{"id":"https://openalex.org/W4401750589","doi":"https://doi.org/10.1109/isbi56570.2024.10635805","title":"Diffusion Model-Based Posterior Distribution Prediction for Kinetic Parameter Estimation in Dynamic PET","display_name":"Diffusion Model-Based Posterior Distribution Prediction for Kinetic Parameter Estimation in Dynamic PET","publication_year":2024,"publication_date":"2024-05-27","ids":{"openalex":"https://openalex.org/W4401750589","doi":"https://doi.org/10.1109/isbi56570.2024.10635805","pmid":"https://pubmed.ncbi.nlm.nih.gov/39530051"},"language":"en","primary_location":{"id":"doi:10.1109/isbi56570.2024.10635805","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi56570.2024.10635805","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11554386/pdf/nihms-2033589.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027995660","display_name":"Yanis Djebra","orcid":"https://orcid.org/0000-0003-0756-571X"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Y. Djebra","raw_affiliation_strings":["Massachusetts General Hospital and Harvard Medical School,Boston,MA,USA"],"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School,Boston,MA,USA","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107953666","display_name":"X. Liu","orcid":null},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"X. Liu","raw_affiliation_strings":["Massachusetts General Hospital and Harvard Medical School,Boston,MA,USA"],"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School,Boston,MA,USA","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069758006","display_name":"Thibault Marin","orcid":"https://orcid.org/0000-0002-8669-1003"},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Marin","raw_affiliation_strings":["Massachusetts General Hospital and Harvard Medical School,Boston,MA,USA"],"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School,Boston,MA,USA","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048705942","display_name":"Ali Tiss","orcid":"https://orcid.org/0000-0002-3024-5370"},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Tiss","raw_affiliation_strings":["Massachusetts General Hospital and Harvard Medical School,Boston,MA,USA"],"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School,Boston,MA,USA","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043683105","display_name":"Ma\u00ebva Dhaynaut","orcid":"https://orcid.org/0000-0002-8529-5746"},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Dhaynaut","raw_affiliation_strings":["Massachusetts General Hospital and Harvard Medical School,Boston,MA,USA"],"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School,Boston,MA,USA","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035181499","display_name":"Nicolas J. Guehl","orcid":"https://orcid.org/0000-0001-6876-8292"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Guehl","raw_affiliation_strings":["Massachusetts General Hospital and Harvard Medical School,Boston,MA,USA"],"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School,Boston,MA,USA","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090842068","display_name":"Keith A. Johnson","orcid":"https://orcid.org/0000-0002-5916-6043"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Johnson","raw_affiliation_strings":["Massachusetts General Hospital and Harvard Medical School,Boston,MA,USA"],"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School,Boston,MA,USA","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053436378","display_name":"Georges El Fakhri","orcid":"https://orcid.org/0000-0002-9005-6993"},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. El Fakhri","raw_affiliation_strings":["Yale School of Medicine,New Haven,CT,USA"],"affiliations":[{"raw_affiliation_string":"Yale School of Medicine,New Haven,CT,USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062325991","display_name":"Chao Ma","orcid":"https://orcid.org/0000-0002-2016-8084"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Ma","raw_affiliation_strings":["Massachusetts General Hospital and Harvard Medical School,Boston,MA,USA"],"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School,Boston,MA,USA","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101740893","display_name":"Jinsong Ouyang","orcid":"https://orcid.org/0000-0003-4245-170X"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Ouyang","raw_affiliation_strings":["Massachusetts General Hospital and Harvard Medical School,Boston,MA,USA"],"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital and Harvard Medical School,Boston,MA,USA","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5027995660"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.22176132,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2024","issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.9836000204086304,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estimation-theory","display_name":"Estimation theory","score":0.6321570873260498},{"id":"https://openalex.org/keywords/diffusion","display_name":"Diffusion","score":0.6226459741592407},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5334223508834839},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.4354907274246216},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.4353831112384796},{"id":"https://openalex.org/keywords/distribution","display_name":"Distribution (mathematics)","score":0.41635096073150635},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.28434717655181885},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2413826882839203},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.21562403440475464},{"id":"https://openalex.org/keywords/thermodynamics","display_name":"Thermodynamics","score":0.11045566201210022},{"id":"https://openalex.org/keywords/mathematical-analysis","display_name":"Mathematical analysis","score":0.08117887377738953}],"concepts":[{"id":"https://openalex.org/C167928553","wikidata":"https://www.wikidata.org/wiki/Q1376021","display_name":"Estimation theory","level":2,"score":0.6321570873260498},{"id":"https://openalex.org/C69357855","wikidata":"https://www.wikidata.org/wiki/Q163214","display_name":"Diffusion","level":2,"score":0.6226459741592407},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5334223508834839},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.4354907274246216},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4353831112384796},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.41635096073150635},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.28434717655181885},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2413826882839203},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.21562403440475464},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.11045566201210022},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.08117887377738953},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/isbi56570.2024.10635805","is_oa":false,"landing_page_url":"https://doi.org/10.1109/isbi56570.2024.10635805","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE International Symposium on Biomedical Imaging (ISBI)","raw_type":"proceedings-article"},{"id":"pmid:39530051","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39530051","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. IEEE International Symposium on Biomedical Imaging","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11554386","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11554386","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11554386/pdf/nihms-2033589.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc IEEE Int Symp Biomed Imaging","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11554386","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11554386","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11554386/pdf/nihms-2033589.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc IEEE Int Symp Biomed Imaging","raw_type":"Text"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G181372539","display_name":null,"funder_award_id":"P41EB022544","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3411609741","display_name":null,"funder_award_id":"R01AG076153","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4524227679","display_name":null,"funder_award_id":"R01EB033582","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320338440","display_name":"HORIZON EUROPE Health","ror":null}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401750589.pdf"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W1483015670","https://openalex.org/W2030773481","https://openalex.org/W2062340864","https://openalex.org/W2064890293","https://openalex.org/W2151130155","https://openalex.org/W2909883195","https://openalex.org/W2924334974","https://openalex.org/W2963098834","https://openalex.org/W2977883299","https://openalex.org/W3036167779","https://openalex.org/W4308180051","https://openalex.org/W4361253332","https://openalex.org/W4385245566","https://openalex.org/W6779823529","https://openalex.org/W6788990321"],"related_works":["https://openalex.org/W2386796262","https://openalex.org/W3177740930","https://openalex.org/W1484549928","https://openalex.org/W1974805659","https://openalex.org/W2811388477","https://openalex.org/W2011653655","https://openalex.org/W1982781720","https://openalex.org/W4281941122","https://openalex.org/W2027328791","https://openalex.org/W2390836331"],"abstract_inverted_index":{"Positron":[0],"Emission":[1],"Tomography":[2],"(PET)":[3],"is":[4,123],"a":[5,23,66,134],"valuable":[6],"imaging":[7],"method":[8,130],"for":[9],"studying":[10],"molecular-level":[11],"processes":[12],"in":[13,50,56,65,148],"the":[14,57,70,90,111,128],"body,":[15],"such":[16],"as":[17],"hyperphosphorylated":[18],"tau":[19],"(p-tau)":[20],"protein":[21],"aggregates,":[22],"hallmark":[24],"of":[25,73,127],"several":[26],"neurodegenerative":[27],"diseases":[28],"including":[29],"Alzheimer's":[30],"disease.":[31],"P-tau":[32],"density":[33],"and":[34,137,157,166],"cerebral":[35],"perfusion":[36],"can":[37,62,85],"be":[38,63,86],"quantified":[39,64],"from":[40],"PET":[41,51,77],"data":[42],"using":[43,117],"tracer":[44],"kinetic":[45,59,74],"modeling":[46],"techniques.":[47],"However,":[48],"noise":[49],"images":[52],"leads":[53],"to":[54,88,103,109,139],"uncertainty":[55],"estimated":[58],"parameters.":[60],"This":[61],"Bayesian":[67],"framework":[68],"by":[69],"posterior":[71,91,112,174],"distribution":[72],"parameters":[75],"given":[76],"measurements.":[78],"Markov":[79],"Chain":[80],"Monte":[81],"Carlo":[82],"(MCMC)":[83],"techniques":[84],"employed":[87],"estimate":[89],"distribution,":[92],"although":[93],"with":[94],"significant":[95,146],"computational":[96],"needs.":[97],"In":[98],"this":[99],"paper,":[100],"we":[101],"propose":[102],"leverage":[104],"deep":[105],"learning":[106],"inference":[107],"efficiency":[108],"infer":[110],"distribution.":[113],"A":[114],"novel":[115],"approach":[116,144],"denoising":[118],"diffusion":[119],"probabilistic":[120],"model":[121],"(DDPM)":[122],"introduced.":[124],"The":[125],"performance":[126],"proposed":[129],"was":[131],"evaluated":[132],"on":[133],"[18F]MK6240":[135],"study":[136],"compared":[138],"an":[140],"MCMC":[141],"method.":[142],"Our":[143],"offered":[145],"reduction":[147],"computation":[149],"time":[150],"(over":[151],"30":[152],"times":[153],"faster":[154],"than":[155],"MCMC)":[156],"consistently":[158],"predicted":[159],"accurate":[160],"(<":[161,168],"0.8":[162],"%":[163,170],"mean":[164],"error)":[165,173],"precise":[167],"5.77":[169],"standard":[171],"deviation":[172],"distributions.":[175]},"counts_by_year":[],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
