{"id":"https://openalex.org/W4220746119","doi":"https://doi.org/10.1109/isscc42614.2022.9731629","title":"A CMOS Cellular Interface Array for Digital Physiology Featuring High-Density Multi-Modal Pixels and Reconfigurable Sampling Rate","display_name":"A CMOS Cellular Interface Array for Digital Physiology Featuring High-Density Multi-Modal Pixels and Reconfigurable Sampling Rate","publication_year":2022,"publication_date":"2022-02-20","ids":{"openalex":"https://openalex.org/W4220746119","doi":"https://doi.org/10.1109/isscc42614.2022.9731629"},"language":"en","primary_location":{"id":"doi:10.1109/isscc42614.2022.9731629","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isscc42614.2022.9731629","pdf_url":null,"source":{"id":"https://openalex.org/S4363607897","display_name":"2022 IEEE International Solid- State Circuits Conference (ISSCC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE International Solid- State Circuits Conference (ISSCC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101829658","display_name":"Adam Wang","orcid":"https://orcid.org/0000-0003-3492-1943"},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Adam Y. Wang","raw_affiliation_strings":["Georuia Institute of Technology,Atlanta,GA","Georuia Institute of Technology, Atlanta, GA"],"affiliations":[{"raw_affiliation_string":"Georuia Institute of Technology,Atlanta,GA","institution_ids":["https://openalex.org/I130701444"]},{"raw_affiliation_string":"Georuia Institute of Technology, Atlanta, GA","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050623467","display_name":"Yuguo Sheng","orcid":"https://orcid.org/0000-0003-1763-3624"},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuguo Sheng","raw_affiliation_strings":["Georuia Institute of Technology,Atlanta,GA","Georuia Institute of Technology, Atlanta, GA"],"affiliations":[{"raw_affiliation_string":"Georuia Institute of Technology,Atlanta,GA","institution_ids":["https://openalex.org/I130701444"]},{"raw_affiliation_string":"Georuia Institute of Technology, Atlanta, GA","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100759492","display_name":"Wanlu Li","orcid":"https://orcid.org/0000-0003-2677-2765"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wanlu Li","raw_affiliation_strings":["Harvard University,Brigham and Women's Hospital,Cambridge,MA"],"affiliations":[{"raw_affiliation_string":"Harvard University,Brigham and Women's Hospital,Cambridge,MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002205020","display_name":"Doohwan Jung","orcid":"https://orcid.org/0000-0002-3852-8164"},"institutions":[{"id":"https://openalex.org/I4210087596","display_name":"Qualcomm (United States)","ror":"https://ror.org/002zrf773","country_code":"US","type":"company","lineage":["https://openalex.org/I4210087596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Doohwan Jung","raw_affiliation_strings":["Qualcomm,San Diego,CA","Qualcomm, San Diego, CA"],"affiliations":[{"raw_affiliation_string":"Qualcomm,San Diego,CA","institution_ids":["https://openalex.org/I4210087596"]},{"raw_affiliation_string":"Qualcomm, San Diego, CA","institution_ids":["https://openalex.org/I4210087596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071151922","display_name":"Greg Junek","orcid":null},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Greg Junek","raw_affiliation_strings":["Georuia Institute of Technology,Atlanta,GA","Georuia Institute of Technology, Atlanta, GA"],"affiliations":[{"raw_affiliation_string":"Georuia Institute of Technology,Atlanta,GA","institution_ids":["https://openalex.org/I130701444"]},{"raw_affiliation_string":"Georuia Institute of Technology, Atlanta, GA","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101588588","display_name":"Jong-Seok Park","orcid":"https://orcid.org/0000-0003-2856-2833"},"institutions":[{"id":"https://openalex.org/I1343180700","display_name":"Intel (United States)","ror":"https://ror.org/01ek73717","country_code":"US","type":"company","lineage":["https://openalex.org/I1343180700"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jongseok Park","raw_affiliation_strings":["Intel,Hillsboro,OR","Intel, Hillsboro, OR"],"affiliations":[{"raw_affiliation_string":"Intel,Hillsboro,OR","institution_ids":["https://openalex.org/I1343180700"]},{"raw_affiliation_string":"Intel, Hillsboro, OR","institution_ids":["https://openalex.org/I1343180700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100405087","display_name":"Dongwon Lee","orcid":"https://orcid.org/0000-0002-1568-2249"},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dongwon Lee","raw_affiliation_strings":["Georuia Institute of Technology,Atlanta,GA","Georuia Institute of Technology, Atlanta, GA"],"affiliations":[{"raw_affiliation_string":"Georuia Institute of Technology,Atlanta,GA","institution_ids":["https://openalex.org/I130701444"]},{"raw_affiliation_string":"Georuia Institute of Technology, Atlanta, GA","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100784742","display_name":"Mian Wang","orcid":"https://orcid.org/0000-0001-8311-8394"},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mian Wang","raw_affiliation_strings":["Harvard University,Brigham and Women's Hospital,Cambridge,MA"],"affiliations":[{"raw_affiliation_string":"Harvard University,Brigham and Women's Hospital,Cambridge,MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007552775","display_name":"Sushila Maharjan","orcid":"https://orcid.org/0000-0003-3957-3976"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sushila Maharjan","raw_affiliation_strings":["Harvard University,Brigham and Women's Hospital,Cambridge,MA"],"affiliations":[{"raw_affiliation_string":"Harvard University,Brigham and Women's Hospital,Cambridge,MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080234241","display_name":"Sagar Kumashi","orcid":"https://orcid.org/0000-0002-1587-9762"},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sagar Kumashi","raw_affiliation_strings":["Georuia Institute of Technology,Atlanta,GA","Georuia Institute of Technology, Atlanta, GA"],"affiliations":[{"raw_affiliation_string":"Georuia Institute of Technology,Atlanta,GA","institution_ids":["https://openalex.org/I130701444"]},{"raw_affiliation_string":"Georuia Institute of Technology, Atlanta, GA","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045391521","display_name":"Jin Hao","orcid":"https://orcid.org/0000-0002-6685-2017"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jin Hao","raw_affiliation_strings":["Harvard University,Brigham and Women's Hospital,Cambridge,MA"],"affiliations":[{"raw_affiliation_string":"Harvard University,Brigham and Women's Hospital,Cambridge,MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067842712","display_name":"Yu Shrike Zhang","orcid":"https://orcid.org/0000-0002-0045-0808"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Shrike Zhang","raw_affiliation_strings":["Harvard University,Brigham and Women's Hospital,Cambridge,MA"],"affiliations":[{"raw_affiliation_string":"Harvard University,Brigham and Women's Hospital,Cambridge,MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064730165","display_name":"Kevin Eggan","orcid":"https://orcid.org/0000-0003-4436-8467"},"institutions":[{"id":"https://openalex.org/I2801851002","display_name":"Harvard University Press","ror":"https://ror.org/006v7bf86","country_code":"US","type":"other","lineage":["https://openalex.org/I136199984","https://openalex.org/I2801851002"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Eggan","raw_affiliation_strings":["Harvard University,Cambridge,MA","Harvard University, Cambridge, MA"],"affiliations":[{"raw_affiliation_string":"Harvard University,Cambridge,MA","institution_ids":["https://openalex.org/I2801851002"]},{"raw_affiliation_string":"Harvard University, Cambridge, MA","institution_ids":["https://openalex.org/I2801851002"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100646268","display_name":"Hua Wang","orcid":"https://orcid.org/0000-0003-4952-5505"},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hua Wang","raw_affiliation_strings":["Georuia Institute of Technology,Atlanta,GA","Georuia Institute of Technology, Atlanta, GA"],"affiliations":[{"raw_affiliation_string":"Georuia Institute of Technology,Atlanta,GA","institution_ids":["https://openalex.org/I130701444"]},{"raw_affiliation_string":"Georuia Institute of Technology, Atlanta, GA","institution_ids":["https://openalex.org/I130701444"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5101829658"],"corresponding_institution_ids":["https://openalex.org/I130701444"],"apc_list":null,"apc_paid":null,"fwci":0.6513,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.70866142,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"202","last_page":"204"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11992","display_name":"CCD and CMOS Imaging Sensors","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-physiology","display_name":"Cell physiology","score":0.637053906917572},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5856562256813049},{"id":"https://openalex.org/keywords/medical-diagnosis","display_name":"Medical diagnosis","score":0.481594055891037},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.26402056217193604},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.21004745364189148},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.20663407444953918},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.14856120944023132}],"concepts":[{"id":"https://openalex.org/C191141034","wikidata":"https://www.wikidata.org/wiki/Q3087369","display_name":"Cell physiology","level":3,"score":0.637053906917572},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5856562256813049},{"id":"https://openalex.org/C534262118","wikidata":"https://www.wikidata.org/wiki/Q177719","display_name":"Medical diagnosis","level":2,"score":0.481594055891037},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26402056217193604},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.21004745364189148},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.20663407444953918},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14856120944023132},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isscc42614.2022.9731629","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isscc42614.2022.9731629","pdf_url":null,"source":{"id":"https://openalex.org/S4363607897","display_name":"2022 IEEE International Solid- State Circuits Conference (ISSCC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 IEEE International Solid- State Circuits Conference (ISSCC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8299999833106995,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W1971982506","https://openalex.org/W2180930892","https://openalex.org/W3046687035","https://openalex.org/W3152563317"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4249377076","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4210389441","https://openalex.org/W4396696052"],"abstract_inverted_index":{"With":[0],"the":[1,4,17,73],"recent":[2],"pandemic,":[3],"necessity":[5],"of":[6,11,105],"digital":[7,95],"physiology/pathology,":[8],"a":[9,56,68,102],"set":[10],"high-resolution":[12,49],"cellular/tissue-level":[13],"images":[14],"uploaded":[15],"to":[16,39,55,72],"cloud":[18],"for":[19],"remote":[20],"analytics":[21],"and":[22,35,52],"diagnostics,":[23],"has":[24],"skyrocketed":[25],"as":[26],"in-person":[27],"lab":[28],"services":[29],"are":[30],"limited":[31],"by":[32],"processing":[33],"throughputs":[34],"increased":[36],"exposure":[37],"risks":[38],"patients/medical":[40],"professionals":[41],"[1]\u2013[2].":[42],"Presently,":[43],"cellular":[44,90,97],"physiology":[45,96],"diagnoses":[46],"rely":[47],"on":[48,89],"medical":[50],"imaging":[51],"when":[53],"translated":[54],"cellular/tissue-level,":[57],"these":[58],"images,":[59],"albeit":[60],"with":[61,112],"different":[62,108],"biomarkers,":[63],"may":[64],"not":[65],"holistically":[66],"characterize":[67],"pathogen's":[69],"effect":[70],"due":[71],"cell's":[74],"complex":[75],"multi-physiological":[76],"responses":[77],"[3].":[78],"In":[79],"particular,":[80],"new":[81],"pathogen/virus":[82],"variants":[83],"often":[84],"exhibit":[85],"unknown":[86],"pathological":[87],"effects":[88],"physiological":[91,114],"functions.":[92],"Hence,":[93],"desired":[94],"platforms":[98],"should":[99],"support":[100],"sensing":[101],"wide":[103],"variety":[104],"cells":[106],"under":[107],"conditions,":[109],"including":[110],"those":[111],"rapid":[113],"features,":[115],"e.g.,":[116],"neuron/cardiac":[117],"cells.":[118]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}