{"id":"https://openalex.org/W4410296644","doi":"https://doi.org/10.1109/isbi60581.2025.10981136","title":"Few-Shot Sample-Specific Deep Learning Multiclass Segmentation and Fiber Tractography using 3D-Microscopy with Ultraviolet Surface Excitation (3D-Muse) Images of Human Vagus Nerve","display_name":"Few-Shot Sample-Specific Deep Learning Multiclass Segmentation and Fiber Tractography using 3D-Microscopy with Ultraviolet Surface Excitation (3D-Muse) Images of Human Vagus Nerve","publication_year":2025,"publication_date":"2025-04-14","ids":{"openalex":"https://openalex.org/W4410296644","doi":"https://doi.org/10.1109/isbi60581.2025.10981136"},"language":"en","primary_location":{"id":"doi:10.1109/isbi60581.2025.10981136","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi60581.2025.10981136","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 22nd International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037795294","display_name":"Naomi Joseph","orcid":null},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Naomi Joseph","raw_affiliation_strings":["Case Western Reserve University,Department of Biomedical Engineering,Cleveland,OH,44106"],"affiliations":[{"raw_affiliation_string":"Case Western Reserve University,Department of Biomedical Engineering,Cleveland,OH,44106","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103229239","display_name":"Ian Marshall","orcid":"https://orcid.org/0000-0003-4445-1551"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ian Marshall","raw_affiliation_strings":["Case Western Reserve University,Department of Biomedical Engineering,Cleveland,OH,44106"],"affiliations":[{"raw_affiliation_string":"Case Western Reserve University,Department of Biomedical Engineering,Cleveland,OH,44106","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031834338","display_name":"James M. Seckler","orcid":"https://orcid.org/0000-0003-3895-7257"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Seckler","raw_affiliation_strings":["Case Western Reserve University,Department of Biomedical Engineering,Cleveland,OH,44106"],"affiliations":[{"raw_affiliation_string":"Case Western Reserve University,Department of Biomedical Engineering,Cleveland,OH,44106","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116884072","display_name":"Nathan Petranka","orcid":null},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan Petranka","raw_affiliation_strings":["Case Western Reserve University,Department of Biomedical Engineering,Cleveland,OH,44106"],"affiliations":[{"raw_affiliation_string":"Case Western Reserve University,Department of Biomedical Engineering,Cleveland,OH,44106","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Juri Moon","orcid":null},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juri Moon","raw_affiliation_strings":["Case Western Reserve University,Department of Biomedical Engineering,Cleveland,OH,44106"],"affiliations":[{"raw_affiliation_string":"Case Western Reserve University,Department of Biomedical Engineering,Cleveland,OH,44106","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064135065","display_name":"Kaichen Yu","orcid":null},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaichen Yu","raw_affiliation_strings":["Case Western Reserve University,Department of Biomedical Engineering,Cleveland,OH,44106"],"affiliations":[{"raw_affiliation_string":"Case Western Reserve University,Department of Biomedical Engineering,Cleveland,OH,44106","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Suyash More","orcid":null},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suyash More","raw_affiliation_strings":["Case Western Reserve University,Department of Biomedical Engineering,Cleveland,OH,44106"],"affiliations":[{"raw_affiliation_string":"Case Western Reserve University,Department of Biomedical Engineering,Cleveland,OH,44106","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Vo Linh Chi","orcid":null},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vo Linh Chi","raw_affiliation_strings":["Case Western Reserve University,Department of Biomedical Engineering,Cleveland,OH,44106"],"affiliations":[{"raw_affiliation_string":"Case Western Reserve University,Department of Biomedical Engineering,Cleveland,OH,44106","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016519698","display_name":"Nicole A. Pelot","orcid":"https://orcid.org/0000-0003-2844-0190"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole A. Pelot","raw_affiliation_strings":["Duke University,Department of Biomedical Engineering,Durham,NC,27708"],"affiliations":[{"raw_affiliation_string":"Duke University,Department of Biomedical Engineering,Durham,NC,27708","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046811880","display_name":"Andrew J. Shoffstall","orcid":"https://orcid.org/0000-0002-0881-2180"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Shoffstall","raw_affiliation_strings":["Case Western Reserve University,Department of Biomedical Engineering,Cleveland,OH,44106"],"affiliations":[{"raw_affiliation_string":"Case Western Reserve University,Department of Biomedical Engineering,Cleveland,OH,44106","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086264408","display_name":"Michael W. Jenkins","orcid":"https://orcid.org/0000-0002-8908-5383"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael W. Jenkins","raw_affiliation_strings":["Case Western Reserve University,Department of Biomedical Engineering,Cleveland,OH,44106"],"affiliations":[{"raw_affiliation_string":"Case Western Reserve University,Department of Biomedical Engineering,Cleveland,OH,44106","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059314323","display_name":"David L. Wilson","orcid":"https://orcid.org/0000-0001-9763-1463"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Wilson","raw_affiliation_strings":["Case Western Reserve University,Department of Biomedical Engineering,Cleveland,OH,44106"],"affiliations":[{"raw_affiliation_string":"Case Western Reserve University,Department of Biomedical Engineering,Cleveland,OH,44106","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5037795294"],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09119203,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.8705000281333923,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.8705000281333923,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10863","display_name":"Voice and Speech Disorders","score":0.862500011920929,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tractography","display_name":"Tractography","score":0.583820104598999},{"id":"https://openalex.org/keywords/single-shot","display_name":"Single shot","score":0.5474631190299988},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.5362132787704468},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5017185211181641},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.47857311367988586},{"id":"https://openalex.org/keywords/sample","display_name":"Sample (material)","score":0.4763343930244446},{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.46461689472198486},{"id":"https://openalex.org/keywords/fiber","display_name":"Fiber","score":0.42573416233062744},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.41599223017692566},{"id":"https://openalex.org/keywords/nerve-fiber","display_name":"Nerve fiber","score":0.41079437732696533},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.3619915843009949},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.29436907172203064},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.27411144971847534},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.25637608766555786},{"id":"https://openalex.org/keywords/diffusion-mri","display_name":"Diffusion MRI","score":0.1963385045528412},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.17821639776229858},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.1604766547679901},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.08676889538764954}],"concepts":[{"id":"https://openalex.org/C84787856","wikidata":"https://www.wikidata.org/wiki/Q3076659","display_name":"Tractography","level":4,"score":0.583820104598999},{"id":"https://openalex.org/C3019835501","wikidata":"https://www.wikidata.org/wiki/Q1310130","display_name":"Single shot","level":2,"score":0.5474631190299988},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.5362132787704468},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5017185211181641},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.47857311367988586},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.4763343930244446},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.46461689472198486},{"id":"https://openalex.org/C519885992","wikidata":"https://www.wikidata.org/wiki/Q161","display_name":"Fiber","level":2,"score":0.42573416233062744},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.41599223017692566},{"id":"https://openalex.org/C2776823239","wikidata":"https://www.wikidata.org/wiki/Q48834737","display_name":"Nerve fiber","level":2,"score":0.41079437732696533},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3619915843009949},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.29436907172203064},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.27411144971847534},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.25637608766555786},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.1963385045528412},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17821639776229858},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.1604766547679901},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.08676889538764954},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi60581.2025.10981136","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi60581.2025.10981136","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 22nd International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1578285471","https://openalex.org/W2035379092","https://openalex.org/W2097925212","https://openalex.org/W2330479957","https://openalex.org/W2337818477","https://openalex.org/W2624453644","https://openalex.org/W2898529289","https://openalex.org/W2912684384","https://openalex.org/W2914190779","https://openalex.org/W2923997689","https://openalex.org/W2998733648","https://openalex.org/W3095110852","https://openalex.org/W3180612993","https://openalex.org/W4221003229","https://openalex.org/W4283069672","https://openalex.org/W4324134283","https://openalex.org/W4378803142","https://openalex.org/W4399766140","https://openalex.org/W4402083402"],"related_works":["https://openalex.org/W2159208769","https://openalex.org/W2550828940","https://openalex.org/W2951846649","https://openalex.org/W2801933823","https://openalex.org/W2100478897","https://openalex.org/W4380353731","https://openalex.org/W2611398135","https://openalex.org/W4319733470","https://openalex.org/W4200499527","https://openalex.org/W3200881363"],"abstract_inverted_index":{"At":[0],"CWRU,":[1],"the":[2,9,24,44],"Reconstructing":[3],"Vagal":[4],"Anatomy":[5],"(REVA)":[6],"project":[7],"images":[8],"vagal":[10],"complex":[11],"from":[12],"brainstem":[13],"to":[14,69,130],"abdomen":[15],"using":[16],"multiple":[17],"modalities":[18],"and":[19,41,46,57,73,106,123,126,133,141],"resolutions.":[20],"Here":[21],"we":[22,84],"describe":[23],"analysis":[25],"of":[26,43,48,65,99],"3D":[27],"Microscopy":[28],"with":[29,89,101,108],"Ultraviolet":[30],"Surface":[31],"Excitation":[32],"(3D-MUSE),":[33],"a":[34,77,86],"section-and-image":[35],"system":[36],"that":[37],"enables":[38],"microscopic":[39],"visualization":[40],"quantification":[42],"morphology":[45],"microanatomy":[47],"15-mm":[49],"vagus":[50],"nerve":[51,115],"samples.":[52],"Variations":[53],"in":[54],"staining,":[55],"tissue,":[56],"image":[58,112],"quality":[59],"across":[60],"samples":[61],"require":[62],"few-shot":[63],"training":[64,104],"sample-based":[66],"neural":[67],"networks":[68],"segment":[70],"fascicles,":[71],"perineurium,":[72],"epineurium.":[74],"After":[75],"pre-training":[76],"Vision":[78],"Transformer":[79,88],"on":[80],"all":[81],"unlabeled":[82],"images,":[83,105],"fine-tuned":[85],"U-Net":[87],"1-10%":[90],"segmented":[91],"images.":[92],"Highest":[93],"performance":[94],"achieved":[95],"mean":[96],"Dice":[97],"scores":[98],"0.91\u00b10.02":[100],"1%":[102],"(10)":[103],"0.94\u00b10.01":[107],"4%":[109],"(40)":[110],"MUSE":[111],"segmentations":[113],"reveal":[114],"density":[116],"variations,":[117],"positive":[118],"correlation":[119],"between":[120],"perineurium":[121],"thickness":[122,127],"fascicle":[124,131,147],"diameter,":[125],"variation":[128],"due":[129],"splits":[132],"merges.":[134],"Fiber":[135],"tractography":[136],"reveals":[137],"dynamic":[138],"fascicular":[139],"organization":[140],"requires":[142],"further":[143],"investigation":[144],"into":[145],"small":[146],"(<150\u00b5m-diameter)":[148],"behavior.":[149]},"counts_by_year":[],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
