{"id":"https://openalex.org/W2016332126","doi":"https://doi.org/10.1109/jbhi.2015.2403397","title":"A Novel Approach to Multiple Sequence Alignment Using Multiobjective Evolutionary Algorithm Based on Decomposition","display_name":"A Novel Approach to Multiple Sequence Alignment Using Multiobjective Evolutionary Algorithm Based on Decomposition","publication_year":2015,"publication_date":"2015-02-12","ids":{"openalex":"https://openalex.org/W2016332126","doi":"https://doi.org/10.1109/jbhi.2015.2403397","mag":"2016332126","pmid":"https://pubmed.ncbi.nlm.nih.gov/25700475"},"language":"en","primary_location":{"id":"doi:10.1109/jbhi.2015.2403397","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2015.2403397","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063471224","display_name":"Huazheng Zhu","orcid":"https://orcid.org/0000-0001-7963-5559"},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huazheng Zhu","raw_affiliation_strings":["College of Computer Science, Chongqing University, Chongqing, China","College of Computer Science, Chongqing University Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer Science, Chongqing University, Chongqing, China","institution_ids":["https://openalex.org/I158842170"]},{"raw_affiliation_string":"College of Computer Science, Chongqing University Chongqing, China","institution_ids":["https://openalex.org/I158842170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100676074","display_name":"Zhongshi He","orcid":"https://orcid.org/0009-0007-3682-0464"},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhongshi He","raw_affiliation_strings":["College of Computer Science, Chongqing University, Chongqing, China","College of Computer Science, Chongqing University Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer Science, Chongqing University, Chongqing, China","institution_ids":["https://openalex.org/I158842170"]},{"raw_affiliation_string":"College of Computer Science, Chongqing University Chongqing, China","institution_ids":["https://openalex.org/I158842170"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100669029","display_name":"Yuanyuan Jia","orcid":"https://orcid.org/0000-0003-1296-634X"},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Jia","raw_affiliation_strings":["College of Computer Science, Chongqing University, Chongqing, China","College of Computer Science, Chongqing University Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer Science, Chongqing University, Chongqing, China","institution_ids":["https://openalex.org/I158842170"]},{"raw_affiliation_string":"College of Computer Science, Chongqing University Chongqing, China","institution_ids":["https://openalex.org/I158842170"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I158842170"],"apc_list":null,"apc_paid":null,"fwci":2.8081,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.90918796,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"20","issue":"2","first_page":"717","last_page":"727"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9919000267982483,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9896000027656555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sequence-alignment","display_name":"Multiple sequence alignment","score":0.759002149105072},{"id":"https://openalex.org/keywords/initialization","display_name":"Initialization","score":0.7446378469467163},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7018112540245056},{"id":"https://openalex.org/keywords/benchmark","display_name":"Benchmark (surveying)","score":0.6921959519386292},{"id":"https://openalex.org/keywords/evolutionary-algorithm","display_name":"Evolutionary algorithm","score":0.6529443264007568},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.5059060454368591},{"id":"https://openalex.org/keywords/sequence-alignment","display_name":"Sequence alignment","score":0.459064781665802},{"id":"https://openalex.org/keywords/key","display_name":"Key (lock)","score":0.45423242449760437},{"id":"https://openalex.org/keywords/phylogenetic-tree","display_name":"Phylogenetic tree","score":0.4509704113006592},{"id":"https://openalex.org/keywords/multi-objective-optimization","display_name":"Multi-objective optimization","score":0.4456098675727844},{"id":"https://openalex.org/keywords/evolutionary-computation","display_name":"Evolutionary computation","score":0.4404483437538147},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4370208978652954},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.4366809129714966},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.4276520609855652},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3813968598842621},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.35725390911102295},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.10569685697555542}],"concepts":[{"id":"https://openalex.org/C88031987","wikidata":"https://www.wikidata.org/wiki/Q1377767","display_name":"Multiple sequence alignment","level":5,"score":0.759002149105072},{"id":"https://openalex.org/C114466953","wikidata":"https://www.wikidata.org/wiki/Q6034165","display_name":"Initialization","level":2,"score":0.7446378469467163},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7018112540245056},{"id":"https://openalex.org/C185798385","wikidata":"https://www.wikidata.org/wiki/Q1161707","display_name":"Benchmark (surveying)","level":2,"score":0.6921959519386292},{"id":"https://openalex.org/C159149176","wikidata":"https://www.wikidata.org/wiki/Q14489129","display_name":"Evolutionary algorithm","level":2,"score":0.6529443264007568},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.5059060454368591},{"id":"https://openalex.org/C45484198","wikidata":"https://www.wikidata.org/wiki/Q827246","display_name":"Sequence alignment","level":4,"score":0.459064781665802},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.45423242449760437},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.4509704113006592},{"id":"https://openalex.org/C68781425","wikidata":"https://www.wikidata.org/wiki/Q2052203","display_name":"Multi-objective optimization","level":2,"score":0.4456098675727844},{"id":"https://openalex.org/C105902424","wikidata":"https://www.wikidata.org/wiki/Q1197129","display_name":"Evolutionary computation","level":2,"score":0.4404483437538147},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4370208978652954},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.4366809129714966},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4276520609855652},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3813968598842621},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.35725390911102295},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10569685697555542},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.0},{"id":"https://openalex.org/C13280743","wikidata":"https://www.wikidata.org/wiki/Q131089","display_name":"Geodesy","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/jbhi.2015.2403397","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2015.2403397","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},{"id":"pmid:25700475","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25700475","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE journal of biomedical and health informatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W11515763","https://openalex.org/W1519266993","https://openalex.org/W1550820576","https://openalex.org/W1590240800","https://openalex.org/W1969153299","https://openalex.org/W1976471311","https://openalex.org/W1980913156","https://openalex.org/W1982693868","https://openalex.org/W1984814148","https://openalex.org/W1987316540","https://openalex.org/W2002638840","https://openalex.org/W2011289056","https://openalex.org/W2028624874","https://openalex.org/W2029848394","https://openalex.org/W2036295979","https://openalex.org/W2044164898","https://openalex.org/W2072649575","https://openalex.org/W2074231493","https://openalex.org/W2076958907","https://openalex.org/W2091384774","https://openalex.org/W2102941368","https://openalex.org/W2106882534","https://openalex.org/W2110241016","https://openalex.org/W2120866529","https://openalex.org/W2121691652","https://openalex.org/W2127122014","https://openalex.org/W2127322768","https://openalex.org/W2128613007","https://openalex.org/W2130625618","https://openalex.org/W2132926880","https://openalex.org/W2136570298","https://openalex.org/W2140872496","https://openalex.org/W2143210482","https://openalex.org/W2143381319","https://openalex.org/W2144362290","https://openalex.org/W2145232949","https://openalex.org/W2148311769","https://openalex.org/W2154730959","https://openalex.org/W2160378127","https://openalex.org/W2170831688","https://openalex.org/W3100565357","https://openalex.org/W6600477597"],"related_works":["https://openalex.org/W2051969447","https://openalex.org/W2111937814","https://openalex.org/W2162923930","https://openalex.org/W1482324242","https://openalex.org/W2133116680","https://openalex.org/W2091678889","https://openalex.org/W2029514038","https://openalex.org/W2149492307","https://openalex.org/W1985408726","https://openalex.org/W2141411672"],"abstract_inverted_index":{"Multiple":[0],"sequence":[1],"alignment":[2,42,106,122,141,197],"(MSA)":[3],"is":[4,59,75,191],"a":[5,51,62,88,94],"fundamental":[6],"and":[7,24,93,115,117,138,150,186],"key":[8],"step":[9],"for":[10,77],"implementing":[11],"other":[12],"tasks":[13],"in":[14,181,199],"bioinformatics,":[15],"such":[16,124],"as":[17,61,125],"phylogenetic":[18],"analyses,":[19,175],"identification":[20],"of":[21,102,170,183,201,203],"conserved":[22],"motifs":[23],"domains,":[25],"structure":[26],"prediction,":[27],"etc.":[28],"Despite":[29],"the":[30,83,100,160,168,194],"fact":[31],"that":[32,156,189],"there":[33],"are":[34,44,143],"many":[35],"methods":[36,107],"to":[37,54],"implement":[38],"MSA,":[39,56,79],"biologically":[40],"perfect":[41],"approaches":[43,198],"not":[45],"found":[46],"hitherto.":[47],"This":[48],"paper":[49],"proposes":[50],"novel":[52,95],"idea":[53],"perform":[55],"where":[57],"MSA":[58],"treated":[60],"multiobjective":[63,68],"optimization":[64],"problem.":[65],"A":[66],"famous":[67],"evolutionary":[69,110],"algorithm":[70],"framework":[71],"based":[72,108],"on":[73,109,145,167],"decomposition":[74],"applied":[76],"solving":[78],"named":[80],"MOMSA.":[81],"In":[82],"MOMSA":[84,103,157,190],"algorithm,":[85],"we":[86],"develop":[87],"new":[89],"population":[90],"initialization":[91],"method":[92],"mutation":[96],"operator.":[97],"We":[98],"compare":[99],"performance":[101],"with":[104,119,193],"several":[105],"algorithms,":[111],"including":[112],"VDGA,":[113,165],"GAPAM,":[114],"IMSA,":[116],"also":[118,187],"state-of-the-art":[120],"progressive":[121,196],"approaches,":[123],"MSAprobs,":[126],"Probalign,":[127],"MAFFT,":[128],"Procons,":[129],"Clustal":[130],"omega,":[131],"T-Coffee,":[132],"Kalign2,":[133],"MUSCLE,":[134],"FSA,":[135],"Dialign,":[136],"PRANK,":[137],"CLUSTALW.":[139],"These":[140],"algorithms":[142],"tested":[144],"benchmark":[146],"datasets":[147],"BAliBASE":[148,151],"2.0":[149],"3.0.":[152],"Experimental":[153],"results":[154],"show":[155],"can":[158],"obtain":[159],"significantly":[161],"better":[162,177],"alignments":[163,178],"than":[164,179],"GAPAM":[166],"most":[169],"test":[171],"cases":[172],"by":[173],"statistical":[174],"produce":[176],"IMSA":[180],"terms":[182,200],"TC":[184],"scores,":[185],"indicate":[188],"comparable":[192],"leading":[195],"quality":[202],"alignments.":[204]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
