{"id":"https://openalex.org/W2800219806","doi":"https://doi.org/10.1109/iscas.2018.8351848","title":"Brain-on-a chip technologies for investigating neuronal diseases: Toward precision medicine applications","display_name":"Brain-on-a chip technologies for investigating neuronal diseases: Toward precision medicine applications","publication_year":2018,"publication_date":"2018-05-01","ids":{"openalex":"https://openalex.org/W2800219806","doi":"https://doi.org/10.1109/iscas.2018.8351848","mag":"2800219806"},"language":"en","primary_location":{"id":"doi:10.1109/iscas.2018.8351848","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iscas.2018.8351848","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE International Symposium on Circuits and Systems (ISCAS)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000602972","display_name":"Monica Frega","orcid":"https://orcid.org/0000-0002-9697-3282"},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"M. Frega","raw_affiliation_strings":["Donders Institute for Brain Cognition and Behaviour, Nijmegen, Netherlands"],"affiliations":[{"raw_affiliation_string":"Donders Institute for Brain Cognition and Behaviour, Nijmegen, Netherlands","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058126558","display_name":"Britt Mossink","orcid":"https://orcid.org/0000-0002-4393-5506"},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"B. Mossink","raw_affiliation_strings":["Donders Institute for Brain Cognition and Behaviour, Nijmegen, Netherlands"],"affiliations":[{"raw_affiliation_string":"Donders Institute for Brain Cognition and Behaviour, Nijmegen, Netherlands","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073806066","display_name":"Katrin Linda","orcid":"https://orcid.org/0000-0002-5426-4373"},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"K. Linda","raw_affiliation_strings":["Donders Institute for Brain Cognition and Behaviour, Nijmegen, Netherlands"],"affiliations":[{"raw_affiliation_string":"Donders Institute for Brain Cognition and Behaviour, Nijmegen, Netherlands","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034379903","display_name":"Jason Keller","orcid":"https://orcid.org/0000-0001-9839-7293"},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J. Keller","raw_affiliation_strings":["Donders Institute for Brain Cognition and Behaviour, Nijmegen, Netherlands"],"affiliations":[{"raw_affiliation_string":"Donders Institute for Brain Cognition and Behaviour, Nijmegen, Netherlands","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056438582","display_name":"Dirk Schubert","orcid":"https://orcid.org/0000-0002-1202-4363"},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"D. Schubert","raw_affiliation_strings":["Donders Institute for Brain Cognition and Behaviour, Nijmegen, Netherlands"],"affiliations":[{"raw_affiliation_string":"Donders Institute for Brain Cognition and Behaviour, Nijmegen, Netherlands","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049588515","display_name":"Nael Nadif Kasri","orcid":"https://orcid.org/0000-0002-7448-9289"},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"N. Nadif Kasri","raw_affiliation_strings":["Radboudumc, Nijmegen (the Netherlands), Department of Human Genetics"],"affiliations":[{"raw_affiliation_string":"Radboudumc, Nijmegen (the Netherlands), Department of Human Genetics","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5000602972"],"corresponding_institution_ids":["https://openalex.org/I145872427"],"apc_list":null,"apc_paid":null,"fwci":0.3584,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.67955346,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.7243301868438721},{"id":"https://openalex.org/keywords/hypotonia","display_name":"Hypotonia","score":0.614915132522583},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5345014929771423},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.5278489589691162},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cell","display_name":"Induced pluripotent stem cell","score":0.5264212489128113},{"id":"https://openalex.org/keywords/synapse","display_name":"Synapse","score":0.5129282474517822},{"id":"https://openalex.org/keywords/biological-neural-network","display_name":"Biological neural network","score":0.487356036901474},{"id":"https://openalex.org/keywords/neurology","display_name":"Neurology","score":0.47093573212623596},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4451950192451477},{"id":"https://openalex.org/keywords/intellectual-disability","display_name":"Intellectual disability","score":0.4114036560058594},{"id":"https://openalex.org/keywords/embryonic-stem-cell","display_name":"Embryonic stem cell","score":0.21849164366722107},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.18928256630897522}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7243301868438721},{"id":"https://openalex.org/C2779546488","wikidata":"https://www.wikidata.org/wiki/Q1753547","display_name":"Hypotonia","level":2,"score":0.614915132522583},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5345014929771423},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5278489589691162},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.5264212489128113},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.5129282474517822},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.487356036901474},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.47093573212623596},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4451950192451477},{"id":"https://openalex.org/C551499885","wikidata":"https://www.wikidata.org/wiki/Q183560","display_name":"Intellectual disability","level":2,"score":0.4114036560058594},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.21849164366722107},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18928256630897522}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/iscas.2018.8351848","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iscas.2018.8351848","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE International Symposium on Circuits and Systems (ISCAS)","raw_type":"proceedings-article"},{"id":"pmh:oai:iris.unige.it:11567/1233091","is_oa":false,"landing_page_url":"https://hdl.handle.net/11567/1233091","pdf_url":null,"source":{"id":"https://openalex.org/S4377196291","display_name":"CINECA IRIS Institutial Research Information System (University of Genoa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I83816512","host_organization_name":"University of Genoa","host_organization_lineage":["https://openalex.org/I83816512"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W786500739","https://openalex.org/W1967128964","https://openalex.org/W1968916422","https://openalex.org/W2054643398","https://openalex.org/W2075764106","https://openalex.org/W2089343670","https://openalex.org/W2089360863","https://openalex.org/W2100663971","https://openalex.org/W2107597848","https://openalex.org/W2121444603","https://openalex.org/W2130730667","https://openalex.org/W2138977668","https://openalex.org/W2147140183","https://openalex.org/W2163771097","https://openalex.org/W2186309023","https://openalex.org/W2217090715","https://openalex.org/W2220722149","https://openalex.org/W2234991739","https://openalex.org/W2346272392","https://openalex.org/W2537142116","https://openalex.org/W2570036960","https://openalex.org/W4401008196","https://openalex.org/W6714855545"],"related_works":["https://openalex.org/W2896376224","https://openalex.org/W2032888454","https://openalex.org/W147530051","https://openalex.org/W2196495761","https://openalex.org/W2027045802","https://openalex.org/W4238867771","https://openalex.org/W2539367695","https://openalex.org/W3119304807","https://openalex.org/W3097442141","https://openalex.org/W2304861098"],"abstract_inverted_index":{"Neurodevelopmental":[0],"disorders":[1],"(NDDs)":[2],"are":[3,57,185],"a":[4,82,92],"collection":[5],"of":[6,11,18,33,59,76,85,143,160,179,205],"heterogeneous":[7],"syndromes":[8],"involving":[9],"disruption":[10],"early":[12],"neurobiological":[13,41],"development.":[14],"While":[15],"the":[16,30,47,60,72,140,203],"identification":[17],"disease":[19],"genes":[20,35,108,184],"has":[21],"great":[22],"benefits":[23],"for":[24,29,81,187,198],"diagnostic":[25],"and":[26,49,69,103,145,176],"prognostic":[27],"purposes,":[28],"vast":[31],"majority":[32],"these":[34,86],"there":[36],"is":[37,78,91],"little":[38],"knowledge":[39],"about":[40],"mechanisms":[42],"that":[43,55,152,182],"they":[44],"control":[45,144,165],"at":[46],"cellular":[48],"network":[50,67,118,174,189,193],"level.":[51],"Recent":[52],"studies":[53],"demonstrate":[54],"NDDs":[56,77],"\"diseases":[58],"synapse\".":[61],"Synaptic":[62],"malfunction":[63],"can":[64],"severely":[65],"affect":[66],"connectivity":[68],"dynamic.":[70],"Understanding":[71],"neural":[73],"circuit":[74],"basis":[75],"therefore":[79],"imperial":[80],"better":[83],"understanding":[84],"disorders.":[87],"Kleefstra":[88],"syndrome":[89],"(KS)":[90],"NDD":[93],"characterized":[94,139],"by":[95],"moderate":[96],"to":[97,164],"severe":[98],"intellectual":[99],"disability,":[100],"childhood":[101],"hypotonia,":[102],"facial":[104],"dysmorphism":[105],"associated":[106],"with":[107],"deficiency.":[109],"Here,":[110],"we":[111,138],"studied":[112],"how":[113],"KS":[114,128,146,153,169,183],"genes-deficiency":[115,170],"affects":[116],"neuronal":[117,122,148,155,192],"maturation":[119],"using":[120],"dissociated":[121],"cultures":[123],"(i.e.":[124],"from":[125],"rodent":[126],"or":[127],"patient":[129],"induced":[130,171],"pluripotent":[131],"stem":[132],"cells).":[133],"Using":[134],"micro-electrode":[135],"arrays":[136],"technology":[137],"electrophysiological":[141],"activity":[142,162],"genes-deficient":[147,154],"networks.":[149],"We":[150],"showed":[151],"networks":[156],"exhibited":[157],"different":[158],"pattern":[159,178],"synchronous":[161],"compared":[163],"condition.":[166],"In":[167],"particular,":[168],"an":[172],"inappropriate":[173],"organization":[175],"irregular":[177],"activity,":[180],"indicating":[181],"required":[186],"proper":[188],"formation.":[190],"The":[191],"phenotype":[194],"found":[195],"here,":[196],"provides":[197],"relevant":[199],"future":[200],"directions":[201],"in":[202,207],"elucidation":[204],"pathophysiology":[206],"KS.":[208]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
