{"id":"https://openalex.org/W1975635963","doi":"https://doi.org/10.1109/iscas.2010.5537382","title":"An integrated patch-clamp system with dual Input","display_name":"An integrated patch-clamp system with dual Input","publication_year":2010,"publication_date":"2010-05-01","ids":{"openalex":"https://openalex.org/W1975635963","doi":"https://doi.org/10.1109/iscas.2010.5537382","mag":"1975635963"},"language":"en","primary_location":{"id":"doi:10.1109/iscas.2010.5537382","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iscas.2010.5537382","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of 2010 IEEE International Symposium on Circuits and Systems","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089743110","display_name":"Pujitha Weerakoon","orcid":null},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pujitha Weerakoon","raw_affiliation_strings":["Yale University, New Heaven, CT, USA","Yale University , New Haven, CT, 06520"],"affiliations":[{"raw_affiliation_string":"Yale University, New Heaven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale University , New Haven, CT, 06520","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051541998","display_name":"Fred J. Sigworth","orcid":"https://orcid.org/0000-0002-7178-8494"},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fred Sigworth","raw_affiliation_strings":["Yale University, New Heaven, CT, USA","Yale University , New Haven, CT, 06520"],"affiliations":[{"raw_affiliation_string":"Yale University, New Heaven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale University , New Haven, CT, 06520","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059908736","display_name":"P. J. Kindlmann","orcid":null},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Kindlmann","raw_affiliation_strings":["Yale University, New Heaven, CT, USA","Yale University , New Haven, CT, 06520"],"affiliations":[{"raw_affiliation_string":"Yale University, New Heaven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale University , New Haven, CT, 06520","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074863255","display_name":"Joseph Santos\u2010Sacchi","orcid":"https://orcid.org/0000-0002-8274-7751"},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Santos-Sacchi","raw_affiliation_strings":["Yale University, New Heaven, CT, USA","Yale University , New Haven, CT, 06520"],"affiliations":[{"raw_affiliation_string":"Yale University, New Heaven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale University , New Haven, CT, 06520","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054240804","display_name":"Youshan Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Youshan Yang","raw_affiliation_strings":["Yale University, New Heaven, CT, USA","Yale University , New Haven, CT, 06520"],"affiliations":[{"raw_affiliation_string":"Yale University, New Heaven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale University , New Haven, CT, 06520","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056573998","display_name":"Eugenio Culurciello","orcid":"https://orcid.org/0000-0002-9918-3956"},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugenio Culurciello","raw_affiliation_strings":["Yale University, New Heaven, CT, USA","Yale University , New Haven, CT, 06520"],"affiliations":[{"raw_affiliation_string":"Yale University, New Heaven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale University , New Haven, CT, 06520","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5089743110"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":null,"apc_paid":null,"fwci":0.1149,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.41087794,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"1523","last_page":"1526"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/capacitance","display_name":"Capacitance","score":0.7210366725921631},{"id":"https://openalex.org/keywords/pipette","display_name":"Pipette","score":0.6134814620018005},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.5944622755050659},{"id":"https://openalex.org/keywords/electrode","display_name":"Electrode","score":0.5929967164993286},{"id":"https://openalex.org/keywords/bandwidth","display_name":"Bandwidth (computing)","score":0.5617677569389343},{"id":"https://openalex.org/keywords/power-consumption","display_name":"Power consumption","score":0.5451892018318176},{"id":"https://openalex.org/keywords/optoelectronics","display_name":"Optoelectronics","score":0.4580380916595459},{"id":"https://openalex.org/keywords/patch-clamp","display_name":"Patch clamp","score":0.43682825565338135},{"id":"https://openalex.org/keywords/electronic-engineering","display_name":"Electronic engineering","score":0.42546093463897705},{"id":"https://openalex.org/keywords/shunt","display_name":"Shunt (medical)","score":0.4223420023918152},{"id":"https://openalex.org/keywords/silicon","display_name":"Silicon","score":0.4102674722671509},{"id":"https://openalex.org/keywords/electrical-engineering","display_name":"Electrical engineering","score":0.3654436469078064},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3475738763809204},{"id":"https://openalex.org/keywords/power","display_name":"Power (physics)","score":0.25846362113952637},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.24833762645721436},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.20600613951683044},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.1988910436630249},{"id":"https://openalex.org/keywords/telecommunications","display_name":"Telecommunications","score":0.08261781930923462}],"concepts":[{"id":"https://openalex.org/C30066665","wikidata":"https://www.wikidata.org/wiki/Q164399","display_name":"Capacitance","level":3,"score":0.7210366725921631},{"id":"https://openalex.org/C151552171","wikidata":"https://www.wikidata.org/wiki/Q163373","display_name":"Pipette","level":2,"score":0.6134814620018005},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5944622755050659},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.5929967164993286},{"id":"https://openalex.org/C2776257435","wikidata":"https://www.wikidata.org/wiki/Q1576430","display_name":"Bandwidth (computing)","level":2,"score":0.5617677569389343},{"id":"https://openalex.org/C2984118289","wikidata":"https://www.wikidata.org/wiki/Q29954","display_name":"Power consumption","level":3,"score":0.5451892018318176},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.4580380916595459},{"id":"https://openalex.org/C147944092","wikidata":"https://www.wikidata.org/wiki/Q176366","display_name":"Patch clamp","level":3,"score":0.43682825565338135},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.42546093463897705},{"id":"https://openalex.org/C2780968331","wikidata":"https://www.wikidata.org/wiki/Q1890115","display_name":"Shunt (medical)","level":2,"score":0.4223420023918152},{"id":"https://openalex.org/C544956773","wikidata":"https://www.wikidata.org/wiki/Q670","display_name":"Silicon","level":2,"score":0.4102674722671509},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.3654436469078064},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3475738763809204},{"id":"https://openalex.org/C163258240","wikidata":"https://www.wikidata.org/wiki/Q25342","display_name":"Power (physics)","level":2,"score":0.25846362113952637},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.24833762645721436},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.20600613951683044},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1988910436630249},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.08261781930923462},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/iscas.2010.5537382","is_oa":false,"landing_page_url":"https://doi.org/10.1109/iscas.2010.5537382","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of 2010 IEEE International Symposium on Circuits and Systems","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Affordable and clean energy","score":0.8899999856948853,"id":"https://metadata.un.org/sdg/7"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337345","display_name":"Office of Naval Research","ror":"https://ror.org/00rk2pe57"},{"id":"https://openalex.org/F4320337398","display_name":"Division of Biological Infrastructure","ror":"https://ror.org/04qn9mx93"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W178865619","https://openalex.org/W1597620877","https://openalex.org/W2009667219","https://openalex.org/W2026490774","https://openalex.org/W2073295255","https://openalex.org/W2108755675","https://openalex.org/W2461047275"],"related_works":["https://openalex.org/W3198526530","https://openalex.org/W50277463","https://openalex.org/W2273033797","https://openalex.org/W2294306521","https://openalex.org/W2029882011","https://openalex.org/W2116617724","https://openalex.org/W2025319075","https://openalex.org/W3184911172","https://openalex.org/W2139056451","https://openalex.org/W3036169729"],"abstract_inverted_index":{"We":[0],"present":[1],"the":[2,53,58,79],"first,":[3],"fully":[4],"integrated,":[5],"multi-channel":[6],"implementation":[7],"of":[8,40,57],"a":[9,18,37,44],"patch-clamp":[10],"measurement":[11],"system.":[12],"The":[13,23,48,69],"system":[14,24,49,70],"was":[15],"implemented":[16],"in":[17,43],"0.5":[19],"\u03bcm":[20],"silicon-on-sapphire":[21],"process.":[22],"can":[25,50],"record":[26],"two":[27],"simultaneous":[28],"cell":[29],"membrane":[30],"currents":[31],"up":[32,61],"to":[33,62],"\u00b120":[34],"\u03bcA":[35],"with":[36],"rms":[38],"noise":[39],"8":[41],"pA":[42],"10":[45,63],"kHz":[46],"bandwidth.":[47],"compensate":[51],"for":[52],"capacitance":[54],"and":[55,65,78],"resistance":[56],"pipette":[59],"electrode,":[60],"pF":[64],"100":[66],"M\u03a9":[67],"respectively.":[68],"die":[71],"size":[72],"is":[73,82],"3":[74,76],"\u00d7":[75],"mm":[77],"power":[80],"consumption":[81],"5":[83],"mW":[84],"per":[85],"channel":[86],"at":[87],"3.3":[88],"V.":[89]},"counts_by_year":[{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}