{"id":"https://openalex.org/W4410295314","doi":"https://doi.org/10.1109/isbi60581.2025.10980971","title":"Versatile Stain Transfer in Histopathology Using a Unified Diffusion Framework","display_name":"Versatile Stain Transfer in Histopathology Using a Unified Diffusion Framework","publication_year":2025,"publication_date":"2025-04-14","ids":{"openalex":"https://openalex.org/W4410295314","doi":"https://doi.org/10.1109/isbi60581.2025.10980971"},"language":"en","primary_location":{"id":"doi:10.1109/isbi60581.2025.10980971","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi60581.2025.10980971","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 22nd International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029017875","display_name":"Xudong Yan","orcid":"https://orcid.org/0000-0001-5302-2850"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xudong Yan","raw_affiliation_strings":["Peking University,Beijing,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peking University,Beijing,China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021464875","display_name":"Mingze Yuan","orcid":null},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingze Yuan","raw_affiliation_strings":["Peking University,Beijing,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peking University,Beijing,China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001787815","display_name":"Yao Lu","orcid":"https://orcid.org/0000-0001-8511-3642"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210130930","display_name":"Peking University First Hospital","ror":"https://ror.org/02z1vqm45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yao Lu","raw_affiliation_strings":["Peking University First Hospital,Beijing,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peking University First Hospital,Beijing,China","institution_ids":["https://openalex.org/I4210130930","https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100386104","display_name":"Ying Zhang","orcid":"https://orcid.org/0000-0002-2674-1638"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Zhang","raw_affiliation_strings":["Peking University,Beijing,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peking University,Beijing,China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019559271","display_name":"Zifan Chen","orcid":"https://orcid.org/0000-0002-1928-3755"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zifan Chen","raw_affiliation_strings":["Peking University,Beijing,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peking University,Beijing,China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067190598","display_name":"Peng Bao","orcid":"https://orcid.org/0000-0002-7875-7420"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Bao","raw_affiliation_strings":["Peking University,Beijing,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peking University,Beijing,China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100722189","display_name":"Zehua Li","orcid":"https://orcid.org/0009-0007-7407-8758"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210130930","display_name":"Peking University First Hospital","ror":"https://ror.org/02z1vqm45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zehua Li","raw_affiliation_strings":["Peking University First Hospital,Beijing,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peking University First Hospital,Beijing,China","institution_ids":["https://openalex.org/I4210130930","https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101641531","display_name":"Bin Dong","orcid":"https://orcid.org/0000-0003-1869-3784"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Dong","raw_affiliation_strings":["Peking University,Beijing,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peking University,Beijing,China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100421479","display_name":"Yang Li","orcid":"https://orcid.org/0000-0002-2955-0298"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210130930","display_name":"Peking University First Hospital","ror":"https://ror.org/02z1vqm45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Yang","raw_affiliation_strings":["Peking University First Hospital,Beijing,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peking University First Hospital,Beijing,China","institution_ids":["https://openalex.org/I4210130930","https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100425448","display_name":"Li Zhang","orcid":"https://orcid.org/0000-0001-7914-0679"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Zhang","raw_affiliation_strings":["Peking University,Beijing,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peking University,Beijing,China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091906220","display_name":"Fangxu Zhou","orcid":null},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fangxu Zhou","raw_affiliation_strings":["Peking University,Beijing,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peking University,Beijing,China","institution_ids":["https://openalex.org/I20231570"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.5175,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.92410121,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9110000133514404,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6380533576011658},{"id":"https://openalex.org/keywords/diffusion","display_name":"Diffusion","score":0.5047813653945923},{"id":"https://openalex.org/keywords/stain","display_name":"Stain","score":0.4631945490837097},{"id":"https://openalex.org/keywords/histopathology","display_name":"Histopathology","score":0.4500187635421753},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.115052729845047},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.10714918375015259},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.06076154112815857},{"id":"https://openalex.org/keywords/thermodynamics","display_name":"Thermodynamics","score":0.057790905237197876},{"id":"https://openalex.org/keywords/staining","display_name":"Staining","score":0.05777156352996826}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6380533576011658},{"id":"https://openalex.org/C69357855","wikidata":"https://www.wikidata.org/wiki/Q163214","display_name":"Diffusion","level":2,"score":0.5047813653945923},{"id":"https://openalex.org/C2781294515","wikidata":"https://www.wikidata.org/wiki/Q2733470","display_name":"Stain","level":3,"score":0.4631945490837097},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.4500187635421753},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.115052729845047},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10714918375015259},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06076154112815857},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.057790905237197876},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.05777156352996826}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi60581.2025.10980971","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi60581.2025.10980971","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 22nd International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W2603777577","https://openalex.org/W2962793481","https://openalex.org/W2962974533","https://openalex.org/W2963073614","https://openalex.org/W2963767194","https://openalex.org/W3034600949","https://openalex.org/W3191728126","https://openalex.org/W3212516020","https://openalex.org/W4283813454","https://openalex.org/W4292089000","https://openalex.org/W4312419008","https://openalex.org/W4312933868","https://openalex.org/W4385283815","https://openalex.org/W4387211463","https://openalex.org/W4390874575","https://openalex.org/W4391109864","https://openalex.org/W6779823529","https://openalex.org/W6795288823","https://openalex.org/W6838639034","https://openalex.org/W6858058756"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3039419443","https://openalex.org/W4386772532","https://openalex.org/W4393212117","https://openalex.org/W2115661411","https://openalex.org/W2399391471","https://openalex.org/W2400254106","https://openalex.org/W2970729894"],"abstract_inverted_index":{"Histological":[0],"staining":[1,20],"is":[2],"vital":[3],"in":[4,62],"clinical":[5],"pathology":[6,146],"for":[7,58,142],"visualizing":[8],"tissue":[9],"structures.":[10],"However,":[11],"these":[12],"techniques":[13],"are":[14],"laborious":[15],"and":[16,40,68,86,118],"time-consuming.":[17],"Digital":[18],"virtual":[19,137],"offers":[21],"a":[22,53,73,92,109],"promising":[23],"solution,":[24],"but":[25],"existing":[26],"methods":[27],"typically":[28],"rely":[29],"on":[30,108],"Generative":[31],"Adversarial":[32],"Networks":[33],"(GANs),":[34],"which":[35],"may":[36],"suffer":[37],"from":[38],"artifacts":[39],"mode":[41],"collapse.":[42],"Motivated":[43],"by":[44],"the":[45,79,84,98,130,140],"success":[46],"of":[47,82,132],"diffusion":[48,133],"models,":[49],"we":[50,71,90],"present":[51],"DUST,":[52],"novel":[54],"Diffusion-based":[55],"Unified":[56],"framework":[57],"versatile":[59,123],"Stain":[60],"Transfer":[61],"histopathology.":[63],"To":[64],"enhance":[65],"domain":[66],"awareness":[67],"task-specific":[69],"performance,":[70],"propose":[72],"dual":[74],"encoding":[75],"strategy":[76],"that":[77],"integrates":[78],"stain":[80,124],"types":[81],"both":[83],"source":[85],"target":[87],"domains.":[88],"Additionally,":[89],"introduce":[91],"dynamic":[93],"dual-output":[94],"head":[95],"to":[96,135],"address":[97],"unstable":[99],"intensity":[100],"issue":[101],"encountered":[102],"with":[103],"conventional":[104],"DDPM":[105],"implementations.":[106],"Validated":[107],"curated":[110],"four-stain":[111],"kidney":[112],"histopathological":[113],"dataset":[114],"(H&E,":[115],"MT,":[116],"PAS,":[117],"PASM),":[119],"DUST":[120],"demonstrates":[121],"superior":[122],"transfer":[125],"capabilities.":[126],"Our":[127],"research":[128],"highlights":[129],"potential":[131],"models":[134],"advance":[136],"staining,":[138],"paving":[139],"way":[141],"more":[143],"efficient":[144],"digital":[145],"analyses.":[147]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}