{"id":"https://openalex.org/W1987335167","doi":"https://doi.org/10.1109/iscas.2013.6572289","title":"Hybrid modelling of the general middle-sized genetic regulatory networks","display_name":"Hybrid modelling of the general middle-sized genetic regulatory networks","publication_year":2013,"publication_date":"2013-05-01","ids":{"openalex":"https://openalex.org/W1987335167","doi":"https://doi.org/10.1109/iscas.2013.6572289","mag":"1987335167"},"language":"en","primary_location":{"id":"doi:10.1109/iscas.2013.6572289","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iscas.2013.6572289","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 IEEE International Symposium on Circuits and Systems (ISCAS2013)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100462649","display_name":"Pei Wang","orcid":"https://orcid.org/0000-0002-8149-756X"},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Pei Wang","raw_affiliation_strings":["School Maths Information Science, Henan University, Kaifeng, China","Sch. Math. Inf. Sci., Henan Univ., Kaifeng, China"],"affiliations":[{"raw_affiliation_string":"School Maths Information Science, Henan University, Kaifeng, China","institution_ids":["https://openalex.org/I173899330"]},{"raw_affiliation_string":"Sch. Math. Inf. Sci., Henan Univ., Kaifeng, China","institution_ids":["https://openalex.org/I173899330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069617479","display_name":"Renquan Lu","orcid":null},"institutions":[{"id":"https://openalex.org/I50760025","display_name":"Hangzhou Dianzi University","ror":"https://ror.org/0576gt767","country_code":"CN","type":"education","lineage":["https://openalex.org/I50760025"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Renquan Lu","raw_affiliation_strings":["Institute Information Control, Hangzhou Dianzi University, Hangzhou, China","Inst. Inf. Contr., Hangzhou Dianzi Univ., Hangzhou, China"],"affiliations":[{"raw_affiliation_string":"Institute Information Control, Hangzhou Dianzi University, Hangzhou, China","institution_ids":["https://openalex.org/I50760025"]},{"raw_affiliation_string":"Inst. Inf. Contr., Hangzhou Dianzi Univ., Hangzhou, China","institution_ids":["https://openalex.org/I50760025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100394256","display_name":"Yao Chen","orcid":"https://orcid.org/0000-0002-5798-2282"},"institutions":[{"id":"https://openalex.org/I21193070","display_name":"Beijing Jiaotong University","ror":"https://ror.org/01yj56c84","country_code":"CN","type":"education","lineage":["https://openalex.org/I21193070"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yao Chen","raw_affiliation_strings":["School Electrical Information Engineering, Beijing Jiaotong University, Beijing, China","Sch. Electr. Inf. Eng., Beijing Jiaotong Univ., Beijing, China"],"affiliations":[{"raw_affiliation_string":"School Electrical Information Engineering, Beijing Jiaotong University, Beijing, China","institution_ids":["https://openalex.org/I21193070"]},{"raw_affiliation_string":"Sch. Electr. Inf. Eng., Beijing Jiaotong Univ., Beijing, China","institution_ids":["https://openalex.org/I21193070"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5115588373","display_name":"Xiaoqun Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoqun Wu","raw_affiliation_strings":["School\u00a0of Mathematics and\u00a0Statistics, Wuhan University, Wuhan, China","Sch. Math. Stat., Wuhan Univ., Wuhan, China"],"affiliations":[{"raw_affiliation_string":"School\u00a0of Mathematics and\u00a0Statistics, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]},{"raw_affiliation_string":"Sch. Math. Stat., Wuhan Univ., Wuhan, China","institution_ids":["https://openalex.org/I37461747"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100462649"],"corresponding_institution_ids":["https://openalex.org/I173899330"],"apc_list":null,"apc_paid":null,"fwci":0.4386,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.63919764,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"309","issue":null,"first_page":"2103","last_page":"2106"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6789641976356506},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.5455164909362793},{"id":"https://openalex.org/keywords/hybrid-system","display_name":"Hybrid system","score":0.5309340953826904},{"id":"https://openalex.org/keywords/differential-equation","display_name":"Differential equation","score":0.5231534242630005},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.47055888175964355},{"id":"https://openalex.org/keywords/continuous-modelling","display_name":"Continuous modelling","score":0.43567150831222534},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.37649351358413696},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.3550034761428833},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.23317289352416992},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.20221710205078125},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.1588277518749237},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.12052005529403687}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6789641976356506},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5455164909362793},{"id":"https://openalex.org/C50897621","wikidata":"https://www.wikidata.org/wiki/Q2665508","display_name":"Hybrid system","level":2,"score":0.5309340953826904},{"id":"https://openalex.org/C78045399","wikidata":"https://www.wikidata.org/wiki/Q11214","display_name":"Differential equation","level":2,"score":0.5231534242630005},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.47055888175964355},{"id":"https://openalex.org/C10184394","wikidata":"https://www.wikidata.org/wiki/Q5165491","display_name":"Continuous modelling","level":2,"score":0.43567150831222534},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.37649351358413696},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.3550034761428833},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.23317289352416992},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.20221710205078125},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.1588277518749237},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12052005529403687},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/iscas.2013.6572289","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iscas.2013.6572289","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 IEEE International Symposium on Circuits and Systems (ISCAS2013)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1486453207","https://openalex.org/W1599207601","https://openalex.org/W1616975058","https://openalex.org/W1645305843","https://openalex.org/W1677575702","https://openalex.org/W1971224531","https://openalex.org/W1982353649","https://openalex.org/W1988602492","https://openalex.org/W1992810881","https://openalex.org/W2031369606","https://openalex.org/W2038819846","https://openalex.org/W2043113143","https://openalex.org/W2043308539","https://openalex.org/W2049982841","https://openalex.org/W2053961182","https://openalex.org/W2098127225","https://openalex.org/W2129903089","https://openalex.org/W2133401281","https://openalex.org/W2136559804","https://openalex.org/W2136977672","https://openalex.org/W2150750144","https://openalex.org/W2978790822"],"related_works":["https://openalex.org/W2130939068","https://openalex.org/W3163717165","https://openalex.org/W2114466827","https://openalex.org/W249159571","https://openalex.org/W2791736663","https://openalex.org/W2806770614","https://openalex.org/W2129949791","https://openalex.org/W2131550814","https://openalex.org/W1710460698","https://openalex.org/W3199739261"],"abstract_inverted_index":{"It":[0],"is":[1,46,89],"well":[2],"known":[3],"that":[4],"theoretical":[5],"analysis":[6],"based":[7],"on":[8],"the":[9,22,39,57,60,79,94,102],"mathematical":[10,36],"predictive":[11],"models":[12,109],"of":[13,59,104],"middle-sized":[14,40,81,95],"genetic":[15,82],"regulatory":[16,83],"networks":[17,99],"are":[18],"crucial":[19],"to":[20,50,72,91],"understand":[21],"life":[23],"at":[24],"system":[25],"level":[26],"for":[27,38,78],"systems":[28],"biology.":[29],"Since":[30],"there":[31],"doesn't":[32],"exist":[33],"an":[34],"efficient":[35],"model":[37],"or":[41,96],"large-sized":[42,97],"biological":[43,98],"systems,":[44],"it":[45],"also":[47],"a":[48,74],"challenge":[49],"theoretically":[51],"investigate":[52,93],"these":[53],"networks.":[54,84],"To":[55],"overcome":[56],"limitations":[58],"traditional":[61],"continuous":[62,106],"differential":[63,107],"equations":[64],"and":[65,110],"discrete":[66],"Boolean":[67,111],"models,":[68],"this":[69],"paper":[70],"aims":[71],"introduce":[73],"hybrid":[75,86],"modelling":[76,87],"approach":[77],"general":[80],"This":[85],"method":[88],"able":[90],"quantitatively":[92],"by":[100],"merging":[101],"advantages":[103],"both":[105],"equation":[108],"models.":[112]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}