{"id":"https://openalex.org/W4385079970","doi":"https://doi.org/10.1109/iscas46773.2023.10181826","title":"Enhanced sgRNA On-Target Cleavage Efficacy Prediction using Conditional GANs","display_name":"Enhanced sgRNA On-Target Cleavage Efficacy Prediction using Conditional GANs","publication_year":2023,"publication_date":"2023-05-21","ids":{"openalex":"https://openalex.org/W4385079970","doi":"https://doi.org/10.1109/iscas46773.2023.10181826"},"language":"en","primary_location":{"id":"doi:10.1109/iscas46773.2023.10181826","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iscas46773.2023.10181826","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE International Symposium on Circuits and Systems (ISCAS)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033329367","display_name":"Konstantinos Fanaras","orcid":null},"institutions":[{"id":"https://openalex.org/I71920554","display_name":"King Abdullah University of Science and Technology","ror":"https://ror.org/01q3tbs38","country_code":"SA","type":"education","lineage":["https://openalex.org/I71920554"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Konstantinos Fanaras","raw_affiliation_strings":["King Abdullah University of Science and Technology (KAUST),Innovative Technologies Laboratories (ITL),Thuwal,Saudi Arabia","Innovative Technologies Laboratories (ITL), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Abdullah University of Science and Technology (KAUST),Innovative Technologies Laboratories (ITL),Thuwal,Saudi Arabia","institution_ids":["https://openalex.org/I71920554"]},{"raw_affiliation_string":"Innovative Technologies Laboratories (ITL), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia","institution_ids":["https://openalex.org/I71920554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041803182","display_name":"Charalampos Antoniadis","orcid":"https://orcid.org/0000-0002-5902-5240"},"institutions":[{"id":"https://openalex.org/I71920554","display_name":"King Abdullah University of Science and Technology","ror":"https://ror.org/01q3tbs38","country_code":"SA","type":"education","lineage":["https://openalex.org/I71920554"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Charalampos Antoniadis","raw_affiliation_strings":["King Abdullah University of Science and Technology (KAUST),Innovative Technologies Laboratories (ITL),Thuwal,Saudi Arabia","Innovative Technologies Laboratories (ITL), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Abdullah University of Science and Technology (KAUST),Innovative Technologies Laboratories (ITL),Thuwal,Saudi Arabia","institution_ids":["https://openalex.org/I71920554"]},{"raw_affiliation_string":"Innovative Technologies Laboratories (ITL), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia","institution_ids":["https://openalex.org/I71920554"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057380866","display_name":"Yehia Massoud","orcid":"https://orcid.org/0000-0002-6701-0639"},"institutions":[{"id":"https://openalex.org/I71920554","display_name":"King Abdullah University of Science and Technology","ror":"https://ror.org/01q3tbs38","country_code":"SA","type":"education","lineage":["https://openalex.org/I71920554"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Yehia Massoud","raw_affiliation_strings":["King Abdullah University of Science and Technology (KAUST),Innovative Technologies Laboratories (ITL),Thuwal,Saudi Arabia","Innovative Technologies Laboratories (ITL), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Abdullah University of Science and Technology (KAUST),Innovative Technologies Laboratories (ITL),Thuwal,Saudi Arabia","institution_ids":["https://openalex.org/I71920554"]},{"raw_affiliation_string":"Innovative Technologies Laboratories (ITL), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia","institution_ids":["https://openalex.org/I71920554"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.428,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.66280047,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.9857000112533569,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crispr","display_name":"CRISPR","score":0.9210542440414429},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7963857650756836},{"id":"https://openalex.org/keywords/cas9","display_name":"Cas9","score":0.7618597745895386},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.572472095489502},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5351247787475586},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.5232623815536499},{"id":"https://openalex.org/keywords/generative-grammar","display_name":"Generative grammar","score":0.46164482831954956},{"id":"https://openalex.org/keywords/genome-editing","display_name":"Genome editing","score":0.4562860429286957},{"id":"https://openalex.org/keywords/palindrome","display_name":"Palindrome","score":0.451644629240036},{"id":"https://openalex.org/keywords/subgenomic-mrna","display_name":"Subgenomic mRNA","score":0.43777328729629517},{"id":"https://openalex.org/keywords/training-set","display_name":"Training set","score":0.4315011501312256},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.11243793368339539},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.06266987323760986}],"concepts":[{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.9210542440414429},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7963857650756836},{"id":"https://openalex.org/C132455925","wikidata":"https://www.wikidata.org/wiki/Q16965677","display_name":"Cas9","level":4,"score":0.7618597745895386},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.572472095489502},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5351247787475586},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.5232623815536499},{"id":"https://openalex.org/C39890363","wikidata":"https://www.wikidata.org/wiki/Q36108","display_name":"Generative grammar","level":2,"score":0.46164482831954956},{"id":"https://openalex.org/C144501496","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome editing","level":4,"score":0.4562860429286957},{"id":"https://openalex.org/C44667518","wikidata":"https://www.wikidata.org/wiki/Q12321","display_name":"Palindrome","level":4,"score":0.451644629240036},{"id":"https://openalex.org/C189819185","wikidata":"https://www.wikidata.org/wiki/Q384283","display_name":"Subgenomic mRNA","level":4,"score":0.43777328729629517},{"id":"https://openalex.org/C51632099","wikidata":"https://www.wikidata.org/wiki/Q3985153","display_name":"Training set","level":2,"score":0.4315011501312256},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11243793368339539},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06266987323760986},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/iscas46773.2023.10181826","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iscas46773.2023.10181826","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2023 IEEE International Symposium on Circuits and Systems (ISCAS)","raw_type":"proceedings-article"},{"id":"pmh:oai:repository.kaust.edu.sa:10754/693182","is_oa":false,"landing_page_url":"http://hdl.handle.net/10754/693182","pdf_url":null,"source":{"id":"https://openalex.org/S4306401596","display_name":"King Abdullah University of Science and Technology Repository (King Abdullah University of Science and Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I71920554","host_organization_name":"King Abdullah University of Science and Technology","host_organization_lineage":["https://openalex.org/I71920554"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Conference Paper"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.7400000095367432}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W2125389028","https://openalex.org/W2252568502","https://openalex.org/W2295598076","https://openalex.org/W2740658361","https://openalex.org/W2782551527","https://openalex.org/W2786426577","https://openalex.org/W2810756255","https://openalex.org/W2891210592","https://openalex.org/W2902305894","https://openalex.org/W2972884635","https://openalex.org/W2981368271","https://openalex.org/W2982510384","https://openalex.org/W2998932094","https://openalex.org/W3007485829","https://openalex.org/W4220962329","https://openalex.org/W6678815747","https://openalex.org/W6767777941"],"related_works":["https://openalex.org/W4393183656","https://openalex.org/W2626278962","https://openalex.org/W4288777264","https://openalex.org/W4311501380","https://openalex.org/W3137982617","https://openalex.org/W2590355459","https://openalex.org/W2390994276","https://openalex.org/W2603161682","https://openalex.org/W3176685793","https://openalex.org/W3139199881"],"abstract_inverted_index":{"The":[0,43],"wide":[1],"usage":[2],"of":[3,21,46,62],"the":[4,13,22,59,89,136,145,154],"Clustered":[5],"Regularly":[6],"Inter-spaced":[7],"Short":[8],"Palindromic":[9],"Repeats":[10],"associated":[11],"with":[12],"Cas9":[14],"enzyme":[15],"(CRISPR/Cas9)":[16],"system,":[17],"which":[18],"is":[19],"one":[20],"latest":[23],"genome-editing":[24],"methods,":[25],"has":[26],"shed":[27],"light":[28],"on":[29],"pathways":[30],"that":[31,117,135],"were":[32],"inconceivable":[33],"before,":[34],"from":[35],"enhancing":[36],"fruit":[37],"nutrition":[38],"to":[39,58,126],"treating":[40],"incurable":[41],"diseases.":[42],"precise":[44],"prediction":[45,75],"single":[47],"guide":[48],"RNA":[49],"(sgRNA)":[50],"on-target":[51,129,155],"knockout":[52,130],"efficacy":[53,158],"poses":[54],"a":[55,99,107,112],"substantial":[56],"challenge":[57],"practical":[60],"application":[61],"CRISPR/Cas9":[63,80,160],"systems.":[64,161],"Although":[65],"many":[66,85],"Machine":[67,114],"Learning":[68,115],"(ML)-based":[69],"techniques":[70],"have":[71],"yielded":[72],"encouraging":[73],"results,":[74],"accuracy":[76],"still":[77],"needs":[78],"improvement.":[79],"datasets":[81],"do":[82],"not":[83],"contain":[84],"examples":[86],"for":[87,101,152],"training":[88,104],"models.":[90],"Generative":[91],"Adversarial":[92],"Networks":[93,121],"(GAN)s":[94],"are":[95],"good":[96],"at":[97],"learning":[98],"model":[100,116,138],"generating":[102],"new":[103],"data":[105],"given":[106],"dataset.":[108],"This":[109],"work":[110],"proposes":[111],"novel":[113],"combines":[118],"Convolutional":[119],"Neural":[120],"and":[122,149],"conditional":[123],"GANs":[124],"(coGAN)s":[125],"predict":[127],"sgRNA":[128,156],"efficacy.":[131],"Experimental":[132],"results":[133],"showed":[134],"proposed":[137,143],"could":[139],"outperform":[140],"other":[141],"models":[142],"in":[144,147,159],"literature":[146],"regression":[148],"classification":[150],"tasks":[151],"predicting":[153],"cleavage":[157]},"counts_by_year":[{"year":2025,"cited_by_count":3}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
