{"id":"https://openalex.org/W1975545135","doi":"https://doi.org/10.1109/jbhi.2014.2305445","title":"A Multistaged Automatic Restoration of Noisy Microscopy Cell Images","display_name":"A Multistaged Automatic Restoration of Noisy Microscopy Cell Images","publication_year":2014,"publication_date":"2014-02-10","ids":{"openalex":"https://openalex.org/W1975545135","doi":"https://doi.org/10.1109/jbhi.2014.2305445","mag":"1975545135","pmid":"https://pubmed.ncbi.nlm.nih.gov/25291801"},"language":"en","primary_location":{"id":"doi:10.1109/jbhi.2014.2305445","is_oa":true,"landing_page_url":"https://doi.org/10.1109/jbhi.2014.2305445","pdf_url":"https://ieeexplore.ieee.org/ielx7/6221020/6999985/06736071.pdf","source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ieeexplore.ieee.org/ielx7/6221020/6999985/06736071.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088703563","display_name":"Jinwei Xu","orcid":"https://orcid.org/0000-0003-1242-4217"},"institutions":[{"id":"https://openalex.org/I188329596","display_name":"University of Canberra","ror":"https://ror.org/04s1nv328","country_code":"AU","type":"education","lineage":["https://openalex.org/I188329596"]},{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Jinwei Xu","raw_affiliation_strings":["School of Engineering and Information Technology, The University of New South Wales, Canberra, A.C.T., Australia","School of Engineering and Information Technology The University of New South Wales, Canberra, Australia"],"affiliations":[{"raw_affiliation_string":"School of Engineering and Information Technology, The University of New South Wales, Canberra, A.C.T., Australia","institution_ids":["https://openalex.org/I188329596","https://openalex.org/I31746571"]},{"raw_affiliation_string":"School of Engineering and Information Technology The University of New South Wales, Canberra, Australia","institution_ids":["https://openalex.org/I188329596","https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075234257","display_name":"Jiankun Hu","orcid":"https://orcid.org/0000-0003-0230-1432"},"institutions":[{"id":"https://openalex.org/I188329596","display_name":"University of Canberra","ror":"https://ror.org/04s1nv328","country_code":"AU","type":"education","lineage":["https://openalex.org/I188329596"]},{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jiankun Hu","raw_affiliation_strings":["School of Engineering and Information Technology, The University of New South Wales, Canberra, A.C.T., Australia","School of Engineering and Information Technology The University of New South Wales, Canberra, Australia"],"affiliations":[{"raw_affiliation_string":"School of Engineering and Information Technology, The University of New South Wales, Canberra, A.C.T., Australia","institution_ids":["https://openalex.org/I188329596","https://openalex.org/I31746571"]},{"raw_affiliation_string":"School of Engineering and Information Technology The University of New South Wales, Canberra, Australia","institution_ids":["https://openalex.org/I188329596","https://openalex.org/I31746571"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024631382","display_name":"Xiuping Jia","orcid":"https://orcid.org/0000-0001-9916-6382"},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I188329596","display_name":"University of Canberra","ror":"https://ror.org/04s1nv328","country_code":"AU","type":"education","lineage":["https://openalex.org/I188329596"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Xiuping Jia","raw_affiliation_strings":["School of Engineering and Information Technology, The University of New South Wales, Canberra, A.C.T., Australia","School of Engineering and Information Technology The University of New South Wales, Canberra, Australia"],"affiliations":[{"raw_affiliation_string":"School of Engineering and Information Technology, The University of New South Wales, Canberra, A.C.T., Australia","institution_ids":["https://openalex.org/I188329596","https://openalex.org/I31746571"]},{"raw_affiliation_string":"School of Engineering and Information Technology The University of New South Wales, Canberra, Australia","institution_ids":["https://openalex.org/I188329596","https://openalex.org/I31746571"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5088703563"],"corresponding_institution_ids":["https://openalex.org/I188329596","https://openalex.org/I31746571"],"apc_list":null,"apc_paid":null,"fwci":1.205,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.84849942,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"19","issue":"1","first_page":"367","last_page":"376"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13114","display_name":"Image Processing Techniques and Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2214","display_name":"Media Technology"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9822999835014343,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6776750683784485},{"id":"https://openalex.org/keywords/image-restoration","display_name":"Image restoration","score":0.6721231937408447},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.597436785697937},{"id":"https://openalex.org/keywords/noise","display_name":"Noise (video)","score":0.5932413339614868},{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.5898979306221008},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.5357235074043274},{"id":"https://openalex.org/keywords/signal-to-noise-ratio","display_name":"Signal-to-noise ratio (imaging)","score":0.459231972694397},{"id":"https://openalex.org/keywords/pixel","display_name":"Pixel","score":0.44942259788513184},{"id":"https://openalex.org/keywords/noise-reduction","display_name":"Noise reduction","score":0.4425826370716095},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.4294567108154297},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.42690736055374146},{"id":"https://openalex.org/keywords/image-processing","display_name":"Image processing","score":0.4057326912879944},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3938361704349518},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.17851394414901733},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.1378345489501953},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.07394644618034363}],"concepts":[{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6776750683784485},{"id":"https://openalex.org/C106430172","wikidata":"https://www.wikidata.org/wiki/Q6002272","display_name":"Image restoration","level":4,"score":0.6721231937408447},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.597436785697937},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.5932413339614868},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.5898979306221008},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.5357235074043274},{"id":"https://openalex.org/C13944312","wikidata":"https://www.wikidata.org/wiki/Q7512748","display_name":"Signal-to-noise ratio (imaging)","level":2,"score":0.459231972694397},{"id":"https://openalex.org/C160633673","wikidata":"https://www.wikidata.org/wiki/Q355198","display_name":"Pixel","level":2,"score":0.44942259788513184},{"id":"https://openalex.org/C163294075","wikidata":"https://www.wikidata.org/wiki/Q581861","display_name":"Noise reduction","level":2,"score":0.4425826370716095},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.4294567108154297},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.42690736055374146},{"id":"https://openalex.org/C9417928","wikidata":"https://www.wikidata.org/wiki/Q1070689","display_name":"Image processing","level":3,"score":0.4057326912879944},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3938361704349518},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.17851394414901733},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.1378345489501953},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07394644618034363},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007089","descriptor_name":"Image Enhancement","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007089","descriptor_name":"Image Enhancement","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007089","descriptor_name":"Image Enhancement","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016477","descriptor_name":"Artifacts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016477","descriptor_name":"Artifacts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016477","descriptor_name":"Artifacts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058948","descriptor_name":"Cell Tracking","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058948","descriptor_name":"Cell Tracking","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058948","descriptor_name":"Cell Tracking","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059629","descriptor_name":"Signal-To-Noise Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059629","descriptor_name":"Signal-To-Noise Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059629","descriptor_name":"Signal-To-Noise Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/jbhi.2014.2305445","is_oa":true,"landing_page_url":"https://doi.org/10.1109/jbhi.2014.2305445","pdf_url":"https://ieeexplore.ieee.org/ielx7/6221020/6999985/06736071.pdf","source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},{"id":"pmid:25291801","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25291801","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE journal of biomedical and health informatics","raw_type":null}],"best_oa_location":{"id":"doi:10.1109/jbhi.2014.2305445","is_oa":true,"landing_page_url":"https://doi.org/10.1109/jbhi.2014.2305445","pdf_url":"https://ieeexplore.ieee.org/ielx7/6221020/6999985/06736071.pdf","source":{"id":"https://openalex.org/S2495854775","display_name":"IEEE Journal of Biomedical and Health Informatics","issn_l":"2168-2194","issn":["2168-2194","2168-2208"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Journal of Biomedical and Health Informatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Sustainable cities and communities","id":"https://metadata.un.org/sdg/11","score":0.5699999928474426}],"awards":[],"funders":[{"id":"https://openalex.org/F4320310094","display_name":"University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320320965","display_name":"University of New South Wales","ror":"https://ror.org/03r8z3t63"},{"id":"https://openalex.org/F4320324016","display_name":"University of Aizu","ror":"https://ror.org/02pg0e883"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1975545135.pdf","grobid_xml":"https://content.openalex.org/works/W1975545135.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1512101844","https://openalex.org/W1530741631","https://openalex.org/W1535305972","https://openalex.org/W1545982050","https://openalex.org/W1627054999","https://openalex.org/W1963969681","https://openalex.org/W1965542110","https://openalex.org/W1975150215","https://openalex.org/W1979580700","https://openalex.org/W1985317603","https://openalex.org/W1993465480","https://openalex.org/W1995945562","https://openalex.org/W2006587375","https://openalex.org/W2008125086","https://openalex.org/W2014936832","https://openalex.org/W2020221684","https://openalex.org/W2027792629","https://openalex.org/W2028201091","https://openalex.org/W2029214058","https://openalex.org/W2035737465","https://openalex.org/W2036163530","https://openalex.org/W2059311958","https://openalex.org/W2085770918","https://openalex.org/W2087254073","https://openalex.org/W2089004337","https://openalex.org/W2095283721","https://openalex.org/W2097073572","https://openalex.org/W2099244020","https://openalex.org/W2100138660","https://openalex.org/W2103559027","https://openalex.org/W2111202632","https://openalex.org/W2113846729","https://openalex.org/W2123992117","https://openalex.org/W2133665775","https://openalex.org/W2136396015","https://openalex.org/W2136861779","https://openalex.org/W2148743296","https://openalex.org/W2150134853","https://openalex.org/W2150490197","https://openalex.org/W2150876784","https://openalex.org/W2154241803","https://openalex.org/W2155563862","https://openalex.org/W2167439109","https://openalex.org/W2168297493","https://openalex.org/W2189007309","https://openalex.org/W3106889297","https://openalex.org/W3138063419","https://openalex.org/W3149760511","https://openalex.org/W4210300258","https://openalex.org/W4239974144","https://openalex.org/W4248173958","https://openalex.org/W4285719527","https://openalex.org/W4298221226"],"related_works":["https://openalex.org/W2357322570","https://openalex.org/W90581812","https://openalex.org/W2997591215","https://openalex.org/W2227541280","https://openalex.org/W2038232617","https://openalex.org/W2974904990","https://openalex.org/W2029783634","https://openalex.org/W2072705653","https://openalex.org/W4385545089","https://openalex.org/W2588237537"],"abstract_inverted_index":{"Automated":[0],"cell":[1,5,18,22,51,82,115],"segmentation":[2,60,166],"for":[3,13,50,58,79,109,164],"microscopy":[4,21,81,114,153],"images":[6,23],"has":[7],"recently":[8],"become":[9],"an":[10,148],"initial":[11],"step":[12],"further":[14],"image":[15,48],"analysis":[16],"in":[17,41,131,140],"biology.":[19],"However,":[20],"are":[24,71,77],"easily":[25],"degraded":[26],"by":[27],"noise":[28,38,142],"during":[29],"the":[30,65,105,110,157,160],"readout":[31],"procedure":[32],"via":[33],"optical-electronic":[34],"imaging":[35],"systems.":[36],"Such":[37],"degradations":[39],"result":[40],"low":[42],"signal-to-noise":[43,135],"ratio":[44,136],"(SNR)":[45],"and":[46,61,104,137],"poor":[47],"quality":[49],"identification.":[52],"In":[53,84],"order":[54],"to":[55],"improve":[56],"SNR":[57],"subsequent":[59],"image-based":[62],"quantitative":[63],"analysis,":[64,100],"commonly":[66],"used":[67],"state-of-art":[68,128],"restoration":[69,111,129,162],"techniques":[70,130],"applied":[72],"but":[73],"few":[74],"of":[75,97,112,133,159],"them":[76],"suitable":[78],"corrupted":[80],"images.":[83,116],"this":[85,119],"paper,":[86],"we":[87],"propose":[88],"a":[89,94],"multistaged":[90,120],"method":[91,163],"based":[92],"on":[93,150],"novel":[95],"integration":[96],"trend":[98],"surface":[99],"quantile-quantile":[101],"plot,":[102],"bootstrapping,":[103],"Gaussian":[106],"spatial":[107],"kernel":[108],"noisy":[113,152],"We":[117],"show":[118],"approach":[121],"achieves":[122],"higher":[123],"performance":[124],"compared":[125],"with":[126],"other":[127],"terms":[132],"peak":[134],"structure":[138],"similarity":[139],"synthetic":[141],"experiments.":[143],"This":[144],"paper":[145],"also":[146],"reports":[147],"experiment":[149],"real":[151],"data":[154],"which":[155],"demonstrated":[156],"advantages":[158],"proposed":[161],"improving":[165],"performance.":[167]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}