{"id":"https://openalex.org/W4401749013","doi":"https://doi.org/10.1109/isbi56570.2024.10635869","title":"Weakly Supervised IDH-Status Glioma Classification from H&E-Stained Whole Slide Images","display_name":"Weakly Supervised IDH-Status Glioma Classification from H&E-Stained Whole Slide Images","publication_year":2024,"publication_date":"2024-05-27","ids":{"openalex":"https://openalex.org/W4401749013","doi":"https://doi.org/10.1109/isbi56570.2024.10635869"},"language":"en","primary_location":{"id":"doi:10.1109/isbi56570.2024.10635869","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi56570.2024.10635869","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008932408","display_name":"Shubham Innani","orcid":"https://orcid.org/0000-0003-3616-0308"},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shubham Innani","raw_affiliation_strings":["Indiana University,Division of Computational Pathology,Department of Pathology and Laboratory Medicine, School of Medicine,Indianapolis,IN,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University,Division of Computational Pathology,Department of Pathology and Laboratory Medicine, School of Medicine,Indianapolis,IN,USA","institution_ids":["https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004972442","display_name":"Bhakti Baheti","orcid":"https://orcid.org/0000-0001-5475-3903"},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bhakti Baheti","raw_affiliation_strings":["Indiana University,Division of Computational Pathology,Department of Pathology and Laboratory Medicine, School of Medicine,Indianapolis,IN,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University,Division of Computational Pathology,Department of Pathology and Laboratory Medicine, School of Medicine,Indianapolis,IN,USA","institution_ids":["https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052402717","display_name":"MacLean P. Nasrallah","orcid":"https://orcid.org/0000-0003-4861-0898"},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MacLean P. Nasrallah","raw_affiliation_strings":["University of Pennsylvania,Perelman School of Medicine,Department of Pathology & Laboratory Medicine,Philadelphia,PA,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania,Perelman School of Medicine,Department of Pathology & Laboratory Medicine,Philadelphia,PA,USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043497448","display_name":"Spyridon Bakas","orcid":"https://orcid.org/0000-0001-8734-6482"},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Spyridon Bakas","raw_affiliation_strings":["Indiana University,Division of Computational Pathology,Department of Pathology and Laboratory Medicine, School of Medicine,Indianapolis,IN,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University,Division of Computational Pathology,Department of Pathology and Laboratory Medicine, School of Medicine,Indianapolis,IN,USA","institution_ids":["https://openalex.org/I55769427"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":18.2909,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.98605578,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10036","display_name":"Advanced Neural Network Applications","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioma","display_name":"Glioma","score":0.5939034819602966},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.46236470341682434},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.44954413175582886},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3483428955078125},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.3350992202758789},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22696998715400696},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.1553657054901123}],"concepts":[{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.5939034819602966},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.46236470341682434},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.44954413175582886},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3483428955078125},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3350992202758789},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22696998715400696},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.1553657054901123}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi56570.2024.10635869","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi56570.2024.10635869","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","score":0.46000000834465027,"display_name":"Zero hunger"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320338440","display_name":"HORIZON EUROPE Health","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W2083927153","https://openalex.org/W2194775991","https://openalex.org/W2878436114","https://openalex.org/W2897601127","https://openalex.org/W3021598653","https://openalex.org/W3135547872","https://openalex.org/W3174246647","https://openalex.org/W3194280965","https://openalex.org/W4282932245","https://openalex.org/W4313397115","https://openalex.org/W4383533409","https://openalex.org/W4386537548","https://openalex.org/W4386538880","https://openalex.org/W4388588790","https://openalex.org/W4389992531"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W2935759653","https://openalex.org/W3105167352","https://openalex.org/W54078636","https://openalex.org/W2954470139","https://openalex.org/W1501425562","https://openalex.org/W2902782467","https://openalex.org/W2033914206","https://openalex.org/W2042327336"],"abstract_inverted_index":{"Gliomas":[0],"are":[1],"the":[2,10,120],"most":[3],"common":[4],"malignant":[5],"primary":[6],"brain":[7],"tumors":[8],"in":[9,24,52],"Central":[11],"Nervous":[12],"System.":[13],"Isocitrate":[14],"dehydrogenase":[15],"(IDH)":[16],"mutation":[17],"is":[18],"a":[19,28,49,66,84,98,132,138],"key":[20],"driver":[21],"of":[22,129,135,145],"gliomagenesis":[23],"infiltrating":[25],"gliomas":[26],"and":[27,39,60,124,131],"diagnostic":[29],"criterion":[30],"with":[31],"prognostic":[32],"relevance.":[33],"Determining":[34],"IDH":[35,71,146],"status":[36,72,147],"from":[37,73,116,119],"hematoxylin":[38],"eosin":[40],"(H&E)":[41],"stained":[42],"Whole":[43],"Slide":[44],"Images":[45],"(WSI)":[46],"would":[47,57],"be":[48],"valuable":[50],"tool":[51],"precision":[53],"oncology":[54],"as":[55],"it":[56],"expedite":[58],"diagnosis":[59],"downstream":[61],"patient":[62],"treatment.":[63],"We":[64],"seek":[65],"computational":[67],"approach":[68,81],"to":[69,88,152],"predict":[70],"digitized":[74,113],"histopathology":[75],"glioma":[76],"sections":[77,115],"(WSI).":[78],"The":[79],"proposed":[80],"first":[82],"applies":[83],"comprehensive":[85],"curation":[86],"step":[87],"remove":[89],"artifactual":[90],"content":[91],"on":[92,102,111,137],"each":[93],"H&E-stained":[94],"WSI,":[95],"followed":[96],"by":[97],"classification":[99],"mechanism":[100],"based":[101],"weakly":[103],"supervised":[104],"attention-based":[105],"multiple":[106],"instance":[107],"learning.":[108],"Quantitative":[109],"evaluation":[110],"1,534":[112],"tissue":[114],"799":[117],"cases":[118],"publicly":[121],"available":[122],"TCGA-GBM":[123],"TCGA-LGG":[125],"dataset":[126],"revealed":[127],"AUC":[128],"0.92":[130],"balanced":[133],"accuracy":[134],"0.85":[136],"10-fold":[139],"cross-validation":[140],"(10CV)":[141],"schema.":[142],"Histological":[143],"prediction":[144],"represents":[148],"an":[149],"ideal":[150],"prototype":[151],"interrogate":[153],"WSI":[154],"towards":[155],"identifying":[156],"clinically-relevant":[157],"tumor":[158],"biomarkers.":[159]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}