{"id":"https://openalex.org/W7161759509","doi":"https://doi.org/10.1109/isbi61048.2026.11515558","title":"Role of Sex in Structural MRI Prediction of Cognition Severity in Autism","display_name":"Role of Sex in Structural MRI Prediction of Cognition Severity in Autism","publication_year":2026,"publication_date":"2026-04-08","ids":{"openalex":"https://openalex.org/W7161759509","doi":"https://doi.org/10.1109/isbi61048.2026.11515558"},"language":null,"primary_location":{"id":"doi:10.1109/isbi61048.2026.11515558","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi61048.2026.11515558","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2026 IEEE 23rd International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102529991","display_name":"Mostafa Abdelrahim","orcid":null},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mostafa Abdelrahim","raw_affiliation_strings":["University of Louisville,Bioengineering Department,KY,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Louisville,Bioengineering Department,KY,USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092372083","display_name":"Mohamed Khudri","orcid":null},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohamed Khudri","raw_affiliation_strings":["University of Louisville,Bioengineering Department,KY,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Louisville,Bioengineering Department,KY,USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128262035","display_name":"A Mahmoud","orcid":null},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ali Mahmoud","raw_affiliation_strings":["University of Louisville,Bioengineering Department,KY,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Louisville,Bioengineering Department,KY,USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133618072","display_name":"Ahmed Shalaby","orcid":null},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ahmed Shalaby","raw_affiliation_strings":["UTSW Medical Center,Lyda Hill Department of Bioinformatics,Dallas,TX,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UTSW Medical Center,Lyda Hill Department of Bioinformatics,Dallas,TX,USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136528936","display_name":"Moumen El-Melegy","orcid":null},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Moumen El-Melegy","raw_affiliation_strings":["University of Louisville,Bioengineering Department,KY,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Louisville,Bioengineering Department,KY,USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108167435","display_name":"Asem Ali","orcid":"https://orcid.org/0000-0002-0503-4838"},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Asem Ali","raw_affiliation_strings":["University of Louisville,Bioengineering Department,KY,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Louisville,Bioengineering Department,KY,USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136572385","display_name":"Mohammed A. Ghazal","orcid":null},"institutions":[{"id":"https://openalex.org/I117222138","display_name":"Abu Dhabi University","ror":"https://ror.org/01r3kjq03","country_code":"AE","type":"education","lineage":["https://openalex.org/I117222138"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Mohammed A. Ghazal","raw_affiliation_strings":["Abu Dhabi University,Electrical and Computer Engineering Department,Abu Dhabi,UAE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abu Dhabi University,Electrical and Computer Engineering Department,Abu Dhabi,UAE","institution_ids":["https://openalex.org/I117222138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020726177","display_name":"Fatma Taher","orcid":null},"institutions":[{"id":"https://openalex.org/I91044093","display_name":"Zayed University","ror":"https://ror.org/03snqfa66","country_code":"AE","type":"education","lineage":["https://openalex.org/I91044093"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Fatma Taher","raw_affiliation_strings":["College of Technological Innovation, Zayed University,Abu Dhabi,UAE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Technological Innovation, Zayed University,Abu Dhabi,UAE","institution_ids":["https://openalex.org/I91044093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133593126","display_name":"Ashraf Khalil","orcid":null},"institutions":[{"id":"https://openalex.org/I91044093","display_name":"Zayed University","ror":"https://ror.org/03snqfa66","country_code":"AE","type":"education","lineage":["https://openalex.org/I91044093"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Ashraf Khalil","raw_affiliation_strings":["College of Technological Innovation, Zayed University,Abu Dhabi,UAE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Technological Innovation, Zayed University,Abu Dhabi,UAE","institution_ids":["https://openalex.org/I91044093"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135130240","display_name":"Sohail Contractor","orcid":null},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sohail Contractor","raw_affiliation_strings":["University of Louisville,Department of Radiology,Louisville,KY,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Louisville,Department of Radiology,Louisville,KY,USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102421900","display_name":"Gregory N. Barnes","orcid":null},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory N. Barnes","raw_affiliation_strings":["University of Louisville,Department of Neurology,Louisville,KY,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Louisville,Department of Neurology,Louisville,KY,USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103615414","display_name":"Ayman EL-BAZ","orcid":null},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ayman El-Baz","raw_affiliation_strings":["University of Louisville,Bioengineering Department,KY,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Louisville,Bioengineering Department,KY,USA","institution_ids":["https://openalex.org/I142740786"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5102529991"],"corresponding_institution_ids":["https://openalex.org/I142740786"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.93082457,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.8289999961853027,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.8289999961853027,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.03530000150203705,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12552","display_name":"Fetal and Pediatric Neurological Disorders","score":0.021900000050663948,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autism","display_name":"Autism","score":0.6924999952316284},{"id":"https://openalex.org/keywords/cognition","display_name":"Cognition","score":0.6370000243186951},{"id":"https://openalex.org/keywords/perception","display_name":"Perception","score":0.26409998536109924},{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"Autism spectrum disorder","score":0.24879999458789825}],"concepts":[{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.6924999952316284},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.6370000243186951},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4607999920845032},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3749000132083893},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.3538999855518341},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.3449000120162964},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.26750001311302185},{"id":"https://openalex.org/C26760741","wikidata":"https://www.wikidata.org/wiki/Q160402","display_name":"Perception","level":2,"score":0.26409998536109924},{"id":"https://openalex.org/C2778538070","wikidata":"https://www.wikidata.org/wiki/Q1436063","display_name":"Autism spectrum disorder","level":3,"score":0.24879999458789825},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.24449999630451202}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi61048.2026.11515558","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi61048.2026.11515558","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2026 IEEE 23rd International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.40312132239341736,"id":"https://metadata.un.org/sdg/5","display_name":"Gender equality"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1987617697","https://openalex.org/W1999466943","https://openalex.org/W2005342778","https://openalex.org/W2043653988","https://openalex.org/W2101135654","https://openalex.org/W2148143831","https://openalex.org/W2171646828","https://openalex.org/W2255438920","https://openalex.org/W2968726102","https://openalex.org/W2978631110","https://openalex.org/W3119607864","https://openalex.org/W3126337977","https://openalex.org/W4241074797","https://openalex.org/W4387444722","https://openalex.org/W4390730860","https://openalex.org/W4409458169"],"related_works":[],"abstract_inverted_index":{"Autism":[0],"and":[1,50,58,72,83,88,92,153],"structural":[2,199],"MRI":[3],"(sMRI)":[4],"are":[5,60],"closely":[6],"linked":[7],"through":[8],"measurable":[9],"brain":[10],"morphology":[11,169,200],"differences":[12],"that":[13,186],"reflect":[14],"disorder":[15],"severity,":[16],"which":[17],"is":[18],"measured":[19],"by":[20,178],"the":[21,46,103,172],"Social":[22],"Responsiveness":[23],"Scale":[24],"(SRS)":[25],"Cognition":[26],"subscore.":[27],"This":[28],"study":[29],"investigates":[30],"whether":[31],"adding":[32],"sex":[33,85,116,187],"information":[34,86,117],"improves":[35],"sMRI-based":[36],"prediction":[37],"of":[38,175],"autism":[39,195],"severity.":[40],"Using":[41],"T1-weighted":[42],"sMRI":[43],"data":[44],"from":[45],"ABIDE-II":[47],"cohort,":[48],"cortical":[49],"subcortical":[51],"morphometric":[52],"features":[53],"(e.g.,":[54],"area,":[55],"volume,":[56],"thickness,":[57],"curvature)":[59],"extracted":[61],"via":[62],"FreeSurfer":[63],"to":[64],"classify":[65],"typically":[66],"developing":[67],"(TD)":[68],"versus":[69],"mild,":[70],"moderate,":[71],"severe":[73,154],"autistic":[74],"groups.":[75],"Four":[76],"experimental":[77],"variants":[78],"were":[79],"evaluated":[80],"both":[81],"with":[82,97],"without":[84],"inclusion":[87],"Recursive":[89],"Feature":[90],"Elimination":[91],"Cross-Validation":[93],"(RFECV).":[94],"Ridge-based":[95],"RFECV":[96],"a":[98,136],"SMOTE":[99],"Ridge":[100],"classifier":[101],"achieved":[102],"highest":[104],"overall":[105],"performance.":[106],"Prediction":[107],"performance":[108],"was":[109,118],"mostly":[110],"enhanced":[111],"for":[112,140],"mild":[113,176],"cases":[114],"when":[115],"added":[119],"(<tex":[120],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[121,128,143,156,180],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$\\mathrm{F}":[122],"1=77.0":[123],"\\pm":[124,130,146,150,159,164],"16.8":[125],"{\\%}$</tex>,":[126],"<tex":[127,142,155,179],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$\\text{AUC}=94.8":[129],"8.6":[131],"{\\%}$</tex>).":[132],"Morphology":[133],"alone":[134,170],"had":[135],"little":[137],"higher":[138,203],"results":[139],"moderate":[141],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$(\\mathrm{F}1":[144,157],"=72.7":[145],"10.0":[147],"{\\%},":[148,161],"\\text{AUC}=92.3":[149],"5.9":[151],"{\\%})$</tex>":[152,166],"=72.0":[158],"11.5":[160],"\\text{AUC}":[162],"=90.2":[163],"7.0":[165],"levels,":[167],"although":[168],"decreased":[171],"F1":[173],"score":[174],"level":[177],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">$&gt;8.5":[181],"{\\%}$</tex>.":[182],"These":[183],"findings":[184],"suggest":[185],"contributes":[188],"additional":[189],"discriminative":[190],"value":[191],"mainly":[192],"at":[193,202],"early":[194],"severity":[196],"stages,":[197],"whereas":[198],"dominates":[201],"levels.":[204]},"counts_by_year":[],"updated_date":"2026-05-22T06:13:13.366637","created_date":"2026-05-21T00:00:00"}
