,215],"conductances":[113,217],"stochastic":[116],"version":[117],"O'Hara":[123],"et":[124],"al.":[125],"were":[127,170,192,265],"obtained":[128],"DGDR.":[130],"Those":[131],"served":[133],"initialize":[135],"update":[137],"parameter":[139,280],"UKF":[143,232,255,316],"method":[144],"based":[145],"on":[146],"formulation":[147],"associated":[150,211],"nonlinear":[151],"state-space":[152],"representation":[153],"joint":[155],"estimation":[156,213,284,303],"variables.":[162],"Similarly,":[163],"\u03b2-AS-induced":[164],"phosphorylation":[165,222],"levels":[166,223],"cellular":[168],"substrates":[169],"estimated":[171],"DGDR-UKF":[174,202,270,275],"methodology.":[175,271],"Performance":[176],"was":[177,236,246],"tested":[178],"building":[180],"experimentally-calibrated":[182],"population":[183],"virtual":[185],"cells,":[186],"from":[187,290],"which":[188,245],"synthetic":[189],"traces":[191,293],"generated":[193],"\u03b2-AS":[197,225],"conditions.":[198],"RESULTS:":[199],"The":[200],"combined":[201,274],"led":[204],"25%":[206],"reduction":[207],"error":[210],"current":[216],"respect":[227,251,311],"individual":[229,254,313],"DGDR":[230,314],"methods.":[233],"improvement":[235],"not":[237],"expense":[240],"higher":[242],"computational":[243,324],"load,":[244],"diminished":[247],"90%":[249],"method.":[256],"Both":[257],"accurately":[266],"characterized":[267],"CONCLUSIONS:":[272],"A":[273],"is":[277],"variable":[283],"cell":[288],"models":[289],"available":[291],"improves":[301],"performance":[304],"reduces":[306],"convergence":[308],"time":[309],"methods":[317],"renders":[319],"suitable":[321],"approach":[322],"be":[331],"used":[332],"ascertainment":[334],"mechanisms":[337],"its":[339],"relation":[340],"arrhythmogenesis.":[342]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2020-04-10T00:00:00"}
