{"id":"https://openalex.org/W4410298081","doi":"https://doi.org/10.1109/isbi60581.2025.10980901","title":"Hierarchical Latent Space Clustering for Synthetic Cell Images","display_name":"Hierarchical Latent Space Clustering for Synthetic Cell Images","publication_year":2025,"publication_date":"2025-04-14","ids":{"openalex":"https://openalex.org/W4410298081","doi":"https://doi.org/10.1109/isbi60581.2025.10980901"},"language":"en","primary_location":{"id":"doi:10.1109/isbi60581.2025.10980901","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi60581.2025.10980901","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 22nd International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113577101","display_name":"J.P. Bacon","orcid":null},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Jack Bacon","raw_affiliation_strings":["University of Warwick,Department of Computer Science,Coventry,United Kingdom,CV4 7AL"],"affiliations":[{"raw_affiliation_string":"University of Warwick,Department of Computer Science,Coventry,United Kingdom,CV4 7AL","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038006060","display_name":"Scott Brooks","orcid":null},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Scott Brooks","raw_affiliation_strings":["Centre for Mechanochemical Cell Biology, University of Warwick,Coventry,United Kingdom,CV4 7AL"],"affiliations":[{"raw_affiliation_string":"Centre for Mechanochemical Cell Biology, University of Warwick,Coventry,United Kingdom,CV4 7AL","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081582588","display_name":"Nigel J. Burroughs","orcid":"https://orcid.org/0000-0002-4632-1550"},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nigel J. Burroughs","raw_affiliation_strings":["Centre for Mechanochemical Cell Biology, University of Warwick,Coventry,United Kingdom,CV4 7AL"],"affiliations":[{"raw_affiliation_string":"Centre for Mechanochemical Cell Biology, University of Warwick,Coventry,United Kingdom,CV4 7AL","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045705655","display_name":"Andrew D. McAinsh","orcid":"https://orcid.org/0000-0001-6808-0711"},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew D. McAinsh","raw_affiliation_strings":["Centre for Mechanochemical Cell Biology, University of Warwick,Coventry,United Kingdom,CV4 7AL"],"affiliations":[{"raw_affiliation_string":"Centre for Mechanochemical Cell Biology, University of Warwick,Coventry,United Kingdom,CV4 7AL","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074864006","display_name":"Till Bretschneider","orcid":"https://orcid.org/0000-0002-5317-603X"},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Till Bretschneider","raw_affiliation_strings":["University of Warwick,Department of Computer Science,Coventry,United Kingdom,CV4 7AL"],"affiliations":[{"raw_affiliation_string":"University of Warwick,Department of Computer Science,Coventry,United Kingdom,CV4 7AL","institution_ids":["https://openalex.org/I39555362"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5113577101"],"corresponding_institution_ids":["https://openalex.org/I39555362"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08297751,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10824","display_name":"Image Retrieval and Classification Techniques","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10824","display_name":"Image Retrieval and Classification Techniques","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12874","display_name":"Digital Imaging for Blood Diseases","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.6680781841278076},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.632236897945404},{"id":"https://openalex.org/keywords/space","display_name":"Space (punctuation)","score":0.5403234958648682},{"id":"https://openalex.org/keywords/hierarchical-clustering","display_name":"Hierarchical clustering","score":0.5203613638877869},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4746713638305664},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.45354947447776794}],"concepts":[{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.6680781841278076},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.632236897945404},{"id":"https://openalex.org/C2778572836","wikidata":"https://www.wikidata.org/wiki/Q380933","display_name":"Space (punctuation)","level":2,"score":0.5403234958648682},{"id":"https://openalex.org/C92835128","wikidata":"https://www.wikidata.org/wiki/Q1277447","display_name":"Hierarchical clustering","level":3,"score":0.5203613638877869},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4746713638305664},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.45354947447776794},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/isbi60581.2025.10980901","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi60581.2025.10980901","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 22nd International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},{"id":"pmh:oai:wrap.warwick.ac.uk:189529","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306400665","display_name":"Warwick Research Archive Portal (University of Warwick)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39555362","host_organization_name":"University of Warwick","host_organization_lineage":["https://openalex.org/I39555362"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"NonPeerReviewed"},{"id":"pmh:oai:wrap.warwick.ac.uk:189529","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ISBI60581.2025.10980901","pdf_url":null,"source":{"id":"https://openalex.org/S4306400665","display_name":"Warwick Research Archive Portal (University of Warwick)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39555362","host_organization_name":"University of Warwick","host_organization_lineage":["https://openalex.org/I39555362"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"NonPeerReviewed"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3551890654","display_name":null,"funder_award_id":"MR/R015910/1,2430216","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G6449143542","display_name":null,"funder_award_id":"2882348,EP/V062522/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4298130764","https://openalex.org/W2804364458","https://openalex.org/W2132641928","https://openalex.org/W4310225030","https://openalex.org/W2090259340","https://openalex.org/W1926736923","https://openalex.org/W2158836806","https://openalex.org/W3200375535","https://openalex.org/W2033914206","https://openalex.org/W2042327336"],"abstract_inverted_index":{"We":[0,58],"propose":[1],"an":[2,16],"interactive":[3,163],"learning":[4,111,164],"approach":[5,165],"to":[6,49,70,129,134,141,155,173],"generate":[7,50],"synthetic":[8,104],"cell":[9,105,149],"microscopy":[10],"images.":[11],"Synthetic":[12],"data":[13,184],"can":[14,67,96],"play":[15],"important":[17],"role":[18],"in":[19,36,45,91,116,158,186],"augmenting":[20,180],"unbalanced":[21],"or":[22,31],"rare":[23],"datasets":[24],"when":[25],"training":[26,176,183],"neural":[27],"networks":[28],"for":[29],"classification":[30],"feature":[32],"detection.":[33],"Recent":[34],"advances":[35],"Variational":[37],"Autoencoders":[38],"and":[39,98,181],"Generative":[40],"Adversarial":[41],"Networks":[42],"enable":[43],"clustering":[44,63],"the":[46,76,113,159,170],"latent":[47],"space":[48],"samples":[51],"from":[52],"different":[53,117],"classes":[54,79],"with":[55,82,107],"distinct":[56,83,143],"features.":[57,84],"demonstrate":[59],"that":[60,151],"repeated":[61],"binary":[62],"of":[64,80,86,103,121,145],"input":[65],"images":[66,81,106,120],"be":[68],"employed":[69],"derive":[71],"a":[72,100,187],"hierarchical":[73],"tree":[74],"where":[75],"leaves":[77],"represent":[78],"Instead":[85],"experts":[87],"annotating":[88],"individual":[89],"cells":[90],"raw":[92,160],"image":[93],"data,":[94,177],"they":[95],"review":[97],"classify":[99],"larger":[101],"collection":[102],"similar":[108],"appearance,":[109],"also":[110,179],"about":[112],"variation":[114],"observed":[115],"classes.":[118,137],"Using":[119],"dividing":[122],"cells,":[123],"we":[124],"show":[125],"it":[126],"is":[127],"possible":[128],"assign":[130],"biologically":[131],"meaningful":[132],"labels":[133],"automatically":[135],"derived":[136],"Our":[138,162],"method":[139],"helped":[140],"resolve":[142],"sub-classes":[144],"stages":[146],"during":[147],"mitotic":[148],"division":[150],"are":[152],"almost":[153],"impossible":[154],"label":[156,175],"unambiguously":[157],"data.":[161],"not":[166],"only":[167],"promises":[168],"reducing":[169],"time":[171],"required":[172],"accurately":[174],"but":[178],"balancing":[182],"sets":[185],"principled":[188],"way.":[189]},"counts_by_year":[],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}
