{"id":"https://openalex.org/W4410295920","doi":"https://doi.org/10.1109/isbi60581.2025.10980862","title":"Scar-Aware Late Mechanical Activation Detection Network for Optimal Cardiac Resynchronization Therapy Planning","display_name":"Scar-Aware Late Mechanical Activation Detection Network for Optimal Cardiac Resynchronization Therapy Planning","publication_year":2025,"publication_date":"2025-04-14","ids":{"openalex":"https://openalex.org/W4410295920","doi":"https://doi.org/10.1109/isbi60581.2025.10980862","pmid":"https://pubmed.ncbi.nlm.nih.gov/41019920"},"language":"en","primary_location":{"id":"doi:10.1109/isbi60581.2025.10980862","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi60581.2025.10980862","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 22nd International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12467527/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053371530","display_name":"Jiarui Xing","orcid":null},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiarui Xing","raw_affiliation_strings":["University of Virginia,Department of Electrical and Computer Engineering,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia,Department of Electrical and Computer Engineering,USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100703108","display_name":"Shuo Wang","orcid":"https://orcid.org/0000-0003-4919-5390"},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuo Wang","raw_affiliation_strings":["School of Medicine, University of Virginia Health System,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, University of Virginia Health System,USA","institution_ids":["https://openalex.org/I2799765794"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117518086","display_name":"Amit R. Petal","orcid":null},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amit R. Petal","raw_affiliation_strings":["School of Medicine, University of Virginia Health System,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, University of Virginia Health System,USA","institution_ids":["https://openalex.org/I2799765794"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063695524","display_name":"Kenneth C. Bilchick","orcid":"https://orcid.org/0000-0002-5188-3603"},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth C. Bilchick","raw_affiliation_strings":["School of Medicine, University of Virginia Health System,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, University of Virginia Health System,USA","institution_ids":["https://openalex.org/I2799765794"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065140237","display_name":"Frederick H. Epstein","orcid":"https://orcid.org/0000-0002-1954-1988"},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederick H. Epstein","raw_affiliation_strings":["University of Virginia Health System,Department of Biomedical Engineering,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia Health System,Department of Biomedical Engineering,USA","institution_ids":["https://openalex.org/I2799765794"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100357912","display_name":"Miaomiao Zhang","orcid":"https://orcid.org/0000-0003-0457-3335"},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miaomiao Zhang","raw_affiliation_strings":["University of Virginia,Department of Electrical and Computer Engineering,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia,Department of Electrical and Computer Engineering,USA","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0148,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.74821784,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"2025","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-resynchronization-therapy","display_name":"Cardiac resynchronization therapy","score":0.7465699315071106},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.48767387866973877},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.35019850730895996},{"id":"https://openalex.org/keywords/heart-failure","display_name":"Heart failure","score":0.2806096374988556},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2628494203090668}],"concepts":[{"id":"https://openalex.org/C2776034619","wikidata":"https://www.wikidata.org/wiki/Q3428020","display_name":"Cardiac resynchronization therapy","level":4,"score":0.7465699315071106},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48767387866973877},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.35019850730895996},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.2806096374988556},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2628494203090668},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1109/isbi60581.2025.10980862","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi60581.2025.10980862","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 22nd International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},{"id":"pmid:41019920","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41019920","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. IEEE International Symposium on Biomedical Imaging","raw_type":null},{"id":"pmh:oai:europepmc.org:11275893","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12467527","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12467527","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12467527/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc IEEE Int Symp Biomed Imaging","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:12467527","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12467527/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc IEEE Int Symp Biomed Imaging","raw_type":"Text"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3429725638","display_name":null,"funder_award_id":"R21 EB032597","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"}],"funders":[{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W203530735","https://openalex.org/W1818584899","https://openalex.org/W2063467501","https://openalex.org/W2145240384","https://openalex.org/W2996179920","https://openalex.org/W3164435966","https://openalex.org/W4280592883","https://openalex.org/W4386350460","https://openalex.org/W4386362556","https://openalex.org/W4401749891"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W3183948672","https://openalex.org/W3173606202","https://openalex.org/W3110381201","https://openalex.org/W2948807893","https://openalex.org/W2899084033","https://openalex.org/W2778153218","https://openalex.org/W2758277628","https://openalex.org/W1531601525","https://openalex.org/W2010774097"],"abstract_inverted_index":{"Accurate":[0],"identification":[1],"of":[2,117,141],"late":[3,76,118],"mechanical":[4],"activation":[5,39],"(LMA)":[6],"regions":[7],"is":[8],"crucial":[9],"for":[10,185],"optimal":[11],"cardiac":[12,22],"resynchronization":[13],"therapy":[14],"(CRT)":[15],"lead":[16],"implantation.":[17],"However,":[18],"existing":[19],"approaches":[20],"using":[21,75],"magnetic":[23],"resonance":[24],"(CMR)":[25],"imaging":[26],"often":[27],"overlook":[28],"myocardial":[29,55,169],"scar":[30,56,72,111,158],"information,":[31],"which":[32],"may":[33],"be":[34,124],"mistakenly":[35],"identified":[36],"as":[37],"delayed":[38],"regions.":[40,64,159],"To":[41],"address":[42],"this":[43],"issue,":[44],"we":[45],"propose":[46],"a":[47,70,82,102],"scar-aware":[48,104],"LMA":[49,59,83,154,174],"detection":[50,84,155,175],"network":[51,74,85],"that":[52,107],"simultaneously":[53],"detects":[54],"and":[57,167],"prevents":[58],"localization":[60],"in":[61,156,177],"these":[62],"scarred":[63],"More":[65],"specifically,":[66],"our":[67,134,162],"model":[68,122,135,163],"integrates":[69],"pre-trained":[71],"segmentation":[73],"gadolinium":[77],"enhancement":[78],"(LGE)":[79],"CMRs":[80],"into":[81],"based":[86],"on":[87,164],"highly":[88],"accurate":[89],"strain":[90,148],"derived":[91],"from":[92,147],"displacement":[93],"encoding":[94],"with":[95,126,166],"stimulated":[96],"echoes":[97],"(DENSE)":[98],"CMRs.":[99],"We":[100,160],"introduce":[101],"novel":[103],"loss":[105],"function":[106],"utilizes":[108],"the":[109,139,183],"segmented":[110],"information":[112],"to":[113,151,191],"discourage":[114],"false-positive":[115,153],"detections":[116],"activated":[119],"areas.":[120],"Our":[121,180],"can":[123],"trained":[125],"or":[127],"without":[128,168],"paired":[129],"LGE":[130,142],"data.":[131],"During":[132],"inference,":[133],"does":[136],"not":[137],"require":[138],"input":[140],"images,":[143],"leveraging":[144],"learned":[145],"patterns":[146],"data":[149],"alone":[150],"mitigate":[152],"potential":[157],"evaluate":[161],"subjects":[165],"scar,":[170],"demonstrating":[171],"significantly":[172],"improved":[173,186],"accuracy":[176],"both":[178],"scenarios.":[179],"work":[181],"paves":[182],"way":[184],"CRT":[187],"planning,":[188],"potentially":[189],"leading":[190],"better":[192],"patient":[193],"outcomes.":[194]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}