{"id":"https://openalex.org/W4235365390","doi":"https://doi.org/10.1109/isspit.2018.8642641","title":"Predictive Biomarkers for Neoadjuvant Chemotherapy Response in Muscle-Invasive Bladder Cancer: A survey","display_name":"Predictive Biomarkers for Neoadjuvant Chemotherapy Response in Muscle-Invasive Bladder Cancer: A survey","publication_year":2018,"publication_date":"2018-12-01","ids":{"openalex":"https://openalex.org/W4235365390","doi":"https://doi.org/10.1109/isspit.2018.8642641"},"language":"en","primary_location":{"id":"doi:10.1109/isspit.2018.8642641","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isspit.2018.8642641","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE International Symposium on Signal Processing and Information Technology (ISSPIT)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013943918","display_name":"Hisham Abdeltawab","orcid":"https://orcid.org/0000-0001-6268-5955"},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hisham Abdeltawab","raw_affiliation_strings":["Bioengineering Department, University of Louisville, Louisville, KY, USA"],"affiliations":[{"raw_affiliation_string":"Bioengineering Department, University of Louisville, Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003428654","display_name":"Fahmi Khalifa","orcid":"https://orcid.org/0000-0003-3318-2851"},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fahmi Khalifa","raw_affiliation_strings":["Bioengineering Department, University of Louisville, Louisville, KY, USA"],"affiliations":[{"raw_affiliation_string":"Bioengineering Department, University of Louisville, Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020634024","display_name":"Mohammed Ghazal","orcid":"https://orcid.org/0000-0002-9045-6698"},"institutions":[{"id":"https://openalex.org/I117222138","display_name":"Abu Dhabi University","ror":"https://ror.org/01r3kjq03","country_code":"AE","type":"education","lineage":["https://openalex.org/I117222138"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Mohammed Ghazal","raw_affiliation_strings":["Electrical and Computer Engineering Department, Abu Dhabi University, Abu Dhabi, UAE"],"affiliations":[{"raw_affiliation_string":"Electrical and Computer Engineering Department, Abu Dhabi University, Abu Dhabi, UAE","institution_ids":["https://openalex.org/I117222138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057895882","display_name":"Ahmed Haddad","orcid":"https://orcid.org/0000-0002-9836-5352"},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ahmed Haddad","raw_affiliation_strings":["Department of Urology, University of Louisville, Louisville, KY, USA"],"affiliations":[{"raw_affiliation_string":"Department of Urology, University of Louisville, Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038493219","display_name":"Tamer Mohamed","orcid":"https://orcid.org/0000-0002-8435-808X"},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tamer Mohamed","raw_affiliation_strings":["Institute of Molecular Cardiology, University of Louisville, Louisville, KY, USA"],"affiliations":[{"raw_affiliation_string":"Institute of Molecular Cardiology, University of Louisville, Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069633988","display_name":"Guruprasad A. Giridharan","orcid":"https://orcid.org/0000-0003-3263-9354"},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guruprasad Giridharan","raw_affiliation_strings":["Bioengineering Department, University of Louisville, Louisville, KY, USA"],"affiliations":[{"raw_affiliation_string":"Bioengineering Department, University of Louisville, Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075057705","display_name":"Ayman El\u2010Baz","orcid":"https://orcid.org/0000-0001-7264-1323"},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ayman El-Baz","raw_affiliation_strings":["Bioengineering Department, University of Louisville, Louisville, KY, USA"],"affiliations":[{"raw_affiliation_string":"Bioengineering Department, University of Louisville, Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5013943918"],"corresponding_institution_ids":["https://openalex.org/I142740786"],"apc_list":null,"apc_paid":null,"fwci":0.2332,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.63663789,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"35","issue":null,"first_page":"270","last_page":"275"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12695","display_name":"Urinary and Genital Oncology Studies","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.9578999876976013,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cystectomy","display_name":"Cystectomy","score":0.9045618772506714},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"Bladder cancer","score":0.8789587020874023},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.8169118165969849},{"id":"https://openalex.org/keywords/cisplatin","display_name":"Cisplatin","score":0.7488197088241577},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"Chemotherapy","score":0.7141785621643066},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.6652504205703735},{"id":"https://openalex.org/keywords/malignancy","display_name":"Malignancy","score":0.6304185390472412},{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.528428852558136},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.5245880484580994},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.48548319935798645},{"id":"https://openalex.org/keywords/neoadjuvant-therapy","display_name":"Neoadjuvant therapy","score":0.4583936929702759},{"id":"https://openalex.org/keywords/urinary-system","display_name":"Urinary system","score":0.42164579033851624},{"id":"https://openalex.org/keywords/urology","display_name":"Urology","score":0.3888351321220398},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.049730390310287476}],"concepts":[{"id":"https://openalex.org/C2775910329","wikidata":"https://www.wikidata.org/wiki/Q245995","display_name":"Cystectomy","level":4,"score":0.9045618772506714},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.8789587020874023},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8169118165969849},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.7488197088241577},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.7141785621643066},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6652504205703735},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.6304185390472412},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.528428852558136},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5245880484580994},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48548319935798645},{"id":"https://openalex.org/C2778292576","wikidata":"https://www.wikidata.org/wiki/Q6991934","display_name":"Neoadjuvant therapy","level":4,"score":0.4583936929702759},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.42164579033851624},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3888351321220398},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.049730390310287476},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isspit.2018.8642641","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isspit.2018.8642641","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE International Symposium on Signal Processing and Information Technology (ISSPIT)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5099999904632568,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1529806421","https://openalex.org/W1560204041","https://openalex.org/W1757407923","https://openalex.org/W1800122197","https://openalex.org/W1893588230","https://openalex.org/W1975918912","https://openalex.org/W1987604182","https://openalex.org/W2009143398","https://openalex.org/W2010464208","https://openalex.org/W2019581078","https://openalex.org/W2023289001","https://openalex.org/W2026762663","https://openalex.org/W2046082575","https://openalex.org/W2049108030","https://openalex.org/W2073304532","https://openalex.org/W2103192876","https://openalex.org/W2103725052","https://openalex.org/W2111298806","https://openalex.org/W2113156769","https://openalex.org/W2131178190","https://openalex.org/W2162813066","https://openalex.org/W2170705825","https://openalex.org/W2318856916","https://openalex.org/W2462649057","https://openalex.org/W2515715601","https://openalex.org/W2568206670","https://openalex.org/W2619249519","https://openalex.org/W2796166731","https://openalex.org/W2800693676","https://openalex.org/W2807653691","https://openalex.org/W2809302619","https://openalex.org/W2809550065","https://openalex.org/W2883885644","https://openalex.org/W2885876342","https://openalex.org/W2886980981","https://openalex.org/W4211053712","https://openalex.org/W6752453538"],"related_works":["https://openalex.org/W3128330365","https://openalex.org/W2189722039","https://openalex.org/W3127820018","https://openalex.org/W2904128870","https://openalex.org/W2383341741","https://openalex.org/W2167198546","https://openalex.org/W2899655305","https://openalex.org/W2109785281","https://openalex.org/W3027336582","https://openalex.org/W4393991810"],"abstract_inverted_index":{"Bladder":[0],"cancer":[1,27],"is":[2,10,28,34,76,86],"the":[3,13,29,54,58,67,82,113,139],"most":[4],"prevalent":[5],"urinary":[6],"tract":[7],"malignancy":[8],"and":[9,74,102,141],"associated":[11],"with":[12,24],"highest":[14],"treatment":[15],"cost":[16],"among":[17],"cancers.":[18],"The":[19],"standard":[20],"therapy":[21,129],"for":[22],"patients":[23,63],"muscle-invasive":[25],"bladder":[26,133],"radical":[30],"cystectomy.":[31,43],"Nevertheless,":[32],"there":[33,75,85],"a":[35,87,110,125],"high":[36],"mortality":[37],"rate":[38],"within":[39],"five":[40],"years":[41],"after":[42],"Neoadjuvant":[44],"chemotherapy":[45,68,119],"of":[46,57,112,127,143,152],"cisplatin-based":[47],"combinations":[48],"have":[49],"been":[50],"shown":[51],"to":[52,70,72,80,89,97,117,123],"increase":[53],"overall":[55],"survival":[56],"patients.":[59],"However,":[60],"not":[61],"all":[62],"get":[64],"benefit":[65],"from":[66],"due":[69],"resistance":[71],"cisplatin,":[73],"no":[77],"reliable":[78],"biomarker":[79],"identify":[81,90],"non-responders.":[83],"Therefore":[84],"need":[88],"chemoresistant":[91],"patients,":[92],"by":[93],"finding":[94],"cisplatin-response":[95],"biomarkers,":[96],"avoid":[98],"unnecessary":[99],"surgery":[100],"delay":[101],"drug":[103],"toxicity.":[104],"In":[105],"this":[106,150],"paper,":[107],"we":[108,136],"present":[109],"review":[111],"current":[114],"predictive":[115],"biomarkers":[116],"neoadjuvant":[118],"response":[120],"that":[121],"aim":[122],"provide":[124],"way":[126],"individualized":[128],"in":[130,149],"muscle":[131],"invasive":[132],"cancer.":[134],"Furthermore,":[135],"will":[137,154],"discuss":[138],"effectiveness":[140],"limitations":[142],"these":[144],"biomarkers.":[145],"Finally,":[146],"future":[147],"trends":[148],"area":[151],"research":[153],"be":[155],"discussed.":[156]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}