{"id":"https://openalex.org/W1971982506","doi":"https://doi.org/10.1109/isscc.2015.7062999","title":"11.7 A multimodality CMOS sensor array for cell-based assay and drug screening","display_name":"11.7 A multimodality CMOS sensor array for cell-based assay and drug screening","publication_year":2015,"publication_date":"2015-02-01","ids":{"openalex":"https://openalex.org/W1971982506","doi":"https://doi.org/10.1109/isscc.2015.7062999","mag":"1971982506"},"language":"en","primary_location":{"id":"doi:10.1109/isscc.2015.7062999","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isscc.2015.7062999","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 IEEE International Solid-State Circuits Conference - (ISSCC) Digest of Technical Papers","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027905068","display_name":"Jong Seok Park","orcid":"https://orcid.org/0000-0003-4537-6223"},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jong Seok Park","raw_affiliation_strings":["Georgia Institute of Technology","Georgia Institute of Technology Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgia Institute of Technology","institution_ids":["https://openalex.org/I130701444"]},{"raw_affiliation_string":"Georgia Institute of Technology Atlanta, GA","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014439819","display_name":"Taiyun Chi","orcid":"https://orcid.org/0000-0003-3286-1262"},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taiyun Chi","raw_affiliation_strings":["Georgia Institute of Technology","Georgia Institute of Technology Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgia Institute of Technology","institution_ids":["https://openalex.org/I130701444"]},{"raw_affiliation_string":"Georgia Institute of Technology Atlanta, GA","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102853627","display_name":"Jessica C. Butts","orcid":"https://orcid.org/0000-0003-3193-7165"},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Butts","raw_affiliation_strings":["Georgia Institute of Technology","Georgia Institute of Technology Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgia Institute of Technology","institution_ids":["https://openalex.org/I130701444"]},{"raw_affiliation_string":"Georgia Institute of Technology Atlanta, GA","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024749463","display_name":"Tracy A. Hookway","orcid":"https://orcid.org/0000-0003-2781-0911"},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tracy Hookway","raw_affiliation_strings":["Georgia Institute of Technology","Georgia Institute of Technology Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgia Institute of Technology","institution_ids":["https://openalex.org/I130701444"]},{"raw_affiliation_string":"Georgia Institute of Technology Atlanta, GA","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024616884","display_name":"Todd C. McDevitt","orcid":"https://orcid.org/0000-0002-8905-4931"},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd McDevitt","raw_affiliation_strings":["Georgia Institute of Technology","Georgia Institute of Technology Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgia Institute of Technology","institution_ids":["https://openalex.org/I130701444"]},{"raw_affiliation_string":"Georgia Institute of Technology Atlanta, GA","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100646268","display_name":"Hua Wang","orcid":"https://orcid.org/0000-0003-4952-5505"},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hua Wang","raw_affiliation_strings":["Georgia Institute of Technology","Georgia Institute of Technology Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgia Institute of Technology","institution_ids":["https://openalex.org/I130701444"]},{"raw_affiliation_string":"Georgia Institute of Technology Atlanta, GA","institution_ids":["https://openalex.org/I130701444"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I130701444"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11472","display_name":"Analytical Chemistry and Sensors","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1502","display_name":"Bioengineering"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.6180641055107117},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.5810841917991638},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5399686098098755},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.48810872435569763},{"id":"https://openalex.org/keywords/cell-type","display_name":"Cell type","score":0.42665937542915344},{"id":"https://openalex.org/keywords/high-throughput-screening","display_name":"High-throughput screening","score":0.416822612285614},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.37623274326324463},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.36734986305236816},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3177563548088074},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.3070509433746338},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.2977657914161682},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.22570332884788513},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.0790223479270935}],"concepts":[{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.6180641055107117},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5810841917991638},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5399686098098755},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.48810872435569763},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.42665937542915344},{"id":"https://openalex.org/C51323132","wikidata":"https://www.wikidata.org/wiki/Q626251","display_name":"High-throughput screening","level":2,"score":0.416822612285614},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37623274326324463},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.36734986305236816},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3177563548088074},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3070509433746338},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2977657914161682},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22570332884788513},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0790223479270935},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isscc.2015.7062999","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isscc.2015.7062999","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 IEEE International Solid-State Circuits Conference - (ISSCC) Digest of Technical Papers","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/9","display_name":"Industry, innovation and infrastructure","score":0.4699999988079071}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W2078293058","https://openalex.org/W2126555345","https://openalex.org/W2135107819","https://openalex.org/W2163340398","https://openalex.org/W2166305181","https://openalex.org/W2174225487","https://openalex.org/W2180930892","https://openalex.org/W6670140098"],"related_works":["https://openalex.org/W2614037532","https://openalex.org/W2551232629","https://openalex.org/W4307993920","https://openalex.org/W2086566345","https://openalex.org/W1865162173","https://openalex.org/W2070584259","https://openalex.org/W1898241694","https://openalex.org/W2186189251","https://openalex.org/W2113270614","https://openalex.org/W2121665137"],"abstract_inverted_index":{"Cell-based":[0,35],"assays":[1,36,89],"are":[2,37,53,90],"powerful":[3],"tools":[4],"to":[5,55,66,137],"characterize":[6,56],"cell-":[7],"or":[8,96],"tissue-specific":[9],"physiological":[10,28,106],"behaviors":[11],"under":[12],"external":[13],"biochemical":[14,17],"stimuli.":[15],"External":[16],"stimuli":[18],"trigger":[19],"endogenous":[20],"cellular":[21],"mechanisms":[22],"that":[23],"produce":[24],"a":[25,142],"cascade":[26],"of":[27,61,63,104,123,129],"changes,":[29],"resulting":[30],"in":[31,44,49,74,117,141],"easily":[32],"measurable":[33],"signals.":[34],"widely":[38],"used":[39,54],"for":[40],"large-scale":[41],"drug":[42,68,83],"screening":[43],"the":[45,57,102],"pharmaceutical":[46],"industry,":[47],"where":[48],"vitro":[50],"cultured":[51],"cells":[52,79],"potency":[58],"and":[59,120],"toxicity":[60],"thousands":[62],"chemicals,":[64],"leading":[65],"new":[67],"development.":[69],"This":[70],"is":[71,135],"particularly":[72],"relevant":[73],"individualized":[75],"medicine":[76],"as":[77],"patient-derived":[78],"can":[80],"test":[81],"personalized":[82],"responses.":[84,107],"However,":[85],"most":[86],"current":[87],"cell-based":[88],"conducted":[91],"on":[92],"single-modality":[93],"sensors":[94],"(electrical":[95],"optical":[97],"only),":[98],"which":[99],"cannot":[100],"capture":[101],"complexity":[103],"multi-parameter":[105],"Sequentially":[108],"transporting":[109],"cell":[110,124,144],"samples":[111,131],"through":[112],"different":[113,133],"sensor":[114],"platforms":[115],"results":[116],"low":[118],"throughput":[119],"potential":[121],"abrogation":[122],"functions,":[125],"while":[126],"parallel":[127],"monitoring":[128],"multiple":[130],"with":[132],"modalities":[134],"subject":[136],"cell-to-cell":[138],"variation":[139],"even":[140],"homogeneous":[143],"population.":[145]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}