{"id":"https://openalex.org/W7161832969","doi":"https://doi.org/10.1109/isbi61048.2026.11515549","title":"Image Imputation for Real-World Defective Microscopy Images of Mouse Brains","display_name":"Image Imputation for Real-World Defective Microscopy Images of Mouse Brains","publication_year":2026,"publication_date":"2026-04-08","ids":{"openalex":"https://openalex.org/W7161832969","doi":"https://doi.org/10.1109/isbi61048.2026.11515549"},"language":null,"primary_location":{"id":"doi:10.1109/isbi61048.2026.11515549","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi61048.2026.11515549","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2026 IEEE 23rd International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044614265","display_name":"Tao Wen","orcid":null},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tao Wen","raw_affiliation_strings":["University of North Carolina at Chapel Hill,Department of Psychiatry,NC,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill,Department of Psychiatry,NC,USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136522561","display_name":"Ziquan Wei","orcid":null},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ziquan Wei","raw_affiliation_strings":["University of North Carolina at Chapel Hill,Department of Computer Science,NC,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill,Department of Computer Science,NC,USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088548858","display_name":"Tingting Dan","orcid":"https://orcid.org/0000-0001-6936-2649"},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tingting Dan","raw_affiliation_strings":["University of North Carolina at Chapel Hill,Department of Psychiatry,NC,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill,Department of Psychiatry,NC,USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005113165","display_name":"Felix A. Kyere","orcid":null},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I1333535994","display_name":"University of North Carolina Health Care","ror":"https://ror.org/00qz24g20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1333535994"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Felix A. Kyere","raw_affiliation_strings":["University of North Carolina at Chapel Hill,UNC Neuroscience Center,NC,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill,UNC Neuroscience Center,NC,USA","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I1333535994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066973824","display_name":"Ian Curtin","orcid":null},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I1333535994","display_name":"University of North Carolina Health Care","ror":"https://ror.org/00qz24g20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1333535994"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ian Curtin","raw_affiliation_strings":["University of North Carolina at Chapel Hill,UNC Neuroscience Center,NC,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill,UNC Neuroscience Center,NC,USA","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I1333535994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136553418","display_name":"Jason L. Stein","orcid":null},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I1333535994","display_name":"University of North Carolina Health Care","ror":"https://ror.org/00qz24g20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1333535994"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason L. Stein","raw_affiliation_strings":["University of North Carolina at Chapel Hill,UNC Neuroscience Center,NC,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill,UNC Neuroscience Center,NC,USA","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I1333535994"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5136574962","display_name":"Guorong Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guorong Wu","raw_affiliation_strings":["University of North Carolina at Chapel Hill,Department of Psychiatry,NC,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill,Department of Psychiatry,NC,USA","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5044614265"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.93121463,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.8011000156402588,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.8011000156402588,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13114","display_name":"Image Processing Techniques and Applications","score":0.035599999129772186,"subfield":{"id":"https://openalex.org/subfields/2214","display_name":"Media Technology"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.03099999949336052,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.5016000270843506},{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.39629998803138733},{"id":"https://openalex.org/keywords/image-processing","display_name":"Image processing","score":0.38519999384880066},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.32749998569488525},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.3025999963283539}],"concepts":[{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6194000244140625},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.5169000029563904},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.5016000270843506},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.46369999647140503},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.39629998803138733},{"id":"https://openalex.org/C9417928","wikidata":"https://www.wikidata.org/wiki/Q1070689","display_name":"Image processing","level":3,"score":0.38519999384880066},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.32749998569488525},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3156000077724457},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.3025999963283539},{"id":"https://openalex.org/C169274487","wikidata":"https://www.wikidata.org/wiki/Q840211","display_name":"Fluorescence microscope","level":3,"score":0.25369998812675476},{"id":"https://openalex.org/C58041806","wikidata":"https://www.wikidata.org/wiki/Q1660484","display_name":"Imputation (statistics)","level":3,"score":0.25110000371932983}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi61048.2026.11515549","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi61048.2026.11515549","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2026 IEEE 23rd International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G6462753615","display_name":null,"funder_award_id":"R01NS110791,R01MH121433","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W2068391384","https://openalex.org/W3010665766","https://openalex.org/W3136958399","https://openalex.org/W3144276858","https://openalex.org/W4312497550"],"related_works":[],"abstract_inverted_index":{"Recent":[0],"advance":[1],"in":[2,15,107,177],"tissue":[3,31,182],"clearing":[4,35,183],"technology":[5],"and":[6,37,110,141,184],"light-sheet":[7],"microscopy":[8,24,52,150,167,185],"enables":[9],"rapid":[10],"cellular":[11],"resolution":[12],"image":[13,20,55,77,94,145,157],"acquisition":[14],"intact":[16],"whole":[17],"brains.":[18],"During":[19],"acquisition,":[21],"light":[22],"sheet":[23],"images":[25,151,168],"often":[26],"exhibit":[27],"cracks":[28],"or":[29],"missing":[30],"due":[32],"to":[33,46,58,62,79,88,119,144],"aggressive":[34],"protocols":[36],"physical":[38],"handling.":[39],"However,":[40],"little":[41],"attention":[42],"has":[43,160],"been":[44],"paid":[45],"assessing":[47],"the":[48,101,138,142,148,174],"impact":[49],"of":[50,76,152],"defective":[51],"samples":[53],"on":[54,147],"registration,":[56],"not":[57,116],"mention":[59],"finding":[60],"solution":[61],"address":[63],"this":[64,67],"issue.":[65],"In":[66],"context,":[68],"we":[69],"present":[70],"a":[71],"novel":[72],"mask-free":[73],"generative":[74],"model":[75,99],"imputation":[78,139],"\u201cdigitally\u201d":[80],"restoring":[81],"sample":[82,120],"damage,":[83],"which":[84],"eventually":[85],"allows":[86],"us":[87],"prevent":[89],"biologically":[90],"unrealistic":[91],"results":[92,140],"during":[93],"registration.":[95],"Since":[96],"our":[97,113],"deep":[98],"lifts":[100],"restrictions":[102],"for":[103,128,165],"manually":[104],"labeled":[105],"mask":[106],"both":[108],"training":[109],"testing":[111],"stage,":[112],"method":[114],"is":[115],"only":[117],"robust":[118],"defects":[121],"with":[122,130,169],"various":[123],"shapes":[124],"but":[125],"also":[126],"scalable":[127],"integration":[129],"most":[131],"pre-trained":[132],"diffusion":[133],"models.":[134],"We":[135],"have":[136],"evaluated":[137],"benefit":[143],"registration":[146,158],"realworld":[149],"mouse":[153],"brain.":[154],"Our":[155],"automatic":[156],"pipeline":[159],"achieved":[161],"reasonable":[162],"alignment":[163],"even":[164],"defected":[166],"significant":[170],"structure":[171],"loss,":[172],"suggesting":[173],"great":[175],"potential":[176],"facilitating":[178],"neuroscience":[179],"research":[180],"using":[181],"imaging":[186],"techniques.":[187]},"counts_by_year":[],"updated_date":"2026-05-22T06:13:13.366637","created_date":"2026-05-21T00:00:00"}