{"id":"https://openalex.org/W4416300622","doi":"https://doi.org/10.1109/isbi61048.2026.11515697","title":"Evaluating Sample-Size Efficiency and Sensitivity of Tractometry in Alzheimer's Disease","display_name":"Evaluating Sample-Size Efficiency and Sensitivity of Tractometry in Alzheimer's Disease","publication_year":2026,"publication_date":"2026-04-08","ids":{"openalex":"https://openalex.org/W4416300622","doi":"https://doi.org/10.1109/isbi61048.2026.11515697","pmid":"https://pubmed.ncbi.nlm.nih.gov/41292900"},"language":"en","primary_location":{"id":"doi:10.1109/isbi61048.2026.11515697","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi61048.2026.11515697","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2026 IEEE 23rd International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2025/11/13/2025.11.11.687878.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056780680","display_name":"Yixue Feng","orcid":"https://orcid.org/0000-0003-1015-4209"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I2800817003","display_name":"California Southern University","ror":"https://ror.org/058zz0t50","country_code":"US","type":"education","lineage":["https://openalex.org/I2800817003"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yixue Feng","raw_affiliation_strings":["Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, United States","University of Southern California"],"raw_orcid":"https://orcid.org/0000-0003-1015-4209","affiliations":[{"raw_affiliation_string":"Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, United States","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"University of Southern California","institution_ids":["https://openalex.org/I2800817003","https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070275145","display_name":"Julio E. Villal\u00f3n\u2010Reina","orcid":"https://orcid.org/0009-0005-9039-4924"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I2800817003","display_name":"California Southern University","ror":"https://ror.org/058zz0t50","country_code":"US","type":"education","lineage":["https://openalex.org/I2800817003"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julio E. Villal\u00f3n-Reina","raw_affiliation_strings":["Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, United States","University of Southern California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, United States","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"University of Southern California","institution_ids":["https://openalex.org/I2800817003","https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056731663","display_name":"Iyad Ba Gari","orcid":"https://orcid.org/0000-0003-1443-8786"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I2800817003","display_name":"California Southern University","ror":"https://ror.org/058zz0t50","country_code":"US","type":"education","lineage":["https://openalex.org/I2800817003"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Iyad Ba Gari","raw_affiliation_strings":["Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, United States","University of Southern California"],"raw_orcid":"https://orcid.org/0000-0003-1443-8786","affiliations":[{"raw_affiliation_string":"Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, United States","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"University of Southern California","institution_ids":["https://openalex.org/I2800817003","https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119354212","display_name":"Jonathan Davis Alibrando","orcid":null},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I2800817003","display_name":"California Southern University","ror":"https://ror.org/058zz0t50","country_code":"US","type":"education","lineage":["https://openalex.org/I2800817003"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Davis Alibrando","raw_affiliation_strings":["Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, United States","University of Southern California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, United States","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"University of Southern California","institution_ids":["https://openalex.org/I2800817003","https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076060041","display_name":"Talia M. Nir","orcid":"https://orcid.org/0000-0002-7106-7443"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I2800817003","display_name":"California Southern University","ror":"https://ror.org/058zz0t50","country_code":"US","type":"education","lineage":["https://openalex.org/I2800817003"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Talia M. Nir","raw_affiliation_strings":["Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, United States","University of Southern California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, United States","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"University of Southern California","institution_ids":["https://openalex.org/I2800817003","https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019781190","display_name":"Neda Jahanshad","orcid":"https://orcid.org/0000-0003-4401-8950"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I2800817003","display_name":"California Southern University","ror":"https://ror.org/058zz0t50","country_code":"US","type":"education","lineage":["https://openalex.org/I2800817003"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neda Jahanshad","raw_affiliation_strings":["Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, United States","University of Southern California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, United States","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"University of Southern California","institution_ids":["https://openalex.org/I2800817003","https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024772201","display_name":"Bramsh Q. Chandio","orcid":"https://orcid.org/0000-0002-8949-4937"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bramsh Q. Chandio","raw_affiliation_strings":["Department of Chemical and Biomedical Engineering, Statler College of Engineering and Mineral Resources, West Virginia University, Morgantown, WV, United States","Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, United States","West Virginia University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomedical Engineering, Statler College of Engineering and Mineral Resources, West Virginia University, Morgantown, WV, United States","institution_ids":["https://openalex.org/I12097938"]},{"raw_affiliation_string":"Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, United States","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"West Virginia University","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100606557","display_name":"Paul M. Thompson","orcid":"https://orcid.org/0000-0002-4720-8867"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I2800817003","display_name":"California Southern University","ror":"https://ror.org/058zz0t50","country_code":"US","type":"education","lineage":["https://openalex.org/I2800817003"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Paul M. Thompson","raw_affiliation_strings":["Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, United States","University of Southern California"],"raw_orcid":"https://orcid.org/0000-0002-4720-8867","affiliations":[{"raw_affiliation_string":"Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, United States","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"University of Southern California","institution_ids":["https://openalex.org/I2800817003","https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100606557"],"corresponding_institution_ids":["https://openalex.org/I1174212","https://openalex.org/I2800817003"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.972100019454956,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.972100019454956,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.012600000016391277,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sensitivity","display_name":"Sensitivity (control systems)","score":0.671500027179718},{"id":"https://openalex.org/keywords/sample-size-determination","display_name":"Sample size determination","score":0.6370999813079834},{"id":"https://openalex.org/keywords/diffusion-mri","display_name":"Diffusion MRI","score":0.5081999897956848},{"id":"https://openalex.org/keywords/sample","display_name":"Sample (material)","score":0.38760000467300415},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3521000146865845},{"id":"https://openalex.org/keywords/magnitude","display_name":"Magnitude (astronomy)","score":0.334199994802475},{"id":"https://openalex.org/keywords/large-sample","display_name":"Large sample","score":0.3174000084400177}],"concepts":[{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.671500027179718},{"id":"https://openalex.org/C129848803","wikidata":"https://www.wikidata.org/wiki/Q2564360","display_name":"Sample size determination","level":2,"score":0.6370999813079834},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.5081999897956848},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.4449999928474426},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.38760000467300415},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3547999858856201},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3521000146865845},{"id":"https://openalex.org/C126691448","wikidata":"https://www.wikidata.org/wiki/Q2028919","display_name":"Magnitude (astronomy)","level":2,"score":0.334199994802475},{"id":"https://openalex.org/C3020318244","wikidata":"https://www.wikidata.org/wiki/Q4812187","display_name":"Large sample","level":2,"score":0.3174000084400177},{"id":"https://openalex.org/C2776035688","wikidata":"https://www.wikidata.org/wiki/Q1606558","display_name":"Affect (linguistics)","level":2,"score":0.31679999828338623},{"id":"https://openalex.org/C2986587452","wikidata":"https://www.wikidata.org/wiki/Q938438","display_name":"Statistical analysis","level":2,"score":0.31369999051094055},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3125999867916107},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3100000023841858},{"id":"https://openalex.org/C69357855","wikidata":"https://www.wikidata.org/wiki/Q163214","display_name":"Diffusion","level":2,"score":0.30730000138282776},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.2987000048160553},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2904999852180481},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.28540000319480896},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2754000127315521},{"id":"https://openalex.org/C155281189","wikidata":"https://www.wikidata.org/wiki/Q3518150","display_name":"Tensor (intrinsic definition)","level":2,"score":0.2572000026702881}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1109/isbi61048.2026.11515697","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi61048.2026.11515697","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2026 IEEE 23rd International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},{"id":"doi:10.1101/2025.11.11.687878","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.11.11.687878","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/11/13/2025.11.11.687878.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:41292900","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41292900","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":null},{"id":"pmh:oai:europepmc.org:11449337","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12642613","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1101/2025.11.11.687878","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.11.11.687878","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/11/13/2025.11.11.687878.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2054317424","display_name":null,"funder_award_id":"R01MH134004","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G424656186","display_name":null,"funder_award_id":"RF1NS136995,R01AG087513,T32AG058507,R01MH134004,S10OD032285","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7298852491","display_name":null,"funder_award_id":"T32AG058507","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7740618942","display_name":null,"funder_award_id":"S10OD032285","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306219","display_name":"Alzheimer's Association","ror":"https://ror.org/0375f4d26"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416300622.pdf","grobid_xml":"https://content.openalex.org/works/W4416300622.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W2027903877","https://openalex.org/W2028748733","https://openalex.org/W2060171712","https://openalex.org/W2124030567","https://openalex.org/W2150667092","https://openalex.org/W2151712416","https://openalex.org/W2157804335","https://openalex.org/W2170480020","https://openalex.org/W3092593892","https://openalex.org/W3173173220","https://openalex.org/W4292658370","https://openalex.org/W4312087247","https://openalex.org/W4395958893","https://openalex.org/W4401362659","https://openalex.org/W4405488993","https://openalex.org/W4413421057"],"related_works":[],"abstract_inverted_index":{"Tractometry":[0],"allows":[1],"quantitative":[2],"analysis":[3,40],"of":[4,16,60,148],"white":[5],"matter":[6],"microstructure":[7],"along":[8],"the":[9,14,58,142],"brain's":[10],"fiber":[11],"tracts,":[12],"but":[13,131],"impact":[15],"study":[17,132],"design":[18,133],"parameters-such":[19],"as":[20],"sample":[21,152],"size":[22,153],"and":[23,27,62,72,96,107,124,146,155],"along-tract":[24,67],"resolution-on":[25],"sensitivity":[26,71],"specificity":[28,123],"is":[29],"not":[30],"well":[31],"understood.":[32],"In":[33],"this":[34],"study,":[35],"we":[36],"conducted":[37],"tractometry":[38,119],"bootstrap":[39],"using":[41],"linear-mixed":[42],"models":[43],"across":[44],"four":[45],"diffusion":[46],"tensor":[47],"imaging":[48],"(DTI)":[49],"metrics":[50],"to":[51,80,112,137,150],"systematically":[52],"evaluate":[53],"how":[54],"these":[55],"factors":[56],"affect":[57],"detection":[59],"dementia-":[61],"amyloid-related":[63,102],"effects.":[64,90],"While":[65],"coarser":[66],"segments":[68,78],"yield":[69],"greater":[70],"higher":[73,82],"mean":[74],"effect":[75,84],"sizes,":[76,85],"finer":[77],"tend":[79],"produce":[81],"peak":[83],"revealing":[86],"more":[87,94,105],"spatially":[88],"localized":[89],"Dementia-related":[91],"effects":[92,103],"were":[93,104],"widespread":[95],"detectable":[97],"with":[98],"fewer":[99],"subjects,":[100],"whereas":[101],"subtle":[106],"localized,":[108],"requiring":[109],"larger":[110],"cohorts":[111],"detect":[113,127],"them.":[114],"These":[115],"findings":[116],"highlight":[117],"that":[118],"offers":[120],"improved":[121],"spatial":[122,144],"can":[125],"reliably":[126],"small,":[128],"fine-scale":[129],"effects,":[130,149],"should":[134],"be":[135],"tailored":[136],"specific":[138],"research":[139],"questions,":[140],"considering":[141],"expected":[143],"extent":[145],"magnitude":[147],"optimize":[151],"efficiency":[154],"interpretability.":[156]},"counts_by_year":[],"updated_date":"2026-07-15T18:14:33.161393","created_date":"2025-11-13T00:00:00"}
