{"id":"https://openalex.org/W3091564065","doi":"https://doi.org/10.1109/iscas45731.2020.9181097","title":"A Combined ISFET-Electric Field Actuation System for Enhanced Detection of DNA: A Proof-of-Concept","display_name":"A Combined ISFET-Electric Field Actuation System for Enhanced Detection of DNA: A Proof-of-Concept","publication_year":2020,"publication_date":"2020-09-29","ids":{"openalex":"https://openalex.org/W3091564065","doi":"https://doi.org/10.1109/iscas45731.2020.9181097","mag":"3091564065"},"language":"en","primary_location":{"id":"doi:10.1109/iscas45731.2020.9181097","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iscas45731.2020.9181097","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 IEEE International Symposium on Circuits and Systems (ISCAS)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034801516","display_name":"Lewis Keeble","orcid":"https://orcid.org/0000-0001-8267-708X"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lewis Keeble","raw_affiliation_strings":["Centre for Bio-Inspired Technology, Institute of Biomedical Engineering and the Department of Electrical and Electronic Engineering, Both Imperial College London, London, SW7 2AZ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Bio-Inspired Technology, Institute of Biomedical Engineering and the Department of Electrical and Electronic Engineering, Both Imperial College London, London, SW7 2AZ, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054027777","display_name":"Nicolas Moser","orcid":"https://orcid.org/0000-0002-6689-0486"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicolas Moser","raw_affiliation_strings":["Centre for Bio-Inspired Technology, Institute of Biomedical Engineering and the Department of Electrical and Electronic Engineering, Both Imperial College London, London, SW7 2AZ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Bio-Inspired Technology, Institute of Biomedical Engineering and the Department of Electrical and Electronic Engineering, Both Imperial College London, London, SW7 2AZ, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039531510","display_name":"Jes\u00fas Rodr\u00edguez-Manzano","orcid":"https://orcid.org/0000-0002-2583-8366"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jesus Rodriguez-Manzano","raw_affiliation_strings":["Centre for Bio-Inspired Technology, Institute of Biomedical Engineering and the Department of Electrical and Electronic Engineering, Both Imperial College London, London, SW7 2AZ, United Kingdom; Department of Infectious Diseases, Faculty of Medicine, Both Imperial College London, London, SW7 2AZ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Bio-Inspired Technology, Institute of Biomedical Engineering and the Department of Electrical and Electronic Engineering, Both Imperial College London, London, SW7 2AZ, United Kingdom; Department of Infectious Diseases, Faculty of Medicine, Both Imperial College London, London, SW7 2AZ, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069244062","display_name":"Pantelis Georgiou","orcid":"https://orcid.org/0000-0003-2476-3857"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Pantelis Georgiou","raw_affiliation_strings":["Centre for Bio-Inspired Technology, Institute of Biomedical Engineering and the Department of Electrical and Electronic Engineering, Both Imperial College London, London, SW7 2AZ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Bio-Inspired Technology, Institute of Biomedical Engineering and the Department of Electrical and Electronic Engineering, Both Imperial College London, London, SW7 2AZ, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":null,"apc_paid":null,"fwci":0.0871,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.40828517,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11472","display_name":"Analytical Chemistry and Sensors","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1502","display_name":"Bioengineering"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isfet","display_name":"ISFET","score":0.9675611257553101},{"id":"https://openalex.org/keywords/dielectrophoresis","display_name":"Dielectrophoresis","score":0.6707234978675842},{"id":"https://openalex.org/keywords/electric-field","display_name":"Electric field","score":0.5317807197570801},{"id":"https://openalex.org/keywords/cmos","display_name":"CMOS","score":0.5032829642295837},{"id":"https://openalex.org/keywords/electrode","display_name":"Electrode","score":0.49410346150398254},{"id":"https://openalex.org/keywords/transistor","display_name":"Transistor","score":0.4614698886871338},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.4365270435810089},{"id":"https://openalex.org/keywords/field-effect-transistor","display_name":"Field-effect transistor","score":0.4171645939350128},{"id":"https://openalex.org/keywords/optoelectronics","display_name":"Optoelectronics","score":0.4020942449569702},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.36422133445739746},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.3617306351661682},{"id":"https://openalex.org/keywords/voltage","display_name":"Voltage","score":0.3364328145980835},{"id":"https://openalex.org/keywords/electrical-engineering","display_name":"Electrical engineering","score":0.33549052476882935},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.30503547191619873},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.192030131816864},{"id":"https://openalex.org/keywords/microfluidics","display_name":"Microfluidics","score":0.1765078604221344}],"concepts":[{"id":"https://openalex.org/C154275363","wikidata":"https://www.wikidata.org/wiki/Q904133","display_name":"ISFET","level":5,"score":0.9675611257553101},{"id":"https://openalex.org/C106825181","wikidata":"https://www.wikidata.org/wiki/Q902890","display_name":"Dielectrophoresis","level":3,"score":0.6707234978675842},{"id":"https://openalex.org/C60799052","wikidata":"https://www.wikidata.org/wiki/Q46221","display_name":"Electric field","level":2,"score":0.5317807197570801},{"id":"https://openalex.org/C46362747","wikidata":"https://www.wikidata.org/wiki/Q173431","display_name":"CMOS","level":2,"score":0.5032829642295837},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.49410346150398254},{"id":"https://openalex.org/C172385210","wikidata":"https://www.wikidata.org/wiki/Q5339","display_name":"Transistor","level":3,"score":0.4614698886871338},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4365270435810089},{"id":"https://openalex.org/C145598152","wikidata":"https://www.wikidata.org/wiki/Q176097","display_name":"Field-effect transistor","level":4,"score":0.4171645939350128},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.4020942449569702},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.36422133445739746},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3617306351661682},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.3364328145980835},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.33549052476882935},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.30503547191619873},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.192030131816864},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.1765078604221344},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/iscas45731.2020.9181097","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iscas45731.2020.9181097","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 IEEE International Symposium on Circuits and Systems (ISCAS)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/7","display_name":"Affordable and clean energy","score":0.5400000214576721}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W208653037","https://openalex.org/W1506928604","https://openalex.org/W1548240020","https://openalex.org/W1590810554","https://openalex.org/W1728839049","https://openalex.org/W1982639390","https://openalex.org/W1985558877","https://openalex.org/W1985694070","https://openalex.org/W1990178293","https://openalex.org/W1991106495","https://openalex.org/W2009356442","https://openalex.org/W2027436128","https://openalex.org/W2032118018","https://openalex.org/W2040520643","https://openalex.org/W2072931302","https://openalex.org/W2082133857","https://openalex.org/W2083263151","https://openalex.org/W2087074238","https://openalex.org/W2123806661","https://openalex.org/W2149629305","https://openalex.org/W2309441999","https://openalex.org/W2588921444","https://openalex.org/W2791995217","https://openalex.org/W2799381285","https://openalex.org/W2941373552","https://openalex.org/W3198167246","https://openalex.org/W4240996151","https://openalex.org/W4248096216","https://openalex.org/W6630356818"],"related_works":["https://openalex.org/W2124014882","https://openalex.org/W2063174160","https://openalex.org/W1997963871","https://openalex.org/W4250442938","https://openalex.org/W2333264988","https://openalex.org/W4250415373","https://openalex.org/W2022856681","https://openalex.org/W2031348296","https://openalex.org/W2307187547","https://openalex.org/W2083672075"],"abstract_inverted_index":{"The":[0],"ion-sensitive":[1],"field-effect":[2],"transistor":[3],"(ISFET)":[4],"has":[5,29],"emerged":[6],"as":[7,138,140,167],"an":[8,65,170],"ideal":[9],"candidate":[10],"to":[11,43,82],"carry":[12,50],"out":[13,51],"point-of-care":[14],"diagnosis":[15],"through":[16,56],"detection":[17,35],"of":[18,24,54,86,102,132,162,169],"hydrogen":[19],"ions":[20],"produced":[21,110],"during":[22],"amplification":[23],"pathogenic":[25],"DNA.":[26],"This":[27,59],"group":[28],"previously":[30],"hypothesised":[31],"that":[32,49,109],"ISFET-based":[33],"DNA":[34,41,55,69,134],"could":[36],"be":[37],"enhanced":[38],"by":[39],"positioning":[40],"close":[42],"the":[44,75,84,87],"ISFET":[45],"surface":[46],"using":[47],"electrodes":[48,108],"low-power":[52],"manipulation":[53],"dielectrophoresis":[57],"(DEP).":[58],"paper":[60],"provides":[61],"a":[62,147],"proof-of-concept":[63],"for":[64,68,153],"ISFET-DEP":[66],"system":[67,97],"detection,":[70],"combining":[71],"information":[72],"gathered":[73],"from":[74],"literature":[76],"and":[77,89,104,129],"FEM":[78],"electric":[79,113],"field":[80,114],"simulations":[81],"test":[83],"validity":[85],"hypothesis":[88],"highlight":[90],"key":[91],"challenges":[92],"in":[93],"implementation.":[94],"An":[95],"electrode":[96],"was":[98,151],"designed":[99],"with":[100,135],"sets":[101],"line":[103],"rectangular":[105],"castellated":[106],"interdigitated":[107],"simulated":[111],"maximum":[112],"strengths":[115],"between":[116],"2.58":[117],"-":[118],"7.70":[119],"\u00d7":[120,159,164,172],"10":[121],"<sup":[122,126],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[123,127],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">5</sup>":[124],"Vm":[125],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">-1</sup>":[128],"is":[130],"capable":[131],"trapping":[133],"applied":[136],"voltages":[137],"low":[139],"(0.50":[141],"\u00b1":[142],"0.05)V.":[143],"Using":[144],"this":[145],"design,":[146],"180nm":[148],"CMOS":[149],"prototype":[150],"developed":[152],"preliminary":[154],"testing,":[155],"containing":[156],"three":[157],"5":[158],"2":[160],"arrays":[161],"20\u03bcm":[163,165],"ISFETs":[166],"part":[168],"800\u03bcm":[171],"400\u03bcm":[173],"chip.":[174]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-06-26T08:34:08.712188","created_date":"2025-10-10T00:00:00"}
