{"id":"https://openalex.org/W4410295428","doi":"https://doi.org/10.1109/isbi60581.2025.10981228","title":"A Bayesian Method for Tracing Filamentous Structures in Cryo-Electron Microscopy Images","display_name":"A Bayesian Method for Tracing Filamentous Structures in Cryo-Electron Microscopy Images","publication_year":2025,"publication_date":"2025-04-14","ids":{"openalex":"https://openalex.org/W4410295428","doi":"https://doi.org/10.1109/isbi60581.2025.10981228"},"language":"en","primary_location":{"id":"doi:10.1109/isbi60581.2025.10981228","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi60581.2025.10981228","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 22nd International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014691822","display_name":"Mingtao Huang","orcid":"https://orcid.org/0000-0002-8367-569X"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingtao Huang","raw_affiliation_strings":["Tsinghua University,Department of Electronic Engineering,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tsinghua University,Department of Electronic Engineering,China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101883892","display_name":"Tianyuan Li","orcid":"https://orcid.org/0000-0003-3883-8813"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianyuan Li","raw_affiliation_strings":["Tsinghua University,Department of Electronic Engineering,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tsinghua University,Department of Electronic Engineering,China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056872955","display_name":"Weilin Huang","orcid":"https://orcid.org/0000-0003-1692-4868"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weilin Huang","raw_affiliation_strings":["Tsinghua University,Department of Electronic Engineering,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tsinghua University,Department of Electronic Engineering,China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100421871","display_name":"Xueming Li","orcid":"https://orcid.org/0000-0002-8451-9947"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xueming Li","raw_affiliation_strings":["School of Life Sciences, Tsinghua University,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Tsinghua University,China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052022779","display_name":"Yuan Shen","orcid":"https://orcid.org/0000-0002-9396-1964"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Shen","raw_affiliation_strings":["Tsinghua University,Department of Electronic Engineering,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tsinghua University,Department of Electronic Engineering,China","institution_ids":["https://openalex.org/I99065089"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08498799,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12039","display_name":"Electron and X-Ray Spectroscopy Techniques","score":0.9918000102043152,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12039","display_name":"Electron and X-Ray Spectroscopy Techniques","score":0.9918000102043152,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.9764000177383423,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tracing","display_name":"Tracing","score":0.6529903411865234},{"id":"https://openalex.org/keywords/electron-microscope","display_name":"Electron microscope","score":0.6040342450141907},{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.5747586488723755},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.49854230880737305},{"id":"https://openalex.org/keywords/cryo-electron-microscopy","display_name":"Cryo-electron microscopy","score":0.4865114092826843},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4748663902282715},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.4104066491127014},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.2725149095058441},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.20570743083953857},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.1998317539691925},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.14785027503967285}],"concepts":[{"id":"https://openalex.org/C138673069","wikidata":"https://www.wikidata.org/wiki/Q322229","display_name":"Tracing","level":2,"score":0.6529903411865234},{"id":"https://openalex.org/C93877712","wikidata":"https://www.wikidata.org/wiki/Q132560","display_name":"Electron microscope","level":2,"score":0.6040342450141907},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.5747586488723755},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.49854230880737305},{"id":"https://openalex.org/C20702342","wikidata":"https://www.wikidata.org/wiki/Q5190506","display_name":"Cryo-electron microscopy","level":2,"score":0.4865114092826843},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4748663902282715},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.4104066491127014},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.2725149095058441},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.20570743083953857},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1998317539691925},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14785027503967285},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi60581.2025.10981228","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi60581.2025.10981228","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 22nd International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W2072404529","https://openalex.org/W2144526119","https://openalex.org/W2160010342","https://openalex.org/W2299689158","https://openalex.org/W2587625522","https://openalex.org/W2771893808","https://openalex.org/W2951384153","https://openalex.org/W2952729952","https://openalex.org/W3009153763","https://openalex.org/W3036690596","https://openalex.org/W4229041984","https://openalex.org/W4386362623","https://openalex.org/W4392101216"],"related_works":["https://openalex.org/W1995785876","https://openalex.org/W1971080731","https://openalex.org/W2106173226","https://openalex.org/W3169882331","https://openalex.org/W1506992858","https://openalex.org/W3111994488","https://openalex.org/W168865677","https://openalex.org/W2072424450","https://openalex.org/W2567303839","https://openalex.org/W1520158892"],"abstract_inverted_index":{"To":[0],"reveal":[1],"the":[2,15,59,75,94],"structures":[3],"and":[4,53,74],"functions":[5],"of":[6,14,61,78,96],"filamentous":[7],"assemblies":[8],"using":[9],"cryo-electron":[10],"microscopy":[11],"(Cryo-EM),":[12],"one":[13],"most":[16],"crucial":[17],"yet":[18],"labor-intensive":[19],"tasks":[20],"is":[21],"filament":[22,32,51,111],"tracing.":[23],"Existing":[24],"tracing":[25,52,82],"algorithms":[26],"are":[27],"designed":[28],"primarily":[29],"for":[30,50],"sparse":[31],"networks,":[33],"often":[34],"resulting":[35],"in":[36,39,108],"missed":[37],"detection":[38],"dense":[40,110],"configurations.":[41],"In":[42,99],"this":[43],"paper,":[44],"we":[45],"established":[46],"a":[47,63],"Bayesian":[48],"framework":[49],"proposed":[54],"an":[55],"algorithm":[56],"based":[57],"on":[58,84,89],"principle":[60],"maximum":[62],"posteriori":[64],"probability":[65],"(MAP)":[66],"estimation.":[67],"Our":[68],"approach":[69],"simultaneously":[70],"considers":[71],"observed":[72],"data":[73],"continuous":[76],"nature":[77],"filaments,":[79],"achieving":[80],"precise":[81],"even":[83],"challenging":[85],"datasets.":[86],"Experimental":[87],"results":[88],"diverse":[90],"real":[91],"images":[92],"demonstrate":[93],"robustness":[95],"our":[97],"method.":[98],"particular,":[100],"it":[101],"achieves":[102],"superior":[103],"performance":[104],"over":[105],"existing":[106],"techniques":[107],"handling":[109],"networks.":[112]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}