{"id":"https://openalex.org/W4410296232","doi":"https://doi.org/10.1109/isbi60581.2025.10981269","title":"Towards Patient-Specific Surgical Planning for Bicuspid Aortic Valve Repair: Fully Automated Segmentation of the Aortic Valve in 4D CT","display_name":"Towards Patient-Specific Surgical Planning for Bicuspid Aortic Valve Repair: Fully Automated Segmentation of the Aortic Valve in 4D CT","publication_year":2025,"publication_date":"2025-04-14","ids":{"openalex":"https://openalex.org/W4410296232","doi":"https://doi.org/10.1109/isbi60581.2025.10981269","pmid":"https://pubmed.ncbi.nlm.nih.gov/40630832"},"language":"en","primary_location":{"id":"doi:10.1109/isbi60581.2025.10981269","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi60581.2025.10981269","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 22nd International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12237532","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Zaiyang Guo","orcid":null},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zaiyang Guo","raw_affiliation_strings":["University of Pennsylvania,Philadelphia,PA,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania,Philadelphia,PA,USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101426415","display_name":"Nana Dong","orcid":"https://orcid.org/0000-0003-1669-9808"},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ningjun J Dong","raw_affiliation_strings":["University of Pennsylvania,Philadelphia,PA,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania,Philadelphia,PA,USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005340751","display_name":"Harold Litt","orcid":"https://orcid.org/0000-0003-2394-6053"},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harold Litt","raw_affiliation_strings":["University of Pennsylvania,Philadelphia,PA,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania,Philadelphia,PA,USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069109473","display_name":"Natalie Yushkevich","orcid":null},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalie Yushkevich","raw_affiliation_strings":["University of Pennsylvania,Philadelphia,PA,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania,Philadelphia,PA,USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063161704","display_name":"Melanie Freas","orcid":"https://orcid.org/0000-0003-4621-2896"},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melanie Freas","raw_affiliation_strings":["University of Pennsylvania,Philadelphia,PA,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania,Philadelphia,PA,USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074496627","display_name":"Jessica Nu\u00f1ez","orcid":null},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Nunez","raw_affiliation_strings":["University of Pennsylvania,Philadelphia,PA,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania,Philadelphia,PA,USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061713920","display_name":"Victor A. Ferrari","orcid":"https://orcid.org/0000-0001-8696-3243"},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor Ferrari","raw_affiliation_strings":["University of Pennsylvania,Philadelphia,PA,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania,Philadelphia,PA,USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033686761","display_name":"Jilei Hao","orcid":null},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jilei Hao","raw_affiliation_strings":["University of Pennsylvania,Philadelphia,PA,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania,Philadelphia,PA,USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114596868","display_name":"Shir Goldfinger","orcid":null},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shir Goldfinger","raw_affiliation_strings":["University of Pennsylvania,Philadelphia,PA,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania,Philadelphia,PA,USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018251647","display_name":"Matthew A. Jolley","orcid":"https://orcid.org/0000-0002-5626-0130"},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew A. Jolley","raw_affiliation_strings":["Children's Hospital of Philadelphia,Philadelphia,PA,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital of Philadelphia,Philadelphia,PA,USA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012389323","display_name":"Joseph E. Bavaria","orcid":"https://orcid.org/0000-0001-7145-0453"},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Bavaria","raw_affiliation_strings":["Thomas Jefferson University,Philadelphia,PA,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thomas Jefferson University,Philadelphia,PA,USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083041891","display_name":"Nimesh Desai","orcid":null},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nimesh Desai","raw_affiliation_strings":["University of Pennsylvania,Philadelphia,PA,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania,Philadelphia,PA,USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073734860","display_name":"Alison M. Pouch","orcid":"https://orcid.org/0000-0001-8854-5301"},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alison M. Pouch","raw_affiliation_strings":["University of Pennsylvania,Philadelphia,PA,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania,Philadelphia,PA,USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"2025","issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9944999814033508,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9944999814033508,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10983","display_name":"Aortic aneurysm repair treatments","score":0.9825999736785889,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10618","display_name":"Aortic Disease and Treatment Approaches","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bicuspid-aortic-valve","display_name":"Bicuspid aortic valve","score":0.9038060903549194},{"id":"https://openalex.org/keywords/aortic-valve","display_name":"Aortic valve","score":0.5581793189048767},{"id":"https://openalex.org/keywords/surgical-planning","display_name":"Surgical planning","score":0.5400022268295288},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5276039242744446},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.4109608232975006},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.40985730290412903},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.3888528347015381}],"concepts":[{"id":"https://openalex.org/C2781355080","wikidata":"https://www.wikidata.org/wiki/Q860167","display_name":"Bicuspid aortic valve","level":3,"score":0.9038060903549194},{"id":"https://openalex.org/C2780714102","wikidata":"https://www.wikidata.org/wiki/Q616071","display_name":"Aortic valve","level":2,"score":0.5581793189048767},{"id":"https://openalex.org/C2779370443","wikidata":"https://www.wikidata.org/wiki/Q1776627","display_name":"Surgical planning","level":2,"score":0.5400022268295288},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5276039242744446},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4109608232975006},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40985730290412903},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3888528347015381}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/isbi60581.2025.10981269","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi60581.2025.10981269","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 22nd International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},{"id":"pmid:40630832","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40630832","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. IEEE International Symposium on Biomedical Imaging","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:12237532","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12237532","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc IEEE Int Symp Biomed Imaging","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:12237532","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12237532","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc IEEE Int Symp Biomed Imaging","raw_type":"Text"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G631933002","display_name":null,"funder_award_id":"R01 HL163202","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6536973286","display_name":null,"funder_award_id":"R01-HL163202","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2555617626","https://openalex.org/W1982035017","https://openalex.org/W2770793773","https://openalex.org/W2038873514","https://openalex.org/W2907247546","https://openalex.org/W2145024053","https://openalex.org/W2134187895","https://openalex.org/W2084976525","https://openalex.org/W2388369356","https://openalex.org/W3013827454"],"abstract_inverted_index":{"The":[0,138],"bicuspid":[1],"aortic":[2,72,186],"valve":[3,106],"(BAV)":[4],"is":[5,27,79],"the":[6,33,46,71,116,120,160,189,224],"most":[7],"prevalent":[8],"congenital":[9],"heart":[10],"defect":[11],"and":[12,22,66,74,89,156,159,176,188,200],"may":[13],"require":[14],"surgery":[15,26],"for":[16,51,87,183,219],"complications":[17],"such":[18],"as":[19],"stenosis,":[20],"regurgitation,":[21],"aortopathy.":[23],"BAV":[24,36,132,206],"repair":[25],"effective":[28],"but":[29,223],"challenging":[30],"due":[31],"to":[32,44,143,230],"heterogeneity":[34],"of":[35,49,70,97,115,119,173,208,227],"morphology.":[37],"Multiple":[38],"imaging":[39],"modalities":[40],"can":[41,214],"be":[42,231],"employed":[43],"assist":[45],"quantitative":[47,113],"assessment":[48,114],"BAVs":[50],"surgical":[52,220],"planning.":[53],"Contrast-enhanced":[54],"4D":[55,212],"computed":[56],"tomography":[57],"(CT)":[58],"produces":[59],"volumetric":[60],"temporal":[61,225],"sequences":[62],"with":[63],"excellent":[64],"contrast":[65],"spatial":[67],"resolution.":[68],"Segmentation":[69],"cusps":[73,187],"root":[75,190],"in":[76,83,211],"these":[77],"images":[78],"an":[80],"essential":[81],"step":[82],"creating":[84],"patient-specific":[85],"models":[86],"visualization":[88],"quantification.":[90],"While":[91],"deep":[92],"learning-based":[93],"methods":[94],"are":[95],"capable":[96],"fully":[98,129,204],"automated":[99,130,205],"segmentation,":[100],"no":[101],"BAV-specific":[102],"model":[103],"exists.":[104],"Among":[105],"segmentation":[107,121,133,168,207],"studies,":[108],"there":[109],"has":[110],"been":[111],"limited":[112],"clinical":[117],"usability":[118],"results.":[122],"In":[123],"this":[124],"work,":[125],"we":[126],"developed":[127],"a":[128],"multi-label":[131],"pipeline":[134],"based":[135],"on":[136],"nnU-Net.":[137],"predicted":[139,201],"segmentations":[140,228],"were":[141,162],"used":[142],"carry":[144],"out":[145],"surgically":[146],"relevant":[147,193],"morphological":[148],"measurements":[149,218],"including":[150],"geometric":[151],"cusp":[152],"height,":[153],"commissural":[154],"angle":[155],"annulus":[157],"diameter,":[158],"results":[161],"compared":[163],"against":[164],"manual":[165,199],"segmentation.":[166],"Automated":[167],"achieved":[169],"average":[170],"Dice":[171],"scores":[172],"over":[174],"0.7":[175,181],"symmetric":[177],"mean":[178],"distance":[179],"below":[180],"mm":[182],"all":[184],"three":[185],"wall.":[191],"Clinically":[192],"benchmarks":[194],"showed":[195],"good":[196],"consistency":[197,226],"between":[198],"segmentations.":[202],"Overall,":[203],"3D":[209],"frames":[210],"CT":[213],"produce":[215],"clinically":[216],"usable":[217],"risk":[221],"stratification,":[222],"needs":[229],"improved.":[232]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}