{"id":"https://openalex.org/W7161805979","doi":"https://doi.org/10.1109/isbi61048.2026.11516051","title":"Human-Aligned Learning of Interpretable Biomarkers for Lung Ultrasound Diagnosis","display_name":"Human-Aligned Learning of Interpretable Biomarkers for Lung Ultrasound Diagnosis","publication_year":2026,"publication_date":"2026-04-08","ids":{"openalex":"https://openalex.org/W7161805979","doi":"https://doi.org/10.1109/isbi61048.2026.11516051"},"language":null,"primary_location":{"id":"doi:10.1109/isbi61048.2026.11516051","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi61048.2026.11516051","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2026 IEEE 23rd International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5136600823","display_name":"Gautam Gare","orcid":null},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gautam Gare","raw_affiliation_strings":["Carnegie Mellon University,Pittsburgh,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carnegie Mellon University,Pittsburgh,USA","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037062867","display_name":"Tom Fox","orcid":null},"institutions":[{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tom Fox","raw_affiliation_strings":["LSUHSC Internal Medicine,New Orleans,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LSUHSC Internal Medicine,New Orleans,USA","institution_ids":["https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013660161","display_name":"Peter Lowery","orcid":null},"institutions":[{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Lowery","raw_affiliation_strings":["LSUHSC Internal Medicine,New Orleans,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LSUHSC Internal Medicine,New Orleans,USA","institution_ids":["https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136608232","display_name":"Kevin Zamora","orcid":null},"institutions":[{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Zamora","raw_affiliation_strings":["LSUHSC Internal Medicine,New Orleans,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LSUHSC Internal Medicine,New Orleans,USA","institution_ids":["https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136597670","display_name":"Hai Tran","orcid":null},"institutions":[{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hai Tran","raw_affiliation_strings":["LSUHSC Internal Medicine,New Orleans,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LSUHSC Internal Medicine,New Orleans,USA","institution_ids":["https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093975917","display_name":"Beam Chansangavej","orcid":null},"institutions":[{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beam Chansangavej","raw_affiliation_strings":["LSUHSC Internal Medicine,New Orleans,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LSUHSC Internal Medicine,New Orleans,USA","institution_ids":["https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136575924","display_name":"Laura Hutchins","orcid":null},"institutions":[{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Hutchins","raw_affiliation_strings":["LSUHSC Internal Medicine,New Orleans,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LSUHSC Internal Medicine,New Orleans,USA","institution_ids":["https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136534000","display_name":"David Montgomery","orcid":null},"institutions":[{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Montgomery","raw_affiliation_strings":["LSUHSC Internal Medicine,New Orleans,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LSUHSC Internal Medicine,New Orleans,USA","institution_ids":["https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125940419","display_name":"A Krishnan","orcid":null},"institutions":[{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amita Krishnan","raw_affiliation_strings":["LSUHSC Internal Medicine,New Orleans,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LSUHSC Internal Medicine,New Orleans,USA","institution_ids":["https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102732373","display_name":"Deva Ramanan","orcid":"https://orcid.org/0009-0007-3773-0954"},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deva Ramanan","raw_affiliation_strings":["Carnegie Mellon University,Pittsburgh,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carnegie Mellon University,Pittsburgh,USA","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136600229","display_name":"Ricardo Rodriguez","orcid":null},"institutions":[{"id":"https://openalex.org/I4210104460","display_name":"American Academy of Cosmetic Surgery","ror":"https://ror.org/01ckx3t21","country_code":"US","type":"other","lineage":["https://openalex.org/I4210104460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ricardo Rodriguez","raw_affiliation_strings":["Cosmetic Surgery Facility LLC,Baltimore,MD,USA,21093"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cosmetic Surgery Facility LLC,Baltimore,MD,USA,21093","institution_ids":["https://openalex.org/I4210104460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136565981","display_name":"Bennett DeBoisblanc","orcid":null},"institutions":[{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bennett DeBoisblanc","raw_affiliation_strings":["LSUHSC Internal Medicine,New Orleans,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LSUHSC Internal Medicine,New Orleans,USA","institution_ids":["https://openalex.org/I75420490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5136557201","display_name":"John Galeotti","orcid":null},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Galeotti","raw_affiliation_strings":["Carnegie Mellon University,Pittsburgh,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carnegie Mellon University,Pittsburgh,USA","institution_ids":["https://openalex.org/I74973139"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11738","display_name":"Ultrasound in Clinical Applications","score":0.7146999835968018,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11738","display_name":"Ultrasound in Clinical Applications","score":0.7146999835968018,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12419","display_name":"Phonocardiography and Auscultation Techniques","score":0.07590000331401825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12026","display_name":"Explainable Artificial Intelligence (XAI)","score":0.032499998807907104,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ultrasound","display_name":"Ultrasound","score":0.37869998812675476},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.33469998836517334},{"id":"https://openalex.org/keywords/lung-ultrasound","display_name":"Lung ultrasound","score":0.3312000036239624},{"id":"https://openalex.org/keywords/computed-tomography","display_name":"Computed tomography","score":0.30820000171661377},{"id":"https://openalex.org/keywords/lung","display_name":"Lung","score":0.2736000120639801}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7254999876022339},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.5184999704360962},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.37869998812675476},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.33469998836517334},{"id":"https://openalex.org/C2992160955","wikidata":"https://www.wikidata.org/wiki/Q234904","display_name":"Lung ultrasound","level":3,"score":0.3312000036239624},{"id":"https://openalex.org/C544519230","wikidata":"https://www.wikidata.org/wiki/Q32566","display_name":"Computed tomography","level":2,"score":0.30820000171661377},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.29420000314712524},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.2736000120639801},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.26600000262260437},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2655999958515167},{"id":"https://openalex.org/C534262118","wikidata":"https://www.wikidata.org/wiki/Q177719","display_name":"Medical diagnosis","level":2,"score":0.25}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi61048.2026.11516051","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi61048.2026.11516051","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2026 IEEE 23rd International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4016719162464142,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W2806986802","https://openalex.org/W2921801169","https://openalex.org/W2990152177","https://openalex.org/W3025576489","https://openalex.org/W3086200677","https://openalex.org/W3165231405","https://openalex.org/W3213071027","https://openalex.org/W4410297059"],"related_works":[],"abstract_inverted_index":{"Lung":[0],"ultrasound":[1],"(LUS)":[2],"offers":[3],"rapid,":[4],"radiation-free":[5],"bedside":[6],"imaging,":[7],"yet":[8],"automated":[9],"interpretation":[10],"remains":[11],"constrained":[12],"by":[13,34],"the":[14,128],"opacity":[15],"of":[16,83,130],"end-to-end":[17],"deep":[18],"learning":[19],"models.":[20],"We":[21],"propose":[22],"a":[23,62,81],"framework":[24],"that":[25,106],"explicitly":[26],"aligns":[27],"learned":[28],"representations":[29,132],"with":[30],"human":[31],"clinical":[32],"reasoning":[33],"supervising":[35],"models":[36,89],"to":[37,54,117,123],"predict":[38],"interpretable":[39],"visual":[40],"biomarkers":[41],"-":[42,52],"clinician-recognized":[43],"patterns":[44],"such":[45],"as":[46,61],"A-lines,":[47],"B-lines,":[48],"and":[49,77,137],"pleural":[50],"irregularities":[51],"prior":[53],"diagnostic":[55,140],"inference.":[56],"This":[57],"biomarker-aligned":[58],"representation":[59],"serves":[60],"compact,":[63],"semantically":[64],"meaningful":[65],"intermediate":[66],"space":[67],"for":[68],"downstream":[69],"tasks":[70],"including":[71],"lungseverity":[72],"scoring,":[73],"S/F":[74],"ratio":[75],"estimation,":[76],"disease":[78],"classification.":[79],"On":[80],"dataset":[82],"189":[84],"patients":[85],"(718":[86],"LUS":[87],"videos),":[88],"trained":[90],"via":[91],"biomarker":[92,112],"alignment":[93],"outperform":[94],"conventional":[95,124],"task-specific":[96],"networks":[97],"while":[98],"maintaining":[99],"interpretability.":[100],"A":[101],"complementary":[102],"user":[103],"study":[104],"demonstrates":[105],"decision":[107],"tree":[108],"explanations":[109],"derived":[110],"from":[111],"features":[113],"enhance":[114],"clinicians'":[115],"ability":[116],"identify":[118],"incorrect":[119],"model":[120],"predictions":[121],"compared":[122],"saliency":[125],"maps,":[126],"underscoring":[127],"value":[129],"human-aligned":[131],"in":[133,139],"achieving":[134],"both":[135],"accuracy":[136],"transparency":[138],"AI.":[141]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2026-05-21T00:00:00"}