{"id":"https://openalex.org/W7161829796","doi":"https://doi.org/10.1109/isbi61048.2026.11515867","title":"Assessing the Influence of Tractography Methods on Detected White Matter Microstructure in Alzheimers Disease","display_name":"Assessing the Influence of Tractography Methods on Detected White Matter Microstructure in Alzheimers Disease","publication_year":2026,"publication_date":"2026-04-08","ids":{"openalex":"https://openalex.org/W7161829796","doi":"https://doi.org/10.1109/isbi61048.2026.11515867"},"language":null,"primary_location":{"id":"doi:10.1109/isbi61048.2026.11515867","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi61048.2026.11515867","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2026 IEEE 23rd International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5136559498","display_name":"Yuhan Shuai","orcid":null},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuhan Shuai","raw_affiliation_strings":["Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California,Imaging Genetics Center,Marina del Rey,CA,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California,Imaging Genetics Center,Marina del Rey,CA,USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134068236","display_name":"Yixue Feng","orcid":null},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yixue Feng","raw_affiliation_strings":["Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California,Imaging Genetics Center,Marina del Rey,CA,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California,Imaging Genetics Center,Marina del Rey,CA,USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136569147","display_name":"Julio E. Villalon-Reina","orcid":null},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julio E. Villalon-Reina","raw_affiliation_strings":["Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California,Imaging Genetics Center,Marina del Rey,CA,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California,Imaging Genetics Center,Marina del Rey,CA,USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136521015","display_name":"Talia M. Nir","orcid":null},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Talia M. Nir","raw_affiliation_strings":["Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California,Imaging Genetics Center,Marina del Rey,CA,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California,Imaging Genetics Center,Marina del Rey,CA,USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136514395","display_name":"Sophia I. Thomopoulos","orcid":null},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sophia I. Thomopoulos","raw_affiliation_strings":["Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California,Imaging Genetics Center,Marina del Rey,CA,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California,Imaging Genetics Center,Marina del Rey,CA,USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136581582","display_name":"Paul M. Thompson","orcid":"https://orcid.org/0000-0002-4720-8867"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul M. Thompson","raw_affiliation_strings":["Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California,Imaging Genetics Center,Marina del Rey,CA,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California,Imaging Genetics Center,Marina del Rey,CA,USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5134049832","display_name":"Bramsh Q. Chandio","orcid":null},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bramsh Q. Chandio","raw_affiliation_strings":["Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California,Imaging Genetics Center,Marina del Rey,CA,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California,Imaging Genetics Center,Marina del Rey,CA,USA","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.668215,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9447000026702881,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9447000026702881,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimers-disease","display_name":"Alzheimer's disease","score":0.5888000130653381},{"id":"https://openalex.org/keywords/white-matter","display_name":"White matter","score":0.574400007724762},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.44510000944137573},{"id":"https://openalex.org/keywords/degenerative-disease","display_name":"Degenerative disease","score":0.37929999828338623},{"id":"https://openalex.org/keywords/tractography","display_name":"Tractography","score":0.36390000581741333}],"concepts":[{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5888000130653381},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.574400007724762},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5446000099182129},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.44510000944137573},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3921000063419342},{"id":"https://openalex.org/C2777427615","wikidata":"https://www.wikidata.org/wiki/Q954257","display_name":"Degenerative disease","level":3,"score":0.37929999828338623},{"id":"https://openalex.org/C84787856","wikidata":"https://www.wikidata.org/wiki/Q3076659","display_name":"Tractography","level":4,"score":0.36390000581741333},{"id":"https://openalex.org/C87976508","wikidata":"https://www.wikidata.org/wiki/Q1498213","display_name":"Microstructure","level":2,"score":0.3278999924659729},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.29350000619888306},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2842999994754791},{"id":"https://openalex.org/C2779281540","wikidata":"https://www.wikidata.org/wiki/Q5062122","display_name":"Central nervous system disease","level":2,"score":0.27619999647140503},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.25429999828338623}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi61048.2026.11515867","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi61048.2026.11515867","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2026 IEEE 23rd International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.5229262709617615}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W241994552","https://openalex.org/W1984939243","https://openalex.org/W2019307288","https://openalex.org/W2027903877","https://openalex.org/W2028748733","https://openalex.org/W2085297965","https://openalex.org/W2089201011","https://openalex.org/W2104004753","https://openalex.org/W2110065044","https://openalex.org/W2142059961","https://openalex.org/W2145132952","https://openalex.org/W2170596158","https://openalex.org/W2735700022","https://openalex.org/W2766639217","https://openalex.org/W2793043361","https://openalex.org/W2803837136","https://openalex.org/W2916005830","https://openalex.org/W2951488689","https://openalex.org/W3092593892","https://openalex.org/W4226203773","https://openalex.org/W4312087719","https://openalex.org/W4404622643","https://openalex.org/W4405951663","https://openalex.org/W4412640250","https://openalex.org/W4417472978","https://openalex.org/W7118021618"],"related_works":[],"abstract_inverted_index":{"Tractometry":[0],"enables":[1],"detailed":[2],"mapping":[3],"of":[4,74,143,156,176],"white":[5,93],"matter":[6,94],"microstructure":[7],"along":[8],"individual":[9],"tracts":[10],"and":[11,42,62,79,83,114,124,174],"is":[12],"widely":[13],"used":[14],"to":[15,130,170],"study":[16],"disease":[17,25,162],"effects":[18,118],"such":[19],"as":[20],"those":[21],"seen":[22],"in":[23,51,89,119,139],"Alzheimer's":[24,53],"(AD).":[26],"However,":[27],"how":[28],"different":[29],"tractography":[30,44,108,157],"algorithms":[31],"influence":[32],"tractometry":[33],"outcomes":[34],"remains":[35],"unclear.":[36],"Here,":[37],"we":[38],"compared":[39],"whole-brain":[40],"deterministic":[41,134],"probabilistic":[43],"using":[45],"the":[46,52,71,106,120,140,144,154,165,172],"BUndle":[47],"ANalytics":[48],"(BUAN)":[49],"framework":[50],"Disease":[54],"Neuroimaging":[55],"Initiative":[56],"(ADNI)":[57],"dataset,":[58],"including":[59],"118":[60],"AD":[61],"728":[63],"cognitively":[64],"normal":[65],"(CN)":[66],"participants.":[67],"Both":[68],"approaches":[69],"revealed":[70],"expected":[72],"pattern":[73],"lower":[75],"fractional":[76],"anisotropy":[77],"(FA)":[78],"higher":[80],"mean,":[81],"radial,":[82],"axial":[84],"diffusivity":[85],"(MD,":[86],"RD,":[87],"AxD)":[88],"AD,":[90],"consistent":[91],"with":[92],"degeneration.":[95],"Despite":[96],"broadly":[97],"similar":[98],"global":[99],"trends,":[100],"substantial":[101],"bundle-level":[102],"differences":[103],"emerged":[104],"between":[105],"two":[107],"methods.":[109],"Probabilistic":[110],"tracking":[111,135],"produced":[112],"stronger":[113],"more":[115],"spatially":[116],"extended":[117],"fornix,":[121],"a":[122],"small":[123],"highly":[125],"curved":[126],"limbic":[127],"pathway":[128],"vulnerable":[129],"AD-related":[131],"degeneration,":[132],"whereas":[133],"showed":[136],"greater":[137],"sensitivity":[138],"posterior":[141],"segments":[142],"right":[145],"superior":[146],"longitudinal":[147],"fasciculus":[148],"(SLF_R).":[149],"These":[150],"discrepancies":[151],"highlight":[152],"that":[153],"choice":[155],"algorithm":[158],"can":[159],"alter":[160],"detecting":[161],"effects,":[163],"emphasizing":[164],"need":[166],"for":[167],"cross-method":[168],"validation":[169],"ensure":[171],"robustness":[173],"interpretability":[175],"along-tract":[177],"measures.":[178]},"counts_by_year":[],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2026-05-21T00:00:00"}
