{"id":"https://openalex.org/W2914287897","doi":"https://doi.org/10.1109/jbhi.2019.2898471","title":"A Novel MKL Method for GBM Prognosis Prediction by Integrating Histopathological Image and Multi-Omics Data","display_name":"A Novel MKL Method for GBM Prognosis Prediction by Integrating Histopathological Image and Multi-Omics Data","publication_year":2019,"publication_date":"2019-02-12","ids":{"openalex":"https://openalex.org/W2914287897","doi":"https://doi.org/10.1109/jbhi.2019.2898471","mag":"2914287897","pmid":"https://pubmed.ncbi.nlm.nih.gov/30763249"},"language":"en","primary_location":{"id":"doi:10.1109/jbhi.2019.2898471","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2019.2898471","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101989499","display_name":"Ya Zhang","orcid":"https://orcid.org/0000-0001-7231-0575"},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ya Zhang","raw_affiliation_strings":["School of Information Science and Technology, University of Science and Technology of China, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information Science and Technology, University of Science and Technology of China, Hefei, China","institution_ids":["https://openalex.org/I126520041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100359729","display_name":"Ao Li","orcid":"https://orcid.org/0000-0001-9910-8967"},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ao Li","raw_affiliation_strings":["School of Information Science and Technology, Center for Biomedical Engineering, University of Science and Technology of China, Hefei, China"],"raw_orcid":"https://orcid.org/0000-0001-9910-8967","affiliations":[{"raw_affiliation_string":"School of Information Science and Technology, Center for Biomedical Engineering, University of Science and Technology of China, Hefei, China","institution_ids":["https://openalex.org/I126520041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100685161","display_name":"Jie He","orcid":"https://orcid.org/0000-0002-0285-5403"},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210129412","display_name":"Anhui Provincial Hospital","ror":"https://ror.org/03n5gdd09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129412"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie He","raw_affiliation_strings":["Department of Pathology, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China","Department of Pathology, Anhui Provincial Cancer Hospital, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China","institution_ids":["https://openalex.org/I126520041"]},{"raw_affiliation_string":"Department of Pathology, Anhui Provincial Cancer Hospital, Hefei, China","institution_ids":["https://openalex.org/I4210129412"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100376902","display_name":"Minghui Wang","orcid":"https://orcid.org/0000-0002-5788-894X"},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minghui Wang","raw_affiliation_strings":["Research Center for Biomedical Engineering, University of Science and Technology of China, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Biomedical Engineering, University of Science and Technology of China, Hefei, China","institution_ids":["https://openalex.org/I126520041"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5743,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.8315445,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"24","issue":"1","first_page":"171","last_page":"179"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9923999905586243,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.9898999929428101,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medical-diagnosis","display_name":"Medical diagnosis","score":0.5752282738685608},{"id":"https://openalex.org/keywords/multiple-kernel-learning","display_name":"Multiple kernel learning","score":0.5670160055160522},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"Glioblastoma","score":0.5524338483810425},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.528335452079773},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4938252866268158},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.4434019923210144},{"id":"https://openalex.org/keywords/pathological","display_name":"Pathological","score":0.427796334028244},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.42394495010375977},{"id":"https://openalex.org/keywords/kernel","display_name":"Kernel (algebra)","score":0.4203869700431824},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.41941362619400024},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"Precision medicine","score":0.4146164357662201},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.24584698677062988},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.24144309759140015},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.18350043892860413},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.13948854804039001},{"id":"https://openalex.org/keywords/kernel-method","display_name":"Kernel method","score":0.11475124955177307},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10643243789672852}],"concepts":[{"id":"https://openalex.org/C534262118","wikidata":"https://www.wikidata.org/wiki/Q177719","display_name":"Medical diagnosis","level":2,"score":0.5752282738685608},{"id":"https://openalex.org/C2776879701","wikidata":"https://www.wikidata.org/wiki/Q25048660","display_name":"Multiple kernel learning","level":4,"score":0.5670160055160522},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.5524338483810425},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.528335452079773},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4938252866268158},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.4434019923210144},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.427796334028244},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.42394495010375977},{"id":"https://openalex.org/C74193536","wikidata":"https://www.wikidata.org/wiki/Q574844","display_name":"Kernel (algebra)","level":2,"score":0.4203869700431824},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.41941362619400024},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.4146164357662201},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24584698677062988},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24144309759140015},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18350043892860413},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.13948854804039001},{"id":"https://openalex.org/C122280245","wikidata":"https://www.wikidata.org/wiki/Q620622","display_name":"Kernel method","level":3,"score":0.11475124955177307},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10643243789672852},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/jbhi.2019.2898471","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2019.2898471","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},{"id":"pmid:30763249","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30763249","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE journal of biomedical and health informatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4199516844","display_name":"\u9762\u5411\u65b0\u4e00\u4ee3\u6d4b\u5e8f\u7684\u764c\u75c7\u62f7\u8d1d\u6570\u5f02\u5e38\u68c0\u6d4b\u53ca\u5176\u5173\u952e\u53d8\u5f02\u7684\u8ba1\u7b97\u53d1\u73b0\u7814\u7a76","funder_award_id":"61571414","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G679960866","display_name":null,"funder_award_id":"81872055","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7078069131","display_name":"\u764c\u75c7\u76f8\u5173\u78f7\u9178\u5316\u4fe1\u53f7\u8f6c\u5bfc\u7f51\u7edc\u653b\u51fb\u53d8\u5f02\u7684\u8ba1\u7b97\u8bc6\u522b\u548c\u5206\u6790\u7814\u7a76","funder_award_id":"61871361","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7348074014","display_name":"\u78f7\u9178\u5316\u76f8\u5173\u7684\u86cb\u767d\u8d28\u7ffb\u8bd1\u540e\u4fee\u9970Crosstalk\u53ca\u6fc0\u9176\u7684\u8ba1\u7b97\u8bc6\u522b\u65b9\u6cd5\u548c\u5206\u6790\u7814\u7a76","funder_award_id":"61471331","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1977653087","https://openalex.org/W1989756883","https://openalex.org/W2019024625","https://openalex.org/W2025183726","https://openalex.org/W2043299645","https://openalex.org/W2078495963","https://openalex.org/W2096287682","https://openalex.org/W2098341282","https://openalex.org/W2107554012","https://openalex.org/W2109743529","https://openalex.org/W2109816625","https://openalex.org/W2114843025","https://openalex.org/W2131987814","https://openalex.org/W2139484679","https://openalex.org/W2141826465","https://openalex.org/W2146512693","https://openalex.org/W2149108592","https://openalex.org/W2149441684","https://openalex.org/W2155066272","https://openalex.org/W2160382843","https://openalex.org/W2161817637","https://openalex.org/W2296450878","https://openalex.org/W2322942874","https://openalex.org/W2335460486","https://openalex.org/W2366536035","https://openalex.org/W2419587273","https://openalex.org/W2514628397","https://openalex.org/W2526998669","https://openalex.org/W2551668581","https://openalex.org/W2554133913","https://openalex.org/W2745759175","https://openalex.org/W2745940724","https://openalex.org/W2761668583","https://openalex.org/W2797541140","https://openalex.org/W2803035327","https://openalex.org/W2913283787"],"related_works":["https://openalex.org/W2912862995","https://openalex.org/W3129816939","https://openalex.org/W2101501829","https://openalex.org/W2985427592","https://openalex.org/W2003194288","https://openalex.org/W2060263731","https://openalex.org/W391093122","https://openalex.org/W4361305867","https://openalex.org/W1521239975","https://openalex.org/W2113159581"],"abstract_inverted_index":{"Glioblastoma":[0],"multiforme":[1],"(GBM)":[2],"is":[3,194],"one":[4],"of":[5,69,78],"the":[6,53,63,122,183],"most":[7,54],"malignant":[8],"brain":[9],"tumors":[10],"with":[11,109,186],"very":[12],"short":[13],"prognosis":[14,39,61,108,133,185,208],"expectation.":[15],"To":[16],"improve":[17,131],"patients'":[18],"clinical":[19],"treatment":[20],"and":[21,34,44,60,71,101,162,198],"their":[22],"life":[23],"quality":[24],"after":[25],"surgery,":[26],"researches":[27],"have":[28,45,140,176],"developed":[29,141],"tremendous":[30],"in":[31,57,62,205],"silico":[32],"models":[33,96],"tools":[35],"for":[36,91],"predicting":[37],"GBM":[38,107,132,184,207],"based":[40,81,97],"on":[41,82,98],"molecular":[42,100],"datasets":[43,168],"earned":[46],"great":[47,89],"success.":[48],"However,":[49],"pathology":[50],"still":[51],"plays":[52],"critical":[55],"role":[56],"cancer":[58],"diagnosis":[59],"clinic":[64],"at":[65],"present.":[66],"Recent":[67],"advancement":[68],"storing":[70],"processing":[72],"histopathological":[73,83,102,150,160],"images":[74,84,103,161],"has":[75],"drawn":[76],"attention":[77],"researchers.":[79],"Models":[80],"are":[85,112],"developed,":[86],"which":[87,202],"show":[88],"potential":[90],"computer-aided":[92],"pathological":[93],"diagnoses.":[94],"But":[95],"both":[99,159],"that":[104,156,180,192],"could":[105,157,181],"predict":[106,182],"high":[110,187],"accuracy":[111],"not":[113],"present":[114],"yet.":[115],"In":[116,136],"our":[117],"previous":[118],"research,":[119],"we":[120,139,175],"used":[121],"simple":[123],"MKL":[124,200],"method":[125],"to":[126,130],"integrate":[127,158],"multi-omics":[128,163],"data":[129,164],"prediction":[134],"successfully.":[135],"this":[137],"paper,":[138],"a":[142,178,206],"novel":[143],"multiple":[144,152],"kernel":[145,153],"learning":[146,154],"(MKL)":[147],"method,":[148,201],"named":[149],"integrating":[151],"(HI-MKL),":[155],"efficiently.":[165],"By":[166],"using":[167],"from":[169],"The":[170],"Cancer":[171],"Genome":[172],"Atlas":[173],"project,":[174],"built":[177],"system":[179],"accuracy.":[188],"Our":[189],"research":[190],"shows":[191],"HI-MKL":[193],"an":[195],"accurate,":[196],"robust,":[197],"generalized":[199],"performs":[203],"well":[204],"task.":[209]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}