{"id":"https://openalex.org/W4410297279","doi":"https://doi.org/10.1109/isbi60581.2025.10980822","title":"Dose Reduction in Step-and-Shoot 4D CT Imaging via Breathing Signal-Guided Deep Learning-Driven Selective Data Acquisition: A Feasibility Study","display_name":"Dose Reduction in Step-and-Shoot 4D CT Imaging via Breathing Signal-Guided Deep Learning-Driven Selective Data Acquisition: A Feasibility Study","publication_year":2025,"publication_date":"2025-04-14","ids":{"openalex":"https://openalex.org/W4410297279","doi":"https://doi.org/10.1109/isbi60581.2025.10980822"},"language":"en","primary_location":{"id":"doi:10.1109/isbi60581.2025.10980822","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi60581.2025.10980822","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 22nd International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018927512","display_name":"L. Wimmert","orcid":null},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]},{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"L. Wimmert","raw_affiliation_strings":["Institute for Applied Medical Informatics, University Medical Center,Hamburg-Eppendorf"],"affiliations":[{"raw_affiliation_string":"Institute for Applied Medical Informatics, University Medical Center,Hamburg-Eppendorf","institution_ids":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028360498","display_name":"Tobias Gauer","orcid":null},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]},{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T. Gauer","raw_affiliation_strings":["University Medical Center,Department of Radiotherapy and Radiation Oncology,Hamburg-Eppendorf"],"affiliations":[{"raw_affiliation_string":"University Medical Center,Department of Radiotherapy and Radiation Oncology,Hamburg-Eppendorf","institution_ids":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052131603","display_name":"Jannis Dickmann","orcid":"https://orcid.org/0000-0001-8410-3995"},"institutions":[{"id":"https://openalex.org/I4210153902","display_name":"Siemens Healthcare (Germany)","ror":"https://ror.org/0449c4c15","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210153902"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Dickmann","raw_affiliation_strings":["Siemens Healthineers AG,Forchheim,Germany"],"affiliations":[{"raw_affiliation_string":"Siemens Healthineers AG,Forchheim,Germany","institution_ids":["https://openalex.org/I4210153902"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111317879","display_name":"Colin Hofmann","orcid":null},"institutions":[{"id":"https://openalex.org/I4210153902","display_name":"Siemens Healthcare (Germany)","ror":"https://ror.org/0449c4c15","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210153902"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C. Hofmann","raw_affiliation_strings":["Siemens Healthineers AG,Forchheim,Germany"],"affiliations":[{"raw_affiliation_string":"Siemens Healthineers AG,Forchheim,Germany","institution_ids":["https://openalex.org/I4210153902"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075582704","display_name":"Thilo Sentker","orcid":"https://orcid.org/0000-0001-6663-0003"},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]},{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T. Sentker","raw_affiliation_strings":["Institute for Applied Medical Informatics, University Medical Center,Hamburg-Eppendorf"],"affiliations":[{"raw_affiliation_string":"Institute for Applied Medical Informatics, University Medical Center,Hamburg-Eppendorf","institution_ids":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040877289","display_name":"Robert G. Werner","orcid":null},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]},{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R. Werner","raw_affiliation_strings":["Institute for Applied Medical Informatics, University Medical Center,Hamburg-Eppendorf"],"affiliations":[{"raw_affiliation_string":"Institute for Applied Medical Informatics, University Medical Center,Hamburg-Eppendorf","institution_ids":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5018927512"],"corresponding_institution_ids":["https://openalex.org/I159176309","https://openalex.org/I4210108711"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11578908,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12386","display_name":"Advanced X-ray and CT Imaging","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12386","display_name":"Advanced X-ray and CT Imaging","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10844","display_name":"Radiation Dose and Imaging","score":0.9925000071525574,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reduction","display_name":"Reduction (mathematics)","score":0.6294392347335815},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5294584631919861},{"id":"https://openalex.org/keywords/breathing","display_name":"Breathing","score":0.5216415524482727},{"id":"https://openalex.org/keywords/signal","display_name":"SIGNAL (programming language)","score":0.4998013973236084},{"id":"https://openalex.org/keywords/data-acquisition","display_name":"Data acquisition","score":0.4704645574092865},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.39892590045928955},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.358421266078949},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.22152301669120789},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.11522111296653748}],"concepts":[{"id":"https://openalex.org/C111335779","wikidata":"https://www.wikidata.org/wiki/Q3454686","display_name":"Reduction (mathematics)","level":2,"score":0.6294392347335815},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5294584631919861},{"id":"https://openalex.org/C39300077","wikidata":"https://www.wikidata.org/wiki/Q9530","display_name":"Breathing","level":2,"score":0.5216415524482727},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.4998013973236084},{"id":"https://openalex.org/C163985040","wikidata":"https://www.wikidata.org/wiki/Q1172399","display_name":"Data acquisition","level":2,"score":0.4704645574092865},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.39892590045928955},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.358421266078949},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22152301669120789},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.11522111296653748},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi60581.2025.10980822","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi60581.2025.10980822","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 22nd International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W2035601351","https://openalex.org/W2122897083","https://openalex.org/W2158556708","https://openalex.org/W2947857010","https://openalex.org/W3012982787","https://openalex.org/W3013718954","https://openalex.org/W4220680261","https://openalex.org/W4306729893","https://openalex.org/W4362458307","https://openalex.org/W4387613957","https://openalex.org/W4393221307","https://openalex.org/W4401735575"],"related_works":["https://openalex.org/W4210912696","https://openalex.org/W4372306488","https://openalex.org/W2075579715","https://openalex.org/W2388668112","https://openalex.org/W2946070927","https://openalex.org/W2069972811","https://openalex.org/W2104766064","https://openalex.org/W2160652815","https://openalex.org/W2532234348","https://openalex.org/W4287629327"],"abstract_inverted_index":{"Respiration-correlated":[0],"computed":[1],"tomography":[2],"(4D":[3],"CT)":[4],"is":[5,115],"essential":[6],"for":[7,45,93,109,161],"radiotherapy":[8],"of":[9,34,38,80,121,139,147,173,192],"abdominal":[10],"and":[11,143],"thoracic":[12],"tumors.":[13],"Current":[14],"protocols":[15],"mitigate":[16],"motion":[17],"artifacts":[18],"by":[19],"continuously":[20],"acquiring":[21],"projections":[22,41],"throughout":[23],"entire":[24],"breathing":[25,83,119],"cycles":[26],"at":[27],"various":[28],"couch":[29],"positions":[30],"within":[31],"the":[32,39,59,81,131,134,140,144,174,190],"field":[33],"view.":[35],"However,":[36],"many":[37],"acquired":[40],"are":[42],"not":[43],"used":[44],"subsequent":[46],"image":[47,94,210],"reconstruction,":[48],"leading":[49],"to":[50,65,86,104,153,168],"additional":[51],"radiation":[52],"exposure.":[53],"In":[54],"this":[55],"study,":[56],"we":[57],"propose":[58],"first":[60],"deep":[61],"learning":[62],"(DL)-based":[63],"approach":[64],"selectively":[66],"guide":[67],"projection":[68,88,197],"data":[69,89,110,198],"acquisition":[70],"during":[71],"4D":[72,163],"CT":[73,164],"in":[74],"real-time,":[75],"based":[76,116],"on":[77,117,127,209],"online":[78],"analysis":[79],"patient's":[82],"signal,":[84],"aiming":[85],"acquire":[87],"only":[90,206],"when":[91],"relevant":[92],"reconstruction.":[95],"We":[96],"train":[97],"a":[98,137],"long":[99],"short-term":[100],"memory":[101],"(LSTM)":[102],"network":[103],"predict":[105],"suitable":[106],"beam-on":[107,141,176],"events":[108],"acquisition.":[111],"The":[112],"feasibility":[113,191],"study":[114],"1,659":[118],"signals":[120],"369":[122],"patients":[123],"(60/20/20":[124],"train/validation/test":[125],"split":[126],"patient":[128],"level).":[129],"For":[130],"test":[132],"set,":[133],"model":[135],"achieves":[136],"reduction":[138,160,204],"time":[142,185],"imaging":[145],"dose":[146,159,203],"30%":[148],"(median":[149],"value;":[150],"IQR:":[151],"22":[152],"37%),":[154],"translating":[155],"into":[156],"8\u201316":[157],"mGy":[158],"standard":[162],"CT-DIvol":[165],"values.":[166],"Compared":[167],"an":[169],"ideal":[170],"setting,":[171],"98%":[172],"predicted":[175],"starting":[177],"points":[178],"align":[179],"closely":[180],"with":[181,205],"corresponding":[182],"ground":[183],"truth":[184],"points.":[186],"These":[187],"results":[188],"demonstrate":[189],"respiratory":[193],"signal-guided,":[194],"DL-driven":[195],"selective":[196],"acquisition,":[199],"which":[200],"promises":[201],"substantial":[202],"minor":[207],"impact":[208],"quality.":[211]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}