{"id":"https://openalex.org/W2080833794","doi":"https://doi.org/10.1109/jbhi.2015.2398512","title":"Modeling the Interplay Between Tumor Volume Regression and Oxygenation in Uterine Cervical Cancer During Radiotherapy Treatment","display_name":"Modeling the Interplay Between Tumor Volume Regression and Oxygenation in Uterine Cervical Cancer During Radiotherapy Treatment","publication_year":2015,"publication_date":"2015-01-30","ids":{"openalex":"https://openalex.org/W2080833794","doi":"https://doi.org/10.1109/jbhi.2015.2398512","mag":"2080833794","pmid":"https://pubmed.ncbi.nlm.nih.gov/25647734"},"language":"en","primary_location":{"id":"doi:10.1109/jbhi.2015.2398512","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2015.2398512","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056235763","display_name":"Antonella Belfatto","orcid":"https://orcid.org/0000-0002-1955-0075"},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Antonella Belfatto","raw_affiliation_strings":["Department of Electronics, Politecnico di Milano University, Milan, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Electronics, Politecnico di Milano University, Milan, Italy","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083196840","display_name":"Marco Riboldi","orcid":"https://orcid.org/0000-0002-2431-4966"},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]},{"id":"https://openalex.org/I4210101051","display_name":"National Center for Oncological Hadrontherapy","ror":"https://ror.org/016fa9e26","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210101051"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Riboldi","raw_affiliation_strings":["Centro Nazionale di Adroterapia Oncologica, Pavia, Italy","Department of Electronics, Information and Bioengineering, Politecnico di Milano University, Milan, Italy"],"affiliations":[{"raw_affiliation_string":"Centro Nazionale di Adroterapia Oncologica, Pavia, Italy","institution_ids":["https://openalex.org/I4210101051"]},{"raw_affiliation_string":"Department of Electronics, Information and Bioengineering, Politecnico di Milano University, Milan, Italy","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025460525","display_name":"D. Ciardo","orcid":"https://orcid.org/0000-0001-6691-0208"},"institutions":[{"id":"https://openalex.org/I6141010","display_name":"European Institute of Oncology","ror":"https://ror.org/02vr0ne26","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I6141010"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Delia Ciardo","raw_affiliation_strings":["Advanced Radiotherapy Center, European Institute of Oncology, Milan, Italy"],"affiliations":[{"raw_affiliation_string":"Advanced Radiotherapy Center, European Institute of Oncology, Milan, Italy","institution_ids":["https://openalex.org/I6141010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068250967","display_name":"Federica Cattani","orcid":"https://orcid.org/0000-0002-2488-7385"},"institutions":[{"id":"https://openalex.org/I6141010","display_name":"European Institute of Oncology","ror":"https://ror.org/02vr0ne26","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I6141010"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Federica Cattani","raw_affiliation_strings":["Advanced Radiotherapy Center, European Institute of Oncology, Milan, Italy"],"affiliations":[{"raw_affiliation_string":"Advanced Radiotherapy Center, European Institute of Oncology, Milan, Italy","institution_ids":["https://openalex.org/I6141010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030095580","display_name":"Agnese Cecconi","orcid":null},"institutions":[{"id":"https://openalex.org/I6141010","display_name":"European Institute of Oncology","ror":"https://ror.org/02vr0ne26","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I6141010"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Agnese Cecconi","raw_affiliation_strings":["Advanced Radiotherapy Center, European Institute of Oncology, Milan, Italy"],"affiliations":[{"raw_affiliation_string":"Advanced Radiotherapy Center, European Institute of Oncology, Milan, Italy","institution_ids":["https://openalex.org/I6141010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026922940","display_name":"Roberta Lazzari","orcid":null},"institutions":[{"id":"https://openalex.org/I6141010","display_name":"European Institute of Oncology","ror":"https://ror.org/02vr0ne26","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I6141010"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberta Lazzari","raw_affiliation_strings":["Advanced Radiotherapy Center, European Institute of Oncology, Milan, Italy"],"affiliations":[{"raw_affiliation_string":"Advanced Radiotherapy Center, European Institute of Oncology, Milan, Italy","institution_ids":["https://openalex.org/I6141010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054413808","display_name":"Barbara Alicja Jereczek\u2010Fossa","orcid":"https://orcid.org/0000-0001-8151-3673"},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I6141010","display_name":"European Institute of Oncology","ror":"https://ror.org/02vr0ne26","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I6141010"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Barbara Alicja Jereczek-Fossa","raw_affiliation_strings":["Advanced Radiotherapy Center, European Institute of Oncology, Milan, Italy","Department of Health Sciences, University of Milan, Milan, Italy"],"affiliations":[{"raw_affiliation_string":"Advanced Radiotherapy Center, European Institute of Oncology, Milan, Italy","institution_ids":["https://openalex.org/I6141010"]},{"raw_affiliation_string":"Department of Health Sciences, University of Milan, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053972376","display_name":"Roberto Orecchia","orcid":null},"institutions":[{"id":"https://openalex.org/I6141010","display_name":"European Institute of Oncology","ror":"https://ror.org/02vr0ne26","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I6141010"]},{"id":"https://openalex.org/I4210101051","display_name":"National Center for Oncological Hadrontherapy","ror":"https://ror.org/016fa9e26","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210101051"]},{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberto Orecchia","raw_affiliation_strings":["Advanced Radiotherapy Center, European Institute of Oncology, Milan, Italy","Centro Nazionale di Adroterapia Oncologica, Pavia, Italy","Department of Health Sciences, University of Milan, Milan, Italy"],"affiliations":[{"raw_affiliation_string":"Advanced Radiotherapy Center, European Institute of Oncology, Milan, Italy","institution_ids":["https://openalex.org/I6141010"]},{"raw_affiliation_string":"Centro Nazionale di Adroterapia Oncologica, Pavia, Italy","institution_ids":["https://openalex.org/I4210101051"]},{"raw_affiliation_string":"Department of Health Sciences, University of Milan, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000570208","display_name":"G. Baroni","orcid":"https://orcid.org/0000-0002-5464-0164"},"institutions":[{"id":"https://openalex.org/I4210101051","display_name":"National Center for Oncological Hadrontherapy","ror":"https://ror.org/016fa9e26","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210101051"]},{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Guido Baroni","raw_affiliation_strings":["Centro Nazionale di Adroterapia Oncologica, Pavia, Italy","Department of Electronics, Information and Bioengineering, Politecnico di Milano University, Milan, Italy"],"affiliations":[{"raw_affiliation_string":"Centro Nazionale di Adroterapia Oncologica, Pavia, Italy","institution_ids":["https://openalex.org/I4210101051"]},{"raw_affiliation_string":"Department of Electronics, Information and Bioengineering, Politecnico di Milano University, Milan, Italy","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079877840","display_name":"Pietro Cerveri","orcid":"https://orcid.org/0000-0003-3995-8673"},"institutions":[{"id":"https://openalex.org/I4210101051","display_name":"National Center for Oncological Hadrontherapy","ror":"https://ror.org/016fa9e26","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210101051"]},{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pietro Cerveri","raw_affiliation_strings":["Centro Nazionale di Adroterapia Oncologica, Pavia, Italy","Department of Electronics, Information and Bioengineering, Politecnico di Milano University, Milan, Italy"],"affiliations":[{"raw_affiliation_string":"Centro Nazionale di Adroterapia Oncologica, Pavia, Italy","institution_ids":["https://openalex.org/I4210101051"]},{"raw_affiliation_string":"Department of Electronics, Information and Bioengineering, Politecnico di Milano University, Milan, Italy","institution_ids":["https://openalex.org/I93860229"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5056235763"],"corresponding_institution_ids":["https://openalex.org/I93860229"],"apc_list":null,"apc_paid":null,"fwci":1.1363,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.79808945,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"20","issue":"2","first_page":"596","last_page":"605"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiation-therapy","display_name":"Radiation therapy","score":0.6893932223320007},{"id":"https://openalex.org/keywords/oxygenation","display_name":"Oxygenation","score":0.5794963836669922},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"Cervical cancer","score":0.5491717457771301},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.42685744166374207},{"id":"https://openalex.org/keywords/radiosensitivity","display_name":"Radiosensitivity","score":0.4171096384525299},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4162628650665283},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.34717562794685364},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.3078969120979309},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.287710964679718}],"concepts":[{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.6893932223320007},{"id":"https://openalex.org/C70289976","wikidata":"https://www.wikidata.org/wiki/Q17143603","display_name":"Oxygenation","level":2,"score":0.5794963836669922},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.5491717457771301},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42685744166374207},{"id":"https://openalex.org/C206684579","wikidata":"https://www.wikidata.org/wiki/Q4387689","display_name":"Radiosensitivity","level":3,"score":0.4171096384525299},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4162628650665283},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.34717562794685364},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3078969120979309},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.287710964679718}],"mesh":[{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011836","descriptor_name":"Radiation Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011836","descriptor_name":"Radiation Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011836","descriptor_name":"Radiation Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047368","descriptor_name":"Tumor Burden","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047368","descriptor_name":"Tumor Burden","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047368","descriptor_name":"Tumor Burden","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054893","descriptor_name":"Cone-Beam Computed Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054893","descriptor_name":"Cone-Beam Computed Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054893","descriptor_name":"Cone-Beam Computed Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/jbhi.2015.2398512","is_oa":false,"landing_page_url":"https://doi.org/10.1109/jbhi.2015.2398512","pdf_url":null,"source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},{"id":"pmid:25647734","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25647734","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE journal of biomedical and health informatics","raw_type":null},{"id":"pmh:oai:re.public.polimi.it:11311/972903","is_oa":false,"landing_page_url":"http://hdl.handle.net/11311/972903","pdf_url":null,"source":{"id":"https://openalex.org/S4306400312","display_name":"Virtual Community of Pathological Anatomy (University of Castilla La Mancha)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I79189158","host_organization_name":"University of Castilla-La Mancha","host_organization_lineage":["https://openalex.org/I79189158"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8500000238418579,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1491348262","https://openalex.org/W1578077707","https://openalex.org/W1799770165","https://openalex.org/W1965353261","https://openalex.org/W1967636871","https://openalex.org/W1973215254","https://openalex.org/W1984865136","https://openalex.org/W1997925433","https://openalex.org/W1998235211","https://openalex.org/W1998706118","https://openalex.org/W2001134174","https://openalex.org/W2014787187","https://openalex.org/W2030637153","https://openalex.org/W2035212378","https://openalex.org/W2037179242","https://openalex.org/W2037183541","https://openalex.org/W2041434590","https://openalex.org/W2047067845","https://openalex.org/W2049713049","https://openalex.org/W2050384133","https://openalex.org/W2050744793","https://openalex.org/W2050941645","https://openalex.org/W2052811447","https://openalex.org/W2062292121","https://openalex.org/W2065974430","https://openalex.org/W2068555514","https://openalex.org/W2077725802","https://openalex.org/W2083336230","https://openalex.org/W2089253822","https://openalex.org/W2102722137","https://openalex.org/W2112699943","https://openalex.org/W2124496728","https://openalex.org/W2124617257","https://openalex.org/W2136543444","https://openalex.org/W2139899744","https://openalex.org/W2161528372","https://openalex.org/W2161780396","https://openalex.org/W2167229055","https://openalex.org/W2167623148","https://openalex.org/W2305690716","https://openalex.org/W2317663146","https://openalex.org/W2335263648","https://openalex.org/W2412190362","https://openalex.org/W3011574205","https://openalex.org/W6638361062","https://openalex.org/W6683969921","https://openalex.org/W6697928653","https://openalex.org/W6715049405"],"related_works":["https://openalex.org/W2377869450","https://openalex.org/W2375910701","https://openalex.org/W2111712489","https://openalex.org/W2392186915","https://openalex.org/W2380110850","https://openalex.org/W2359746517","https://openalex.org/W2354257850","https://openalex.org/W2379959646","https://openalex.org/W2330651042","https://openalex.org/W2753601988"],"abstract_inverted_index":{"This":[0],"paper":[1],"describes":[2],"a":[3,16,43,69,114,149],"patient-specific":[4],"mathematical":[5],"model":[6,24,89,116,154,168],"to":[7,93,102,153,160],"predict":[8],"the":[9,34,46,56,83,86,103,108,164,172],"evolution":[10],"of":[11,27,45,71,85,98,107,123,137,174],"uterine":[12],"cervical":[13],"tumors":[14],"at":[15],"macroscopic":[17],"scale,":[18],"during":[19,163],"fractionated":[20],"external":[21],"radiotherapy.":[22],"The":[23,88,111,167],"provides":[25],"estimates":[26],"tumor":[28,37,47,62,109,138,182],"regrowth":[29],"and":[30,40,60,101],"dead-cell":[31,99],"reabsorption,":[32],"incorporating":[33],"interplay":[35],"between":[36,58],"regression":[38],"rate":[39],"radiosensitivity,":[41,151],"as":[42,184,186],"function":[44],"oxygenation":[48,190],"level.":[49],"Model":[50],"parameters":[51],"were":[52],"estimated":[53,96],"by":[54,146],"minimizing":[55],"difference":[57],"predicted":[59,104],"measured":[61],"volumes,":[63],"these":[64],"latter":[65],"being":[66],"obtained":[67],"from":[68,156],"set":[70],"154":[72],"serial":[73],"cone-beam":[74],"computed":[75],"tomography":[76],"scans":[77],"acquired":[78],"on":[79],"16":[80],"patients":[81,91,176],"along":[82],"course":[84],"therapy.":[87],"stratified":[90],"according":[92],"two":[94],"different":[95],"dynamics":[97],"removal":[100],"initial":[105,157],"value":[106,129],"oxygenation.":[110],"comparison":[112],"with":[113],"simpler":[115],"demonstrated":[117],"an":[118],"improvement":[119],"in":[120,135],"fitting":[121],"properties":[122],"this":[124],"approach":[125],"(fitting":[126],"error":[127],"average":[128],"<5%,":[130],"p":[131],"<":[132],"0.01),":[133],"especially":[134],"case":[136],"late":[139],"responses,":[140],"which":[141],"can":[142],"hardly":[143],"be":[144],"handled":[145],"models":[147],"entailing":[148],"constant":[150],"failing":[152],"changes":[155],"severe":[158],"hypoxia":[159],"aerobic":[161],"conditions":[162,188],"treatment":[165],"course.":[166],"predictive":[169],"capabilities":[170],"suggest":[171],"need":[173],"clustering":[175],"accounting":[177],"for":[178],"cancer":[179],"cell":[180],"line,":[181],"staging,":[183],"well":[185],"microenvironment":[187],"(e.g.,":[189],"level).":[191]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-03-17T09:09:15.849793","created_date":"2025-10-10T00:00:00"}
