{"id":"https://openalex.org/W4401750118","doi":"https://doi.org/10.1109/isbi56570.2024.10635850","title":"Weakly Supervised 3d Image Segmentation in Fluorescence Microscopy Using Maximum Intensity Projections","display_name":"Weakly Supervised 3d Image Segmentation in Fluorescence Microscopy Using Maximum Intensity Projections","publication_year":2024,"publication_date":"2024-05-27","ids":{"openalex":"https://openalex.org/W4401750118","doi":"https://doi.org/10.1109/isbi56570.2024.10635850"},"language":"en","primary_location":{"id":"doi:10.1109/isbi56570.2024.10635850","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/isbi56570.2024.10635850","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dspace.library.uu.nl/handle/1874/482299","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111033430","display_name":"Tijmen H. de Wolf","orcid":null},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Tijmen H. de Wolf","raw_affiliation_strings":["Erasmus University Medical Center,Department of of Molecular Genetics,Rotterdam,Netherlands"],"affiliations":[{"raw_affiliation_string":"Erasmus University Medical Center,Department of of Molecular Genetics,Rotterdam,Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113342691","display_name":"Daria Roman","orcid":null},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Daria Roman","raw_affiliation_strings":["Erasmus University Medical Center,Department of of Molecular Genetics,Rotterdam,Netherlands"],"affiliations":[{"raw_affiliation_string":"Erasmus University Medical Center,Department of of Molecular Genetics,Rotterdam,Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070230556","display_name":"Julie Nonnekens","orcid":"https://orcid.org/0000-0002-9644-7522"},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Julie Nonnekens","raw_affiliation_strings":["Erasmus University Medical Center,Department of of Molecular Genetics,Rotterdam,Netherlands"],"affiliations":[{"raw_affiliation_string":"Erasmus University Medical Center,Department of of Molecular Genetics,Rotterdam,Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026507016","display_name":"Ihor Smal","orcid":"https://orcid.org/0000-0001-7576-7028"},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ihor Smal","raw_affiliation_strings":["Utrecht University,Department of Biology,Utrecht,The Netherlands"],"affiliations":[{"raw_affiliation_string":"Utrecht University,Department of Biology,Utrecht,The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5111033430"],"corresponding_institution_ids":["https://openalex.org/I2801952686"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12548225,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9401000142097473,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9401000142097473,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13114","display_name":"Image Processing Techniques and Applications","score":0.9337000250816345,"subfield":{"id":"https://openalex.org/subfields/2214","display_name":"Media Technology"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6394126415252686},{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.6333336234092712},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.6206673979759216},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.5593041181564331},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.5427068471908569},{"id":"https://openalex.org/keywords/intensity","display_name":"Intensity (physics)","score":0.49109768867492676},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.43768173456192017},{"id":"https://openalex.org/keywords/maximum-intensity-projection","display_name":"Maximum intensity projection","score":0.4252889156341553},{"id":"https://openalex.org/keywords/fluorescence","display_name":"Fluorescence","score":0.4206983745098114},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.39868488907814026},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.37407028675079346},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.3126989006996155},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.19534334540367126},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.07920721173286438},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.06483662128448486}],"concepts":[{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6394126415252686},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.6333336234092712},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.6206673979759216},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.5593041181564331},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.5427068471908569},{"id":"https://openalex.org/C93038891","wikidata":"https://www.wikidata.org/wiki/Q1061524","display_name":"Intensity (physics)","level":2,"score":0.49109768867492676},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.43768173456192017},{"id":"https://openalex.org/C110021049","wikidata":"https://www.wikidata.org/wiki/Q1539231","display_name":"Maximum intensity projection","level":3,"score":0.4252889156341553},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.4206983745098114},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.39868488907814026},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.37407028675079346},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.3126989006996155},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.19534334540367126},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07920721173286438},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.06483662128448486},{"id":"https://openalex.org/C2780643987","wikidata":"https://www.wikidata.org/wiki/Q468414","display_name":"Angiography","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/isbi56570.2024.10635850","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/isbi56570.2024.10635850","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},{"id":"pmh:oai:dspace.library.uu.nl:1874/482299","is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/482299","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Part of book"}],"best_oa_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/482299","is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/482299","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Part of book"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/13","score":0.41999998688697815,"display_name":"Climate action"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W2103706175","https://openalex.org/W2168237413","https://openalex.org/W2534633786","https://openalex.org/W2905562891","https://openalex.org/W2983246216","https://openalex.org/W3212631749"],"related_works":["https://openalex.org/W2002088038","https://openalex.org/W2090363770","https://openalex.org/W1974173024","https://openalex.org/W2013465847","https://openalex.org/W2370564155","https://openalex.org/W2508513904","https://openalex.org/W4379231730","https://openalex.org/W2361254178","https://openalex.org/W2126798690","https://openalex.org/W1522196789"],"abstract_inverted_index":{"In":[0],"recent":[1],"years,":[2],"biomedical":[3],"research":[4],"has":[5],"greatly":[6],"benefited":[7],"from":[8],"the":[9,26,60],"developments":[10],"of":[11,59,107,115,121],"deep":[12,32],"learning":[13,33],"techniques":[14],"for":[15,40,91],"image":[16,42,90],"and":[17,62,118],"data":[18,61,94,120],"analysis.":[19],"Widespread":[20],"adoption":[21],"is,":[22],"however,":[23],"hampered":[24],"by":[25],"annotation":[27],"effort":[28],"required":[29],"to":[30,97],"train":[31],"algorithms.":[34],"To":[35],"alleviate":[36],"this":[37],"laborious":[38],"task":[39,78],"3D":[41,75,93,101],"data,":[43],"we":[44,71],"propose":[45],"a":[46,63,74,84],"solution":[47],"based":[48,68],"purely":[49],"on":[50,69],"2D":[51],"maximum":[52,87],"intensity":[53,88],"projections.":[54],"By":[55],"utilising":[56],"\"flip\"":[57],"symmetry":[58],"specifically":[64],"designed":[65],"loss":[66],"function":[67],"super-Gaussians,":[70],"demonstrate":[72],"how":[73],"semantic":[76],"segmentation":[77],"can":[79],"be":[80],"solved":[81],"using":[82,99,112,126],"only":[83],"single":[85],"annotated":[86],"projection":[89],"each":[92],"sample,":[95],"compared":[96],"training":[98],"full":[100],"ground":[102],"truth":[103],"annotations.":[104],"The":[105],"effectiveness":[106],"our":[108],"approach":[109],"is":[110],"demonstrated":[111],"simulated":[113],"images":[114],"virus":[116],"particles":[117],"experimental":[119],"radiation":[122],"induced":[123],"foci":[124],"imaged":[125],"confocal":[127],"microscopy.":[128]},"counts_by_year":[],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}