{"id":"https://openalex.org/W4410296552","doi":"https://doi.org/10.1109/isbi60581.2025.10981230","title":"Using Off-Target-Disease Data to Improve Target-Disease Lesion Segmentation","display_name":"Using Off-Target-Disease Data to Improve Target-Disease Lesion Segmentation","publication_year":2025,"publication_date":"2025-04-14","ids":{"openalex":"https://openalex.org/W4410296552","doi":"https://doi.org/10.1109/isbi60581.2025.10981230"},"language":"en","primary_location":{"id":"doi:10.1109/isbi60581.2025.10981230","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi60581.2025.10981230","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 22nd International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078385256","display_name":"Jingpeng Li","orcid":"https://orcid.org/0000-0002-6758-0084"},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jingpeng Li","raw_affiliation_strings":["Boston Children&#x0027;s Hospital and Harvard Medical School,Boston,MA,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Children&#x0027;s Hospital and Harvard Medical School,Boston,MA,USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064975660","display_name":"Sheng He","orcid":"https://orcid.org/0000-0003-4159-8611"},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheng He","raw_affiliation_strings":["Boston Children&#x0027;s Hospital and Harvard Medical School,Boston,MA,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Children&#x0027;s Hospital and Harvard Medical School,Boston,MA,USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101570496","display_name":"Rina Bao","orcid":"https://orcid.org/0000-0003-2367-2590"},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rina Bao","raw_affiliation_strings":["Boston Children&#x0027;s Hospital and Harvard Medical School,Boston,MA,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Children&#x0027;s Hospital and Harvard Medical School,Boston,MA,USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063053273","display_name":"Atle Bj\u00f8rnerud","orcid":"https://orcid.org/0000-0002-3486-3141"},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Atle Bj\u00f8rnerud","raw_affiliation_strings":["Oslo University Hospital,Oslo,Norway,0372"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oslo University Hospital,Oslo,Norway,0372","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069652684","display_name":"P. Ellen Grant","orcid":"https://orcid.org/0000-0003-1005-4013"},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ellen Grant","raw_affiliation_strings":["Boston Children&#x0027;s Hospital and Harvard Medical School,Boston,MA,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Children&#x0027;s Hospital and Harvard Medical School,Boston,MA,USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049789399","display_name":"Yangming Ou","orcid":"https://orcid.org/0000-0002-7726-6208"},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yangming Ou","raw_affiliation_strings":["Boston Children&#x0027;s Hospital and Harvard Medical School,Boston,MA,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Children&#x0027;s Hospital and Harvard Medical School,Boston,MA,USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14321838,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.8133999705314636,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.8133999705314636,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6410011053085327},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5609008073806763},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.5420042872428894},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5310965776443481},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.48168763518333435},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.4506792724132538},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3778415024280548},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2366926372051239},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.1336120069026947}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6410011053085327},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5609008073806763},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.5420042872428894},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5310965776443481},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.48168763518333435},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.4506792724132538},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3778415024280548},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2366926372051239},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1336120069026947}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi60581.2025.10981230","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi60581.2025.10981230","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 22nd International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4379231730","https://openalex.org/W4389858081","https://openalex.org/W2501551404","https://openalex.org/W4298131179","https://openalex.org/W2113201962","https://openalex.org/W4385583601","https://openalex.org/W4395685956","https://openalex.org/W3159516372","https://openalex.org/W4398146871","https://openalex.org/W1522196789"],"abstract_inverted_index":{"Does":[0],"increasing":[1],"the":[2,10,62,106,125,131,137,142,149,156],"training":[3,112,121,145],"data":[4,92],"in":[5,103],"deep":[6,83],"learning":[7],"always":[8],"improve":[9],"accuracy":[11,104,150],"of":[12,25,61,151],"lesion":[13,27,80,153],"segmentation":[14,28,81,154],"on":[15,29,66,105,136,155],"brain":[16,32,64,74],"MRIs?":[17],"To":[18,114],"answer":[19],"this":[20],"question,":[21],"we":[22,117],"conduct":[23],"experiments":[24],"small-diffuse":[26,152],"8":[30],"public":[31],"MRI":[33,65],"datasets":[34],"with":[35],"3":[36],"different":[37],"diseases,":[38],"including":[39],"Multiple":[40],"Sclerosis":[41],"(MS),":[42],"White":[43],"Matter":[44],"Hyperintensities":[45],"(WMH),":[46],"and":[47],"Chronic":[48],"Stroke":[49],"(CS).":[50],"These":[51],"diseases":[52,96,129,139],"all":[53],"have":[54],"small":[55],"lesions":[56],"(lesions":[57],"occupying":[58],"<":[59],"2%":[60],"whole":[63],"average)":[67],"that":[68,89,141],"are":[69],"often":[70,97],"diffuse":[71],"(injuring":[72],"multiple":[73],"regions),":[75],"posing":[76],"considerable":[77],"challenges":[78],"for":[79],"using":[82,109],"learning.":[84],"Our":[85],"experimental":[86],"results":[87],"show":[88,140],"adding":[90],"more":[91],"from":[93,127],"other":[94],"off-target":[95,128],"led":[98],"to":[99,123,130],"a":[100,110,119],"surprising":[101],"decrease":[102],"target":[107,132],"disease":[108],"Na\u00efve":[111],"strategy.":[113],"address":[115],"this,":[116],"propose":[118],"disease-switch":[120,144],"strategy":[122,146],"learn":[124],"knowledge":[126],"disease.":[133],"The":[134],"accuracies":[135],"three":[138,157],"proposed":[143],"consistently":[147],"improves":[148],"diseases.":[158]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}