{"id":"https://openalex.org/W7161819922","doi":"https://doi.org/10.1109/isbi61048.2026.11515711","title":"Disdiff: Self-Supervised Segmentation on Histopathology Images Using Diffusion Models and Distance Maps","display_name":"Disdiff: Self-Supervised Segmentation on Histopathology Images Using Diffusion Models and Distance Maps","publication_year":2026,"publication_date":"2026-04-08","ids":{"openalex":"https://openalex.org/W7161819922","doi":"https://doi.org/10.1109/isbi61048.2026.11515711"},"language":null,"primary_location":{"id":"doi:10.1109/isbi61048.2026.11515711","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi61048.2026.11515711","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2026 IEEE 23rd International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5094579212","display_name":"Zhang Xuanke","orcid":null},"institutions":[{"id":"https://openalex.org/I6469544","display_name":"City University of Macau","ror":"https://ror.org/04gpd4q15","country_code":"MO","type":"education","lineage":["https://openalex.org/I6469544"]}],"countries":["MO"],"is_corresponding":false,"raw_author_name":"Xuanke Zhang","raw_affiliation_strings":["City University of Macau,Faculty of Data Science,Macau,SAR,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"City University of Macau,Faculty of Data Science,Macau,SAR,China","institution_ids":["https://openalex.org/I6469544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136585690","display_name":"Qi Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I6469544","display_name":"City University of Macau","ror":"https://ror.org/04gpd4q15","country_code":"MO","type":"education","lineage":["https://openalex.org/I6469544"]}],"countries":["MO"],"is_corresponding":false,"raw_author_name":"Qi Zhang","raw_affiliation_strings":["City University of Macau,Faculty of Data Science,Macau,SAR,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"City University of Macau,Faculty of Data Science,Macau,SAR,China","institution_ids":["https://openalex.org/I6469544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103869705","display_name":"Jia Gu","orcid":null},"institutions":[{"id":"https://openalex.org/I6469544","display_name":"City University of Macau","ror":"https://ror.org/04gpd4q15","country_code":"MO","type":"education","lineage":["https://openalex.org/I6469544"]}],"countries":["MO"],"is_corresponding":false,"raw_author_name":"Jia Gu","raw_affiliation_strings":["City University of Macau,Faculty of Data Science,Macau,SAR,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"City University of Macau,Faculty of Data Science,Macau,SAR,China","institution_ids":["https://openalex.org/I6469544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116749039","display_name":"Runyang Jian","orcid":"https://orcid.org/0009-0000-6435-5802"},"institutions":[{"id":"https://openalex.org/I126345244","display_name":"Portland State University","ror":"https://ror.org/00yn2fy02","country_code":"US","type":"education","lineage":["https://openalex.org/I126345244"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Runyang Jian","raw_affiliation_strings":["Maseeh College of Engineering and Computer Science, Portland State University,Portland,OR,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maseeh College of Engineering and Computer Science, Portland State University,Portland,OR,USA","institution_ids":["https://openalex.org/I126345244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136572789","display_name":"Chongyu Bao","orcid":null},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Chongyu Bao","raw_affiliation_strings":["School of Electrical, Electronic and Mechanical Engineering, University of Bristol,Bristol,United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electrical, Electronic and Mechanical Engineering, University of Bristol,Bristol,United Kingdom","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126632051","display_name":"Ziyang Zhu","orcid":null},"institutions":[{"id":"https://openalex.org/I6469544","display_name":"City University of Macau","ror":"https://ror.org/04gpd4q15","country_code":"MO","type":"education","lineage":["https://openalex.org/I6469544"]}],"countries":["MO"],"is_corresponding":false,"raw_author_name":"Ziyang Zhu","raw_affiliation_strings":["City University of Macau,Faculty of Data Science,Macau,SAR,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"City University of Macau,Faculty of Data Science,Macau,SAR,China","institution_ids":["https://openalex.org/I6469544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085970669","display_name":"\u5c24\u9022\u6c38","orcid":null},"institutions":[{"id":"https://openalex.org/I165911609","display_name":"Changsha Medical University","ror":"https://ror.org/05dt7z971","country_code":"CN","type":"education","lineage":["https://openalex.org/I165911609"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fengyong You","raw_affiliation_strings":["College of Medical Imaging, Changsha Medical University,Changsha,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Medical Imaging, Changsha Medical University,Changsha,China","institution_ids":["https://openalex.org/I165911609"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070575632","display_name":"Jingzhang Sun","orcid":"https://orcid.org/0000-0002-6961-6677"},"institutions":[{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingzhang Sun","raw_affiliation_strings":["School of Cyberspace Security, Hainan University,Haikou,Hainan,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Cyberspace Security, Hainan University,Haikou,Hainan,China","institution_ids":["https://openalex.org/I20942203"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.5620999932289124,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.5620999932289124,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.1898999959230423,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.025100000202655792,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.5471000075340271},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4927999973297119},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.40700000524520874},{"id":"https://openalex.org/keywords/diffusion","display_name":"Diffusion","score":0.40049999952316284},{"id":"https://openalex.org/keywords/scale-space-segmentation","display_name":"Scale-space segmentation","score":0.3059999942779541},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.30559998750686646}],"concepts":[{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6168000102043152},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.5516999959945679},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.5471000075340271},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4927999973297119},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44830000400543213},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.40700000524520874},{"id":"https://openalex.org/C69357855","wikidata":"https://www.wikidata.org/wiki/Q163214","display_name":"Diffusion","level":2,"score":0.40049999952316284},{"id":"https://openalex.org/C65885262","wikidata":"https://www.wikidata.org/wiki/Q7429708","display_name":"Scale-space segmentation","level":4,"score":0.3059999942779541},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.30559998750686646},{"id":"https://openalex.org/C9417928","wikidata":"https://www.wikidata.org/wiki/Q1070689","display_name":"Image processing","level":3,"score":0.288100004196167},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2815999984741211},{"id":"https://openalex.org/C55128770","wikidata":"https://www.wikidata.org/wiki/Q5275440","display_name":"Diffusion map","level":4,"score":0.2727000117301941},{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.25540000200271606}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi61048.2026.11515711","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi61048.2026.11515711","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2026 IEEE 23rd International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3001275180","display_name":null,"funder_award_id":"0002/2024/RIA1","funder_id":"https://openalex.org/F4320323893","funder_display_name":"Fundo para o Desenvolvimento das Ci\u00eancias e da Tecnologia"}],"funders":[{"id":"https://openalex.org/F4320323893","display_name":"Fundo para o Desenvolvimento das Ci\u00eancias e da Tecnologia","ror":"https://ror.org/05vna4324"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1901129140","https://openalex.org/W2089459993","https://openalex.org/W2145033500","https://openalex.org/W2592905743","https://openalex.org/W2625621508","https://openalex.org/W2693096534","https://openalex.org/W2964744899","https://openalex.org/W2980199518","https://openalex.org/W4225007432","https://openalex.org/W4313142698","https://openalex.org/W4372347372","https://openalex.org/W4386352867","https://openalex.org/W4386362585","https://openalex.org/W4401795648","https://openalex.org/W4402125028","https://openalex.org/W4414478177"],"related_works":[],"abstract_inverted_index":{"Histopathological":[0],"image":[1],"segmentation":[2,18,38],"is":[3,12],"crucial":[4],"for":[5,36,83,114],"clinical":[6,115],"diagnosis,":[7],"but":[8],"obtaining":[9],"high-quality":[10],"annotations":[11],"timeconsuming":[13],"and":[14,79,90,105],"labor-intensive.":[15],"To":[16],"improve":[17],"performance":[19,98],"while":[20],"reducing":[21],"annotation":[22],"dependence,":[23],"this":[24],"paper":[25],"presents":[26],"DisDiff,":[27],"a":[28,45,71],"novel":[29],"two-stage":[30],"self-supervised":[31],"framework":[32],"leveraging":[33],"diffusion":[34],"models":[35],"nuclei":[37,85],"without":[39],"pseudo-labels.":[40],"In":[41,62],"the":[42,63],"first":[43],"stage,":[44,65],"Denoising":[46],"Diffusion":[47],"Probabilistic":[48],"Model":[49],"(DDPM)":[50],"with":[51,74,99,108],"Perception":[52],"Prioritized":[53],"(P2)":[54],"weighting":[55],"learns":[56],"robust":[57],"features":[58],"from":[59],"unlabeled":[60],"images.":[61],"second":[64],"pretrained":[66],"weights":[67],"are":[68],"transferred":[69],"to":[70],"U-Net":[72],"enhanced":[73],"Efficient":[75],"Multi-scale":[76],"Attention":[77],"(EMA)":[78],"distance":[80],"map":[81],"post-processing":[82],"effective":[84],"separation.":[86],"Experiments":[87],"on":[88],"TCGA":[89],"TNBC":[91],"datasets":[92],"show":[93],"that":[94],"DisDiff":[95],"achieves":[96],"competitive":[97],"only":[100],"50":[101],"%":[102],"labeled":[103],"data":[104],"superior":[106],"results":[107],"full":[109],"annotations,":[110],"demonstrating":[111],"practical":[112],"value":[113],"applications.":[116]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2026-05-21T00:00:00"}