{"id":"https://openalex.org/W7161759483","doi":"https://doi.org/10.1109/isbi61048.2026.11515608","title":"Healthy Counterfactual Generation with Denoising Diffusion Bridge Models","display_name":"Healthy Counterfactual Generation with Denoising Diffusion Bridge Models","publication_year":2026,"publication_date":"2026-04-08","ids":{"openalex":"https://openalex.org/W7161759483","doi":"https://doi.org/10.1109/isbi61048.2026.11515608"},"language":null,"primary_location":{"id":"doi:10.1109/isbi61048.2026.11515608","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi61048.2026.11515608","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2026 IEEE 23rd International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5116016604","display_name":"Ana Lawry Aguila","orcid":null},"institutions":[{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ana Lawry Aguila","raw_affiliation_strings":["Massachusetts General Hospital and Harvard Medical School,Athinoula A. Martinos Center for Biomedical Imaging,Boston,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School,Athinoula A. Martinos Center for Biomedical Imaging,Boston,USA","institution_ids":["https://openalex.org/I4210127055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072611489","display_name":"Medardo Aguirre","orcid":null},"institutions":[{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marina Crespo Aguirre","raw_affiliation_strings":["Massachusetts General Hospital and Harvard Medical School,Athinoula A. Martinos Center for Biomedical Imaging,Boston,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School,Athinoula A. Martinos Center for Biomedical Imaging,Boston,USA","institution_ids":["https://openalex.org/I4210127055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043572938","display_name":"Peirong Liu","orcid":"https://orcid.org/0000-0001-7645-009X"},"institutions":[{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peirong Liu","raw_affiliation_strings":["Massachusetts General Hospital and Harvard Medical School,Athinoula A. Martinos Center for Biomedical Imaging,Boston,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School,Athinoula A. Martinos Center for Biomedical Imaging,Boston,USA","institution_ids":["https://openalex.org/I4210127055"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054888342","display_name":"Juan Eugenio Iglesias","orcid":"https://orcid.org/0000-0001-7569-173X"},"institutions":[{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan Eugenio Iglesias","raw_affiliation_strings":["Massachusetts General Hospital and Harvard Medical School,Athinoula A. Martinos Center for Biomedical Imaging,Boston,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School,Athinoula A. Martinos Center for Biomedical Imaging,Boston,USA","institution_ids":["https://openalex.org/I4210127055"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210127055"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.60675947,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10775","display_name":"Generative Adversarial Networks and Image Synthesis","score":0.037300001829862595,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10775","display_name":"Generative Adversarial Networks and Image Synthesis","score":0.037300001829862595,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11008","display_name":"Aerodynamics and Acoustics in Jet Flows","score":0.019300000742077827,"subfield":{"id":"https://openalex.org/subfields/2202","display_name":"Aerospace Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10388","display_name":"Advanced Steganography and Watermarking Techniques","score":0.016699999570846558,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/noise","display_name":"Noise (video)","score":0.43479999899864197},{"id":"https://openalex.org/keywords/bridge","display_name":"Bridge (graph theory)","score":0.4291999936103821},{"id":"https://openalex.org/keywords/counterfactual-thinking","display_name":"Counterfactual thinking","score":0.421099990606308},{"id":"https://openalex.org/keywords/noise-reduction","display_name":"Noise reduction","score":0.40220001339912415},{"id":"https://openalex.org/keywords/diffusion","display_name":"Diffusion","score":0.36910000443458557}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4733000099658966},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.43479999899864197},{"id":"https://openalex.org/C100776233","wikidata":"https://www.wikidata.org/wiki/Q2532492","display_name":"Bridge (graph theory)","level":2,"score":0.4291999936103821},{"id":"https://openalex.org/C108650721","wikidata":"https://www.wikidata.org/wiki/Q1783253","display_name":"Counterfactual thinking","level":2,"score":0.421099990606308},{"id":"https://openalex.org/C163294075","wikidata":"https://www.wikidata.org/wiki/Q581861","display_name":"Noise reduction","level":2,"score":0.40220001339912415},{"id":"https://openalex.org/C69357855","wikidata":"https://www.wikidata.org/wiki/Q163214","display_name":"Diffusion","level":2,"score":0.36910000443458557},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.3637999892234802},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3637000024318695},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3346000015735626},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.3188999891281128},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3165000081062317},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.31470000743865967},{"id":"https://openalex.org/C28826006","wikidata":"https://www.wikidata.org/wiki/Q33521","display_name":"Applied mathematics","level":1,"score":0.3140000104904175},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.2529999911785126}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi61048.2026.11515608","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi61048.2026.11515608","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2026 IEEE 23rd International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","score":0.5277018547058105,"display_name":"Zero hunger"}],"awards":[{"id":"https://openalex.org/G1090533433","display_name":null,"funder_award_id":"RF1AG080371,RF1MH123195,R01AG070988,R01EB-031114,UM1MH130981,R21NS138995","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1995992667","https://openalex.org/W2020519533","https://openalex.org/W2560584411","https://openalex.org/W2791723176","https://openalex.org/W2897079521","https://openalex.org/W3167322081","https://openalex.org/W3204867994","https://openalex.org/W4241074797","https://openalex.org/W4296123057","https://openalex.org/W4321760728","https://openalex.org/W4366815603","https://openalex.org/W4385801725","https://openalex.org/W4403054767","https://openalex.org/W4405852678","https://openalex.org/W4413146168"],"related_works":[],"abstract_inverted_index":{"Generating":[0],"healthy":[1,20,56,62,87,147],"counterfactuals":[2,23,57,175],"from":[3],"pathological":[4,47,95,160,164],"images":[5,96],"holds":[6],"significant":[7],"promise":[8],"in":[9,34],"anomaly":[10,204],"detection":[11],"or":[12],"for":[13,19],"application":[14],"of":[15,37,112,117],"analysis":[16],"tools":[17],"designed":[18],"scans.":[21],"These":[22],"should":[24],"represent":[25],"what":[26],"a":[27,68,84,156,167],"patient's":[28,180],"scan":[29],"would":[30],"plausibly":[31],"look":[32],"like":[33],"the":[35,46,65,100,110,115,136,142,146,152,163,179],"absence":[36],"pathology,":[38],"preserving":[39],"individual":[40],"anatomical":[41],"characteristics":[42],"while":[43,182],"modifying":[44],"only":[45,140],"regions.":[48],"Denoising":[49],"diffusion":[50,101,127,137,195],"probabilistic":[51],"models":[52,129,196],"(DDPMs)":[53],"can":[54],"generate":[55,174],"by":[58],"training":[59],"on":[60,141,151],"solely":[61],"data,":[63],"with":[64,114,125],"assumption":[66],"that":[67,176,189],"partial":[69],"denoising":[70,126],"process":[71,138],"will":[72,81],"be":[73],"unable":[74],"to":[75,97,107,173],"model":[76],"disease":[77],"regions":[78],"-":[79,131],"and":[80,197,203],"instead":[82],"reconstruct":[83],"closely":[85,177],"matched":[86],"counterpart.":[88],"More":[89],"recent":[90],"methods":[91],"have":[92],"incorporated":[93],"synthetic":[94],"better":[98],"guide":[99],"process,":[102],"but":[103,149],"it":[104],"remains":[105],"challenging":[106],"effectively":[108],"balances":[109],"removal":[111],"anomalies":[113],"retention":[116],"subject-specific":[118],"features.":[119],"Here,":[120],"we":[121],"solve":[122],"this":[123],"problem":[124],"bridge":[128],"(DDBMs)":[130],"which,":[132],"unlike":[133],"DDPMs,":[134],"condition":[135],"not":[139],"initial":[143],"point":[144,154],"(i.e.,":[145,155],"image),":[148],"also":[150],"final":[153],"corresponding":[157],"synthetically":[158],"generated":[159],"image).":[161],"Treating":[162],"image":[165],"as":[166],"structurally":[168],"informative":[169],"prior":[170],"enables":[171],"us":[172],"match":[178],"anatomy":[181],"selectively":[183],"removing":[184],"pathology.":[185],"The":[186],"results":[187],"show":[188],"our":[190],"DDBM":[191],"outperforms":[192],"previously":[193],"proposed":[194],"fully":[198],"supervised":[199],"approaches":[200],"at":[201],"segmentation":[202],"detection.":[205]},"counts_by_year":[],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2026-05-21T00:00:00"}