{"id":"https://openalex.org/W2964660280","doi":"https://doi.org/10.1109/jbhi.2019.2931997","title":"Inferring Gene Regulatory Networks of Metabolic Enzymes Using Gradient Boosted Trees","display_name":"Inferring Gene Regulatory Networks of Metabolic Enzymes Using Gradient Boosted Trees","publication_year":2019,"publication_date":"2019-07-30","ids":{"openalex":"https://openalex.org/W2964660280","doi":"https://doi.org/10.1109/jbhi.2019.2931997","mag":"2964660280","pmid":"https://pubmed.ncbi.nlm.nih.gov/31380773"},"language":"en","primary_location":{"id":"doi:10.1109/jbhi.2019.2931997","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2019.2931997","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9435551","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100388016","display_name":"Yi Zhang","orcid":"https://orcid.org/0000-0001-5065-2339"},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Zhang","raw_affiliation_strings":["Department of Computer Science, University of Kentucky, Lexington, USA"],"raw_orcid":"https://orcid.org/0000-0001-5065-2339","affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Kentucky, Lexington, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100447051","display_name":"Xiaofei Zhang","orcid":"https://orcid.org/0000-0002-9934-5417"},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaofei Zhang","raw_affiliation_strings":["Department of Computer Science, University of Kentucky, Lexington, USA"],"raw_orcid":"https://orcid.org/0000-0002-9934-5417","affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Kentucky, Lexington, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029157205","display_name":"Andrew N. Lane","orcid":"https://orcid.org/0000-0003-1121-5106"},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew N. Lane","raw_affiliation_strings":["Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, USA"],"raw_orcid":"https://orcid.org/0000-0003-1121-5106","affiliations":[{"raw_affiliation_string":"Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058623652","display_name":"Teresa W.\u2010M. Fan","orcid":"https://orcid.org/0000-0002-7292-8938"},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Teresa W.-M. Fan","raw_affiliation_strings":["Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102842945","display_name":"Jinze Liu","orcid":"https://orcid.org/0000-0003-0555-9412"},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinze Liu","raw_affiliation_strings":["Department of Computer Science, University of Kentucky, Lexington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Kentucky, Lexington, USA","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4274,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.62268592,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"24","issue":"5","first_page":"1528","last_page":"1536"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reprogramming","display_name":"Reprogramming","score":0.7136752605438232},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.7080956697463989},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.64183109998703},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5768108367919922},{"id":"https://openalex.org/keywords/metabolic-pathway","display_name":"Metabolic pathway","score":0.5729572772979736},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5526172518730164},{"id":"https://openalex.org/keywords/metabolic-network","display_name":"Metabolic network","score":0.49806737899780273},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.49383407831192017},{"id":"https://openalex.org/keywords/cancer-cell","display_name":"Cancer cell","score":0.48184502124786377},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.4758322238922119},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4569263458251953},{"id":"https://openalex.org/keywords/glycolysis","display_name":"Glycolysis","score":0.43163496255874634},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.42121049761772156},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.39075368642807007},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.3776838779449463},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.24672561883926392},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.15850353240966797}],"concepts":[{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.7136752605438232},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.7080956697463989},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.64183109998703},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5768108367919922},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.5729572772979736},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5526172518730164},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.49806737899780273},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.49383407831192017},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.48184502124786377},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4758322238922119},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4569263458251953},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.43163496255874634},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.42121049761772156},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.39075368642807007},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3776838779449463},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24672561883926392},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15850353240966797}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/jbhi.2019.2931997","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2019.2931997","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},{"id":"pmid:31380773","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31380773","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE journal of biomedical and health informatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:9435551","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9435551","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE J Biomed Health Inform","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9435551","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9435551","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"IEEE J Biomed Health Inform","raw_type":"Text"},"sustainable_development_goals":[{"score":0.5199999809265137,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G2164305835","display_name":null,"funder_award_id":"1U24DK097215-01A1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6928544818","display_name":null,"funder_award_id":"1P01CA163223-01A1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7269738326","display_name":null,"funder_award_id":"P30CA177558","funder_id":"https://openalex.org/F4320309825","funder_display_name":"University of Kentucky"}],"funders":[{"id":"https://openalex.org/F4320309825","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W1490655572","https://openalex.org/W1678356000","https://openalex.org/W1900337607","https://openalex.org/W1968468939","https://openalex.org/W1999574084","https://openalex.org/W2008634667","https://openalex.org/W2014233861","https://openalex.org/W2026666187","https://openalex.org/W2033250049","https://openalex.org/W2036659083","https://openalex.org/W2039220817","https://openalex.org/W2041596211","https://openalex.org/W2041729369","https://openalex.org/W2042981247","https://openalex.org/W2044525257","https://openalex.org/W2055255976","https://openalex.org/W2056875635","https://openalex.org/W2057034623","https://openalex.org/W2060705109","https://openalex.org/W2074873270","https://openalex.org/W2076513103","https://openalex.org/W2083992760","https://openalex.org/W2096252634","https://openalex.org/W2097259163","https://openalex.org/W2098023402","https://openalex.org/W2101234009","https://openalex.org/W2102322990","https://openalex.org/W2106555403","https://openalex.org/W2109384743","https://openalex.org/W2111840226","https://openalex.org/W2117692326","https://openalex.org/W2117994680","https://openalex.org/W2121695897","https://openalex.org/W2126345910","https://openalex.org/W2129265801","https://openalex.org/W2135030836","https://openalex.org/W2135259589","https://openalex.org/W2154787822","https://openalex.org/W2157230165","https://openalex.org/W2159482845","https://openalex.org/W2162703860","https://openalex.org/W2163296115","https://openalex.org/W2247766769","https://openalex.org/W2295598076","https://openalex.org/W2412359813","https://openalex.org/W2600290945","https://openalex.org/W2611370172","https://openalex.org/W2622514592","https://openalex.org/W2770660823","https://openalex.org/W2785792383","https://openalex.org/W2888432474","https://openalex.org/W2901292166","https://openalex.org/W3099289621","https://openalex.org/W3102476541","https://openalex.org/W3104281729","https://openalex.org/W4255033601","https://openalex.org/W4294216483","https://openalex.org/W6629217341","https://openalex.org/W6674394623","https://openalex.org/W6675354045","https://openalex.org/W6679859970","https://openalex.org/W6682588571"],"related_works":["https://openalex.org/W2966780451","https://openalex.org/W1961707331","https://openalex.org/W2035612098","https://openalex.org/W2341681417","https://openalex.org/W2063475537","https://openalex.org/W2012938657","https://openalex.org/W4388492048","https://openalex.org/W2096004952","https://openalex.org/W1578136679","https://openalex.org/W2087715585"],"abstract_inverted_index":{"Metabolic":[0],"reprogramming":[1,15,51,75],"is":[2],"a":[3,66],"hallmark":[4],"of":[5,24,76,132,137,140,151],"cancer.":[6],"In":[7,60],"cancer":[8,29,58,77,156],"cells,":[9],"transcription":[10,22],"factors":[11],"(TFs)":[12],"govern":[13,49,74],"metabolic":[14,25,39,50,138,143],"through":[16],"abnormally":[17],"increasing":[18],"or":[19],"decreasing":[20],"the":[21,37,82,129,133,141,149],"rate":[23],"enzymes,":[26],"which":[27,146],"provides":[28],"cells":[30],"growth":[31],"advantages":[32],"and":[33,90,107,115],"concurrently":[34],"leads":[35],"to":[36,70],"altered":[38],"phenotypes":[40],"observed":[41],"in":[42,85,153],"many":[43],"cancers.":[44],"Consequently,":[45],"targeting":[46],"TFs":[47,72,89,125],"that":[48,73,126],"can":[52],"be":[53,128],"highly":[54],"effective":[55],"for":[56],"novel":[57],"therapeutics.":[59],"this":[61],"paper,":[62],"we":[63],"present":[64],"TFmeta,":[65],"machine":[67],"learning":[68],"approach":[69,80,121],"uncover":[71],"metabolism.":[78],"Our":[79],"achieves":[81],"state-of-the-art":[83],"performance":[84],"reconstructing":[86],"relations":[87],"between":[88],"their":[91],"target":[92],"genes":[93],"on":[94],"public":[95],"benchmark":[96],"datasets.":[97],"Leveraging":[98],"TF":[99],"binding":[100],"profiles":[101],"inferred":[102],"from":[103,111],"genome-wide":[104],"ChIP-seq":[105],"experiments":[106],"150":[108],"RNA-seq":[109],"samples":[110],"75":[112],"paired":[113],"cancerous":[114],"non-cancerous":[116],"human":[117],"lung":[118,155],"tissues,":[119],"our":[120],"predicted":[122],"19":[123],"key":[124],"may":[127,147],"major":[130],"regulators":[131],"gene":[134],"expression":[135],"changes":[136],"enzymes":[139],"central":[142],"pathway":[144],"glycolysis,":[145],"underlie":[148],"dysregulation":[150],"glycolysis":[152],"non-small-cell":[154],"patients.":[157]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}