{"id":"https://openalex.org/W2904272992","doi":"https://doi.org/10.1109/jbhi.2018.2863202","title":"A Network-Based Perspective in Alzheimer's Disease: Current State and an Integrative Framework","display_name":"A Network-Based Perspective in Alzheimer's Disease: Current State and an Integrative Framework","publication_year":2018,"publication_date":"2018-08-03","ids":{"openalex":"https://openalex.org/W2904272992","doi":"https://doi.org/10.1109/jbhi.2018.2863202","mag":"2904272992","pmid":"https://pubmed.ncbi.nlm.nih.gov/30080151"},"language":"en","primary_location":{"id":"doi:10.1109/jbhi.2018.2863202","is_oa":true,"landing_page_url":"https://doi.org/10.1109/jbhi.2018.2863202","pdf_url":"https://ieeexplore.ieee.org/ielx7/6221020/8602373/08424818.pdf","source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ieeexplore.ieee.org/ielx7/6221020/8602373/08424818.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077677147","display_name":"Andrei Dragomir","orcid":"https://orcid.org/0000-0003-2815-6958"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Andrei Dragomir","raw_affiliation_strings":["Singapore Institute for Neurotechnology, Center of Life Sciences, National University of Singapore, Singapore"],"raw_orcid":"https://orcid.org/0000-0003-2815-6958","affiliations":[{"raw_affiliation_string":"Singapore Institute for Neurotechnology, Center of Life Sciences, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082119404","display_name":"Aristidis G. Vrahatis","orcid":"https://orcid.org/0000-0003-1892-0000"},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Aristidis G. Vrahatis","raw_affiliation_strings":["Department of Medical Physics, School of Medicine, University of Patras, Patras, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physics, School of Medicine, University of Patras, Patras, Greece","institution_ids":["https://openalex.org/I174878644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080347335","display_name":"Anastasios Bezerianos","orcid":"https://orcid.org/0000-0002-8199-6000"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Anastasios Bezerianos","raw_affiliation_strings":["Singapore Institute for Neurotechnology, Center of Life Sciences, National University of Singapore, Singapore"],"raw_orcid":"https://orcid.org/0000-0002-8199-6000","affiliations":[{"raw_affiliation_string":"Singapore Institute for Neurotechnology, Center of Life Sciences, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3179,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.80711708,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"23","issue":"1","first_page":"14","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13283","display_name":"Mental Health Research Topics","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.703084409236908},{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.49187135696411133},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4368242621421814},{"id":"https://openalex.org/keywords/life-expectancy","display_name":"Life expectancy","score":0.4189887046813965},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.41412580013275146},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.37851470708847046},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.37568947672843933},{"id":"https://openalex.org/keywords/intensive-care-medicine","display_name":"Intensive care medicine","score":0.36113280057907104},{"id":"https://openalex.org/keywords/risk-analysis","display_name":"Risk analysis (engineering)","score":0.3484548032283783},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.33941400051116943},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.2912629246711731},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.16888919472694397},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.14901688694953918},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.11399215459823608}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.703084409236908},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.49187135696411133},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4368242621421814},{"id":"https://openalex.org/C133925201","wikidata":"https://www.wikidata.org/wiki/Q188419","display_name":"Life expectancy","level":3,"score":0.4189887046813965},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.41412580013275146},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.37851470708847046},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37568947672843933},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.36113280057907104},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.3484548032283783},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33941400051116943},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2912629246711731},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.16888919472694397},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14901688694953918},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.11399215459823608},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/jbhi.2018.2863202","is_oa":true,"landing_page_url":"https://doi.org/10.1109/jbhi.2018.2863202","pdf_url":"https://ieeexplore.ieee.org/ielx7/6221020/8602373/08424818.pdf","source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},{"id":"pmid:30080151","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30080151","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE journal of biomedical and health informatics","raw_type":null}],"best_oa_location":{"id":"doi:10.1109/jbhi.2018.2863202","is_oa":true,"landing_page_url":"https://doi.org/10.1109/jbhi.2018.2863202","pdf_url":"https://ieeexplore.ieee.org/ielx7/6221020/8602373/08424818.pdf","source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2904272992.pdf","grobid_xml":"https://content.openalex.org/works/W2904272992.grobid-xml"},"referenced_works_count":116,"referenced_works":["https://openalex.org/W610539324","https://openalex.org/W1447565288","https://openalex.org/W1508717233","https://openalex.org/W1566270348","https://openalex.org/W1599740911","https://openalex.org/W1629637340","https://openalex.org/W1820176754","https://openalex.org/W1846949033","https://openalex.org/W1948745668","https://openalex.org/W1964034855","https://openalex.org/W1964869332","https://openalex.org/W1968790254","https://openalex.org/W1969875677","https://openalex.org/W1978763244","https://openalex.org/W1979608286","https://openalex.org/W1987829395","https://openalex.org/W1990678336","https://openalex.org/W1991933335","https://openalex.org/W1994397669","https://openalex.org/W1998486151","https://openalex.org/W1999895438","https://openalex.org/W2009783955","https://openalex.org/W2014022174","https://openalex.org/W2019141334","https://openalex.org/W2019801716","https://openalex.org/W2020706332","https://openalex.org/W2026970282","https://openalex.org/W2030637554","https://openalex.org/W2033105784","https://openalex.org/W2039172538","https://openalex.org/W2042557239","https://openalex.org/W2044987522","https://openalex.org/W2062533676","https://openalex.org/W2067808181","https://openalex.org/W2069440543","https://openalex.org/W2070050178","https://openalex.org/W2079096922","https://openalex.org/W2079861976","https://openalex.org/W2080218141","https://openalex.org/W2087938247","https://openalex.org/W2089572795","https://openalex.org/W2090485842","https://openalex.org/W2092022343","https://openalex.org/W2092902275","https://openalex.org/W2095293504","https://openalex.org/W2100768460","https://openalex.org/W2100980426","https://openalex.org/W2104662311","https://openalex.org/W2106248311","https://openalex.org/W2106960039","https://openalex.org/W2110256992","https://openalex.org/W2110300314","https://openalex.org/W2123925888","https://openalex.org/W2125698969","https://openalex.org/W2126598020","https://openalex.org/W2129030910","https://openalex.org/W2129478224","https://openalex.org/W2130371234","https://openalex.org/W2138991775","https://openalex.org/W2139511828","https://openalex.org/W2141854336","https://openalex.org/W2143502460","https://openalex.org/W2146089088","https://openalex.org/W2146788881","https://openalex.org/W2150176166","https://openalex.org/W2153171432","https://openalex.org/W2170726034","https://openalex.org/W2184188583","https://openalex.org/W2210678500","https://openalex.org/W2228336263","https://openalex.org/W2236822143","https://openalex.org/W2252054300","https://openalex.org/W2254492505","https://openalex.org/W2274582236","https://openalex.org/W2302110566","https://openalex.org/W2311607323","https://openalex.org/W2327547544","https://openalex.org/W2337125453","https://openalex.org/W2399495985","https://openalex.org/W2411834013","https://openalex.org/W2462696571","https://openalex.org/W2479072704","https://openalex.org/W2518298328","https://openalex.org/W2524406955","https://openalex.org/W2527896982","https://openalex.org/W2533881064","https://openalex.org/W2550934658","https://openalex.org/W2556389549","https://openalex.org/W2560584411","https://openalex.org/W2579782328","https://openalex.org/W2581118170","https://openalex.org/W2591046646","https://openalex.org/W2594707750","https://openalex.org/W2603756957","https://openalex.org/W2611573275","https://openalex.org/W2617072792","https://openalex.org/W2737462298","https://openalex.org/W2738632062","https://openalex.org/W2751653332","https://openalex.org/W2752287204","https://openalex.org/W2765306916","https://openalex.org/W2770136486","https://openalex.org/W2770548163","https://openalex.org/W2774306843","https://openalex.org/W2787999987","https://openalex.org/W2792909494","https://openalex.org/W2799757069","https://openalex.org/W2806412533","https://openalex.org/W2949208329","https://openalex.org/W4211091012","https://openalex.org/W4233107814","https://openalex.org/W4234964068","https://openalex.org/W4396952261","https://openalex.org/W6685146747","https://openalex.org/W6686207219","https://openalex.org/W6698064614"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2414388375","https://openalex.org/W257066","https://openalex.org/W3030370935","https://openalex.org/W1997812059","https://openalex.org/W1804307181","https://openalex.org/W4285549808","https://openalex.org/W3204291344","https://openalex.org/W2753550874"],"abstract_inverted_index":{"A":[0],"major":[1],"rise":[2],"in":[3,14,60,158,172,200],"the":[4,15,34,61,70,101,112,122,152,177,186,201,222],"prevalence":[5],"and":[6,84,105,137,160,163,175,191,216,233,243],"impact":[7],"of":[8,36,88,94,103,155,188,204],"Alzheimer's":[9],"disease":[10,62,71,89],"(AD)":[11],"is":[12,41,77,144,170],"projected":[13],"coming":[16],"decades,":[17],"resulting":[18],"from":[19,214],"increasing":[20],"life":[21],"expectancy,":[22],"thus":[23],"leading":[24],"to":[25,82,224],"substantially":[26],"increased":[27],"healthcare":[28],"costs.":[29],"While":[30],"brain":[31,138,192,217,244],"disfunctions":[32],"at":[33,135],"time":[35],"diagnosis":[37,203],"are":[38],"irreversible,":[39],"it":[40],"widely":[42],"accepted":[43],"that":[44],"AD":[45,95],"pathology":[46],"develops":[47],"decades":[48],"before":[49],"clinical":[50],"symptoms":[51],"onset.":[52],"If":[53],"incipient":[54],"processes":[55],"can":[56,72],"be":[57,73],"detected":[58],"early":[59,86,202],"progression,":[63],"prospective":[64],"intervention":[65],"for":[66,114,179,195,211,230],"preventing":[67],"or":[68],"slowing":[69],"designed.":[74],"Currently,":[75],"there":[76],"no":[78],"noninvasive":[79,198,226],"biomarker":[80,166],"available":[81],"detect":[83],"monitor":[85],"stages":[87],"progression.":[90],"The":[91],"complex":[92,117],"etiology":[93],"warrants":[96],"a":[97,196,209],"systems-based":[98],"approach":[99,199],"supporting":[100],"integration":[102],"multimodal":[104],"multilevel":[106],"data,":[107],"while":[108],"network-based":[109,133,181],"modeling":[110],"provides":[111],"scaffolding":[113],"methods":[115],"revealing":[116],"systems-level":[118],"disruptions":[119],"initiated":[120],"by":[121],"disease.":[123],"In":[124],"this":[125],"work,":[126],"we":[127,207],"review":[128],"current":[129],"state-of-the-art,":[130],"focusing":[131],"on":[132,146],"biomarkers":[134],"molecular":[136,159,215],"functional":[139,153],"connectivity":[140,161,218],"levels.":[141],"Particular":[142],"emphasis":[143],"placed":[145],"outlining":[147],"recent":[148],"trends,":[149],"which":[150,220],"highlight":[151],"importance":[154],"modular":[156],"substructures":[157],"networks":[162],"their":[164],"potential":[165,223],"value.":[167],"Our":[168],"perspective":[169],"rooted":[171],"network":[173],"medicine":[174],"summarizes":[176],"pipelines":[178],"identifying":[180],"biomarkers,":[182],"as":[183,185],"well":[184],"benefits":[187],"integrating":[189,212],"genotype":[190,242],"phenotype":[193],"information":[194],"comprehensively":[197],"AD.":[205],"Finally,":[206],"propose":[208],"framework":[210],"knowledge":[213],"levels,":[219],"has":[221],"enable":[225],"diagnosis,":[227],"provide":[228],"support":[229],"monitoring":[231],"therapies,":[232],"help":[234],"understand":[235],"heretofore":[236],"unexamined":[237],"deep":[238],"level":[239],"relations":[240],"between":[241],"phenotype.":[245]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":3}],"updated_date":"2026-07-15T18:14:33.161393","created_date":"2025-10-10T00:00:00"}
