{"id":"https://openalex.org/W4410297919","doi":"https://doi.org/10.1109/isbi60581.2025.10981202","title":"Auxiliary Cyclegan-Guided Task-Aware Domain Translation from Duplex to Monoplex IHC Images","display_name":"Auxiliary Cyclegan-Guided Task-Aware Domain Translation from Duplex to Monoplex IHC Images","publication_year":2025,"publication_date":"2025-04-14","ids":{"openalex":"https://openalex.org/W4410297919","doi":"https://doi.org/10.1109/isbi60581.2025.10981202"},"language":"en","primary_location":{"id":"doi:10.1109/isbi60581.2025.10981202","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi60581.2025.10981202","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 22nd International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019149764","display_name":"Nicolas Brieu","orcid":"https://orcid.org/0000-0001-8791-8022"},"institutions":[{"id":"https://openalex.org/I4210159719","display_name":"AstraZeneca (Germany)","ror":"https://ror.org/054q96n74","country_code":"DE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210159719"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nicolas Brieu","raw_affiliation_strings":["Oncology Research and Development,AstraZeneca Computational Pathology,Munich,Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Research and Development,AstraZeneca Computational Pathology,Munich,Germany","institution_ids":["https://openalex.org/I4210159719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011200227","display_name":"Nicolas Triltsch","orcid":null},"institutions":[{"id":"https://openalex.org/I4210159719","display_name":"AstraZeneca (Germany)","ror":"https://ror.org/054q96n74","country_code":"DE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210159719"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nicolas Triltsch","raw_affiliation_strings":["Oncology Research and Development,AstraZeneca Computational Pathology,Munich,Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Research and Development,AstraZeneca Computational Pathology,Munich,Germany","institution_ids":["https://openalex.org/I4210159719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012180250","display_name":"Philipp Wortmann","orcid":"https://orcid.org/0000-0001-7325-3031"},"institutions":[{"id":"https://openalex.org/I4210159719","display_name":"AstraZeneca (Germany)","ror":"https://ror.org/054q96n74","country_code":"DE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210159719"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Philipp Wortmann","raw_affiliation_strings":["Oncology Research and Development,AstraZeneca Computational Pathology,Munich,Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Research and Development,AstraZeneca Computational Pathology,Munich,Germany","institution_ids":["https://openalex.org/I4210159719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109892108","display_name":"Dominik Winter","orcid":null},"institutions":[{"id":"https://openalex.org/I4210159719","display_name":"AstraZeneca (Germany)","ror":"https://ror.org/054q96n74","country_code":"DE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210159719"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dominik Winter","raw_affiliation_strings":["Oncology Research and Development,AstraZeneca Computational Pathology,Munich,Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Research and Development,AstraZeneca Computational Pathology,Munich,Germany","institution_ids":["https://openalex.org/I4210159719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038418823","display_name":"Shashank Saran","orcid":"https://orcid.org/0009-0005-6212-8450"},"institutions":[{"id":"https://openalex.org/I4210116875","display_name":"AstraZeneca (Brazil)","ror":"https://ror.org/026m9xy48","country_code":"BR","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210116875"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Shashank Saran","raw_affiliation_strings":["Oncology Research and Development,AstraZeneca Translational Pathology,Gaithersburg,US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Research and Development,AstraZeneca Translational Pathology,Gaithersburg,US","institution_ids":["https://openalex.org/I4210116875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109358604","display_name":"Marlon C. Rebelatto","orcid":null},"institutions":[{"id":"https://openalex.org/I4210116875","display_name":"AstraZeneca (Brazil)","ror":"https://ror.org/026m9xy48","country_code":"BR","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210116875"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marlon Rebelatto","raw_affiliation_strings":["Oncology Research and Development,AstraZeneca Translational Pathology,Gaithersburg,US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Research and Development,AstraZeneca Translational Pathology,Gaithersburg,US","institution_ids":["https://openalex.org/I4210116875"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048610000","display_name":"G\u00fcnter Schmidt","orcid":null},"institutions":[{"id":"https://openalex.org/I4210159719","display_name":"AstraZeneca (Germany)","ror":"https://ror.org/054q96n74","country_code":"DE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210159719"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G\u00fcnter Schmidt","raw_affiliation_strings":["Oncology Research and Development,AstraZeneca Computational Pathology,Munich,Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Research and Development,AstraZeneca Computational Pathology,Munich,Germany","institution_ids":["https://openalex.org/I4210159719"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13114","display_name":"Image Processing Techniques and Applications","score":0.932200014591217,"subfield":{"id":"https://openalex.org/subfields/2214","display_name":"Media Technology"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13114","display_name":"Image Processing Techniques and Applications","score":0.932200014591217,"subfield":{"id":"https://openalex.org/subfields/2214","display_name":"Media Technology"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9241999983787537,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7072301506996155},{"id":"https://openalex.org/keywords/task","display_name":"Task (project management)","score":0.578389585018158},{"id":"https://openalex.org/keywords/domain","display_name":"Domain (mathematical analysis)","score":0.5591859221458435},{"id":"https://openalex.org/keywords/natural-language-processing","display_name":"Natural language processing","score":0.4964650273323059},{"id":"https://openalex.org/keywords/translation","display_name":"Translation (biology)","score":0.48915722966194153},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4020546078681946},{"id":"https://openalex.org/keywords/linguistics","display_name":"Linguistics","score":0.3603828549385071},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.12459194660186768},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.1103748083114624},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.10776874423027039}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7072301506996155},{"id":"https://openalex.org/C2780451532","wikidata":"https://www.wikidata.org/wiki/Q759676","display_name":"Task (project management)","level":2,"score":0.578389585018158},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.5591859221458435},{"id":"https://openalex.org/C204321447","wikidata":"https://www.wikidata.org/wiki/Q30642","display_name":"Natural language processing","level":1,"score":0.4964650273323059},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.48915722966194153},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4020546078681946},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.3603828549385071},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.12459194660186768},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1103748083114624},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.10776874423027039},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi60581.2025.10981202","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi60581.2025.10981202","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 22nd International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W2593414223","https://openalex.org/W2962793481","https://openalex.org/W2962793691","https://openalex.org/W2963073614","https://openalex.org/W3092982296","https://openalex.org/W3202416270","https://openalex.org/W3209390330","https://openalex.org/W4213316317","https://openalex.org/W4318014893","https://openalex.org/W4390031214","https://openalex.org/W4399042410","https://openalex.org/W6765117331","https://openalex.org/W6839267659"],"related_works":["https://openalex.org/W4389443772","https://openalex.org/W2512040214","https://openalex.org/W2548721895","https://openalex.org/W2778913187","https://openalex.org/W2373456246","https://openalex.org/W1966038327","https://openalex.org/W2413419736","https://openalex.org/W4238809000","https://openalex.org/W2095245134","https://openalex.org/W2786646446"],"abstract_inverted_index":{"Generative":[0,23],"models":[1,13],"enable":[2],"the":[3,33,43,54,94,114,117],"translation":[4,55,96],"from":[5,97],"a":[6,73,79,109],"source":[7],"image":[8,90],"domain":[9,91],"where":[10],"readily":[11],"trained":[12],"are":[14,27],"available":[15],"to":[16,92,99],"an":[17,39,86],"unseen":[18],"target":[19],"domain.":[20],"While":[21],"Cycle":[22],"Adversarial":[24],"Networks":[25],"(CycleGANs)":[26],"commonly":[28],"used":[29],"for":[30,53],"unpaired":[31,89],"translation,":[32],"associated":[34],"cycle":[35],"consistency":[36],"constrain":[37],"assumes":[38],"invertible":[40],"mapping":[41],"between":[42,56],"two":[44],"domains.":[45],"However,":[46],"this":[47],"assumption":[48],"does":[49],"not":[50],"hold":[51],"true":[52],"images":[57,84],"stained":[58],"with":[59],"chromogenic":[60],"monoplex":[61,100],"and":[62,88,106],"duplex":[63,98],"immunohistochemistry":[64],"(IHC)":[65],"assays.":[66],"To":[67],"address":[68],"this,":[69],"we":[70],"introduce":[71],"of":[72,81,116],"novel":[74],"training":[75],"design":[76],"which":[77],"leverages":[78],"set":[80],"immunofluorescence":[82],"(IF)":[83],"as":[85],"auxiliary":[87],"guide":[93],"direct":[95],"IHC.":[101],"The":[102],"results,":[103],"both":[104],"quantitative":[105],"qualitative,":[107],"on":[108],"downstream":[110],"segmentation":[111],"task":[112],"demonstrate":[113],"advantages":[115],"proposed":[118],"method":[119],"over":[120],"multiple":[121],"baseline":[122],"methods.":[123]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}