{"id":"https://openalex.org/W4410295256","doi":"https://doi.org/10.1109/isbi60581.2025.10981025","title":"Multicenter Radiomic Feature-Based Prediction of PD-L1 Status in Lung Cancer Using Multimodal PET/CT","display_name":"Multicenter Radiomic Feature-Based Prediction of PD-L1 Status in Lung Cancer Using Multimodal PET/CT","publication_year":2025,"publication_date":"2025-04-14","ids":{"openalex":"https://openalex.org/W4410295256","doi":"https://doi.org/10.1109/isbi60581.2025.10981025"},"language":"en","primary_location":{"id":"doi:10.1109/isbi60581.2025.10981025","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi60581.2025.10981025","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 22nd International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029673123","display_name":"Ronrick Da\u2010ano","orcid":"https://orcid.org/0000-0002-5730-4211"},"institutions":[{"id":"https://openalex.org/I4210161065","display_name":"Laboratoire de Traitement de l'Information M\u00e9dicale","ror":"https://ror.org/05mqemx33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105774","https://openalex.org/I4210161065"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"R. Da-Ano","raw_affiliation_strings":["LaTIM UMR 1101, Inserm,Brest,France"],"affiliations":[{"raw_affiliation_string":"LaTIM UMR 1101, Inserm,Brest,France","institution_ids":["https://openalex.org/I4210161065","https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000806340","display_name":"Olena Tankyevych","orcid":null},"institutions":[{"id":"https://openalex.org/I4210161065","display_name":"Laboratoire de Traitement de l'Information M\u00e9dicale","ror":"https://ror.org/05mqemx33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105774","https://openalex.org/I4210161065"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"O. Tankyevych","raw_affiliation_strings":["LaTIM UMR 1101, Inserm,Brest,France"],"affiliations":[{"raw_affiliation_string":"LaTIM UMR 1101, Inserm,Brest,France","institution_ids":["https://openalex.org/I4210161065","https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117517630","display_name":"N. Lem\u00e9e","orcid":null},"institutions":[{"id":"https://openalex.org/I32881790","display_name":"Universit\u00e9 de Poitiers","ror":"https://ror.org/04xhy8q59","country_code":"FR","type":"education","lineage":["https://openalex.org/I32881790"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"N. Lem\u00e9e","raw_affiliation_strings":["University Hospital of Poitiers,Nuclear Medicine,Poitiers,France"],"affiliations":[{"raw_affiliation_string":"University Hospital of Poitiers,Nuclear Medicine,Poitiers,France","institution_ids":["https://openalex.org/I32881790"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014378078","display_name":"Ioanna Stamouli","orcid":null},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"I. Stamouli","raw_affiliation_strings":["University of Patras,3DMI research group,Department of Medical Physics,Patras,Greece"],"affiliations":[{"raw_affiliation_string":"University of Patras,3DMI research group,Department of Medical Physics,Patras,Greece","institution_ids":["https://openalex.org/I174878644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018902188","display_name":"George C. Kagadis","orcid":"https://orcid.org/0000-0002-6983-2863"},"institutions":[{"id":"https://openalex.org/I174878644","display_name":"University of Patras","ror":"https://ror.org/017wvtq80","country_code":"GR","type":"education","lineage":["https://openalex.org/I174878644"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"G. Kagadis","raw_affiliation_strings":["University of Patras,3DMI research group,Department of Medical Physics,Patras,Greece"],"affiliations":[{"raw_affiliation_string":"University of Patras,3DMI research group,Department of Medical Physics,Patras,Greece","institution_ids":["https://openalex.org/I174878644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080021938","display_name":"T. Kalathas","orcid":null},"institutions":[{"id":"https://openalex.org/I4210087568","display_name":"Theageneio General Hospital","ror":"https://ror.org/004hfxk38","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210087568"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"T. Kalathas","raw_affiliation_strings":["Cancer Hospital of Thessaloniki,Nuclear Medicine Department,Thessaloniki,Greece"],"affiliations":[{"raw_affiliation_string":"Cancer Hospital of Thessaloniki,Nuclear Medicine Department,Thessaloniki,Greece","institution_ids":["https://openalex.org/I4210087568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083651238","display_name":"Kuangyu Shi","orcid":"https://orcid.org/0000-0002-8714-3084"},"institutions":[{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]},{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"K. Shi","raw_affiliation_strings":["University of Bern,Lab for Artificial Intelligence Translational Theranostics,Dept. Nuclear Medicine, Inselspital,Switzerland"],"affiliations":[{"raw_affiliation_string":"University of Bern,Lab for Artificial Intelligence Translational Theranostics,Dept. Nuclear Medicine, Inselspital,Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071890065","display_name":"Jicun Hu","orcid":"https://orcid.org/0000-0002-6742-6335"},"institutions":[{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]},{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"J. Hu","raw_affiliation_strings":["University of Bern,Lab for Artificial Intelligence Translational Theranostics,Dept. Nuclear Medicine, Inselspital,Switzerland"],"affiliations":[{"raw_affiliation_string":"University of Bern,Lab for Artificial Intelligence Translational Theranostics,Dept. Nuclear Medicine, Inselspital,Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100460768","display_name":"Hui Wang","orcid":"https://orcid.org/0000-0002-3394-1531"},"institutions":[{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"H. Wang","raw_affiliation_strings":["Ruijin Hospital, Shanghai Jiaotong University,Department of Nuclear Medicine,Shanghai,China"],"affiliations":[{"raw_affiliation_string":"Ruijin Hospital, Shanghai Jiaotong University,Department of Nuclear Medicine,Shanghai,China","institution_ids":["https://openalex.org/I2801556517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084710251","display_name":"Catherine Cheze Le Rest","orcid":"https://orcid.org/0000-0001-9779-9135"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210161065","display_name":"Laboratoire de Traitement de l'Information M\u00e9dicale","ror":"https://ror.org/05mqemx33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105774","https://openalex.org/I4210161065"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C. Cheze Le Rest","raw_affiliation_strings":["LaTIM UMR 1101, Inserm,Brest,France"],"affiliations":[{"raw_affiliation_string":"LaTIM UMR 1101, Inserm,Brest,France","institution_ids":["https://openalex.org/I4210161065","https://openalex.org/I154526488"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017138072","display_name":"Dimitris Visvikis","orcid":"https://orcid.org/0000-0003-0831-3637"},"institutions":[{"id":"https://openalex.org/I4210161065","display_name":"Laboratoire de Traitement de l'Information M\u00e9dicale","ror":"https://ror.org/05mqemx33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210105774","https://openalex.org/I4210161065"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"D. Visvikis","raw_affiliation_strings":["LaTIM UMR 1101, Inserm,Brest,France"],"affiliations":[{"raw_affiliation_string":"LaTIM UMR 1101, Inserm,Brest,France","institution_ids":["https://openalex.org/I4210161065","https://openalex.org/I154526488"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5029673123"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210161065"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18440662,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.994700014591217,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.6426079273223877},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.6189345121383667},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5083152651786804},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.49079689383506775},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4886491894721985},{"id":"https://openalex.org/keywords/multimodal-therapy","display_name":"Multimodal therapy","score":0.4344669282436371},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.37141868472099304},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.32198983430862427},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.22559401392936707},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.12344041466712952}],"concepts":[{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6426079273223877},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.6189345121383667},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5083152651786804},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.49079689383506775},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4886491894721985},{"id":"https://openalex.org/C4441509","wikidata":"https://www.wikidata.org/wiki/Q6418787","display_name":"Multimodal therapy","level":2,"score":0.4344669282436371},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.37141868472099304},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32198983430862427},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.22559401392936707},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12344041466712952},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi60581.2025.10981025","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi60581.2025.10981025","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 22nd International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7799999713897705,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W2156835537","https://openalex.org/W2339631364","https://openalex.org/W2535300095","https://openalex.org/W2747522459","https://openalex.org/W2923501617","https://openalex.org/W2946119674","https://openalex.org/W3022063449","https://openalex.org/W3038062368","https://openalex.org/W3082777092","https://openalex.org/W3092062217","https://openalex.org/W3124556679","https://openalex.org/W3136207749","https://openalex.org/W4293476620"],"related_works":["https://openalex.org/W2064573700","https://openalex.org/W4292002379","https://openalex.org/W2376385980","https://openalex.org/W2967366602","https://openalex.org/W2186113122","https://openalex.org/W1496498748","https://openalex.org/W1523310174","https://openalex.org/W2129774558","https://openalex.org/W2358901620","https://openalex.org/W1997032381"],"abstract_inverted_index":{"With":[0],"the":[1,39,99,146,157],"growing":[2],"utilization":[3],"of":[4,33,41,53,169],"immune":[5],"checkpoint":[6],"inhibitors":[7],"(ICIs),":[8],"there":[9],"is":[10,36],"an":[11],"urgent":[12],"need":[13],"to":[14,37,90,108,205,210,223],"identify":[15],"biomarkers":[16,45],"that":[17],"can":[18,202],"stratify":[19],"patients":[20,68],"into":[21],"responders":[22],"and":[23,48,79,104,131,151,189,226],"non-responders":[24],"based":[25,125],"on":[26,126],"programmed":[27],"death-ligand":[28],"(PD-L1)":[29],"expression.":[30,96],"The":[31],"aim":[32],"this":[34],"study":[35,61],"determine":[38],"feasibility":[40],"building":[42],"imaging-based":[43],"predictive":[44,92],"for":[46,70,94],"PD-L1":[47,95,110,212],"system-atically":[49],"evaluating":[50],"a":[51],"combination":[52],"several":[54],"machine":[55,207],"learning":[56,208],"algorithms.":[57],"A":[58],"retrospective,":[59],"multicenter":[60],"was":[62],"conducted":[63],"involving":[64],"467":[65],"advanced":[66],"NSCLC":[67],"eligible":[69],"ICIs":[71],"across":[72],"four":[73],"various":[74],"centers":[75],"(France,":[76],"China,":[77],"Greece":[78],"Switzerland).":[80],"Radiomic":[81],"features":[82,150,201],"derived":[83],"from":[84],"pretreatment":[85],"PET/CT":[86],"scans":[87],"were":[88,112,152],"used":[89,144,204],"construct":[91],"models":[93,107,216],"After":[97],"splitting":[98],"data":[100],"70/30":[101],"in":[102,179,187,194,220],"training":[103],"testing":[105],"sets,":[106],"predict":[109,211],"status":[111],"built":[113],"using":[114,154],"multivariate":[115],"regression":[116],"(MR)":[117],"with":[118,137,181],"10-fold":[119],"cross":[120],"validation":[121],"after":[122],"feature":[123,139],"selection":[124],"LASSO,":[127],"Random":[128],"Forest":[129],"(RF)":[130],"Support":[132],"Vector":[133],"Machine":[134],"(SVM)":[135],"both":[136],"embedded":[138],"selection.":[140],"All":[141],"three":[142],"pipelines":[143],"either":[145],"untransformed":[147,174],"or":[148],"harmonized":[149],"compared":[153],"Area":[155],"Under":[156],"Curves":[158],"(AUC).":[159],"Among":[160],"all":[161],"3":[162],"models,":[163],"ComBat":[164],"versions":[165],"(whether":[166],"pooled":[167],"together":[168],"split":[170],"by":[171],"centers)":[172],"out-performed":[173],"(AUC":[175],"0.76":[176],"vs.":[177,185,192],"0.70,":[178],"MR":[180],"Lasso,":[182],"AUC":[183,190],"0.78":[184],"0.73,":[186],"RF,":[188],"0.75":[191],"0.72,":[193],"SVM).":[195],"This":[196],"results":[197],"explain":[198],"how":[199],"radiomics":[200],"be":[203,218],"train":[206],"algorithms":[209],"expression":[213],"status.":[214],"Such":[215],"should":[217],"considered":[219],"future":[221],"investigations":[222],"build":[224],"robust":[225],"clinically":[227],"relevant":[228],"pre-dictive":[229],"models.":[230]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}