{"id":"https://openalex.org/W4401751396","doi":"https://doi.org/10.1109/isbi56570.2024.10635830","title":"Mutually-Constrained Cross-Sectional and Longitudinal Non-Negative Matrix Factorization: Application to Modeling Brain Aging Trajectories","display_name":"Mutually-Constrained Cross-Sectional and Longitudinal Non-Negative Matrix Factorization: Application to Modeling Brain Aging Trajectories","publication_year":2024,"publication_date":"2024-05-27","ids":{"openalex":"https://openalex.org/W4401751396","doi":"https://doi.org/10.1109/isbi56570.2024.10635830"},"language":"en","primary_location":{"id":"doi:10.1109/isbi56570.2024.10635830","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/isbi56570.2024.10635830","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089469068","display_name":"Ioanna Skampardoni","orcid":null},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ioanna Skampardoni","raw_affiliation_strings":["University of Pennsylvania,Centre for Biomedical Image Computing and Analytics,Philadelphia,PA,USA"],"affiliations":[{"raw_affiliation_string":"University of Pennsylvania,Centre for Biomedical Image Computing and Analytics,Philadelphia,PA,USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055047310","display_name":"Junhao Wen","orcid":null},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junhao Wen","raw_affiliation_strings":["Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California,Laboratory of AI and Biomedical Science (LABS),Los Angeles,CA,USA"],"affiliations":[{"raw_affiliation_string":"Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California,Laboratory of AI and Biomedical Science (LABS),Los Angeles,CA,USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043164378","display_name":"Guray Erus","orcid":null},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erus Guray","raw_affiliation_strings":["University of Pennsylvania,Centre for Biomedical Image Computing and Analytics,Philadelphia,PA,USA"],"affiliations":[{"raw_affiliation_string":"University of Pennsylvania,Centre for Biomedical Image Computing and Analytics,Philadelphia,PA,USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057578473","display_name":"Haochang Shou","orcid":"https://orcid.org/0000-0002-3043-047X"},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haochang Shou","raw_affiliation_strings":["University of Pennsylvania,Centre for Biomedical Image Computing and Analytics,Philadelphia,PA,USA"],"affiliations":[{"raw_affiliation_string":"University of Pennsylvania,Centre for Biomedical Image Computing and Analytics,Philadelphia,PA,USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082313849","display_name":"Konstantina S. Nikita","orcid":"https://orcid.org/0000-0001-8255-4354"},"institutions":[{"id":"https://openalex.org/I174458059","display_name":"National Technical University of Athens","ror":"https://ror.org/03cx6bg69","country_code":"GR","type":"education","lineage":["https://openalex.org/I174458059"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Konstantina Nikita","raw_affiliation_strings":["National Technical University of Athens,School of Electrical and Computer Engineering,Athens,Greece"],"affiliations":[{"raw_affiliation_string":"National Technical University of Athens,School of Electrical and Computer Engineering,Athens,Greece","institution_ids":["https://openalex.org/I174458059"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034999945","display_name":"Christos Davatzikos","orcid":"https://orcid.org/0000-0002-1025-8561"},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christos Davatzikos","raw_affiliation_strings":["University of Pennsylvania,Centre for Biomedical Image Computing and Analytics,Philadelphia,PA,USA"],"affiliations":[{"raw_affiliation_string":"University of Pennsylvania,Centre for Biomedical Image Computing and Analytics,Philadelphia,PA,USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5089469068"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13967358,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.6085000038146973,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.6085000038146973,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11577","display_name":"Cognitive Abilities and Testing","score":0.5669000148773193,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10057","display_name":"Face and Expression Recognition","score":0.5159000158309937,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/matrix-decomposition","display_name":"Matrix decomposition","score":0.5933897495269775},{"id":"https://openalex.org/keywords/non-negative-matrix-factorization","display_name":"Non-negative matrix factorization","score":0.534821093082428},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5191968679428101},{"id":"https://openalex.org/keywords/factorization","display_name":"Factorization","score":0.4282028079032898},{"id":"https://openalex.org/keywords/matrix","display_name":"Matrix (chemical analysis)","score":0.42047643661499023},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.23608756065368652},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.1146291196346283}],"concepts":[{"id":"https://openalex.org/C42355184","wikidata":"https://www.wikidata.org/wiki/Q1361088","display_name":"Matrix decomposition","level":3,"score":0.5933897495269775},{"id":"https://openalex.org/C152671427","wikidata":"https://www.wikidata.org/wiki/Q10843505","display_name":"Non-negative matrix factorization","level":4,"score":0.534821093082428},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5191968679428101},{"id":"https://openalex.org/C187834632","wikidata":"https://www.wikidata.org/wiki/Q188804","display_name":"Factorization","level":2,"score":0.4282028079032898},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.42047643661499023},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.23608756065368652},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1146291196346283},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C158693339","wikidata":"https://www.wikidata.org/wiki/Q190524","display_name":"Eigenvalues and eigenvectors","level":2,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/isbi56570.2024.10635830","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/isbi56570.2024.10635830","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320338440","display_name":"HORIZON EUROPE Health","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1902027874","https://openalex.org/W2004691878","https://openalex.org/W2017288758","https://openalex.org/W2059745395","https://openalex.org/W2063243332","https://openalex.org/W2117340355","https://openalex.org/W2152723280","https://openalex.org/W2196038229","https://openalex.org/W2275670668","https://openalex.org/W2281357465","https://openalex.org/W2316633345","https://openalex.org/W2528250414","https://openalex.org/W2594949498","https://openalex.org/W2782660935","https://openalex.org/W2808011417","https://openalex.org/W2886738716","https://openalex.org/W2954384599","https://openalex.org/W3214901597","https://openalex.org/W4210777225","https://openalex.org/W4292023222","https://openalex.org/W6765053354"],"related_works":["https://openalex.org/W4390394189","https://openalex.org/W2037504162","https://openalex.org/W2539013788","https://openalex.org/W2792706544","https://openalex.org/W1568451138","https://openalex.org/W2156699640","https://openalex.org/W2045265907","https://openalex.org/W2972997031","https://openalex.org/W2146544734","https://openalex.org/W2075222291"],"abstract_inverted_index":{"Brain":[0],"aging":[1,27,48],"is":[2],"a":[3,16,53,106],"multifaceted":[4],"and":[5,31,36,93],"highly":[6],"heterogeneous":[7],"process":[8],"accompanied":[9],"by":[10,52],"several":[11],"pathologies.":[12],"Here,":[13],"we":[14,40,88],"propose":[15],"method":[17,77],"for":[18,108],"dissecting":[19],"the":[20,43,64,76,85,102],"heterogeneity":[21,44],"of":[22,55,61,97],"neuropathologic":[23,69],"processes":[24,70],"occurring":[25],"with":[26,58],"using":[28],"machine":[29],"learning":[30],"leveraging":[32],"information":[33],"from":[34,84],"cross-sectional":[35],"longitudinal":[37,59],"data.":[38],"Specifically,":[39],"hypothesize":[41],"that":[42],"observed":[45],"in":[46],"brain":[47,62,99],"can":[49],"be":[50],"captured":[51],"set":[54],"patterns":[56],"consistent":[57],"trajectories":[60],"change,":[63,100],"latter":[65],"directly":[66],"capturing":[67],"evolving":[68],"on":[71],"an":[72],"individual":[73],"basis.":[74],"Applying":[75],"to":[78],"structural":[79],"magnetic":[80],"resonance":[81],"imaging":[82],"data":[83],"BLSA":[86],"study,":[87],"derived":[89],"five":[90],"distinct,":[91],"reproducible,":[92],"clinically":[94],"informative":[95],"components":[96],"neuroanatomical":[98],"highlighting":[101],"method\u2019s":[103],"potential":[104],"as":[105],"tool":[107],"precision":[109],"medicine.":[110]},"counts_by_year":[],"updated_date":"2025-12-26T23:08:49.675405","created_date":"2025-10-10T00:00:00"}
