{"id":"https://openalex.org/W4410297391","doi":"https://doi.org/10.1109/isbi60581.2025.10980780","title":"Two-Step Registration Method Boosts Sensitivity in Longitudinal Fixel-Based Analyses","display_name":"Two-Step Registration Method Boosts Sensitivity in Longitudinal Fixel-Based Analyses","publication_year":2025,"publication_date":"2025-04-14","ids":{"openalex":"https://openalex.org/W4410297391","doi":"https://doi.org/10.1109/isbi60581.2025.10980780"},"language":"en","primary_location":{"id":"doi:10.1109/isbi60581.2025.10980780","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi60581.2025.10980780","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 22nd International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hal.science/hal-05070372","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001830757","display_name":"Aur\u00e9lie Lebrun","orcid":"https://orcid.org/0009-0002-6168-8964"},"institutions":[{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210128565","display_name":"CEA Paris-Saclay","ror":"https://ror.org/03n15ch10","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210128565"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"funder","lineage":["https://openalex.org/I2738703131"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Aur\u00e9lie Lebrun","raw_affiliation_strings":["UNIACT, NeuroSpin, CEA, Universit&#x00E9; Paris-Saclay,France"],"affiliations":[{"raw_affiliation_string":"UNIACT, NeuroSpin, CEA, Universit&#x00E9; Paris-Saclay,France","institution_ids":["https://openalex.org/I277688954","https://openalex.org/I2738703131","https://openalex.org/I4210128565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016945907","display_name":"Michel Bottlaender","orcid":"https://orcid.org/0000-0002-2890-3653"},"institutions":[{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"funder","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210128565","display_name":"CEA Paris-Saclay","ror":"https://ror.org/03n15ch10","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210128565"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Michel Bottlaender","raw_affiliation_strings":["UNIACT, NeuroSpin, CEA, Universit&#x00E9; Paris-Saclay,France"],"affiliations":[{"raw_affiliation_string":"UNIACT, NeuroSpin, CEA, Universit&#x00E9; Paris-Saclay,France","institution_ids":["https://openalex.org/I277688954","https://openalex.org/I2738703131","https://openalex.org/I4210128565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017805570","display_name":"Julien Lagarde","orcid":"https://orcid.org/0000-0002-2018-261X"},"institutions":[{"id":"https://openalex.org/I4210128565","display_name":"CEA Paris-Saclay","ror":"https://ror.org/03n15ch10","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210128565"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"funder","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Julien Lagarde","raw_affiliation_strings":["BioMaps, SHFJ, CEA, CNRS, Inserm, Universit&#x00E9; Paris-Saclay,France"],"affiliations":[{"raw_affiliation_string":"BioMaps, SHFJ, CEA, CNRS, Inserm, Universit&#x00E9; Paris-Saclay,France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210128565","https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2738703131"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032426975","display_name":"Marie Sarazin","orcid":"https://orcid.org/0000-0002-5438-8392"},"institutions":[{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"funder","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210128565","display_name":"CEA Paris-Saclay","ror":"https://ror.org/03n15ch10","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210128565"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marie Sarazin","raw_affiliation_strings":["BioMaps, SHFJ, CEA, CNRS, Inserm, Universit&#x00E9; Paris-Saclay,France"],"affiliations":[{"raw_affiliation_string":"BioMaps, SHFJ, CEA, CNRS, Inserm, Universit&#x00E9; Paris-Saclay,France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210128565","https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2738703131"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015063228","display_name":"Yann Leprince","orcid":"https://orcid.org/0000-0002-1846-3869"},"institutions":[{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"funder","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I4210128565","display_name":"CEA Paris-Saclay","ror":"https://ror.org/03n15ch10","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210128565"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yann Leprince","raw_affiliation_strings":["UNIACT, NeuroSpin, CEA, Universit&#x00E9; Paris-Saclay,France"],"affiliations":[{"raw_affiliation_string":"UNIACT, NeuroSpin, CEA, Universit&#x00E9; Paris-Saclay,France","institution_ids":["https://openalex.org/I277688954","https://openalex.org/I2738703131","https://openalex.org/I4210128565"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5001830757"],"corresponding_institution_ids":["https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210128565"],"apc_list":null,"apc_paid":null,"fwci":4.9422,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.94450808,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10136","display_name":"Statistical Methods and Inference","score":0.18080000579357147,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10136","display_name":"Statistical Methods and Inference","score":0.18080000579357147,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sensitivity","display_name":"Sensitivity (control systems)","score":0.7178260087966919},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5227218270301819},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4173116087913513},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.080007404088974},{"id":"https://openalex.org/keywords/electronic-engineering","display_name":"Electronic engineering","score":0.052217841148376465}],"concepts":[{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.7178260087966919},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5227218270301819},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4173116087913513},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.080007404088974},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.052217841148376465}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/isbi60581.2025.10980780","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi60581.2025.10980780","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE 22nd International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},{"id":"pmh:oai:HAL:hal-05070372v1","is_oa":true,"landing_page_url":"https://hal.science/hal-05070372","pdf_url":null,"source":{"id":"https://openalex.org/S4406922461","display_name":"SPIRE - Sciences Po Institutional REpository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://ieeexplore.ieee.org/document/10980780","raw_type":"Conference papers"}],"best_oa_location":{"id":"pmh:oai:HAL:hal-05070372v1","is_oa":true,"landing_page_url":"https://hal.science/hal-05070372","pdf_url":null,"source":{"id":"https://openalex.org/S4406922461","display_name":"SPIRE - Sciences Po Institutional REpository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://ieeexplore.ieee.org/document/10980780","raw_type":"Conference papers"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W239929985","https://openalex.org/W1965894642","https://openalex.org/W2077240096","https://openalex.org/W2139886607","https://openalex.org/W2803890652","https://openalex.org/W2809071881","https://openalex.org/W2970898057","https://openalex.org/W3183687916","https://openalex.org/W4401962230"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":{"Longitudinal":[0],"analyses":[1],"are":[2,97],"increasingly":[3],"used":[4],"in":[5,64,88,109,123,138,152,194,217],"clinical":[6],"studies":[7,86],"as":[8,179,181],"they":[9],"allow":[10],"the":[11,19,33,47,53,67,80,89,102,146,159,162,182,190,203,207,210],"study":[12,48,191],"of":[13,24,49,76,83,133,148,192,209,220],"subtle":[14],"changes":[15,151],"over":[16],"time":[17],"within":[18],"same":[20,95],"subjects.":[21],"In":[22,46,79,126],"most":[23],"these":[25],"studies,":[26],"it":[27,105],"is":[28,62,72],"necessary":[29],"to":[30,36,43,101],"align":[31],"all":[32],"images":[34],"studied":[35],"a":[37,44,73,94,113,139,176],"common":[38],"reference":[39],"by":[40,170,175],"registering":[41],"them":[42],"template.":[45,103],"white":[50,149],"matter":[51,150],"using":[52],"recently":[54],"developed":[55],"fixel-based":[56],"analysis":[57],"(FBA)":[58],"method,":[59],"this":[60,77,127,134,171],"registration":[61,115,136,172,187],"important,":[63],"particular":[65],"because":[66],"fiber":[68],"bundle":[69],"cross-section":[70],"metric":[71],"direct":[74,177],"measure":[75],"registration.":[78],"vast":[81],"majority":[82],"longitudinal":[84,124,141],"FBA":[85,142],"described":[87],"literature,":[90],"sessions":[91],"acquired":[92],"for":[93,189],"subject":[96],"directly":[98],"independently":[99],"registered":[100],"However,":[104],"has":[106],"been":[107],"shown":[108],"T1-based":[110],"morphometry":[111],"that":[112,202],"2-step":[114,135,204],"through":[116],"an":[117,131],"intra-subject":[118],"average":[119],"can":[120],"be":[121],"advantageous":[122],"analyses.":[125,199,221],"work,":[128],"we":[129],"propose":[130],"implementation":[132],"method":[137,173,188,205],"typical":[140],"aimed":[143],"at":[144,158],"investigating":[145],"evolution":[147],"Alzheimer's":[153],"disease":[154],"(AD).":[155],"We":[156,200],"compared":[157],"fixel":[160],"level":[161],"mean":[163],"absolute":[164],"effect":[165],"and":[166,174,197,212],"standard":[167],"deviation":[168],"yielded":[169],"registration,":[178],"well":[180],"results":[183],"obtained":[184],"with":[185],"each":[186],"AD":[193],"both":[195,218],"fixelwise":[196],"tract-based":[198],"found":[201],"reduced":[206],"variability":[208],"measurements":[211],"thus":[213],"enhanced":[214],"statistical":[215],"power":[216],"types":[219]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-04-12T07:58:50.170612","created_date":"2025-10-10T00:00:00"}
